{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:19:28Z","timestamp":1789042768612,"version":"build-2803163510"},"reference-count":145,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The tightly controlled and transient acquisition of a motile phenotype by otherwise static epithelial cells (epithelial\u2013mesenchymal transition, EMT) enables the repair of a damaged epithelium. Conversely, a persistent, dysregulated, and exacerbated EMT characterizes epithelial malignancies such as breast carcinoma (BC) and oral squamous cell carcinoma (OSCC), being key for their metastasis and for their escaping anti-tumor immune responses. Herein, we investigated the relationship between EMT signatures and immune cell infiltration across OSCC and metastatic BC with the aim to identify prognostic markers and\/or therapeutic targets common to both these malignancies, or unique to OSCC or BC. To this end, we analyzed publicly available transcriptomic datasets to identify coding genes involved in EMT with strong correlation to immune cell signatures. The methodology consisted of data selection, correlation analysis, signature overlap determination, and validation using independent databases. Results indicated that in both OSCC and BC the expression of EMT-related genes is strongly associated with that of immunosuppressive and pro-tumor macrophages. Notably, the FN1 gene coding for the extracellular matrix glycoprotein fibronectin (FN) emerged as the EMT gene common to either tumor types. In confirmation of this, FN protein levels were higher in OSCC and BC tissues than in their normal counterparts. Given FN capability of favoring tumor invasion and metastasis while hindering antitumor immune responses, these data encourage the development of FN antagonists to be used as an adjunct to conventional therapy in the treatment of both OSCC and BC.<\/jats:p>","DOI":"10.3390\/ijms27031148","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:41:34Z","timestamp":1769164894000},"page":"1148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fibronectin Is a Likely Therapeutic Target Shared by Oral and Breast Carcinomas"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7007-4238","authenticated-orcid":false,"given":"Silvia","family":"Pomella","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"Department of Hematology and Oncology, Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-8896","authenticated-orcid":false,"given":"Roberto","family":"Bei","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-5186","authenticated-orcid":false,"given":"Ombretta","family":"Melaiu","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-4852","authenticated-orcid":false,"given":"Giovanni","family":"Barillari","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"School of Medicine, Saint Camillus International University of Health and Medical Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Manfioletti, G., and Fedele, M. (2023). Epithelial-Mesenchymal Transition (EMT). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411386"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e34269","DOI":"10.1016\/j.heliyon.2024.e34269","article-title":"Epithelial-Mesenchymal Plasticity (EMP) in Wound Healing: Exploring EMT Mechanisms, Regulatory Network, and Therapeutic Opportunities","volume":"10","author":"Yao","year":"2024","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e108647","DOI":"10.15252\/embj.2021108647","article-title":"Dynamic EMT: A Multi-Tool for Tumor Progression","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1476-4598-11-87","article-title":"IL-1\u03b2 Promotes Stemness and Invasiveness of Colon Cancer Cells through Zeb1 Activation","volume":"11","author":"Li","year":"2012","journal-title":"Mol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ebiom.2018.04.023","article-title":"Runt-Related Transcription Factor 1 (RUNX1) Promotes TGF-\u03b2-Induced Renal Tubular Epithelial-to-Mesenchymal Transition (EMT) and Renal Fibrosis through the PI3K Subunit P110\u03b4","volume":"31","author":"Zhou","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pomella, S., Melaiu, O., Dri, M., Martelli, M., Gargari, M., and Barillari, G. (2024). Effects of Angiogenic Factors on the Epithelial-to-Mesenchymal Transition and Their Impact on the Onset and Progression of Oral Squamous Cell Carcinoma: An Overview. Cells, 13.","DOI":"10.3390\/cells13151294"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12943-021-01355-1","article-title":"Targeting CXCR2 Inhibits the Progression of Lung Cancer and Promotes Therapeutic Effect of Cisplatin","volume":"20","author":"Cheng","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12964-022-00888-2","article-title":"Tumor-Associated Macrophages Promote Epithelial-Mesenchymal Transition and the Cancer Stem Cell Properties in Triple-Negative Breast Cancer through CCL2\/AKT\/\u03b2-Catenin Signaling","volume":"20","author":"Chen","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12967-025-06236-5","article-title":"Single-Cell and Spatial Transcriptome Profiling Reveal CTHRC1+\u2009Fibroblasts Promote EMT through WNT5A Signaling in Colorectal Cancer","volume":"23","author":"Lu","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ciani, L., Libonati, A., Dri, M., Pomella, S., Campanella, V., and Barillari, G. (2024). About a Possible Impact of Endodontic Infections by Fusobacterium Nucleatum or Porphyromonas Gingivalis on Oral Carcinogenesis: A Literature Overview. