{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:22:39Z","timestamp":1770520959863,"version":"3.49.0"},"reference-count":106,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bronchopulmonary dysplasia (BPD) is a chronic lung condition in preterm infants characterized by impaired alveolar development, disrupted vascular growth, and persistent inflammation. These alterations, which often arise from early exposure to mechanical ventilation, oxygen toxicity, and infection, can lead to long-term structural and functional deficits in the developing lung. In adulthood, chronic obstructive pulmonary disease (COPD) represents a major cause of morbidity and mortality and is defined by progressive airflow obstruction, reduced respiratory capacity, and chronic inflammatory responses. Although traditionally considered a disease of adult smokers, growing evidence suggests that early-life respiratory insults play a key role in shaping long-term lung health. Recent studies reveal a biologically plausible link between BPD and later COPD, indicating that premature birth, impaired lung growth, and early inflammatory injury may predispose individuals to earlier or more severe COPD development. This review explores the shared molecular pathways connecting these conditions, focusing on overlapping inflammatory biomarkers such as IL1B, IL6, IL8, TNF, TGFB, and VEGF, which collectively reflect persistent dysregulation of immune and repair mechanisms. Additionally, common genetic variants, including SERPINA1 and HHIP, may contribute to susceptibility across the lifespan. Emerging biomarkers\u2014such as PRMT7, cathelicidin\/LL-37, CRISPLD2, and GDF15\u2014offer further insight into disease progression. Identifying these shared markers may ultimately improve early detection and help clinicians pinpoint infants with BPD who face an elevated risk of developing COPD later in life.<\/jats:p>","DOI":"10.3390\/ijms27031422","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:38:34Z","timestamp":1769794714000},"page":"1422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Common Biomarkers in Chronic Obstructive Pulmonary Disease and Bronchopulmonary Dysplasia: A Narrative Review of an Intriguing Interplay"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-0903","authenticated-orcid":false,"given":"Antonella","family":"Gambadauro","sequence":"first","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7428-6430","authenticated-orcid":false,"given":"Federica","family":"Xerra","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Chirico","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology and Dialysis Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7552-3932","authenticated-orcid":false,"given":"Immacolata","family":"Rulli","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Cacciola","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Mallamace","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloisa","family":"Gitto","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Marina","family":"Marseglia","sequence":"additional","affiliation":[{"name":"Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d, University of Messina, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moreira, A., Noronha, M., Joy, J., Bierwirth, N., Tarriela, A., Naqvi, A., Zoretic, S., Jones, M., Marotta, A., and Valadie, T. (2024). Rates of bronchopulmonary dysplasia in very low birth weight neonates: A systematic review and meta-analysis. Respir. Res., 25.","DOI":"10.1186\/s12931-024-02850-x"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1056\/NEJMra067279","article-title":"Chronic Lung Disease after Premature Birth","volume":"357","author":"Baraldi","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jobe, A.J. (1999). The New BPD: An Arrest of Lung Development. Pediatr. Res., 46.","DOI":"10.1203\/00006450-199912000-00007"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/thx.2008.107474","article-title":"The EPICure study: Maximal exercise and physical activity in school children born extremely preterm","volume":"65","author":"Welsh","year":"2010","journal-title":"Thorax"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Um-Bergstr\u00f6m, P., Hallberg, J., Pourbazargan, M., Berggren-Brostr\u00f6m, E., Ferrara, G., Eriksson, M.J., Nyr\u00e9n, S., Gao, J., Lilja, G., and Lind\u00e9n, A. (2019). Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma. Respir. Res., 20.","DOI":"10.1186\/s12931-019-1075-1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-2600(17)30293-X","article-title":"Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990\u20132015: A systematic analysis for the Global Burden of Disease Study 2015","volume":"5","author":"Soriano","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.mcna.2018.12.005","article-title":"Chronic Obstructive Pulmonary Disease","volume":"103","author":"Duffy","year":"2019","journal-title":"Med. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/bmj.303.6804.671","article-title":"Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease","volume":"303","author":"Barker","year":"1991","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/ppul.25301","article-title":"Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life","volume":"56","author":"Collaco","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/MCP.0000000000000456","article-title":"Lung function trajectories and chronic obstructive pulmonary disease","volume":"24","author":"Krishnan","year":"2018","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/thx.37.8.564","article-title":"Postnatal human lung growth","volume":"37","author":"Thurlbeck","year":"1982","journal-title":"Thorax"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s41372-018-0133-8","article-title":"Preeclampsia predicts higher incidence of bronchopulmonary dysplasia","volume":"38","author":"Rocha","year":"2018","journal-title":"J. Perinatol."