{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:46:53Z","timestamp":1780642013511,"version":"3.54.1"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne zoonotic pathogen of significant public health concern in South Korea, where human cases continue to occur at high levels; however, information on the molecular epidemiology and genotype diversity of SFTSV in goats\u2014an increasingly important livestock species\u2014remains limited. In this study, blood samples were collected from 750 clinically healthy goats during nationwide surveillance in 2024. Viral RNA was detected by RT-PCR targeting the S and M genomic segments. Epidemiological characteristics were analyzed according to season, region, farm size, breed, and sex. Positive samples were subjected to sequencing and phylogenetic analysis to determine SFTSV genotypes. SFTSV RNA was detected in 10 of 750 goats (1.3%), with significantly higher detection rates in autumn compared with summer, in southern regions compared with northern regions, and in female goats compared with males, while no significant association was observed with farm size or breed. Phylogenetic analysis showed that goat-derived SFTSV strains belonged to genotypes B2, D, and F; notably, genotypes D and F were identified in goats for the first time in South Korea. These findings indicate that goats are exposed to genetically diverse SFTSV strains circulating in tick populations and exhibit epidemiological patterns consistent with tick ecology and human SFTS incidence, supporting the role of goats as incidental or sentinel hosts. Continuous molecular surveillance of goats, integrated with vector monitoring programs, may enhance understanding of regional SFTSV transmission dynamics and facilitate early detection of emerging genotypes with public health implication.<\/jats:p>","DOI":"10.3390\/ijms27031264","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:35:42Z","timestamp":1769513742000},"page":"1264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular Epidemiology and Genotype Diversity of Severe Fever with Thrombocytopenia Syndrome Virus in Goats in South Korea"],"prefix":"10.3390","volume":"27","author":[{"given":"In-Ohk","family":"Ouh","sequence":"first","affiliation":[{"name":"Korea Disease Control and Prevention Agency, Osong-eup, Cheongju-si 28160, Chungcheongbuk-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/cid\/cit100","article-title":"Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011\u20132012","volume":"56","author":"Ding","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.3201\/eid1911.130792","article-title":"Severe fever with thrombocytopenia syndrome, South Korea, 2012","volume":"19","author":"Kim","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_3","first-page":"597","article-title":"Genotype Analysis of Severe Fever with Thrombocytopenia Syndrome Virus Detected in Patients","volume":"14","author":"Choi","year":"2021","journal-title":"Public Health Wkly. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Woo, D., Michelow, I.C., Choi, Y., Lee, H., and Park, S. (2025). Transmission of Severe Fever with Thrombocytopenia Syndrome (SFTS) to humans: A systematic review of individual participant data and meta-analysis. J. Infect. Public Health, 18.","DOI":"10.1016\/j.jiph.2025.102685"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Seo, M.G., Noh, B.E., Lee, H.S., Kim, T.K., Song, B.G., and Lee, H.I. (2021). Nationwide Temporal and Geographical Distribution of Tick Populations and Phylogenetic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in Korea, 2020. Microorganisms, 9.","DOI":"10.3390\/microorganisms9081630"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Seo, M.G., Song, B.G., Kim, T.K., Noh, B.E., Lee, H.S., Lee, W.G., and Lee, H.I. (2021). Nationwide Incidence of Chigger Mite Populations and Molecular Detection of Orientia tsutsugamushi in the Republic of Korea, 2020. Microorganisms, 9.","DOI":"10.3390\/microorganisms9081563"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Seo, M.G., Lee, H.S., Yang, S.C., Noh, B.E., Kim, T.K., Lee, W.G., and Lee, H.I. (2021). National Monitoring of Mosquito Populations and Molecular Analysis of Flavivirus in the Republic of Korea in 2020. Microorganisms, 9.","DOI":"10.3390\/microorganisms9102085"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/vbz.2015.1848","article-title":"Detection of Severe Fever with Thrombocytopenia Syndrome Virus from Wild Animals and Ixodidae Ticks in the Republic of Korea","volume":"16","author":"Oh","year":"2016","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lee, Y.J., Kim, B., Kang, Y.M., Kwak, D., and Seo, M.G. (2025). Molecular Epidemiology of Coxiella burnetii in Boer Goats and Their Farm Environment in South Korea with a One Health Approach. Animals, 15.","DOI":"10.3390\/ani15101498"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.vetmic.2014.06.029","article-title":"Molecular and serologic detection of Coxiella burnetii in native Korean goats (Capra hircus coreanae)","volume":"173","author":"Jung","year":"2014","journal-title":"Vet. Microbiol."},{"key":"ref_11","unstructured":"Ministry of Agriculture, Food and Rural Affairs (2026, January 01). Report on Other Livestock Statistics. Available online: https:\/\/www.mafra.go.kr\/sites\/home\/index.do#none."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kim, B., Lee, Y.J., Lee, H.I., Kwak, D., and Seo, M.G. (2024). Surveillance of Vector-Borne Zoonotic Diseases in South Korea: Uncovering Novel Pathogen Carriers Among Rodents and Mites Nationwide. Transbound. Emerg. Dis., 2024.","DOI":"10.1155\/2024\/5544660"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1089\/vbz.2024.0008","article-title":"Prevalence, Isolation, and Molecular Characterization of Severe Fever with Thrombocytopenia Syndrome Virus in Cattle from the Republic of Korea","volume":"24","author":"Chae","year":"2024","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ttbdis.2018.05.001","article-title":"Seroprevalence and genetic characterization of severe fever with thrombocytopenia syndrome virus in domestic goats in South Korea","volume":"9","author":"Yu","year":"2018","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ttbdis.2018.04.018","article-title":"Prevalence of severe fever with thrombocytopenia syndrome virus in black goats (Capra hircus coreanae) in the Republic of Korea","volume":"9","author":"Kang","year":"2018","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Han, S.W., An, J.H., Rim, J.M., Jeong, E., Noh, S., Kang, M., Kang, J.G., and Chae, J.S. (2022). Confirmed cases of severe fever with thrombocytopenia syndrome in companion cats with a history of tick exposure in the Republic of Korea. J. Vet. Sci., 23.","DOI":"10.4142\/jvs.22104"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ttbdis.2017.04.008","article-title":"Molecular detection and phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in shelter dogs and cats in the Republic of Korea","volume":"8","author":"Lee","year":"2017","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yun, S.M., Park, S.J., Kim, Y.I., Park, S.W., Yu, M.A., Kwon, H.I., Kim, E.H., Yu, K.M., Jeong, H.W., and Ryou, J. (2020). Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea. JCI Insight, 5.","DOI":"10.1172\/jci.insight.129531"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.smallrumres.2007.01.006","article-title":"Genetics of disease resistance in sheep and goats","volume":"70","author":"Bishop","year":"2007","journal-title":"Small Rumin. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lu, H.Y., Wu, G.D., Peng, M., Wu, L.B., Luo, Y.M., Xia, B., Xiong, D., Qin, X.R., Guo, F., and Yu, X.J. (2025). SFTSV Prevalence in Ticks and Livestock in an SFTSV-Endemic Area in Central China. Pathogens, 14.","DOI":"10.3390\/pathogens14090944"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Thrusfield, M.V., and Christley, R. (2018). Veterinary Epidemiology, Wiley. [4th ed.].","DOI":"10.1002\/9781118280249"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3201\/eid2008.131857","article-title":"Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013","volume":"20","author":"Yun","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: Molecular Evolutionary Genetics Analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01731581","article-title":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences","volume":"16","author":"Kimura","year":"1980","journal-title":"J. Mol. Evol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1264\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:36:09Z","timestamp":1769513769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031264"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031264","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}