{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:47:29Z","timestamp":1790034449335,"version":"4.0.1"},"reference-count":99,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>FABP4 (fatty acid-binding protein 4) is a lipid chaperone and secreted adipokine linking dysregulated fatty acid handling with inflammation, cellular stress, and insulin resistance in obesity. By modulating nuclear receptor signaling (notably PPAR\u03b3) and enhancing NF-\u03baB\/MAPK activation in adipocytes and macrophages, FABP4 contributes to maladaptive adipose remodeling and systemic metabolic decline. This review critically summarizes recent preclinical evidence on natural bioactive compounds that regulate FABP4 expression and associated adipogenic programs in models of adipogenesis and diet-induced obesity. Data from 3T3-L1\/OP9 adipocytes, rodent studies, and selected alternative models indicate that many plant-derived extracts and phytochemicals (e.g., polyphenols, saponins, coumarins, terpenoids, and fermented products) down-regulate FABP4 at mRNA and\/or protein levels. These effects are frequently accompanied by suppression of PPAR\u03b3\/C\/EBP\u03b1\/SREBP1c signaling, activation of AMPK-related pathways, reduced lipid accumulation, and improved metabolic outcomes including lower weight gain, reduced adipocyte hypertrophy, improved steatosis, and favorable serum lipid profiles. Natural compounds from non-plant sources (animal- and microbe-derived metabolites) further broaden FABP4-targeting strategies, supporting FABP4 as a cross-class therapeutic node. Key translational barriers include poor extract standardization, incomplete identification of active constituents, limited oral bioavailability, microbiome-dependent variability, and scarce clinical validation. Future work should prioritize well-characterized lead scaffolds, targeted delivery, rational combinations, and standardized, adequately powered clinical trials assessing dose, durability of FABP4 suppression, and cardiometabolic safety.<\/jats:p>","DOI":"10.3390\/ijms27031306","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:04:46Z","timestamp":1769612686000},"page":"1306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Natural Bioactive Compounds Targeting FABP4 in Adipogenesis and Obesity: Evidence from In Vitro and In Vivo Studies"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-9846","authenticated-orcid":false,"given":"Jan","family":"Sobczy\u0144ski","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chod\u017aki St. 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Nowaczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chod\u017aki St. 1, 20-093 Lublin, Poland"},{"name":"Doctoral School of the Medical University of Lublin, Chod\u017aki St. 7, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Smoli\u0144ska","sequence":"additional","affiliation":[{"name":"Chronic Wounds Laboratory, Medical University of Lublin, Chod\u017aki St. 7, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lachowicz-Radulska","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chod\u017aki St. 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Serefko","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chod\u017aki St. 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7756-2904","authenticated-orcid":false,"given":"Aleksandra","family":"Szopa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chod\u017aki St. 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abad-Jim\u00e9nez, Z., and Vezza, T. (2025). Obesity: A Global Health Challenge Demanding Urgent Action. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020502"},{"key":"ref_2","unstructured":"(2026, January 25). Obesity and Overweight. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_3","first-page":"1865","article-title":"Modern Management of Cardiometabolic Continuum: From Overweight\/Obesity to Prediabetes\/Type 2 Diabetes Mellitus. Recommendations from the Eastern and Southern Europe Diabetes and Obesity Expert Group","volume":"15","author":"Janez","year":"2024","journal-title":"Diabetes Ther. Res. Treat. Educ. Diabetes Relat. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Banerjee, D., and Mani, A. (2025). Obesity\u2019s Systemic Impact: Exploring Molecular and Physiological Links to Diabetes, Cardiovascular Disease, and Heart Failure. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1681766"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gkrinia, E.M.M., and Belan\u010di\u0107, A. (2025). The Mechanisms of Chronic Inflammation in Obesity and Potential Therapeutic Strategies: A Narrative Review. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47050357"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41418-022-01062-4","article-title":"Cell Death and Inflammation during Obesity: \u201cKnow My Methods, WAT(Son)\u201d","volume":"30","author":"Hildebrandt","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100585","DOI":"10.1016\/j.obmed.2025.100585","article-title":"Cytokines as Key Players in Obesity Low Grade Inflammation and Related Complications","volume":"54","author":"Uti","year":"2025","journal-title":"Obes. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Janssen, J.A.M.J.L. (2024). The Causal Role of Ectopic Fat Deposition in the Pathogenesis of Metabolic Syndrome. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413238"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Iacobini, C., Vitale, M., Haxhi, J., Menini, S., and Pugliese, G. (2024). Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction. Cells, 13.","DOI":"10.3390\/cells13090763"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s40618-020-01446-8","article-title":"Dysmetabolic Adipose Tissue in Obesity: Morphological and Functional Characteristics of Adipose Stem Cells and Mature Adipocytes in Healthy and Unhealthy Obese Subjects","volume":"44","author":"Porro","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bou Matar, D., Zhra, M., Nassar, W.K., Altemyatt, H., Naureen, A., Abotouk, N., Elahi, M.A., and Aljada, A. (2025). Adipose Tissue Dysfunction Disrupts Metabolic Homeostasis: Mechanisms Linking Fat Dysregulation to Disease. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1592683"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Li, H.-L., Wu, X., Xu, A., and Hoo, R.L.-C. (2021). A-FABP in metabolic diseases and the therapeutic implications: An update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179386"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd2388","article-title":"A shared target","volume":"6","author":"Crunkhorn","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2337\/db13-0436","article-title":"FABP4 attenuates PPAR\u03b3 and adipogenesis and is inversely correlated with PPAR\u03b3 in adipose tissues","volume":"63","author":"Rudich","year":"2014","journal-title":"Diabetes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/cells8030227","article-title":"Associations between fatty acid-binding protein 4\u2014A proinflammatory adipokine and insulin resistance, gestational and type 2 diabetes mellitus","volume":"8","author":"Trojnar","year":"2019","journal-title":"Cells"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1194\/jlr.S091793","article-title":"Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses","volume":"60","author":"Prentice","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2464S","DOI":"10.1093\/jn\/134.9.2464S","article-title":"Fatty acid binding proteins\u2014The evolutionary crossroads of inflammatory and metabolic responses","volume":"134","author":"Makowski","year":"2004","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"121209","DOI":"10.1016\/j.biomaterials.2021.121209","article-title":"White adipocyte-targeted dual gene silencing of FABP4\/5 for anti-obesity, anti-inflammation and reversal of insulin resistance: Efficacy and comparison of administration routes","volume":"279","author":"Chung","year":"2021","journal-title":"Biomaterials"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2300840","DOI":"10.1002\/mnfr.202300840","article-title":"A new insight into fatty acid binding protein 4 mechanisms and therapeutic implications in obesity-associated diseases: A mini review","volume":"68","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jid.2024.08.017","article-title":"Inhibition of adipocyte-derived FABP4 reduces adipocyte inflammation, improves angiogenesis, and facilitates wound healing in metabolic dysfunctions","volume":"145","author":"Wu","year":"2025","journal-title":"J. Investig. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/cimb43030133","article-title":"Elucidating drug-like compounds and potential mechanisms of corn silk (Stigma maydis) against obesity: A network pharmacology study","volume":"43","author":"Oh","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chen, Y., Bi, F., and Sun, Z. (2021). A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0252906"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/1745039X.2022.2162800","article-title":"Anti-obesity effects of corn peptide on 3T3-L1 preadipocytes and C57BL\/6J obese mice","volume":"76","author":"Zhang","year":"2022","journal-title":"Arch. Anim. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105227","DOI":"10.1016\/j.jff.2022.105227","article-title":"Corn peptide enhances exercise performance and prevents myocardial damage of mice caused by overtraining through activating autophagy","volume":"97","author":"Wu","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Deng, X., Chen, B., Luo, Q., Zao, X., Liu, H., and Li, Y. (2022). Hulless barley polyphenol extract inhibits adipogenesis in 3T3-L1 cells and obesity related-enzymes. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.933068"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lee, S.-Y., Kim, T.-Y., Hong, J.-Y., Kim, G.-J., Oh, J.-B., Kim, M.-J., Apostolidis, E., Lee, J.-Y., and Kwon, Y.-I. (2022). Anti-obesity and anti-adipogenic effects of administration of arginyl-fructose-enriched Jeju barley (Hordeum vulgare L.) extract in C57BL\/6 mice and in 3T3-L1 preadipocytes models. Molecules, 27.","DOI":"10.3390\/molecules27103248"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/bj20020300","article-title":"Genistein inhibits CCAAT\/enhancer-binding protein \u03b2 (C\/EBP\u03b2) activity and 3T3-L1 adipogenesis by increasing C\/EBP homologous protein expression","volume":"367","author":"Harmon","year":"2002","journal-title":"Biochem. J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Choi, Y.R., Shim, J., and Kim, M.J. (2020). Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent. Molecules, 25, Correction in Molecules 2024, 29, 714. https:\/\/doi.org\/10.3390\/molecules29030714.","DOI":"10.3390\/molecules29030714"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s13197-022-05436-x","article-title":"Resveratrol butyrate esters inhibit lipid biosynthesis in 3T3-L1 cells by AMP-activated protein kinase phosphorylation","volume":"60","author":"Shih","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1142\/S0192415X17500446","article-title":"Cinnamyl alcohol, the bioactive component of chestnut flower absolute, inhibits adipocyte differentiation in 3T3-L1 cells by downregulating adipogenic transcription factors","volume":"45","author":"Hwang","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s43450-021-00138-5","article-title":"Pharmacological studies on cinnamic alcohol and its derivatives","volume":"31","author":"Monteiro","year":"2021","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Choi, Y.R., Kim, Y.-S., and Kim, M.J. (2024). Cinnamyl alcohol attenuates adipogenesis in 3T3-L1 cells by arresting the cell cycle. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020693"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cattod.2019.11.008","article-title":"Continuous flow study of isoeugenol to vanillin: A bio-based iron oxide catalyst","volume":"368","author":"Filiciotto","year":"2021","journal-title":"Catal. Today"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Fabry, P., Weber, S., Teipel, J., Richling, E., Walch, S.G., and Lachenmeier, D.W. (2024). Quantitative NMR spectrometry of phenylpropanoids, including isoeugenol in herbs, spices, and essential oils. Foods, 13.","DOI":"10.3390\/foods13050720"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Choi, Y.R., Na, H.-J., Lee, J., Kim, Y.-S., and Kim, M.J. (2024). Isoeugenol inhibits adipogenesis in 3T3-L1 preadipocytes with impaired mitotic clonal expansion. Nutrients, 16.","DOI":"10.3390\/nu16091262"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.3390\/molecules180910484","article-title":"Salicortin-derivatives from Salix pseudo-lasiogyne twigs inhibit adipogenesis in 3T3-L1 cells via modulation of C\/EBP\u03b1 and SREBP1c dependent pathway","volume":"18","author":"Lee","year":"2013","journal-title":"Molecules"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kim, H.J., Lee, D.E., Park, E.C., Ra, M.-J., Jung, S.-M., Yu, J.-N., Um, S.H., and Kim, K.H. (2022). Anti-adipogenic effects of salicortin from the twigs of weeping willow (Salix pseudo-lasiogyne) in 3T3-L1 cells. Molecules, 27.","DOI":"10.3390\/molecules27206954"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Berger, E., and G\u00e9lo\u00ebn, A. (2023). FABP4 controls fat mass expandability (adipocyte size and number) through inhibition of CD36\/SR-B2 signalling. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021032"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cho, S., Lee, H., Han, J., Lee, H., Kattia, R.O., Nelson, Z.V., Choi, S., Kim, S.-Y., Park, H.-Y., and Jeong, H.G. (2021). Viburnum stellato-tomentosum extract suppresses obesity and hyperglycemia through regulation of lipid metabolism in high-fat diet-fed mice. Molecules, 26.","DOI":"10.3390\/molecules26041052"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hong, S., Park, S., Lee, J., Park, S., Park, J., and Lee, Y. (2024). Anti-obesity effects of Pleurotus ferulae water extract on 3T3-L1 adipocytes and high-fat-diet-induced obese mice. Nutrients, 16.","DOI":"10.3390\/nu16234139"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Jee, W., Cho, H.-S., Kim, S.W., Bae, H., Chung, W.-S., Cho, J.-H., Kim, H., Song, M.-Y., and Jang, H.