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105083"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13045-022-01347-8","article-title":"The Molecular Mechanisms and Therapeutic Strategies of EMT in Tumor Progression and Metastasis","volume":"15","author":"Huang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrc.2017.05.112","article-title":"CPEB4 Promotes Cell Migration and Invasion via Upregulating Vimentin Expression in Breast Cancer","volume":"489","author":"Lu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.18632\/aging.203093","article-title":"Calycosin Inhibits Breast Cancer Cell Migration and Invasion by Suppressing EMT via BATF\/TGF-\u03921","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sangiorgi, B., de Souza, F.C., Mota de Souza Lima, I., Dos Santos Schiavinato, J.L., Corveloni, A.C., Thom\u00e9, C.H., Ara\u00fajo Silva, W., Fa\u00e7a, V.M., Covas, D.T., and Zago, M.A. (2019). A High-Content Screening Approach to Identify MicroRNAs Against Head and Neck Cancer Cell Survival and EMT in an Inflammatory Microenvironment. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.01100"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"152182","DOI":"10.1016\/j.bbrc.2025.152182","article-title":"MiR-24-2 Targets Akt and Inhibits Cell Survival, EMT, and Tumour Growth in Triple-Negative Breast Cancer","volume":"775","author":"Ali","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14463","DOI":"10.1007\/s13277-016-5334-1","article-title":"Regulation of Epithelial-Mesenchymal Transition through MicroRNAs: Clinical and Biological Significance of MicroRNAs in Breast Cancer","volume":"37","author":"Peng","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10585-014-9690-1","article-title":"Epithelial-Mesenchymal Transition (EMT) Markers Have Prognostic Impact in Multiple Primary Oral Squamous Cell Carcinoma","volume":"32","author":"Morand","year":"2015","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113774","DOI":"10.1016\/j.biopha.2022.113774","article-title":"EMT Mechanism in Breast Cancer Metastasis and Drug Resistance: Revisiting Molecular Interactions and Biological Functions","volume":"155","author":"Hashemi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.2147\/OTT.S251518","article-title":"LncRNA MALAT1 Promotes EMT Process and Cisplatin Resistance of Oral Squamous Cell Carcinoma via PI3K\/AKT\/m-TOR Signal Pathway","volume":"13","author":"Wang","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pai, S., Bamodu, O.A., Lin, Y.-K., Lin, C.-S., Chu, P.-Y., Chien, M.-H., Wang, L.-S., Hsiao, M., Yeh, C.-T., and Tsai, J.-T. (2019). CD47-SIRP\u03b1 Signaling Induces Epithelial-Mesenchymal Transition and Cancer Stemness and Links to a Poor Prognosis in Patients with Oral Squamous Cell Carcinoma. Cells, 8.","DOI":"10.3390\/cells8121658"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Soundararajan, R., Fradette, J.J., Konen, J.M., Moulder, S., Zhang, X., Gibbons, D.L., Varadarajan, N., Wistuba, I.I., Tripathy, D., and Bernatchez, C. (2019). Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers, 11.","DOI":"10.3390\/cancers11050714"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3892\/ijo.2016.3785","article-title":"Regulation of PD-L1 Expression in a High-Grade Invasive Human Oral Squamous Cell Carcinoma Microenvironment","volume":"50","author":"Hirai","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.62347\/PNGT6996","article-title":"Immune Evasion and Resistance in Breast Cancer","volume":"15","author":"Ababneh","year":"2025","journal-title":"Am. J. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41368-021-00131-7","article-title":"Tumor Microenvironment and Immune Evasion in Head and Neck Squamous Cell Carcinoma","volume":"13","author":"Elmusrati","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ccr.2009.01.023","article-title":"Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells","volume":"15","author":"Shirako","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ccr.2014.03.021","article-title":"A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis","volume":"25","author":"Su","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/1878-0261.12093","article-title":"New Insights into the Role of EMT in Tumor Immune Escape","volume":"11","author":"Terry","year":"2017","journal-title":"Mol. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1158\/1078-0432.CCR-20-4459","article-title":"Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition","volume":"27","author":"Taki","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00262-020-02669-7","article-title":"Integrated Analysis of Single-Cell RNA-Seq and Bulk RNA-Seq Unravels Tumour Heterogeneity plus M2-like Tumour-Associated Macrophage Infiltration and Aggressiveness in TNBC","volume":"70","author":"Bao","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Messeha, S.S., Zarmouh, N.O., and Soliman, K.F.A. (2021). Polyphenols Modulating Effects of PD-L1\/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer. Nutrients, 13.","DOI":"10.3390\/nu13051718"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41572-019-0111-2","article-title":"Breast Cancer","volume":"5","author":"Harbeck","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/ijc.33352","article-title":"Epithelial-to-Mesenchymal Transition in Oral Squamous Cell Carcinoma: Challenges and Opportunities","volume":"148","author":"Ling","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Parris, T.Z., Aziz, L., Kov\u00e1cs, A., Hajizadeh, S., Nemes, S., Semaan, M., Chen, C.Y., Karlsson, P., and Helou, K. (2014). Clinical Relevance of Breast Cancer-Related Genes as Potential Biomarkers for Oral Squamous Cell Carcinoma. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-324"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2741\/4844","article-title":"EMT in Breast Cancer Metastasis: An Interplay of MicroRNAs, Signaling Pathways and Circulating Tumor Cells","volume":"25","author":"Kumar","year":"2020","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hasmim, M., Xiao, M., Van Moer, K., Kumar, A., Oniga, A., Mittelbronn, M., Duhem, C., Chammout, A., Berchem, G., and Thiery, J.P. (2022). SNAI1-Dependent Upregulation of CD73 Increases Extracellular Adenosine Release to Mediate Immune Suppression in TNBC. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.982821"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, S.-Y., Ren, X.-Y., Wang, C.-Y., Chen, X.-J., Cao, R.-Y., Liu, Q., Pan, X., Zhou, J.-Y., Zhang, W.-L., and Tang, X.-R. (2021). Comprehensive Characterization of Immune Landscape Based on Epithelial-Mesenchymal Transition Signature in OSCC: Implication for Prognosis and Immunotherapy. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.587862"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xavier, F.C.A., Silva, J.C., Rodini, C.O., and Rodrigues, M.F.S.D. (2022). Mechanisms of Immune Evasion by Head and Neck Cancer Stem Cells. Front. Oral Health, 3.","DOI":"10.3389\/froh.2022.957310"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1158\/0008-5472.CAN-23-3803","article-title":"Myeloid Cells Pave the Metastatic Road in Breast Cancer","volume":"84","author":"Michaud","year":"2024","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33159","DOI":"10.18632\/oncotarget.16565","article-title":"Preferential Accumulation of Regulatory T Cells with Highly Immunosuppressive Characteristics in Breast Tumor Microenvironment","volume":"8","author":"Toor","year":"2017","journal-title":"Oncotarget"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lescaille, G., Menashi, S., Cavelier-Balloy, B., Khayati, F., Quemener, C., Podgorniak, M.P., Na\u00efmi, B., Calvo, F., Lebbe, C., and Mourah, S. (2012). EMMPRIN\/CD147 up-Regulates Urokinase-Type Plasminogen Activator: Implications in Oral Tumor Progression. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-115"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"795","DOI":"10.5005\/jp-journals-10024-2129","article-title":"Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma","volume":"18","author":"Satelur","year":"2017","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tripleo.2006.05.028","article-title":"Cell-Surface Density of Complement Restriction Factors (CD46, CD55, and CD59): Oral Squamous Cell Carcinoma versus Other Solid Tumors","volume":"103","author":"Ravindranath","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/ijc.28497","article-title":"Additive Effect of the AZGP1, PIP, S100A8 and UBE2C Molecular Biomarkers Improves Outcome Prediction in Breast Carcinoma","volume":"134","author":"Parris","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1038\/s41467-024-47684-9","article-title":"AZGP1 in POMC Neurons Modulates Energy Homeostasis and Metabolism through Leptin-Mediated STAT3 Phosphorylation","volume":"15","author":"Qiu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpsychires.2018.03.008","article-title":"Changes in Methylation within the STK32B Promoter Are Associated with an Increased Risk for Generalized Anxiety Disorder in Adolescents","volume":"102","author":"Ciuculete","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., and Ma, J. (2018). S100A8\/A9 in Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01298"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1158\/0008-5472.CAN-07-5516","article-title":"Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis","volume":"68","author":"Finetti","year":"2008","journal-title":"Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s13277-010-0137-2","article-title":"The Role of S100 Genes in Breast Cancer Progression","volume":"32","author":"McKiernan","year":"2011","journal-title":"Tumour Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1515\/cclm-2025-1159","article-title":"Predictive Genomic Medicine Enlarges the Spectrum of Predisposing Mutations for Head and Neck Cancers via a Panel of 56 Genes Selected for Human Neoplasia in Southern Italy: A Pilot Study","volume":"64","author":"Togo","year":"2026","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.36740\/WLek\/209542","article-title":"The Role of Menopausal Hormone Therapy in Hormone-Dependent Carcinogenic Mechanisms in the Oral Cavity: A Literature Review","volume":"78","author":"Peterek","year":"2025","journal-title":"Wiad. Lek."