{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:35:46Z","timestamp":1788536146877,"version":"build-2803163510"},"reference-count":135,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["72274067"],"award-info":[{"award-number":["72274067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["72574075"],"award-info":[{"award-number":["72574075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The kidney is among the organs most susceptible to sepsis-induced injury, and acute kidney injury frequently develops in this context, thereby markedly increasing mortality in affected patients. With continued advances in research, a more comprehensive understanding has been achieved regarding the clinical risk factors, pathophysiological mechanisms, therapeutic responses, and renal recovery processes associated with sepsis-associated acute kidney injury (SA-AKI). These advances have strengthened the capacity for prevention, early detection, and effective management of SA-AKI. Despite this progress, substantial gaps remain in the overall understanding of SA-AKI pathogenesis, including the complex interplay among pathophysiological mechanisms and the extensive cross-regulation of multiple signaling pathways. Consequently, SA-AKI remains a major clinical challenge and imposes a substantial global healthcare burden. There is therefore an urgent need for further research to elucidate the underlying mechanisms of SA-AKI and to identify more effective therapeutic strategies. Unlike previous reviews that primarily focused on individual mechanisms or isolated therapeutic targets, the present review synthesizes the most recent evidence on SA-AKI. Particular emphasis is placed on its pathogenic processes, associated molecular mechanisms and signaling pathways, and emerging therapeutic targets. Special attention is given to the hierarchical relationships among distinct mechanisms during disease progression and their implications for clinical translation. This review aims to inform clinical practice and to identify future research directions, thereby providing valuable insights for both researchers and clinicians in this field.<\/jats:p>","DOI":"10.3390\/ijms27031315","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:04:46Z","timestamp":1769612686000},"page":"1315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Current Status and Future Prospects of Research on Sepsis-Related Acute Kidney Injury"],"prefix":"10.3390","volume":"27","author":[{"given":"Yurou","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-03424-1","article-title":"Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI","volume":"25","author":"Star","year":"2021","journal-title":"Crit. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00134-017-4755-7","article-title":"Acute kidney injury in sepsis","volume":"43","author":"Bellomo","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","article-title":"Sepsis-associated acute kidney injury: Consensus report of the 28th Acute Disease Quality Initiative workgroup","volume":"19","author":"Zarbock","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00134-023-07138-0","article-title":"Sepsis-associated acute kidney injury in the intensive care unit: Incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study","volume":"49","author":"White","year":"2023","journal-title":"Intensive Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1001\/jama.2024.22718","article-title":"Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury: A Randomized Clinical Trial","volume":"332","author":"Aklilu","year":"2024","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"R363","DOI":"10.1186\/cc3540","article-title":"Renal blood flow in sepsis","volume":"9","author":"Langenberg","year":"2005","journal-title":"Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12483","DOI":"10.1111\/micc.12483","article-title":"Sepsis-induced acute kidney injury: A disease of the microcirculation","volume":"26","author":"Ma","year":"2018","journal-title":"Microcirculation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000329246","article-title":"Septic acute kidney injury: The glomerular arterioles","volume":"174","author":"Bellomo","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","article-title":"Acute kidney injury from sepsis: Current concepts, epidemiology, pathophysiology, prevention and treatment","volume":"96","author":"Peerapornratana","year":"2019","journal-title":"Kidney Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.kint.2016.07.032","article-title":"Renal perfusion in sepsis: From macro- to microcirculation","volume":"91","author":"Post","year":"2017","journal-title":"Kidney Int."