-J. (2024). Lycium chinense Mill. induces anti-obesity and anti-diabetic effects in vitro and in vivo. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25168572"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lee, M.-S., and Kim, Y. (2020). Chrysanthemum morifolium flower extract inhibits adipogenesis of 3T3-L1 cells via AMPK\/SIRT1 pathway activation. Nutrients, 12.","DOI":"10.3390\/nu12092726"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lamichhane, G., Pandeya, P.R., Lamichhane, R., Rhee, S., Devkota, H.P., and Jung, H.-J. (2022). Anti-obesity potential of Ponciri fructus: Effects of extracts, fractions and compounds on adipogenesis in 3T3-L1 preadipocytes. Molecules, 27.","DOI":"10.3390\/molecules27030676"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Park, E., Lee, C.G., Kim, J., Lim, E., Yeo, S., and Jeong, S.-Y. (2020). Scopolin prevents adipocyte differentiation in 3T3-L1 preadipocytes and weight gain in an ovariectomy-induced obese mouse model. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228699"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Oh, J.-M., and Chun, S. (2022). Ginsenoside CK inhibits the early stage of adipogenesis via the AMPK, MAPK, and AKT signaling pathways. Antioxidants, 11.","DOI":"10.3390\/antiox11101890"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sharma, A., and Lee, H.-J. (2020). Ginsenoside compound K: Insights into recent studies on pharmacokinetics and health-promoting activities. Biomolecules, 10.","DOI":"10.3390\/biom10071028"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105002","DOI":"10.1016\/j.micpath.2021.105002","article-title":"Ginsenoside CK inhibits obese insulin resistance by activating PPAR\u03b3 to interfere with macrophage activation","volume":"157","author":"Wang","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/bab.2573","article-title":"Bacoside-A repressed the differentiation and lipid accumulation of 3T3-L1 preadipocytes by modulating the expression of adipogenic genes","volume":"71","author":"Ramesh","year":"2024","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10852","DOI":"10.1039\/D0FO01909G","article-title":"Akebia saponin D suppresses inflammation in chondrocytes via the NRF2\/HO-1\/NF-\u03baB axis and ameliorates osteoarthritis in mice","volume":"11","author":"Gu","year":"2020","journal-title":"Food Funct."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111441","DOI":"10.1016\/j.biopha.2021.111441","article-title":"Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury","volume":"138","author":"Yang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jgr.2021.09.004","article-title":"Identification of anti-adipogenic withanolides from the roots of indian ginseng (Withania somnifera)","volume":"46","author":"Lee","year":"2022","journal-title":"J. Ginseng Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chaves Filho, G.P., Batista, L.A.N.C., de Medeiros, S.R.B., Rocha, H.A.O., and Moreira, S.M.G. (2022). Sulfated glucan from the green seaweed Caulerpa sertularioides inhibits adipogenesis through suppression of adipogenic and lipogenic key factors. Mar. Drugs, 20.","DOI":"10.3390\/md20080470"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11157","DOI":"10.1021\/jf503068n","article-title":"Isolation of the molecular species of monogalactosyldiacylglycerols from brown edible seaweed Sargassum horneri and their inhibitory effects on triglyceride accumulation in 3T3-L1 adipocytes","volume":"62","author":"Ma","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lee, H.-G., Kim, H.-S., Je, J.-G., Hwang, J., Sanjeewa, K.K.A., Lee, D.-S., Song, K.-M., Choi, Y.-S., Kang, M.-C., and Jeon, Y.-J. (2021). Lipid inhibitory effect of (\u2212)-loliolide isolated from Sargassum horneri in 3T3-L1 adipocytes: Inhibitory mechanism of adipose-specific proteins. Mar. Drugs, 19.","DOI":"10.3390\/md19020096"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lee, H.-G., Lu, Y.-A., Je, J.-G., Jayawardena, T.U., Kang, M.-C., Lee, S.-H., Kim, T.-H., Lee, D.-S., Lee, J.-M., and Yim, M.-J. (2021). Effects of ethanol extracts from Grateloupia elliptica, a red seaweed, and its chlorophyll derivative on 3T3-L1 adipocytes: Suppression of lipid accumulation through downregulation of adipogenic protein expression. Mar. Drugs, 19.","DOI":"10.3390\/md19020091"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"D\u2019Addabbo, T., Argentieri, M.P., Laquale, S., Candido, V., and Avato, P. (2020). Relationship between chemical composition and nematicidal activity of different essential oils. Plants, 9.","DOI":"10.3390\/plants9111546"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.bse.2010.09.018","article-title":"Composition and variability of essential oils of Platycladus orientalis growing in China","volume":"38","author":"Lei","year":"2010","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_59","unstructured":"(2026, January 14). Substances Added to Food (formerly EAFUS). Cedryl Acetate, Available online: https:\/\/hfpappexternal.fda.gov\/scripts\/fdcc\/index.cfm?set=FoodSubstances&id=CEDRYLACETATE."