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2353\/ajpath.2010.090703","article-title":"Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin","volume":"177","author":"Cueni","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.oraloncology.2008.07.018","article-title":"The Val Allele of HER-2 Codon 655 Predicts the Progression of Oral Squamous Cell Carcinoma","volume":"45","author":"Wu","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kawczak, P., Feszak, I.J., and B\u0105czek, T. (2025). Comparative Mechanistic Insights and Therapeutic Potential of Pembrolizumab, Durvalumab, and Ipilimumab as Immune Checkpoint Inhibitors in the Targeted Management of Oral and Head and Neck Squamous Cell Carcinoma. Cancers, 17.","DOI":"10.3390\/cancers17172805"},{"key":"ref_54","first-page":"322","article-title":"The Treatment of Breast Cancer in the Era of Precision Medicine","volume":"22","author":"Bai","year":"2025","journal-title":"Cancer Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41416-020-01178-9","article-title":"EMTome: A Resource for Pan-Cancer Analysis of Epithelial-Mesenchymal Transition Genes and Signatures","volume":"124","author":"Vasaikar","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e006433","DOI":"10.1136\/jitc-2022-006433","article-title":"Invasive Margin Tissue-Resident Macrophages of High CD163 Expression Impede Responses to T Cell-Based Immunotherapy","volume":"11","author":"Labrie","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.7150\/ijbs.91519","article-title":"TREM2 Promotes Macrophage Polarization from M1 to M2 and Suppresses Osteoarthritis through the NF-\u039aB\/CXCL3 Axis","volume":"20","author":"Fang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41392-020-00356-8","article-title":"TREM2 Marks Tumor-Associated Macrophages","volume":"5","author":"Nakamura","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Molgora, M., Esaulova, E., Vermi, W., Hou, J., Chen, Y., Luo, J., Brioschi, S., Bugatti, M., Omodei, A.S., and Ricci, B. (2020). TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell, 182.","DOI":"10.1016\/j.cell.2020.07.013"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e13211","DOI":"10.1016\/j.heliyon.2023.e13211","article-title":"A New Method for Predicting the Prognosis of Colorectal Cancer Patients through a Combination of Multiple Tumor-Associated Macrophage Markers at the Invasive Front","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"16554","DOI":"10.1038\/s41598-020-73624-w","article-title":"M1 Macrophage and M1\/M2 Ratio Defined by Transcriptomic Signatures Resemble Only Part of Their Conventional Clinical Characteristics in Breast Cancer","volume":"10","author":"Oshi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/carcin\/bgt340","article-title":"ZEB2-Sp1 Cooperation Induces Invasion by Upregulating Cadherin-11 and Integrin A5 Expression","volume":"35","author":"Nam","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1038\/s41598-023-37977-2","article-title":"Molecular Determinants of Epithelial Mesenchymal Transition in Mouse Placenta and Trophoblast Stem Cell","volume":"13","author":"Jena","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13048-023-01304-0","article-title":"Proteomic Analysis of Exosomes Secreted during the Epithelial-Mesenchymal Transition and Potential Biomarkers of Mesenchymal High-Grade Serous Ovarian Carcinoma","volume":"16","author":"Ferreira","year":"2023","journal-title":"J. Ovarian Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1186\/s12967-025-06793-9","article-title":"COL6A2 in Clear Cell Renal Cell Carcinoma: A Multifaceted Driver of Tumor Progression, Immune Evasion, and Drug Sensitivity","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"100177","DOI":"10.1016\/j.labinv.2023.100177","article-title":"Expression of Genes Associated with Epithelial-Mesenchymal Transition in Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma","volume":"103","author":"Karpinski","year":"2023","journal-title":"Lab. Investig."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3892\/ol.2022.13657","article-title":"Long Non-Coding RNA PVT1 Promotes the Proliferation, Migration and EMT Process of Ovarian Cancer Cells by Regulating CTGF","volume":"25","author":"Dong","year":"2023","journal-title":"Oncol. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.7150\/thno.38875","article-title":"NOTCH4 Maintains Quiescent Mesenchymal-like Breast Cancer Stem Cells via Transcriptionally Activating SLUG and GAS1 in Triple-Negative Breast Cancer","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13048-025-01705-3","article-title":"Silencing of STX4 Inhibits the Proliferation, Migration and Invasion of Ovarian Cancer Cells via EMT\/MMP2\/CCND1 Signaling Pathway","volume":"18","author":"Ye","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Shi, C., Xie, Y., Li, X., Li, G., Liu, W., Pei, W., Liu, J., Yu, X., and Liu, T. (2021). Identification of Ferroptosis-Related Genes Signature Predicting the Efficiency of Invasion and Metastasis Ability in Colon Adenocarcinoma. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.815104"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40164-023-00419-w","article-title":"Fibronectin Promotes Tumor Angiogenesis and Progression of Non-Small-Cell Lung Cancer by Elevating WISP3 Expression via FAK\/MAPK\/HIF-1\u03b1 Axis and Activating Wnt Signaling Pathway","volume":"12","author":"Zhou","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/mc.23933","article-title":"Downregulation of HTRA1 Promotes EMT and Anoikis Resistance in Colorectal Cancer via Activation of Hippo\/YAP1 Pathway by Facilitating LATS2 Degradation","volume":"64","author":"Jiang","year":"2025","journal-title":"Mol. Carcinog."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.3892\/ijo.2014.2332","article-title":"Biological Characterization and Analysis of Metastasis-Related Genes in Cell Lines Derived from the Primary Lesion and Lymph Node Metastasis of a Squamous Cell Carcinoma Arising in the Mandibular Gingiva","volume":"44","author":"Fujinaga","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wang, N., Eckert, K.A., Zomorrodi, A.R., Xin, P., Pan, W., Shearer, D.A., Weisz, J., Maranus, C.D., and Clawson, G.A. (2012). Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039446"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kartha, V.K., Stawski, L., Han, R., Haines, P., Gallagher, G., Noonan, V., Kukuruzinska, M., Monti, S., and Trojanowska, M. (2016). PDGFR\u03b2 Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154645"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/cbin.11875","article-title":"Silencing of COL3A1 Represses Proliferation, Migration, Invasion, and Immune Escape of Triple Negative Breast Cancer Cells via down-Regulating PD-L1 Expression","volume":"46","author":"Yang","year":"2022","journal-title":"Cell Biol. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"BSR20211615","DOI":"10.1042\/BSR20211615","article-title":"Identification of Potential Genes Related to Breast Cancer Brain Metastasis in Breast Cancer Patients","volume":"41","author":"Zhang","year":"2021","journal-title":"Biosci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e04278","DOI":"10.1002\/smll.202504278","article-title":"Noninvasive and Sensitive Biosensor for the Detection of Oral Cancer Prognostic Biomarkers","volume":"21","author":"Granato","year":"2025","journal-title":"Small"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S1357-2725(99)00090-4","article-title":"SPARC (Osteonectin\/BM-40)","volume":"31","author":"Motamed","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15581","DOI":"10.1002\/jcp.28205","article-title":"SPARC Promotes the Proliferation and Metastasis of Oral Squamous Cell Carcinoma by PI3K\/AKT\/PDGFB\/PDGFR\u03b2 Axis","volume":"234","author":"Jing","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8600419","DOI":"10.1155\/2022\/8600419","article-title":"Prognostic Significance of SPARC Expression in Breast Cancer: A Meta-Analysis and Bioinformatics Analysis","volume":"2022","author":"Shi","year":"2022","journal-title":"Biom. Res. Int."},{"key":"ref_83","first-page":"5529","article-title":"SPARC\/Osteonectin Induces Matrix Metalloproteinase 2 Activation in Human Breast Cancer Cell Lines","volume":"58","author":"Gilles","year":"1998","journal-title":"Cancer Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Efthymiou, G., Saint, A., Ruff, M., Rekad, Z., Ciais, D., and Van Obberghen-Schilling, E. (2020). Shaping Up the Tumor Microenvironment with Cellular Fibronectin. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00641"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, H., Zhang, J., Li, H., Yu, H., Chen, S., Liu, S., Zhang, C., and He, Y. (2022). FN1 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Gastric Cancers. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.918719"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"154179","DOI":"10.1016\/j.prp.2022.154179","article-title":"High FN1 Expression Correlates with Gastric Cancer Progression","volume":"239","author":"Li","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1007\/s00432-023-04572-x","article-title":"Integration of Transcriptomics and Metabolomics Reveals a Novel Gene Signature Guided by FN1 Associated with Immune Response in Oral Squamous Cell Carcinoma Tumorigenesis","volume":"149","author":"Peng","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ko, Y.-C., Lai, T.-Y., Hsu, S.-C., Wang, F.-H., Su, S.-Y., Chen, Y.-L., Tsai, M.-L., Wu, C.-C., Hsiao, J.-R., and Chang, J.-Y. (2020). Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial-Mesenchymal Transition Score in Prognosis Prediction. Cancers, 12.","DOI":"10.3390\/cancers12071718"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"105925","DOI":"10.1016\/j.archoralbio.2024.105925","article-title":"Up-Regulation of Extracellular-Matrix and Inflammation Related Genes in Oral Squamous Cell Carcinoma","volume":"161","author":"Thakore","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"ref_90","first-page":"L726","article-title":"Fibronectin and Its Alpha 5 Beta 1-Integrin Receptor Are Involved in the Wound-Repair Process of Airway Epithelium","volume":"271","author":"Pierrot","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/tox.22410","article-title":"Cinnamomum Cassia Extracts Reverses TGF-\u03921-Induced Epithelial-Mesenchymal Transition in Human Lung Adenocarcinoma Cells and Suppresses Tumor Growth in Vivo","volume":"32","author":"Lin","year":"2017","journal-title":"Environ. Toxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.7150\/thno.46460","article-title":"Cisplatin Prevents Breast Cancer Metastasis through Blocking Early EMT and Retards Cancer Growth Together with Paclitaxel","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/tox.22542","article-title":"Antimetastatic Potentials of Salvianolic Acid A on Oral Squamous Cell Carcinoma by Targeting MMP-2 and the c-Raf\/MEK\/ERK Pathway","volume":"33","author":"Fang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/01635581.2015.1073763","article-title":"Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2\/9","volume":"67","author":"Li","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e32444","DOI":"10.1097\/MD.0000000000032444","article-title":"A Pan-Cancer Analysis of the Oncogenic Role of Procollagen C-Endopeptidase Enhancer (PCOLCE) in Human","volume":"101","author":"Gao","year":"2022","journal-title":"Medicine"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ai, J., Tan, Y., Liu, B., Song, Y., Wang, Y., Xia, X., and Fu, Q. (2023). Systematic Establishment and Verification of an Epithelial-Mesenchymal Transition Gene Signature for Predicting Prognosis of Oral Squamous Cell Carcinoma. Front. Genet., 14.","DOI":"10.3389\/fgene.2023.1113137"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.2147\/CMAR.S238830","article-title":"LncRNA LUADT1 Promotes Oral Squamous Cell Carcinoma Cell Proliferation by Regulating MiR-34a\/GAS1 Axis","volume":"12","author":"Gao","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Wei, Y., Cheng, X., Deng, L., Dong, H., Wei, H., Xie, C., Tuo, Y., Li, G., Yu, D., and Cao, Y. (2023). Expression Signature and Molecular Basis of CDH11 in OSCC Detected by a Combination of Multiple Methods. BMC Med. Genom., 16.","DOI":"10.1186\/s12920-023-01499-7"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1158\/0008-5472.CAN-21-1331","article-title":"Extracellular Vesicle-Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells","volume":"82","author":"Li","year":"2022","journal-title":"Cancer Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/stem.2219","article-title":"LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway","volume":"34","author":"Zhou","year":"2016","journal-title":"Stem Cells"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10565-024-09983-1","article-title":"HSP27\/IL-6 Axis Promotes OSCC Chemoresistance, Invasion and Migration by Orchestrating Macrophages via a Positive Feedback Loop","volume":"41","author":"Qi","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3892\/or.2015.4016","article-title":"HtrA1: Its Future Potential as a Novel Biomarker for Cancer","volume":"34","author":"Altobelli","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Dettogni, R.S., Stur, E., Laus, A.C., da Costa Vieira, R.A., Marques, M.M.C., Santana, I.V.V., Pulido, J.Z., Ribeiro, L.F., de Jesus Parmanhani, N., and Agostini, L.P. (2020). Potential Biomarkers of Ductal Carcinoma in Situ Progression. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-6608-y"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.yexcr.2014.06.016","article-title":"A Soluble Form of GAS1 Inhibits Tumor Growth and Angiogenesis in a Triple Negative Breast Cancer Model","volume":"327","author":"Estudillo","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcyt.2020.09.011","article-title":"The Systemic Administration of Neural Stem Cells Expressing an Inducible and Soluble Form of Growth Arrest Specific 1 Inhibits Mammary Gland Tumor Growth and the Formation of Metastases","volume":"23","author":"Navarrete","year":"2021","journal-title":"Cytotherapy"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1067\/moe.2003.121","article-title":"Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 Expression in Human Oral Squamous Cell Carcinoma and the Effect of Protein Kinase C Inhibitors: Preliminary Observations","volume":"95","author":"Tsai","year":"2003","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Yen, Y.-T., Yang, J.-C., Chang, J.-B., and Tsai, S.