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pais, T., Jorge, S., and Lopes, J.A. (2024). Acute Kidney Injury in Sepsis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115924"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41581-021-00489-1","article-title":"Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury","volume":"18","author":"Molema","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23618","DOI":"10.1073\/pnas.1912409116","article-title":"The in vivo endothelial cell translatome is highly heterogeneous across vascular beds","volume":"116","author":"Cleuren","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gessler, S., Guthmann, C., Schuler, V., Lilienkamp, M., Walz, G., and Yakulov, T.A. (2022). Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147870"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"113076","DOI":"10.1016\/j.intimp.2024.113076","article-title":"Echinocystic acid inhibits sepsis-associated renal inflammation and apoptosis by targeting protein tyrosine phosphatase 1B","volume":"142","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1007\/s12015-021-10323-7","article-title":"Comparison of Single and Repeated Dosing of Anti-Inflammatory Human Umbilical Cord Mesenchymal Stromal Cells in a Mouse Model of Polymicrobial Sepsis","volume":"18","author":"Fazekas","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ndt\/gfw250","article-title":"Emerging role of Lipopolysaccharide binding protein in sepsis-induced acute kidney injury","volume":"32","author":"Stasi","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kounatidis, D., Vallianou, N.G., Psallida, S., Panagopoulos, F., Margellou, E., Tsilingiris, D., Karampela, I., Stratigou, T., and Dalamaga, M. (2024). Sepsis-Associated Acute Kidney Injury: Where Are We Now?. Medicina, 60.","DOI":"10.3390\/medicina60030434"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"F571","DOI":"10.1152\/ajprenal.00294.2022","article-title":"Renal mitochondrial dysfunction in ovine experimental sepsis-associated acute kidney injury","volume":"324","author":"Luther","year":"2023","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"F984","DOI":"10.1152\/ajprenal.00582.2020","article-title":"NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury","volume":"320","author":"Standage","year":"2021","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semnephrol.2015.01.002","article-title":"Sepsis-associated acute kidney injury","volume":"35","author":"Alobaidi","year":"2015","journal-title":"Semin. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40635-016-0106-1","article-title":"Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia","volume":"4","author":"Ergin","year":"2016","journal-title":"Intensive Care Med. Exp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"L640","DOI":"10.1152\/ajplung.00097.2011","article-title":"N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation","volume":"302","author":"Campos","year":"2012","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhao, L., Hao, Y., Tang, S., Han, X., Li, R., and Zhou, X. (2023). Energy metabolic reprogramming regulates programmed cell death of renal tubular epithelial cells and might serve as a new therapeutic target for acute kidney injury. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1276217"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wu, Z., Deng, J., Zhou, H., Tan, W., Lin, L., and Yang, J. (2022). Programmed Cell Death in Sepsis Associated Acute Kidney Injury. Front. Med., 9.","DOI":"10.3389\/fmed.2022.883028"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.23876\/j.krcp.23.294","article-title":"Early single session of hyperbaric oxygen therapy mitigates renal apoptosis in lipopolysaccharides-induced endotoxemia in rats","volume":"44","author":"Lee","year":"2024","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, W., Qi, R., Li, T., Zhang, X., Shi, Y., Xu, M., and Zhu, T. (2021). Kidney Organoids as a Novel Platform to Evaluate Lipopolysaccharide-Induced Oxidative Stress and Apoptosis in Acute Kidney Injury. Front. Med., 8.","DOI":"10.3389\/fmed.2021.766073"},{"key":"ref_31","first-page":"657","article-title":"MicroRNA-223-3p Targeting SGK1 Regulates Apoptosis and Inflammation in Sepsis-Associated Acute Kidney Injury","volume":"49","author":"Chen","year":"2024","journal-title":"Kidney Blood Press. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00134-009-1723-x","article-title":"Histopathology of septic shock induced acute kidney injury: Apoptosis and leukocytic infiltration","volume":"36","author":"Lerolle","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.4049\/jimmunol.172.4.2629","article-title":"Role of Toll-like receptor 4 in endotoxin-induced acute renal failure","volume":"172","author":"Cunningham","year":"2004","journal-title":"J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2307216","DOI":"10.1002\/advs.202307216","article-title":"Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury","volume":"11","author":"Qiao","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1681\/ASN.2021101293","article-title":"Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss","volume":"33","author":"Maremonti","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E961","DOI":"10.1073\/pnas.1613305114","article-title":"Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner","volume":"114","author":"Conos","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e98411","DOI":"10.1172\/jci.insight.98411","article-title":"RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction","volume":"3","author":"Sureshbabu","year":"2018","journal-title":"JCI