{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:10:28Z","timestamp":1777392628576,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"crossref","award":["075-15-2025-486"],"award-info":[{"award-number":["075-15-2025-486"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute respiratory distress syndrome (ARDS) is a common condition among intensive care unit patients and is associated with high mortality. Currently, there are no unified therapeutic strategies, including for the use of systemic glucocorticosteroid (GCS) therapy, in the management of ARDS of various etiologies. Using our previously developed non-surgical and reproducible model of unilateral total diffuse alveolar damage (ARDS\/DAD) in the left lung of ICR mice, we investigated the effects of GCS with different durations of action and administration regimens on lung function recovery. Our data show that repeated-course administration of dexamethasone promoted complete normalization of respiratory function, as well as restoration of aeration and perfusion of the left lung in mice following ARDS\/DAD induction. In contrast, a single administration of the same drug or the use of a prolonged-release formulation, despite exhibiting anti-inflammatory effects, did not provide adequate lung tissue recovery and, in some cases, even exacerbated injury. These results underscore that in ARDS therapy, not just the use but the specific dosing regimen of glucocorticoids is critically important for driving complete functional and structural lung repair.<\/jats:p>","DOI":"10.3390\/ijms27031199","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:14:23Z","timestamp":1769415263000},"page":"1199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Critical Role of Steroid Regimen for Lung Repair in Experimental Diffuse Alveolar Damage"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-1656","authenticated-orcid":false,"given":"Aleksandr","family":"Chernov","sequence":"first","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia"},{"name":"Branch of Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgii","family":"Telegin","sequence":"additional","affiliation":[{"name":"Branch of Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-5932","authenticated-orcid":false,"given":"Evgeny","family":"Sinitsyn","sequence":"additional","affiliation":[{"name":"\u201cPulmonology Scientific Research Institute\u201d Under Federal Medical and Biological Agency of Russian Federation, Moscow 115682, Russia"},{"name":"Department of Faculty Therapy and Occupational Diseases, N.A. Semashko Scientific and Educational Institute of Clinical Medicine, \u201cRussian University of Medicine\u201d Under the Ministry of Health of Russia, Moscow 127006, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3126-5898","authenticated-orcid":false,"given":"Alexey","family":"Dmitriev","sequence":"additional","affiliation":[{"name":"Branch of Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-4477","authenticated-orcid":false,"given":"Viktor","family":"Palikov","sequence":"additional","affiliation":[{"name":"Branch of Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0898-4213","authenticated-orcid":false,"given":"Vitaly","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Branch of Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia"},{"name":"\u201cState Research Center for Applied Microbiology and Biotechnology\u201d, Obolensk 142279, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maksim","family":"Rodionov","sequence":"additional","affiliation":[{"name":"A.F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Obninsk 249036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Rybalkin","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Cardiology Named After Academician E.I. Chazov, Ministry of Health of Russia, Moscow 121552, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-1080","authenticated-orcid":false,"given":"Tatiana","family":"Vlasik","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Cardiology Named After Academician E.I. Chazov, Ministry of Health of Russia, Moscow 121552, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-9621","authenticated-orcid":false,"given":"Alexey","family":"Belogurov","sequence":"additional","affiliation":[{"name":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-2632","authenticated-orcid":false,"given":"Kirill","family":"Zykov","sequence":"additional","affiliation":[{"name":"\u201cPulmonology Scientific Research Institute\u201d Under Federal Medical and Biological Agency of Russian Federation, Moscow 115682, Russia"},{"name":"Department of Faculty Therapy and Occupational Diseases, N.A. Semashko Scientific and Educational Institute of Clinical Medicine, \u201cRussian University of Medicine\u201d Under the Ministry of Health of Russia, Moscow 127006, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","article-title":"A New Global Definition of Acute Respiratory Distress Syndrome","volume":"209","author":"Matthay","year":"2024","journal-title":"Am. J. Respir. Crit. 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