{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:58:58Z","timestamp":1788026338514,"version":"build-2784847793"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2023-00209827"],"award-info":[{"award-number":["RS-2023-00209827"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Heavy metal exposure is increasingly linked to impaired childhood growth, but the biological mechanisms are poorly understood. Here, we assessed associations between heavy metal exposure and growth impairment (idiopathic short stature [ISS] and growth hormone deficiency [GHD]) in 36 children (24 cases, 12 controls, males 41.7%), identifying related alterations in circulating exosomal miRNAs. Blood\/urine concentrations of nine metals, including Pb, As, and Hg were measured, and serum exosomal miRNAs were profiled via sequencing. Elevated heavy metal exposure was associated with significantly increased proportions of ISS and GHD. Specifically, high blood Pb was associated with ISS (p = 0.01) and high urinary As with overall short stature (p = 0.03). Elevated urinary Hg showed a marginal association with GHD (p = 0.07). Differentially expressed miRNAs were identified: hsa-miR-4488 was downregulated in high-Pb and ISS groups, whereas hsa-miR-133a-3p and hsa-miR-4516 were upregulated in high urinary Hg\/As and GHD groups. Predicted targets of these miRNAs involved growth hormone (GH)\u2013insulin-like growth factor-1 (IGF-1) signaling and endochondral ossification. In conclusion, Pb, As, and Hg exposures were associated with impaired growth in children. The dysregulation of related miRNAs suggests biological mechanisms involving both local growth-plate dysfunction and GH-IGF1 signaling disruption.<\/jats:p>","DOI":"10.3390\/ijms27031230","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:48:30Z","timestamp":1769442510000},"page":"1230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Circulating Exosomal MicroRNA Profiles Associated with Heavy Metal Exposure and Short Stature in Children"],"prefix":"10.3390","volume":"27","author":[{"given":"Min Won","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3431-2157","authenticated-orcid":false,"given":"Heeji","family":"Kim","sequence":"additional","affiliation":[{"name":"Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-122X","authenticated-orcid":false,"given":"Shin-Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000471876","article-title":"The physiology of childhood growth: Hormonal regulation","volume":"88","author":"Benyi","year":"2017","journal-title":"Horm. Res. Paediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12020-024-03778-4","article-title":"Epidemiology of growth hormone deficiency in children and adolescents: A systematic review","volume":"85","author":"Mameli","year":"2024","journal-title":"Endocrine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.6065\/apem.2244120.060","article-title":"Growth plate extracellular matrix defects and short stature in children","volume":"27","author":"Saltarelli","year":"2022","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112375","DOI":"10.1016\/j.envres.2021.112375","article-title":"Exposure to metal mixtures and growth indicators at 4\u20135 years. A study in the INMA-Asturias cohort","volume":"204","author":"Karagas","year":"2022","journal-title":"Environ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.envint.2018.11.031","article-title":"Lead exposure during childhood and subsequent anthropometry through adolescence in girls","volume":"122","author":"Deierlein","year":"2019","journal-title":"Environ. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-019-0273-8","article-title":"Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification","volume":"16","author":"Vandenberg","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Balali-Mood, M., Naseri, K., Tahergorabi, Z., Khazdair, M.R., and Sadeghi, M. (2021). Toxic mechanisms of five heavy metals: Mercury, lead, chromium, cadmium, and arsenic. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.643972"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1289\/ehp.1206105","article-title":"Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys","volume":"121","author":"Fleisch","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ahmed, S., Rekha, R.S., Ahsan, K.B., Doi, M., Grand\u00e9r, M., Roy, A.K., Ekstr\u00f6m, E.C., Wagatsuma, Y., Vahter, M., and Raqib, R. (2013). Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081530"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/etc.5296","article-title":"Effects of separate and combined exposure of cadmium and lead on the endochondral ossification in Bufo gargarizans","volume":"41","author":"Chen","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1007\/s00204-024-03772-9","article-title":"Molecular mechanisms of environmental pollutant-induced cartilage damage: From developmental disorders to osteoarthritis","volume":"98","author":"Skalny","year":"2024","journal-title":"Arch. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/aje\/kws437","article-title":"Environmental exposure to metals and children\u2019s growth to age 5 years: A prospective cohort study","volume":"177","author":"Gardner","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106738","DOI":"10.1016\/j.envint.2021.106738","article-title":"Environmental metal exposure and growth to 10 years of age in a longitudinal mother\u2013child cohort in rural Bangladesh","volume":"156","author":"Warnqvist","year":"2021","journal-title":"Environ. Int."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shin, M.W., Kim, H.B., Kwon, A., Park, M.J., and Kim, S.H. (2024). Associations between urinary mercury\/cadmium concentrations and anthropometric features in Korean children. Toxics, 12.","DOI":"10.3390\/toxics12030175"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108736","DOI":"10.1016\/j.envres.2019.108736","article-title":"Blood metal levels and early childhood anthropometric measures in a cohort of Canadian children","volume":"179","author":"Dodds","year":"2019","journal-title":"Environ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/JOM.0000000000002834","article-title":"Association between heavy metals exposure and height in Chinese preschoolers","volume":"65","author":"Li","year":"2023","journal-title":"J. Occup. Environ. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000504669","article-title":"The role of microRNAs in influencing body growth and development","volume":"93","author":"Cirillo","year":"2020","journal-title":"Horm. Res. Paediatr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Thakore, P., and Delany, A.M. (2025). miRNA-based regulation in growth plate cartilage: Mechanisms, targets, and therapeutic potential. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1530374"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110388","DOI":"10.1016\/j.envres.2020.110388","article-title":"Prenatal metal mixtures and fetal size in mid-pregnancy in the MADRES study","volume":"196","author":"Howe","year":"2021","journal-title":"Environ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Catellani, C., Ravegnini, G., Sartori, C., Righi, B., Lazzeroni, P., Bonvicini, L., Poluzzi, S., Cirillo, F., Predieri, B., and Iughetti, L. (2022). Specific miRNAs change after 3 months of GH treatment and contribute to explain the growth response after 12 months. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.896640"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3345\/kjp.2018.61.5.135","article-title":"The 2017 Korean National Growth Charts for children and adolescents: Development, improvement, and prospects","volume":"61","author":"Kim","year":"2018","journal-title":"Korean J. Pediatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jpeds.2011.12.022","article-title":"Windows of lead exposure sensitivity, attained height, and BMI at 48 months","volume":"160","author":"Afeiche","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ahmadi, S., Botton, J., Zoumenou, R., Ayotte, P., Fievet, N., Massougbodji, A., Alao, M.J., Cot, M., Glorennec, P., and Bodeau-Livinec, F. (2022). Lead exposure in infancy and subsequent growth in Beninese children. Toxics, 10.","DOI":"10.20944\/preprints202208.0256.v1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.envint.2017.05.023","article-title":"Peripubertal blood lead levels and growth among Russian boys","volume":"106","author":"Burns","year":"2017","journal-title":"Environ. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1289\/ehp.1003378","article-title":"Pre- and postnatal arsenic exposure and body size to 2 years of age: A cohort study in rural Bangladesh","volume":"120","author":"Saha","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115726","DOI":"10.1016\/j.ecoenv.2023.115726","article-title":"Exposure to metal mixtures and young children\u2019s growth and development: A biomonitoring-based study in Eastern China","volume":"268","author":"Ma","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Contaminants in the Food Chain (CONTAM), Schrenk, D., Bignami, M., Bodin, L., Chipman, J.K., del Mazo, J.K., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L., and Hoogenboom, L.R. (2024). Update of the risk assessment of inorganic arsenic in food. EFSA J., 22, e8488.","DOI":"10.2903\/j.efsa.2024.8488"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.envres.2014.08.047","article-title":"Depressed height gain of children associated with intrauterine exposure to polycyclic aromatic hydrocarbons (PAH) and heavy metals: The cohort prospective study","volume":"136","author":"Jedrychowski","year":"2015","journal-title":"Environ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tem.2009.12.003","article-title":"Pituitary somatostatin receptor signaling","volume":"21","author":"Melmed","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1101\/gad.192955.112","article-title":"PTPN14 is required for the density-dependent control of YAP1","volume":"26","author":"Wang","year":"2012","journal-title":"Genes