Insight"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/imr.12910","article-title":"Pyroptotic and non-pyroptotic effector functions of caspase-11","volume":"297","author":"Amer","year":"2020","journal-title":"Immunol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6636621","DOI":"10.1155\/2021\/6636621","article-title":"Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis","volume":"2021","author":"Yang","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000499685","article-title":"Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury","volume":"44","author":"Ye","year":"2019","journal-title":"Kidney Blood Press. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.pmbts.2020.01.008","article-title":"Autophagy in kidney disease: Advances and therapeutic potential","volume":"172","author":"Bhatia","year":"2020","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_43","first-page":"316","article-title":"Biological effects of autophagy in mice with sepsis-induced acute kidney injury","volume":"17","author":"Wu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Leventhal, J.S., Ni, J., Osmond, M., Lee, K., Gusella, G.L., Salem, F., and Ross, M.J. (2016). Autophagy Limits Endotoxemic Acute Kidney Injury and Alters Renal Tubular Epithelial Cell Cytokine Expression. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150001"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, A.B., Tan, B., Yang, P., Tian, N., Li, J.K., Wang, S.C., Yang, L.S., Ma, L., and Zhang, J.F. (2024). The role of inflammatory response and metabolic reprogramming in sepsis-associated acute kidney injury: Mechanistic insights and therapeutic potential. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1487576"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting Ferroptosis to Iron Out Cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13578-021-00734-x","article-title":"Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury","volume":"11","author":"Xiao","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"123124","DOI":"10.1016\/j.lfs.2024.123124","article-title":"Biochanin A-mediated anti-ferroptosis is associated with reduction of septic kidney injury","volume":"358","author":"Won","year":"2024","journal-title":"Life Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"176194","DOI":"10.1016\/j.ejphar.2023.176194","article-title":"Dexmedetomidine alleviates renal tubular ferroptosis in sepsis-associated AKI by KEAP1 regulating the degradation of GPX4","volume":"961","author":"Li","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41420-024-02113-0","article-title":"Ferroptosis and inflammation are modulated by the NFIL3-ACSL4 axis in sepsis associated-acute kidney injury","volume":"10","author":"Xiao","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00134-023-07271-w","article-title":"Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)","volume":"50","author":"Pickkers","year":"2024","journal-title":"Intensive Care Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13054-024-04837-y","article-title":"Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury","volume":"28","author":"Bruse","year":"2024","journal-title":"Crit. Care"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, J.C., Huang, S.T., Feng, F., Wang, L.J., Chen, T.T., Li, M., and Liu, L.P. (2024). Relationship between low molecular weight heparin calcium therapy and prognosis in severe acute kidney injury in sepsis: Mendelian randomized analysis and retrospective study. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1389354"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.asjsur.2021.02.004","article-title":"Continuous renal replacement therapy in sepsis-associated acute kidney injury: Effects on inflammatory mediators and coagulation function","volume":"44","author":"Wu","year":"2021","journal-title":"Asian J. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000507999","article-title":"Inpatient Kidney Function Recovery among Septic Shock Patients Who Initiated Kidney Replacement Therapy in the Hospital","volume":"144","author":"Chen","year":"2020","journal-title":"Nephron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10815589241290210","article-title":"Association between acetaminophen and risk of mortality in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database","volume":"73","author":"Yu","year":"2024","journal-title":"J. Investig. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, L.Z., Zhang, L.M., Ye, Y., Su, Q., Leong, K.F., Yin, H.Y., Gu, W.J., and Ma, M. (2024). Association of acetaminophen use with mortality and renal recovery in patients with sepsis-associated acute kidney injury. BMC Anesthesiol., 24.","DOI":"10.1186\/s12871-024-02756-7"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"F255","DOI":"10.1152\/ajprenal.00033.2022","article-title":"Choline supplementation attenuates experimental sepsis-associated acute kidney injury","volume":"323","author":"Hasson","year":"2022","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"153986","DOI":"10.1016\/j.jcrc.2022.153986","article-title":"RAS inhibition and sepsis-associated acute kidney injury","volume":"69","author":"Flannery","year":"2022","journal-title":"J. Crit. Care"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"F1015","DOI":"10.1152\/ajprenal.00405.2020","article-title":"Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury","volume":"319","author":"Zhang","year":"2020","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_61","first-page":"10998","article-title":"The renal level of a novel cytokine IL-35 is related to sepsis-associated acute kidney injury in mice","volume":"10","author":"Yao","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhang, L., Rao, J., Liu, X., Wang, X., Wang, C., Fu, S., and Xiao, J. (2023). Attenuation of Sepsis-Induced Acute Kidney Injury by Exogenous H2S via Inhibition of Ferroptosis. Molecules, 28.","DOI":"10.3390\/molecules28124770"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/nep.14335","article-title":"2,5-Dihydroxyacetophenone attenuates acute kidney injury induced by intra-abdominal infection in rats","volume":"29","author":"Han","year":"2024","journal-title":"Nephrology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s11418-024-01813-2","article-title":"Byakangelicin alleviates sepsis-associated acute kidney injury by inhibiting inflammation and apoptosis","volume":"78","author":"Hangda","year":"2024","journal-title":"J. Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"117101","DOI":"10.1016\/j.jep.2023.117101","article-title":"Polygonum cuspidatum Sieb. et Zucc. Extracts improve sepsis-associated acute kidney injury by inhibiting NF-\u03baB-mediated inflammation and pyroptosis","volume":"319","author":"Yang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2313176","DOI":"10.1080\/0886022X.2024.2313176","article-title":"TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4\/NF-\u03baB signaling pathway","volume":"46","author":"Xia","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/jcmm.17108","article-title":"Tacrolimus alleviates LPS-induced AKI by inhibiting TLR4\/MyD88\/NF-\u03baB signalling in mice","volume":"26","author":"Hu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"112668","DOI":"10.1016\/j.intimp.2024.112668","article-title":"SKLB023 protects against inflammation and apoptosis in sepsis-associated acute kidney injury via the inhibition of toll-like receptor 4 signaling","volume":"139","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112527","DOI":"10.1016\/j.intimp.2024.112527","article-title":"Micheliolide ameliorates lipopolysaccharide-induced acute kidney injury through suppression of NLRP3 activation by promoting mitophagy via Nrf2\/PINK1\/Parkin axis","volume":"138","author":"Lei","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"122525","DOI":"10.1016\/j.jchromb.2021.122525","article-title":"Integrating metabolomics and network pharmacology to explore Rhizoma Coptidis extracts against sepsis-associated acute kidney injury","volume":"1164","author":"Zheng","year":"2021","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11033-024-09462-0","article-title":"Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury","volume":"51","author":"Yang","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Qiongyue, Z., Xin, Y., Meng, P., Sulin, M., Yanlin, W., Xinyi, L., and Xuemin, S. (2022). Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1\/Nrf2 Pathway. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.857067"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2290864","DOI":"10.1080\/13510002.2023.2290864","article-title":"Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis","volume":"29","author":"Zan","year":"2023","journal-title":"Redox Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"110850","DOI":"10.1016\/j.cbi.2023.110850","article-title":"Malvidin promotes PGC-1\u03b1\/Nrf2 signaling to attenuate the inflammatory response and restore mitochondrial activity in septic acute kidney injury","volume":"388","author":"Fan","year":"2023","journal-title":"Chem. Interact."