{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:38:26Z","timestamp":1790393906017,"version":"4.1.0"},"reference-count":324,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Synucleinopathies, including Parkinson\u2019s disease (PD), are neurodegenerative disorders characterized by aberrant aggregation of \u03b1-synuclein (\u03b1-syn), a presynaptic protein with an intrinsic disorder nature. The transition of soluble monomers into oligomeric and fibrillar species represents a key molecular event driving neuronal dysfunction and neurodegeneration. Emerging evidence suggests that nutraceuticals, bioactive compounds derived from dietary sources, can modulate \u03b1-syn aggregation at multiple conformational stages. Polyphenols, alkaloids, ginsenosides, and food-derived peptides interfere with \u03b1-syn structure and assembly, suppressing the formation of toxic oligomer species and promoting the clearance of misfolded assemblies. Despite this potential, clinical translational of nutraceuticals is currently limited by poor systemic bioavailability and restricted central nervous system penetration due to blood\u2013brain barrier constraints, which have largely confined research to preclinical studies. In this context, this review summarizes current knowledge of nutraceutical interventions targeting the conformational landscape of \u03b1-syn and highlighting both direct and indirect molecular mechanisms with involved in aggregation-prone species. Furthermore, we critically examine key challenges related to bioavailability and clinical translation, focusing on advanced delivery systems and precision-based approaches to enhance neuroprotective efficacy and support the potential of nutraceuticals as novel or adjunctive therapeutic strategies for PD.<\/jats:p>","DOI":"10.3390\/ijms27031324","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T17:40:22Z","timestamp":1769622022000},"page":"1324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interactions Between Nutraceuticals and \u03b1-Synuclein Conformational States: Molecular Mechanisms and Neuroprotective Implications in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"27","author":[{"given":"Bruna","family":"Amenta","sequence":"first","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, University of Bari \u2018Aldo Moro\u2019, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Minervini","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, University of Bari \u2018Aldo Moro\u2019, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3966-3969","authenticated-orcid":false,"given":"Maria Laura","family":"Matrella","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, University of Bari \u2018Aldo Moro\u2019, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-3460","authenticated-orcid":false,"given":"Tiziana","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience \u201cDiBraiN\u201d, University of Bari \u2018Aldo Moro\u2019, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3940(98)00504-7","article-title":"Filamentous \u03b1-Synuclein Inclusions Link Multiple System Atrophy with Parkinson\u2019s Disease and Dementia with Lewy Bodies","volume":"251","author":"Jakes","year":"1998","journal-title":"Neurosci. 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