{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:24:22Z","timestamp":1787315062425,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of Arag\u00f3n","award":["B36_23R"],"award-info":[{"award-number":["B36_23R"]}]},{"name":"Margarita Salas Fellowship for the Requalification of the Spanish university system"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Biodegradable tracheal stents have been developed to overcome the limitations of metallic and removable stents in benign airway disease. This study evaluated the local and systemic inflammatory response induced by a biodegradable polydioxanone tracheal stent in a rabbit model. Twenty-one rabbits were assigned to three follow-up groups (30, 60, and 90 days). In each group, six animals received a tracheal stent, and one served as a sham control. Clinical status and respiratory symptoms were monitored, and serial peripheral blood interleukin-8 (IL-8) levels were measured. At the end of follow-up, tracheoscopy, IL-8 quantification in tracheal lavage, and necropsy were performed. No deaths or severe respiratory symptoms occurred. Tracheoscopic findings were significantly less severe after stent degradation, with reduced congestion (p = 0.030), inflammation (p = 0.003), and secretions (p = 0.030). Two granulomas and two cases of stenosis were identified. Mean IL-8 expression in tracheal lavage (relative quantification, RQ) was 14,129 \u00b1 3007 when the stent was present and 426 \u00b1 100 after degradation (p = 0.003). Blood IL-8 expression increased significantly on day 1 compared with baseline (p = 0.022) and subsequently decreased (p = 0.034). Inflammatory and structural alterations induced by a polydioxanone tracheal stent decrease after stent degradation.<\/jats:p>","DOI":"10.3390\/ijms27031309","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:04:46Z","timestamp":1769612686000},"page":"1309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Local Damage and Systemic Inflammation Induced by a Biodegradable Polydioxanone Stent Implanted in the Rabbit Trachea Decreases Markedly with Stent Degradation"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-6580","authenticated-orcid":false,"given":"Carolina","family":"Serrano-Casorran","sequence":"first","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Animal Pathology, Universidad de Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-3821","authenticated-orcid":false,"given":"Sergio","family":"Rodriguez-Zapater","sequence":"additional","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Animal Sciences, Universitat de Lleida, 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-7926","authenticated-orcid":false,"given":"Francisco","family":"Rodriguez-Panadero","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IbiS), Hospital Universitario Virgen del Roc\u00edo, CSIC-Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Unidad Medico-Quirurgica de Enfermedades Respiratorias (UMQER), Hospital Universitario Virgen del Roc\u00edo, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4026-1304","authenticated-orcid":false,"given":"Raquel","family":"Gomez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IbiS), Hospital Universitario Virgen del Roc\u00edo, CSIC-Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-9891","authenticated-orcid":false,"given":"Cristina","family":"Bonastre","sequence":"additional","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Animal Pathology, Universidad de Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-5121","authenticated-orcid":false,"given":"Jose Andres","family":"Guirola","sequence":"additional","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Microbiology, Pediatrics, Radiology and Public Health, Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Interventional Radiology Department, Lozano Blesa University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-4959","authenticated-orcid":false,"given":"Jose","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Department of Animal Pathology, Universidad de Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-7519","authenticated-orcid":false,"given":"Miguel Angel","family":"de Gregorio","sequence":"additional","affiliation":[{"name":"Minimally Invasive Research Group (GITMI), Universidad de Zaragoza, 50009 Zaragoza, Spain"},{"name":"Interventional Radiology, Cl\u00ednica Quir\u00f3n, 50012 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.athoracsur.2006.11.066","article-title":"Long-Term Follow-Up of Ultraflex Metallic Stents in Benign and Malignant Central Airway Obstruction","volume":"83","author":"Husain","year":"2007","journal-title":"Ann. 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