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Niu, X., Wang, C., Li, H., and Chen, W. (2024). Role of OPG\/RANKL\/RANK\/TLR4 signaling pathway in sepsis-associated acute kidney injury. BMC Nephrol., 25.","DOI":"10.1186\/s12882-024-03648-1"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"C1353","DOI":"10.1152\/ajpcell.00577.2023","article-title":"TIMP2 protects against sepsis-associated acute kidney injury by cAMP\/NLRP3 axis-mediated pyroptosis","volume":"326","author":"Xu","year":"2024","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2147\/JIR.S442729","article-title":"Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK\/SIRT3 Pathway","volume":"17","author":"Sun","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s10753-024-02161-9","article-title":"Critical Role of S100A9 in Sepsis-associated Acute Kidney Injury: Mechanistic Insights through Pyroptosis Pathway Modulation","volume":"48","author":"Zhang","year":"2024","journal-title":"Inflammation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2379008","DOI":"10.1080\/0886022X.2024.2379008","article-title":"Medicinal evaluation and molecular docking study of osajin as an anti-inflammatory, antioxidant, and antiapoptotic agent against sepsis-associated acute kidney injury in rats","volume":"46","author":"Alhilal","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.18632\/aging.204189","article-title":"Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury","volume":"14","author":"Tang","year":"2022","journal-title":"Aging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2174\/1574888X17666220511151343","article-title":"Mesenchymal Stem Cells Attenuate Sepsis-associated Acute Kidney Injury by Changing the Balance of Th17 cells\/Tregs via Gal-9\/Tim-3","volume":"18","author":"Luo","year":"2023","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_82","first-page":"3194","article-title":"Necrostatin-1 attenuates sepsis-associated acute kidney injury by promoting autophagosome elimination in renal tubular epithelial cells","volume":"17","author":"Dong","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/kjm2.12892","article-title":"Molecular mechanism of ALKBH5-mediated m6A demethylation regulating lipopolysaccharide-induced epithelial-mesenchymal transition in sepsis-induced acute kidney injury","volume":"40","author":"Zhao","year":"2024","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"115523","DOI":"10.1016\/j.bcp.2023.115523","article-title":"Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis","volume":"211","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11936","DOI":"10.1111\/jcmm.15815","article-title":"LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-\u03baB pathway","volume":"24","author":"Zhong","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"111564","DOI":"10.1016\/j.intimp.2024.111564","article-title":"SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury","volume":"129","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e2305563","DOI":"10.1002\/advs.202305563","article-title":"VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2\/HO-1 Signaling Pathway in Diabetic Nephropathy","volume":"11","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"114637","DOI":"10.1016\/j.fct.2024.114637","article-title":"Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2\/NF-\u03baB\/NLRP3\/GSDMD signaling pathways","volume":"187","author":"Mansoure","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"118684","DOI":"10.1016\/j.jep.2024.118684","article-title":"Syzygium cumini (L.) skeels mitigate diabetic nephropathy by regulating Nrf2 pathway and mitocyhondrial dysfunction: In vitro and in vivo studies","volume":"336","author":"Bangar","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2165103","DOI":"10.1080\/0886022X.2023.2165103","article-title":"Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2\/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway","volume":"45","author":"Lv","year":"2023","journal-title":"Ren. Fail."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2022.12.088","article-title":"Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK\/NRF2 pathway","volume":"195","author":"Lu","year":"2022","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1111\/bph.15834","article-title":"Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway","volume":"179","author":"Hu","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1152\/ajprenal.00032.2009","article-title":"Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy","volume":"298","author":"Rane","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"737","DOI":"10.21037\/atm-22-845","article-title":"Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1\u2013Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41419-024-06826-z","article-title":"Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1016\/j.ymthe.2023.08.014","article-title":"AMPK activation coupling SENP1-Sirt3 axis protects against acute kidney injury","volume":"31","author":"Zhu","year":"2023","journal-title":"Mol. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI77632","article-title":"Sirtuin 3\u2013dependent mitochondrial dynamic improvements protect against acute kidney injury","volume":"125","author":"Morigi","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Chen, Y., Jing, H., Tang, S., Liu, P., Cheng, Y., Fan, Y., Chen, H., and Zhou, J. (2022). Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.830924"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1002\/tox.24130","article-title":"lncRNA NORAD alleviates dysfunction of renal proximal tubular epithelial cells during the sepsis-associated acute kidney injury by modulating the miR-155-5p-PDK1 axis","volume":"39","author":"Lu","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12950-024-00409-7","article-title":"Circ_001653 alleviates sepsis associated-acute kidney injury by recruiting BUD13 to regulate KEAP1\/NRF2\/HO-1 signaling pathway","volume":"21","author":"Li","year":"2024","journal-title":"J. Inflamm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1166\/jnn.2021.18642","article-title":"Study on the Regulation of Compound siRNA Nanoparticles on the Rat Model of Kidney Injury Induced by Sepsis by Inhibiting the Expression of NF-\u03baB and P65","volume":"21","author":"Chen","year":"2021","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00018-023-05079-x","article-title":"Discovery and verification of mmu_Circ_26986\/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury","volume":"81","author":"Peng","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2022.03.009","article-title":"The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism","volume":"604","author":"Zhang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2276066","DOI":"10.1080\/08916934.2023.2276066","article-title":"Circ_0006944 aggravates LPS-induced HK2 cell injury via modulating miR-205-5p\/UBL4A pathway","volume":"56","author":"Zhou","year":"2023","journal-title":"Autoimmunity"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10863-021-09925-0","article-title":"Circ-BNIP3L knockdown alleviates LPS-induced renal tubular epithelial cell injury during sepsis-associated acute kidney injury by miR-370-3p\/MYD88 axis","volume":"53","author":"Zhou","year":"2021","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.24976\/Discov.Med.202335179.106","article-title":"LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1","volume":"35","author":"Xu","year":"2023","journal-title":"Discov. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/SHK.0000000000002245","article-title":"KNOCKDOWN of CIRC_0114428 ALLEVIATES LPS-INDUCED HK2 CELL APOPTOSIS and INFLAMMATION INJURY via TARGETING MIR-215-5P\/TRAF6\/NF-\u039aB AXIS in SEPTIC ACUTE KIDNEY INJURY","volume":"61","author":"Li","year":"2023","journal-title":"Shock"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/SHK.0000000000002077","article-title":"CIRC_0114428 influences the progression of septic acute kidney injury via regulating mir-370-3p\/timp2 axis","volume":"59","author":"Zhang","year":"2023","journal-title":"Shock"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10863-023-09975-6","article-title":"Circ_0001714 knockdown alleviates lipopolysaccharide-induced apoptosis and inflammation in renal tubular epithelial cells via miR-129-5p\/TRAF6 axis in septic acute kidney injury","volume":"55","author":"Tan","year":"2023","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"K4891","DOI":"10.1136\/bmj.k4891","article-title":"Sepsis associated acute kidney injury","volume":"364","author":"Poston","year":"2019","journal-title":"BMJ"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2325640","DOI":"10.1080\/0886022X.2024.2325640","article-title":"The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: A post-hoc analysis (the PHENAKI study)","volume":"46","author":"Diouf","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Jia, H., Jiang, Y., and Li, W. (2024). Predictive performance of two types of urinary biomarkers for renal non-recovery in sepsis-associated acute kidney injury: A prospective observational study. BMC Nephrol., 25.","DOI":"10.1186\/s12882-024-03589-9"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13054-023-04554-y","article-title":"Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: Risk-stratified analysis from a prospective observational cohort of pediatric septic shock","volume":"27","author":"Atreya","year":"2023","journal-title":"Crit. Care"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8","DOI":"10.7150\/ijms.50893","article-title":"TREM-1 promoted apoptosis and inhibited autophagy in LPS-treated HK-2 cells through the NF-\u03baB pathway","volume":"18","author":"Pan","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_118","first-page":"607","article-title":"The role of renin-angiotensin system in sepsis-associated acute kidney injury: Mechanisms and therapeutic implications","volume":"29","author":"Garcia","year":"2023","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"13711","DOI":"10.1074\/jbc.RA120.014183","article-title":"Dipeptidyl peptidase 3 modulates the renin\u2013angiotensin system in mice","volume":"295","author":"Jha","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Brozat, J.F., Harbalio\u011flu, N., Hohlstein, P., Abu Jhaisha, S., Pollmanns, M.R., Adams, J.K., Wirtz, T.H., Hamesch, K., Yagmur, E., and Weiskirchen, R. (2024). Elevated Serum KIM-1 in Sepsis Correlates with Kidney Dysfunction and the Severity of Multi-Organ Critical Illness. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115819"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Guo, C., Fan, Y., Cheng, J., Deng, Y., Zhang, X., Chen, Y., Jing, H., Li, W., Liu, P., and Xie, J. (2023). AFM negatively regulates the infiltration of monocytes to mediate sepsis-associated acute kidney injury. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1049536"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.thromres.2024.03.014","article-title":"Sepsis induces heterogeneous transcription of coagulation- and inflammation-associated genes in renal microvasculature","volume":"237","author":"Luxen","year":"2024","journal-title":"Thromb. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e2354923","DOI":"10.1001\/jamanetworkopen.2023.54923","article-title":"Early Sepsis-Associated Acute Kidney Injury and Obesity","volume":"7","author":"Ahn","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Dennhardt, S., Ceanga, I.-A., Baumbach, P., Amiratashani, M., Kr\u00f6ller, S., and Coldewey, S.M. (2024). Cell-free DNA in patients with sepsis: Long term trajectory and association with 28-day mortality and sepsis-associated acute kidney injury. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1382003"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jmii.2024.07.006","article-title":"Plasma SCUBE2 as a novel biomarker associates with survival outcomes in patients with sepsis-associated acute kidney injury","volume":"57","author":"Lee","year":"2024","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e29257","DOI":"10.1016\/j.heliyon.2024.e29257","article-title":"Triglyceride-glucose index predicts sepsis-associated acute kidney injury and length of stay in sepsis: A MIMIC-IV cohort study","volume":"10","author":"Fang","year":"2024","journal-title":"Heliyon"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"117616","DOI":"10.1016\/j.cca.2023.117616","article-title":"Plasma oxidative lipidomics reveals signatures for sepsis-associated acute kidney injury","volume":"551","author":"Zhou","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2212080","DOI":"10.1080\/0886022X.2023.2212080","article-title":"The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: A retrospective cohort study","volume":"45","author":"Liang","year":"2023","journal-title":"Ren. Fail."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e943414","DOI":"10.12659\/MSM.943414","article-title":"Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study","volume":"30","author":"Sun","year":"2024","journal-title":"Med. Sci. Monit."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.2147\/IJGM.S459583","article-title":"Elevated Activated Partial Thromboplastin Time as a Predictor of 28-Day Mortality in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Analysis","volume":"17","author":"Lin","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s10753-023-01928-w","article-title":"Galectin-3 Mediates Endotoxin Internalization and Caspase-4\/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury","volume":"47","author":"Wang","year":"2023","journal-title":"Inflammation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2514186","DOI":"10.1080\/0886022X.2025.2514186","article-title":"A machine learning-based prediction model for sepsis-associated delirium in intensive care unit patients with sepsis-associated acute kidney injury","volume":"47","author":"Yu","year":"2025","journal-title":"Ren. Fail."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2316267","DOI":"10.1080\/0886022X.2024.2316267","article-title":"Machine learning-based prediction of in-hospital mortality for critically ill patients with sepsis-associated acute kidney injury","volume":"46","author":"Gao","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Huang, P., Liu, Y., Li, Y., Xin, Y., Nan, C., Luo, Y., Feng, Y., Jin, N., Peng, Y., and Wang, D. (2025). Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury. BMC Med., 23.","DOI":"10.1186\/s12916-025-03920-7"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Qiao, J., and Cui, L. (2022). Multi-Omics Techniques Make it Possible to Analyze Sepsis-Associated Acute Kidney Injury Comprehensively. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.905601"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:17:41Z","timestamp":1769750261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":135,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031315"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031315","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]}}}