{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:14:52Z","timestamp":1791569692095,"version":"4.3.4"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sub-internal limiting membrane (sub-ILM) hemorrhage is a distinct preretinal bleeding entity in which blood accumulates between the ILM and the retinal nerve fiber layer (RNFL), forming a sharply confined compartment. The ILM\u2019s low permeability and lack of immune cell access create a stagnant microenvironment in which erythrocyte lysis leads to the accumulation of hemoglobin, heme, and iron, promoting the generation of reactive oxygen species. This oxidative burden poses a direct risk to retinal ganglion cells and M\u00fcller cell endfeet. Spectral-domain optical coherence tomography (SD-OCT) enables precise identification of sub-ILM blood through its characteristic dome-shaped elevation and hyperreflective contents, distinguishing it from subhyaloid and vitreous hemorrhage. Management options include observation, neodymium-doped yttrium\u2013aluminum\u2013garnet (Nd: YAG) laser membranotomy, pneumatic displacement, and pars plana vitrectomy (PPV). While small, extrafoveal hemorrhages may resolve spontaneously, prolonged blood entrapment is associated with increased retinal toxicity, tractional changes, and proliferative vitreoretinopathy (PVR). Early intervention generally results in faster clearance and improved visual outcomes, particularly for dense or foveal bleeding. Major gaps remain regarding cellular stress responses, biomarkers that predict irreversible damage, and the optimal timing of intervention. Standardized imaging criteria and evidence-based management algorithms are needed to guide individualized treatment.<\/jats:p>","DOI":"10.3390\/ijms27031336","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:08:57Z","timestamp":1769681337000},"page":"1336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sub-Internal Limiting Membrane Hemorrhage: Molecular Microenvironment and Review of Treatment Modalities"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-0725","authenticated-orcid":false,"given":"Krzysztof","family":"Eder","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Prof. Kornel Gibi\u0144ski University Clinical Center, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Langosz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. Kornel Gibi\u0144ski University Clinical Center, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Danikiewicz-Zaga\u0142a","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. Kornel Gibi\u0144ski University Clinical Center, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Leszczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. Kornel Gibi\u0144ski University Clinical Center, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"},{"name":"Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ceglana 35, 40-514 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Wygl\u0119dowska-Promie\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof. Kornel Gibi\u0144ski University Clinical Center, Medical University of Silesia, ul. 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Ophthalmol. Vis. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1136\/bjo.2007.114025","article-title":"Subhyaloidal and macular haemorrhage: Localisation and treatment strategies","volume":"91","author":"Mennel","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/IAE.0000000000001935","article-title":"Multiple sub\u2013internal limiting membrane hemorrhages with double ring sign in eyes with Valsalva retinopathy","volume":"38","author":"Iwase","year":"2018","journal-title":"Retina"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000502442","article-title":"Histopathological changes and clinical outcomes following intervention for sub-internal limiting membrane haemorrhage","volume":"243","author":"Hussain","year":"2020","journal-title":"Ophthalmologica"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sotani, Y., Imai, H., Kishi, M., Yamada, H., Matsumiya, W., Miki, A., Kusuhara, S., and Nakamura, M. (2024). Removal of sub-internal limiting membrane hemorrhage secondary to Valsalva retinopathy using a fovea-sparing internal limiting membrane fissure creation technique. Case Rep. Ophthalmol. Med., 2774155.","DOI":"10.1155\/2024\/2774155"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3928\/23258160-20161130-11","article-title":"Bilateral prefoveal sub-internal limiting membrane hemorrhage in autoimmune hemolytic anemia","volume":"47","author":"Thomas","year":"2016","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.18240\/ijo.2022.12.23","article-title":"Differentiation of premacular hemorrhages with niveau formation","volume":"15","author":"Kitagawa","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108545","DOI":"10.1016\/j.exer.2021.108545","article-title":"The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies","volume":"206","author":"Zhang","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10384-014-0318-4","article-title":"Preserve the (intraocular) environment: The importance of maintaining normal oxygen gradients in the eye","volume":"58","author":"Beebe","year":"2014","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1167\/iovs.13-12609","article-title":"Computational model for oxygen transport and consumption in human vitreous","volume":"54","author":"Filas","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/ijo.IJO_1112_20","article-title":"Intraoperative optical coherence tomography\u2013guided identification of resolved sub-internal limiting membrane hemorrhage in leukemic retinopathy","volume":"1","author":"Verma","year":"2021","journal-title":"Indian J. Ophthalmol. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/ojo.OJO_310_2020","article-title":"Sub-internal limiting membrane hemorrhage as an unusual presentation of polypoidal choroidal vasculopathy","volume":"14","author":"Manayath","year":"2021","journal-title":"Oman J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.exer.2008.09.003","article-title":"Enzyme-induced posterior vitreous detachment in the rat produces increased lens nuclear pO2 levels","volume":"88","author":"Giblin","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aopr.2023.02.001","article-title":"Research progress of iron metabolism in retinal diseases","volume":"3","author":"Li","year":"2023","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1074\/jbc.M508903200","article-title":"RPE65 Is an Iron(II)-dependent Isomerohydrolase in the Retinoid Visual Cycle","volume":"281","author":"Moiseyev","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_19","first-page":"2343","article-title":"Iron, Ferritin, Transferrin, and Transferrin Receptor in the Adult Rat Retina","volume":"41","author":"Yefimova","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","first-page":"537","article-title":"Impaired Retinal Iron Homeostasis Associated with Defective Phagocytosis in Royal College of Surgeons Rats","volume":"43","author":"Yefimova","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Shahandeh, A., Bui, B.V., Finkelstein, D.I., and Nguyen, C.T.O. (2022). Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.794809"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.preteyeres.2007.07.004","article-title":"Iron homeostasis and toxicity in retinal degeneration","volume":"26","author":"He","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Picard, E., Daruich, A., Youale, J., Courtois, Y., and Behar-Cohen, F. (2020). From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology. Cells, 9.","DOI":"10.3390\/cells9030705"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-079X.2006.00352.x","article-title":"Lipid-protein modifications during ascorbate-Fe2+ peroxidation of photoreceptor membranes: Protective effect of melatonin","volume":"41","author":"Guajardo","year":"2006","journal-title":"J. Pineal Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1034\/j.1600-0749.2002.02054.x","article-title":"Membranes of Retinal Pigment Epithelial Cells In Vitro are Damaged in the Phagocytotic Process of the Photoreceptor Outer Segment Discs Peroxidized by Ferrous Ions","volume":"15","author":"Akeo","year":"2002","journal-title":"Pigment. Cell Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1073\/pnas.1722601115","article-title":"Iron promotes oxidative cell death caused by bisretinoids of retina","volume":"115","author":"Ueda","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0891-5849(94)00241-B","article-title":"DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions","volume":"18","author":"Zastawny","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1167\/iovs.08-2850","article-title":"Dysfunction of the retinal pigment epithelium with age: Increased iron decreases phagocytosis and lysosomal activity","volume":"50","author":"Chen","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhao, N., Li, S., Wu, H., Wei, D., Pu, N., Wang, K., Liu, Y., Tao, Y., and Song, Z. (2025). Ferroptosis: An Energetic Villain of Age-Related Macular Degeneration. Biomedicines, 13.","DOI":"10.3390\/biomedicines13040986"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Xie, Z.-G., Yu, S.-Q., Chen, X., Zhu, J., and Chen, F. (2014). Macular hole secondary to Valsalva retinopathy after doing push-up exercise. BMC Ophthalmol., 14.","DOI":"10.1186\/1471-2415-14-98"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/bjo.2006.104935","article-title":"Changes in the retinal inner limiting membrane associated with Valsalva retinopathy","volume":"91","author":"Gibran","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.4103\/ijo.IJO_337_22","article-title":"Bilateral sub-internal limiting membrane hemorrhage in a COVID-19 patient","volume":"70","author":"Ghodake","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1177\/1120672120934958","article-title":"\u201cArcus retinalis\u201d: A novel clinical marker of sub-internal limiting membrane hemorrhage","volume":"31","author":"Kumar","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_34","first-page":"4865222","article-title":"Valsalva retinopathy presenting as subretinal hemorrhage","volume":"2024","author":"Conci","year":"2024","journal-title":"Case Rep. Ophthalmol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16321","DOI":"10.1038\/s41598-022-20949-3","article-title":"Optical coherence tomography findings after surgery for sub-inner limiting membrane hemorrhage due to ruptured retinal arterial macroaneurysm","volume":"12","author":"Hayamizu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1097\/IAE.0000000000000530","article-title":"Novel outer retinal optical coherence tomography hyperreflective abnormality associated with sub\u2013internal limiting membrane hemorrhage","volume":"35","author":"Suzuki","year":"2015","journal-title":"Retina"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/IAE.0000000000004295","article-title":"Sub\u2013internal limiting membrane foveal hemorrhage under tension: Optical coherence tomography biomarkers predicting macular hole formation after submacular hemorrhage","volume":"45","author":"Miyamoto","year":"2025","journal-title":"Retina"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tjo.2013.12.007","article-title":"Spectral-domain optical coherence tomography findings of subinternal limiting membrane hemorrhage in the macula before and after Nd:YAG laser treatment","volume":"5","author":"Chang","year":"2015","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4103\/IJO.IJO_400_25","article-title":"Persistent pre-macular cavity post-laser membranotomy for Valsalva retinopathy","volume":"5","author":"Majumdar","year":"2025","journal-title":"Indian J. Ophthalmol. Case Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.4103\/jcsr.jcsr_77_23","article-title":"Resolving sub-internal limiting membrane haemorrhage mimicking as endogenous endophthalmitis","volume":"13","author":"Panigrahi","year":"2024","journal-title":"J. Clin. Sci. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1752-1947-6-346","article-title":"Long-term evolution of Valsalva retinopathy: A case series","volume":"6","author":"Navarro","year":"2012","journal-title":"J. Med. Case Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/meajo.MEAJO_32_20","article-title":"Spontaneous Resolution of Foveal Sub-internal Limiting Membrane Hemorrhage with Excellent Visual and Anatomical Outcome in a Patient with Acute Myeloid Leukemia","volume":"27","author":"Alamri","year":"2020","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_43","first-page":"288","article-title":"Treatment options for premacular and sub-internal limiting membrane hemorrhage","volume":"77","author":"Kousal","year":"2021","journal-title":"\u010ceska A Slov. Oftalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1097\/OPX.0000000000000621","article-title":"YAG laser membranotomy for sub-internal limiting membrane hemorrhage","volume":"92","author":"Kim","year":"2015","journal-title":"Optom. Vis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Khadka, D., Bhandari, S., Bajimaya, S., Thapa, R., Paudyal, G., and Pradhan, E. (2016). Nd: YAG laser hyaloidotomy in the management of premacular subhyaloid hemorrhage. BMC Ophthalmol., 16.","DOI":"10.1186\/s12886-016-0218-0"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"562","DOI":"10.18240\/ijo.2025.03.25","article-title":"Traumatic subhyaloid hemorrhage treated with argon laser-assisted hyaloidotomy","volume":"18","author":"Lee","year":"2025","journal-title":"Int. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, J., Cao, X., Zhou, H., Jia, L., Gao, L., Li, Z., Zhang, X., She, H., and Ma, K. (2022). Efficiency and complication of 577-nm laser membranotomy for the treatment of retinal sub-inner limiting membrane hemorrhage. Front. Ophthalmol., 2.","DOI":"10.3389\/fopht.2022.935188"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tjo.2014.10.006","article-title":"Sub-internal limiting membrane hemorrhage treated with intravitreal tissue plasminogen activator followed by octafluoropropane gas injection","volume":"5","author":"Chou","year":"2015","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_49","unstructured":"Jilani, T.N., and Siddiqui, A.H. (2024). Tissue Plasminogen Activator. StatPearls, StatPearls Publishing."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/13816810.2015.1126614","article-title":"Bilateral macular holes and a new onset vitelliform lesion in Best disease","volume":"38","author":"Liu","year":"2017","journal-title":"Ophthalmic Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/08820538.2024.2426483","article-title":"Vitrectomy combined with internal limiting membrane peeling for the treatment of hemorrhagic retinal arterial macroaneurysm with \u201cmultilayered\u201d hemorrhages","volume":"40","author":"Yang","year":"2025","journal-title":"Semin. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/APO.0000000000000534","article-title":"Timely vitrectomy and inner limiting membrane peeling is effective and safe for Terson syndrome with vitreous hemorrhage and sub\u2013inner limiting membrane hemorrhage","volume":"11","author":"Huang","year":"2022","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/bjo.2006.109132","article-title":"Sub-inner limiting membrane haemorrhage: Causes and treatment with vitrectomy","volume":"91","author":"Postelmans","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0161-6420(98)93030-5","article-title":"Terson syndrome: Results of vitrectomy and the significance of vitreous hemorrhage in patients with subarachnoid hemorrhage","volume":"105","author":"Kuhn","year":"1998","journal-title":"Ophthalmology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kimura, A., Imai, H., Iwane, Y., Kishimoto, M., Sotani, Y., Yamada, H., Matsumiya, W., Miki, A., Kusuhara, S., and Nakamura, M. (2023). Removal of Sub-Internal Limiting Membrane Hemorrhage Secondary to Retinal Arterial Macroaneurysm Rupture: Internal Limiting Membrane Non-Peeling Technique. J. Clin. Med., 12.","DOI":"10.3390\/jcm12093291"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chae, W., Kim, W., and Lee, S. (2025). Comparison of fovea-sparing (button-hole) and conventional internal limiting membrane peeling in retinal arterial macroaneurysm rupture: Visual and anatomical outcomes. Retina.","DOI":"10.1097\/IAE.0000000000004724"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/11206721221102258","article-title":"Inverse drainage Nd: YAG membranotomy for pre-macular hemorrhage","volume":"33","author":"Babu","year":"2023","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.4103\/tjo.TJO-D-23-00108","article-title":"Vitrectomy for diabetic retinopathy: A review of indications, techniques, outcomes, and complications","volume":"14","author":"Patel","year":"2024","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_59","first-page":"5258","article-title":"Sub-internal limiting membrane haemorrhage: A clinico-pathological study to guide the timing of surgical intervention. ARVO Annual Meeting Abstracts","volume":"59","author":"Stappler","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3341\/kjo.2020.1124","article-title":"Macular hole formation following vitrectomy for ruptured retinal arterial macroaneurysm","volume":"35","author":"An","year":"2021","journal-title":"Korean J. Ophthalmol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1336\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:09:59Z","timestamp":1769681399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/3\/1336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27031336"],"URL":"https:\/\/doi.org\/10.3390\/ijms27031336","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}