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Guo, J., Li, M., Zhao, Y., Kang, S.-G., Huang, K., and Tong, T. (2023). Dietary supplementation of cedryl acetate ameliorates adiposity and improves glucose homeostasis in high-fat diet-fed mice. Nutrients, 15.","DOI":"10.3390\/nu15040980"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Choi, R.-Y., and Lee, M.-K. (2021). Polygonum multiflorum Thunb. Hot water extract reverses high-fat diet-induced lipid metabolism of white and brown adipose tissues in obese mice. Plants, 10.","DOI":"10.3390\/plants10081509"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Liu, G., Gao, H., Song, Y., Wang, H., Zhang, D., Wang, Y., Liu, S., Li, Z., Liu, C., and Sun, Y. (2025). Multiomic analysis reveals that the flavonoid biosynthesis pathway is associated with cold tolerance in Heracleum moellendorffii Hance. Front. Plant Sci., 16.","DOI":"10.3389\/fpls.2025.1544898"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.plaphy.2019.10.002","article-title":"Differential protein analysis of Heracleum moellendorffii Hance seeds during stratification","volume":"145","author":"Li","year":"2019","journal-title":"Plant Physiol. Biochem. PPB"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1002\/fsn3.2487","article-title":"Anti-obesity activity of Heracleum moellendorffii root extracts in 3T3-L1 adipocytes","volume":"9","author":"Geum","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3746\/pnf.2023.28.1.21","article-title":"Anti-adipogenic and anti-obesity effects of Gongmi tea and Gongmi so extract","volume":"28","author":"Jo","year":"2023","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Park, E., Lee, C.G., Jeong, H., Yeo, S., Kim, J.A., and Jeong, S.-Y. (2020). Antiadipogenic effects of mixtures of Cornus officinalis and Ribes fasciculatum extracts on 3T3-L1 preadipocytes and high-fat diet-induced mice. Molecules, 25.","DOI":"10.3390\/molecules25102350"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1089\/jmf.2022.K.0126","article-title":"Gochujang consumption prevents metabolic syndrome in a high-fat diet induced obese mouse model","volume":"26","author":"Edward","year":"2023","journal-title":"J. Med. Food"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1111\/1750-3841.17551","article-title":"Kombucha enables to inhibit digestive enzymes activity and adipocyte differentiation of OP9 cells","volume":"89","author":"Liu","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1002\/fsn3.4223","article-title":"Drosophila models of the anti-inflammatory and anti-obesity mechanisms of kombucha tea produced by Camellia sinensis leaf fermentation","volume":"12","author":"Tran","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_70","first-page":"155854","article-title":"Hypericum perforatum-derived exosomes-like nanovesicles for adipose tissue photodynamic therapy","volume":"132","author":"Li","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"114604","DOI":"10.1016\/j.ejmech.2022.114604","article-title":"Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022","volume":"240","author":"Floresta","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1107\/S2059798325006242","article-title":"A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding","volume":"81","author":"Casagrande","year":"2025","journal-title":"Acta Crystallogr. Sect. Struct. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"154939","DOI":"10.1016\/j.phymed.2023.154939","article-title":"Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment","volume":"118","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s40001-025-02794-y","article-title":"Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4\/PPARG pathway","volume":"30","author":"Deng","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12672-025-01784-0","article-title":"Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation","volume":"16","author":"Zhou","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/JME-20-0075","article-title":"Oleanolic acid derivative HA-20 inhibits adipogenesis in a manner involving PPAR\u03b3-FABP4\/aP2 pathway","volume":"66","author":"Wang","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jmb.2007.07.040","article-title":"Structural basis for activation of fatty acid-binding protein 4","volume":"372","author":"Gillilan","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4492132","DOI":"10.1155\/2022\/4492132","article-title":"Antiobesity and hepatoprotective effects of protein hydrolysates derived from Protaetia brevitarsis in an obese mouse model","volume":"2022","author":"Lee","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lee, K.D., Ilavenil, S., Karnan, M., Yang, C.