Dev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1038\/s41467-025-57808-4","article-title":"Nf2\u2013FAK signaling axis is critical for cranial bone ossification and regeneration","volume":"16","author":"Liao","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1101\/gad.315531.118","article-title":"Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt\/\u03b2-catenin signaling","volume":"32","author":"Felker","year":"2018","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","article-title":"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling","volume":"13","author":"Lomaga","year":"1999","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.201002111","article-title":"Fra-2\/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production","volume":"190","author":"Bozec","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e202407141","DOI":"10.1083\/jcb.202407141","article-title":"ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway","volume":"224","author":"Jung","year":"2025","journal-title":"J. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.26502\/josm.511500122","article-title":"Karyopherins in the remodeling of extracellular matrix: Implications in tendon injury","volume":"5","author":"Diaz","year":"2023","journal-title":"J. Orthop. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"dev198374","DOI":"10.1242\/dev.198374","article-title":"Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis","volume":"148","author":"Liu","year":"2021","journal-title":"Development"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s42003-021-02944-y","article-title":"Gp130\/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes","volume":"5","author":"Liu","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrendo.2013.5","article-title":"Glucocorticoids and the regulation of growth hormone secretion","volume":"9","author":"Mazziotti","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00018-022-04180-x","article-title":"Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation","volume":"79","author":"Annibalini","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1073\/pnas.1018493108","article-title":"A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/iub.2126","article-title":"Upregulation of microRNA-133a and downregulation of connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma through the JAK\/STAT signaling pathway","volume":"71","author":"Zhang","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1159\/000438653","article-title":"MiR-133a inhibits cell proliferation and invasion by targeting IGF-1R in osteosarcoma","volume":"38","author":"Chen","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/jcp.24608","article-title":"hsa-miR-4516 Mediated downregulation of STAT3\/CDK6\/UBE2N plays a role in PUVA induced apoptosis in keratinocytes","volume":"229","author":"Chowdhari","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.bbadis.2017.08.014","article-title":"MiR-4516, a microRNA downregulated in psoriasis, inhibits keratinocyte motility by targeting fibronectin\/integrin \u03b19 signaling","volume":"1863","author":"Chowdhari","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1038\/s41598-018-26525-y","article-title":"Circulating microRNAs as potential diagnostic biomarkers for osteoporosis","volume":"8","author":"Mandourah","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.21037\/atm-22-6620","article-title":"Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease","volume":"11","author":"Shen","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13059-016-0881-8","article-title":"A survey of best practices for RNA-seq data analysis","volume":"17","author":"Conesa","year":"2016","journal-title":"Genome Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1128\/MCB.01106-14","article-title":"Loss of osteoblast Runx3 produces severe congenital osteopenia","volume":"35","author":"Bauer","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_50","first-page":"1991","article-title":"RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells","volume":"40","author":"Wang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41586-022-05275-y","article-title":"A saturated map of common genetic variants associated with human height","volume":"610","author":"Yengo","year":"2022","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"19544","DOI":"10.1038\/srep19544","article-title":"Mitochondrial dysfunction may explain symptom variation in Phelan\u2013McDermid syndrome","volume":"6","author":"Frye","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bj20030874","article-title":"p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation","volume":"378","author":"Stanton","year":"2004","journal-title":"Biochem. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3892\/mmr.2022.12647","article-title":"A de novo mutation of SALL4 in a Chinese family with Okihiro syndrome","volume":"25","author":"Ma","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, K.Q., Anderson, A., Kawakami, H., Kim, J., Barrett, J., and Kawakami, Y. (2022). Normal embryonic development and neonatal digit regeneration in mice overexpressing a stem cell factor, Sall4. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0267273"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejmg.2013.12.013","article-title":"SALL4 and NFATC2: Two major actors of interstitial 20q13.2 duplication","volume":"57","author":"Martinovic","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1073\/pnas.93.17.9010","article-title":"RXR gamma null mice are apparently normal and compound RXR alpha +\/\u2212\/RXR beta \u2212\/\u2212\/RXR gamma \u2212\/\u2212 mutant mice are viable","volume":"93","author":"Krezel","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Dupuis, H., Pest, M.A., Hadzic, E., Vo, T.X., Hardy, D.B., and Beier, F. (2019). Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model. Int. J. Mol. Sci., 20.","DOI":"10.1101\/774851"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"21366","DOI":"10.1073\/pnas.1219810110","article-title":"Development of the mammalian axial skeleton requires signaling through the G\u03b1i subfamily of heterotrimeric G proteins","volume":"109","author":"Plummer","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"111098","DOI":"10.1016\/j.mce.2020.111098","article-title":"Mice with an RGS-insensitive G\u03b1i2 protein show growth hormone axis dysfunction","volume":"521","author":"Omouessi","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1069398","article-title":"Genomic instability in mice lacking histone H2AX","volume":"296","author":"Celeste","year":"2002","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Arnaud, P., Mougin, Z., Boileau, C., and Le Goff, C. (2021). Cooperative mechanism of ADAMTS\/ADAMTSL and fibrillin-1 in Marfan syndrome and acromelic dysplasias. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.734718"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1074\/jbc.M109.076919","article-title":"ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation","volume":"285","author":"Tsutsui","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Blouin, T., and Saini, N. (2024). Aldehyde-induced DNA\u2013protein crosslinks: DNA damage, repair and mutagenesis. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1478373"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"115849","DOI":"10.1016\/j.celrep.2025.115849","article-title":"Merlin controls limb development and thumb formation by regulating primary cilium\u2013Hedgehog signaling","volume":"44","author":"Wu","year":"2025","journal-title":"Cell Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/hmg\/ddae030","article-title":"Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians","volume":"33","author":"Kobes","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mgene.2017.07.006","article-title":"A homozygous loss-of-function mutation in PTPN14 causes a syndrome of bilateral choanal atresia and early infantile-onset lymphedema","volume":"14","author":"Bordbar","year":"2017","journal-title":"Meta Gene"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ajhg.2010.08.008","article-title":"Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans","volume":"87","author":"Au","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajhg.2018.11.008","article-title":"Leveraging polygenic functional enrichment to improve GWAS power","volume":"104","author":"Kichaev","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s10875-013-9982-2","article-title":"Bone density and fractures in autosomal dominant hyper IgE syndrome","volume":"34","author":"Sowerwine","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Vogel, T.P., Leiding, J.W., Cooper, M.A., and Forbes Satter, L.R. (2023). STAT3 gain-of-function syndrome. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.770077"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2265.2006.02709.x","article-title":"Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia","volume":"66","author":"Lin","year":"2007","journal-title":"Clin. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/humu.21085","article-title":"RFT1 deficiency in three novel CDG patients","volume":"30","author":"Vleugels","year":"2009","journal-title":"Hum. Mutat."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ng.2606","article-title":"Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture","volume":"45","author":"Berndt","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/cge.12916","article-title":"Homozygous deletion of RAG1, RAG2 and the 5\u2032 region of TRAF6 causes severe immune suppression and atypical osteopetrosis","volume":"91","author":"Krauss","year":"2017","journal-title":"Clin. Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1230\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:28:44Z","timestamp":1769578124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031230"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031230","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}