{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:52:42Z","timestamp":1787698362880,"version":"build-2784847793"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, Romania","award":["1300\/50\/13.01.2017"],"award-info":[{"award-number":["1300\/50\/13.01.2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acromegaly is a rare endocrine disease characterized by multiple metabolic abnormalities and high cardiovascular risk. This cross-sectional study evaluated the lipidomic serum profile of 109 participants (59 acromegaly patients versus 50 healthy controls) via high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). The lipidomic profile that differentiated acromegaly from controls included sphingomyelins (SMs), glycerophospholipids, glycerolipids, ceramides, fatty acids, wax esters (WEs), carnitines, and sterol (ST) lipids. SM 34:0;O2 and phosphorylcholine best distinguished acromegaly patients from controls (VIP &gt; 2.49). SM 34:0;O2 levels were significantly elevated in treatment-na\u00efve versus uncontrolled patients (p &lt; 0.0001). Furthermore, SM 34:0;O2 positively correlated with random GH and IGF-1. Lack of therapy predicted SM 34:0;O2 serum titers in acromegaly. Profound alterations of glycerophospholipids and sphingolipids were detected in acromegaly patients with cardiovascular complications. ST 24:1;O3, ceramide (Cer) 38:0;O4, and WE 34:1 were significantly increased in both hypertensive acromegaly patients and those with heart failure in comparison to patients without cardiovascular impairment. In conclusion, SM 34:0;O2 and phosphorylcholine emerged as potential lipidomic biomarkers in acromegaly. Moreover, SM 34:0;O2 potentially reflects disease severity. Identifying lipidomic profile alterations in acromegaly patients with cardiac involvement may provide a basis for further insights into the cardiovascular pathogenesis of the disease.<\/jats:p>","DOI":"10.3390\/ijms27021082","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:16:59Z","timestamp":1769159819000},"page":"1082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-7605","authenticated-orcid":false,"given":"Oana","family":"St\u0103noiu-P\u00eenzariu","sequence":"first","affiliation":[{"name":"5th Department of Medical Sciences, Department of Endocrinology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-8776","authenticated-orcid":false,"given":"Thalijn L. C.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-5057","authenticated-orcid":false,"given":"Carmen","family":"Socaciu","sequence":"additional","affiliation":[{"name":"RTD Center of Applied Biotechnology BIODIATECH, SC Proplanta, 400478 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Alina","family":"Silaghi","sequence":"additional","affiliation":[{"name":"5th Department of Medical Sciences, Department of Endocrinology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-2916","authenticated-orcid":false,"given":"Ana","family":"Valea","sequence":"additional","affiliation":[{"name":"5th Department of Medical Sciences, Department of Endocrinology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-5004","authenticated-orcid":false,"given":"Ioana","family":"Popa-Ilie","sequence":"additional","affiliation":[{"name":"5th Department of Medical Sciences, Department of Endocrinology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgeta","family":"Hazi","sequence":"additional","affiliation":[{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Iulia","family":"Socaciu","sequence":"additional","affiliation":[{"name":"Department of Occupational Health, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-0460","authenticated-orcid":false,"given":"Romana Teodora","family":"Netea-Maier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Emanuela","family":"Georgescu","sequence":"additional","affiliation":[{"name":"5th Department of Medical Sciences, Department of Endocrinology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, Cluj County Emergency Clinical Hospital, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/jc.2010-0570","article-title":"Acromegaly without imaging evidence of pituitary adenoma","volume":"95","author":"Lonser","year":"2010","journal-title":"J. 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