-J., Kim, D., and Choi, K.C. (2022). Novel Bacillus ginsengihumi CMRO6 inhibits adipogenesis via p38MAPK\/Erk44\/42 and stimulates glucose uptake in 3T3-L1 pre-adipocytes through akt\/AS160 signaling. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094727"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6676502","DOI":"10.1155\/2021\/6676502","article-title":"Comparison of cell-free extracts from three newly identified lactobacillus plantarum strains on the inhibitory effect of adipogenic differentiation and insulin resistance in 3T3-L1 adipocytes","volume":"2021","author":"Oh","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12944-024-02423-3","article-title":"The effects of the gut bacterial product, gassericin A, on obesity in mice","volume":"24","author":"Mahdavi","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tim.2011.04.004","article-title":"Structure and genetics of circular bacteriocins","volume":"19","author":"Vederas","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.orcp.2021.08.005","article-title":"A novel approach towards obesity: The use of a bacterial product, gassericin a, in 3T3-L1 cells","volume":"15","author":"Taghizad","year":"2021","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jnutbio.2007.12.007","article-title":"Phytochemicals and regulation of the adipocyte life cycle","volume":"19","author":"Rayalam","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1039\/C6FO01168C","article-title":"Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee","volume":"7","author":"Pan","year":"2016","journal-title":"Food Funct."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrendo.2015.122","article-title":"Metabolic functions of FABPs\u2014Mechanisms and therapeutic implications","volume":"11","author":"Hotamisligil","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets","volume":"7","author":"Furuhashi","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5551\/jat.48710","article-title":"Fatty acid-binding protein 4 in cardiovascular and metabolic diseases","volume":"26","author":"Furuhashi","year":"2019","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/nbu.12278","article-title":"The Role of Polyphenols in Modern Nutrition","volume":"42","author":"Williamson","year":"2017","journal-title":"Nutr. Bull."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/17512433.2018.1464911","article-title":"Nutraceuticals-shedding light on the grey area between pharmaceuticals and food","volume":"11","author":"Santini","year":"2018","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_91","unstructured":"Graham, P., and Conn, F. (2012). Production, standardization and quality control. Fundamentals of Pharmacognosy and Phytotherapy, Elsevier."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"5833945","DOI":"10.1155\/2021\/5833945","article-title":"Advancing the Regulation of Traditional and Complementary Medicine Products: A Comparison of Five Regulatory Systems on Traditional Medicines with a Long History of Use","volume":"2021","author":"Liang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_94","first-page":"348","article-title":"Polyphenols, dietary sources and bioavailability","volume":"43","author":"Filesi","year":"2007","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Saad, A.M., Mohammed, D.M., Alkafaas, S.S., Ghosh, S., Negm, S.H., Salem, H.M., Fahmy, M.A., Semary, H.E., Ibrahim, E.H., and AbuQamar, S.F. (2025). Dietary polyphenols and human health: Sources, biological activities, nutritional and immunological aspects, and bioavailability\u2014A comprehensive review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1653378"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1017\/S0007114510003946","article-title":"Colonic metabolites of berry polyphenols: The missing link to biological activity?","volume":"104","author":"Williamson","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ekor, M. (2014). The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front. Pharmacol., 4.","DOI":"10.3389\/fphar.2013.00177"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-2125.2012.04350.x","article-title":"Herb\u2013drug interactions: An overview of systematic reviews","volume":"75","author":"Posadzki","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:07:43Z","timestamp":1769612863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":99,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031306"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031306","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]}}}