-C. (2021). Down-Regulation of MiR-194-5p for Predicting Metastasis in Breast Cancer Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010325"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1002\/cncr.11395","article-title":"Matrix Metalloproteinase Inhibitor Reversion-inducing Cysteine-rich Protein with Kazal Motifs","volume":"97","author":"Span","year":"2003","journal-title":"Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/apm.12285","article-title":"Expression Patterns of Stromal MMP-2 and Tumoural MMP-2 and -9 Are Significant Prognostic Factors in Invasive Ductal Carcinoma of the Breast","volume":"122","author":"Min","year":"2014","journal-title":"APMIS"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.200212079","article-title":"Regulated Splicing of the Fibronectin EDA Exon Is Essential for Proper Skin Wound Healing and Normal Lifespan","volume":"162","author":"Muro","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1074\/jbc.M111.328120","article-title":"P63 Regulates Human Keratinocyte Proliferation via MYC-Regulated Gene Network and Differentiation Commitment through Cell Adhesion-Related Gene Network","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00690290","article-title":"Fibronectin and Integrins in Invasion and Metastasis","volume":"14","author":"Akiyama","year":"1995","journal-title":"Cancer Metastasis Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2353\/ajpath.2010.090748","article-title":"Metastatic Outgrowth Encompasses COL-I, FN1, and POSTN up-Regulation and Assembly to Fibrillar Networks Regulating Cell Adhesion, Migration, and Growth","volume":"177","author":"Soikkeli","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3892\/mmr.2022.12618","article-title":"GATA6-induced FN1 Activation Promotes the Proliferation, Invasion and Migration of Oral Squamous Cell Carcinoma Cells","volume":"25","author":"Zhai","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.matbio.2019.07.006","article-title":"Scaffold Stiffness Influences Breast Cancer Cell Invasion via EGFR-Linked Mena Upregulation and Matrix Remodeling","volume":"85\u201386","author":"Berger","year":"2020","journal-title":"Matrix Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/s41388-025-03359-3","article-title":"Fibroblast Activation Protein (FAP)+ Cancer-Associated Fibroblasts Induce Macrophage M2-like Polarization via the Fibronectin 1-Integrin A5\u03b21 Axis in Breast Cancer","volume":"44","author":"Chen","year":"2025","journal-title":"Oncogene"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.2147\/IJGM.S364708","article-title":"The Overexpression of Fibronectin 1 Promotes Cancer Progression and Associated with M2 Macrophages Polarization in Head and Neck Squamous Cell Carcinoma Patients","volume":"15","author":"Zhou","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Zhu, X., Li, Y., Liu, H., and Xiao, Z. (2025). FN1 from Cancer-Associated Fibroblasts Orchestrates Pancreatic Cancer Metastasis via Integrin-PI3K\/AKT Signaling. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1595523"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1021\/jo300311q","article-title":"Cyclic Aza-Peptide Integrin Ligand Synthesis and Biological Activity","volume":"77","author":"Spiegel","year":"2012","journal-title":"J. Org. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.4161\/cc.8.14.8980","article-title":"Integrin Alpha5beta1 Controls Invasion of Human Breast Carcinoma Cells by Direct and Indirect Modulation of MMP-2 Collagenase Activity","volume":"8","author":"Morozevich","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1748-717X-8-246","article-title":"In Vitro Study of Combined Cilengitide and Radiation Treatment in Breast Cancer Cell Lines","volume":"8","author":"Lautenschlaeger","year":"2013","journal-title":"Radiat. Oncol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1124\/mol.118.113027","article-title":"Differential Effects of Integrin Av Knockdown and Cilengitide on Sensitization of Triple-Negative Breast Cancer and Melanoma Cells to Microtubule Poisons","volume":"94","author":"Majhen","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/jop.70004","article-title":"A Study on Regulating OSCC Cell Function by Blocking Integrin Av\u03b23 with Cilengitide","volume":"54","author":"Zeng","year":"2025","journal-title":"J. Oral Pathol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/annonc\/mdm140","article-title":"Assessment of the Biological and Pharmacological Effects of the Alpha Nu Beta3 and Alpha Nu Beta5 Integrin Receptor Antagonist, Cilengitide (EMD 121974), in Patients with Advanced Solid Tumors","volume":"18","author":"Hariharan","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2176\/nmc.52.539","article-title":"Cilengitide Treatment for Malignant Glioma: Current Status and Future Direction","volume":"52","author":"Kurozumi","year":"2012","journal-title":"Neurol. Med. Chir."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/neuonc\/noad247","article-title":"Treatment-Associated Imaging Changes in Newly Diagnosed MGMT Promoter-Methylated Glioblastoma Undergoing Chemoradiation with or without Cilengitide","volume":"26","author":"Flies","year":"2024","journal-title":"Neuro Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10637-010-9573-5","article-title":"Phase II Study of Cilengitide (EMD 121974, NSC 707544) in Patients with Non-Metastatic Castration Resistant Prostate Cancer, NCI-6735. A Study by the DOD\/PCF Prostate Cancer Clinical Trials Consortium","volume":"30","author":"Alva","year":"2012","journal-title":"Investig. New Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/annonc\/mdu003","article-title":"Cisplatin, 5-Fluorouracil, and Cetuximab (PFE) with or without Cilengitide in Recurrent\/Metastatic Squamous