{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:34:41Z","timestamp":1769560481632,"version":"3.49.0"},"reference-count":126,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanxi Province Science Foundation","award":["202303021211194"],"award-info":[{"award-number":["202303021211194"]}]},{"name":"Shanxi Province Science Foundation","award":["20210302124333"],"award-info":[{"award-number":["20210302124333"]}]},{"name":"Research Project on Educational Reform of Postgraduate Education in Shanxi Province","award":["2025JG175"],"award-info":[{"award-number":["2025JG175"]}]},{"name":"Program for the Discipline Leaders of Taiyuan Institute of Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Polyoxometalates (POMs) exhibit significant potential for application in Alzheimer\u2019s disease (AD) therapeutics owing to their inherent chemical and physical properties and structural tunability. Through transition metal substitution, functional modification, and the construction of POMs-based nanocomposites, POMs can precisely recognize and effectively modulate various key pathogenic proteins involved in Alzheimer\u2019s disease. They can also intervene in disease progression through multiple mechanisms, including inhibition of A\u03b2 aggregation, disaggregation of amyloid-\u03b2 (A\u03b2), scavenging of reactive oxygen species (ROS), hydrolytic activity, and modulation of enzyme function. In addition, due to their outstanding physicochemical properties, the application of POMs in phototherapy has emerged as a significant direction in AD treatment research. This review systematically summarizes recent advances from 2011 to 2025 in POMs targeting key pathogenic proteins in AD, comprehensively analyzes their specific mechanisms of action across different therapeutic contexts, highlights their significant advantages and broad potential in AD treatment, and provides new insights for the future structural design, functional optimization, and clinical translation of POMs.<\/jats:p>","DOI":"10.3390\/ijms27031257","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:27:11Z","timestamp":1769509631000},"page":"1257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Polyoxometalates Targeting Proteins Associated with Alzheimer\u2019s Disease: From Molecular Mechanisms to Therapeutic Applications"],"prefix":"10.3390","volume":"27","author":[{"given":"Lijuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"},{"name":"School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang 111000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinghao","family":"Lu","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqian","family":"Hua","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoming","family":"Du","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Zhai","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang 111000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiai","family":"Hua","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-5741","authenticated-orcid":false,"given":"Xiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1093\/hmg\/ddq160","article-title":"Molecular mechanisms of neurodegeneration in Alzheimer\u2019s disease","volume":"19","author":"Crews","year":"2010","journal-title":"Hum. 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