Cell Carcinoma of the Head and Neck: Results of the Randomized Phase I\/II ADVANTAGE Trial (Phase II Part)","volume":"25","author":"Vermorken","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Friess, H., Langrehr, J.M., Oettle, H., Raedle, J., Niedergethmann, M., Dittrich, C., Hossfeld, D.K., St\u00f6ger, H., Neyns, B., and Herzog, P. (2006). A Randomized Multi-Center Phase II Trial of the Angiogenesis Inhibitor Cilengitide (EMD 121974) and Gemcitabine Compared with Gemcitabine Alone in Advanced Unresectable Pancreatic Cancer. BMC Cancer, 6.","DOI":"10.1186\/1471-2407-6-285"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/CMR.0b013e32835312e4","article-title":"A Randomized Phase II Study of Cilengitide (EMD 121974) in Patients with Metastatic Melanoma","volume":"22","author":"Kim","year":"2012","journal-title":"Melanoma Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10637-012-9842-6","article-title":"Randomized Phase II Study of Three Doses of the Integrin Inhibitor Cilengitide versus Docetaxel as Second-Line Treatment for Patients with Advanced Non-Small-Cell Lung Cancer","volume":"31","author":"Manegold","year":"2013","journal-title":"Investig. New Drugs"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13058-024-01942-2","article-title":"Cilengitide Sensitivity Is Predicted by Overall Integrin Expression in Breast Cancer","volume":"26","author":"Girnius","year":"2024","journal-title":"Breast Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Dalton, C.J., and Lemmon, C.A. (2021). Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling. Cells, 10.","DOI":"10.20944\/preprints202108.0010.v1"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10585-015-9741-2","article-title":"Cellular Fibronectin 1 Promotes VEGF-C Expression, Lymphangiogenesis and Lymph Node Metastasis Associated with Human Oral Squamous Cell Carcinoma","volume":"32","author":"Morita","year":"2015","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Jin, Y., Zhu, H., Cai, W., Fan, X., Wang, Y., Niu, Y., Song, F., and Bu, Y. (2017). B-Myb Is Up-Regulated and Promotes Cell Growth and Motility in Non-Small Cell Lung Cancer. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18060860"},{"key":"ref_136","first-page":"1201","article-title":"SRY-related HMG Box-2 Role in Anaplastic Thyroid Cancer Aggressiveness Is Related to the Fibronectin 1 and PI3K\/AKT Pathway","volume":"21","author":"Wang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s43556-022-00110-2","article-title":"Targeting the PI3K\/AKT\/MTOR and RAF\/MEK\/ERK Pathways for Cancer Therapy","volume":"3","author":"Li","year":"2022","journal-title":"Mol. Biomed."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"111218","DOI":"10.1016\/j.cbi.2024.111218","article-title":"Alkaloid-Based Modulators of the PI3K\/Akt\/MTOR Pathway for Cancer Therapy: Understandings from Pharmacological Point of View","volume":"402","author":"Mokhfi","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"105579","DOI":"10.1016\/j.phrs.2021.105579","article-title":"Properties of FDA-Approved Small Molecule Phosphatidylinositol 3-Kinase Inhibitors Prescribed for the Treatment of Malignancies","volume":"168","author":"Roskoski","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Pomella, S., D\u2019Archivio, L., Cassandri, M., Aiello, F.A., Melaiu, O., Marampon, F., Rota, R., and Barillari, G. (2025). The HIV Protease Inhibitor Ritonavir Reverts the Mesenchymal Phenotype Induced by Inflammatory Cytokines in Normal and Tumor Oral Keratinocytes to an Epithelial One, Increasing the Radiosensitivity of Tumor Oral Keratinocytes. Cancers, 17.","DOI":"10.3390\/cancers17152519"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/1078-0432.CCR-05-1167","article-title":"Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer","volume":"12","author":"Srirangam","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ijc.29812","article-title":"Ritonavir Inhibits Intratumoral Docetaxel Metabolism and Enhances Docetaxel Antitumor Activity in an Immunocompetent Mouse Breast Cancer Model","volume":"138","author":"Hendrikx","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_143","first-page":"165","article-title":"Protease Inhibitor Plasma Concentrations in HIV Antiretroviral Therapy","volume":"55","author":"Justesen","year":"2008","journal-title":"Dan. Med. Bull."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and Interpreting Cancer Genomics Data via the Xena Platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Pomella, S., Cassandri, M., Melaiu, O., Marampon, F., Gargari, M., Campanella, V., Rota, R., and Barillari, G. (2023). DNA Damage Response Gene Signature as Potential Treatment Markers for Oral Squamous Cell Carcinoma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032673"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1148\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:42:59Z","timestamp":1769164979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":145,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031148"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031148","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]}}}