},{"key":"ref_13","first-page":"55","article-title":"Pulmonary sequelae and functional limitations in children and adults with bronchopulmonary dysplasia","volume":"26","author":"Malleske","year":"2018","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","article-title":"Bronchopulmonary Dysplasia","volume":"175","author":"Abman","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_15","first-page":"270","article-title":"Chronic lung disease of prematurity: Clinical and pathophysiological correlates","volume":"56","author":"Pandya","year":"2001","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jpeds.2017.09.011","article-title":"A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia","volume":"192","author":"Leroy","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Keane, M.P., and Strieter, R.M. (2001). The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir. Res., 3.","DOI":"10.1186\/rr177"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.semperi.2006.04.009","article-title":"Pathogenesis of Bronchopulmonary Dysplasia: The Role of Interleuken 1\u03b2 in the Regulation of Inflammation-Mediated Pulmonary Retinoic Acid Pathways in Transgenic Mice","volume":"30","author":"Bry","year":"2006","journal-title":"Semin. Perinatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"F90","DOI":"10.1136\/fn.72.2.F90","article-title":"Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease","volume":"72","author":"Kotecha","year":"1995","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1242\/jcs.113.23.4319","article-title":"Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: Involvement of Ras-dependent and-independent pathways","volume":"113","author":"Genersch","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0002-9440(10)65624-6","article-title":"Transfer of Tumor Necrosis Factor-\u03b1 to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-\u03b21 and Myofibroblasts","volume":"153","author":"Sime","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08941939.2015.1034898","article-title":"Beneficial Effect of Etanercept on Hyperoxic Lung Injury Model in Neonatal Rats","volume":"29","author":"Oncel","year":"2016","journal-title":"J. Investig. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Neufeld","year":"1999","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1164\/ajrccm.159.5.9806073","article-title":"Vascular Endothelial Growth Factor in Human Preterm Lung","volume":"159","author":"Lassus","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1080\/14767058.2020.1760826","article-title":"Vascular endothelial growth factor levels and bronchopulmonary dysplasia in preterm infants","volume":"35","author":"Mariduena","year":"2022","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Perrone, S., Manti, S., Buttarelli, L., Petrolini, C., Boscarino, G., Filonzi, L., Gitto, E., Esposito, S.M.R., and Marzano, F.N. (2023). Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032729"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2016.05.011","article-title":"Inflammatory mechanisms in patients with chronic obstructive pulmonary disease","volume":"138","author":"Barnes","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"King, P.T. (2015). Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin. Transl. Med., 4.","DOI":"10.1186\/s40169-015-0068-z"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/thoraxjnl-2011-201518","article-title":"Long-term natural history of chronic obstructive pulmonary disease: Severe exacerbations and mortality","volume":"67","author":"Suissa","year":"2012","journal-title":"Thorax"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/resp.12542","article-title":"Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?","volume":"20","author":"Gao","year":"2015","journal-title":"Respirology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"209S","DOI":"10.1378\/chest.121.5_suppl.209S","article-title":"Cytokines and Therapy in COPD","volume":"121","year":"2002","journal-title":"Chest"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/1687-8426.145698","article-title":"A study of IL-6, IL-8, and TNF-\u03b1 as inflammatory markers in COPD patients","volume":"8","author":"Nagy","year":"2014","journal-title":"Egypt. J. Bronchol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4414\/smw.2009.12528","article-title":"TGF-\u00df signaling in COPD: Deciphering genetic and cellular susceptibilities for future therapeutic regimen","volume":"139","author":"Kneidinger","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"ref_36","first-page":"1079","article-title":"Respiratory health effects of indoor air pollution","volume":"14","author":"Schilmann","year":"2010","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"McGrath-Morrow, S.A., and Collaco, J.M. (2019). Bronchopulmonary dysplasia: What are its links to COPD?. Ther. Adv. Respir. Dis., 13.","DOI":"10.1177\/1753466619892492"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1073\/pnas.1713689115","article-title":"Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema","volume":"115","author":"Borel","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1113\/EP089523","article-title":"Association of VEGFA polymorphisms with chronic obstructive pulmonary disease in Chinese Han and Mongolian populations","volume":"106","author":"Gao","year":"2021","journal-title":"Exp. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Khalilian, S., Imani, S.Z.H., and Ghafouri-Fard, S. (2022). Emerging roles and mechanisms of miR-206 in human disorders: A comprehensive review. Cancer Cell Int., 22.","DOI":"10.1186\/s12935-022-02833-2"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12519-021-00427-y","article-title":"Hedgehog signaling pathway gene variant influences bronchopulmonary dysplasia in extremely low birth weight infants","volume":"17","author":"Amatya","year":"2021","journal-title":"World J. Pediatr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bester, J., and Pretorius, E. (2016). Effects of IL-1\u03b2, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity. Sci. Rep., 6.","DOI":"10.1038\/srep32188"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1165\/rcmb.2004-0309OC","article-title":"Interleukin-1\u03b2 Causes Pulmonary Inflammation, Emphysema, and Airway Remodeling in the Adult Murine Lung","volume":"32","author":"Lappalainen","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2147\/COPD.S131877","article-title":"Serum IL-1\u03b2 and IL-17 levels in patients with COPD: Associations with clinical parameters","volume":"12","author":"Zou","year":"2017","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000334900","article-title":"IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory Tests","volume":"84","author":"Grabczak","year":"2012","journal-title":"Respiration"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tanaka, T., Narazaki, M., and Kishimoto, T. (2014). IL-6 in Inflammation, Immunity, and Disease. Cold Spring Harb. Perspect. Biol., 6.","DOI":"10.1101\/cshperspect.a016295"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ferrari, R., Tanni, S.E., Caram, L.M., Corr\u00eaa, C., Corr\u00eaa, C.R., and Godoy, I. (2013). Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease. Respir. Res., 14.","DOI":"10.1186\/1465-9921-14-24"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, M., Luo, C., Shi, Z., Cheng, X., Lei, M., Cao, W., Zhang, J., Ge, J., Song, M., and Ding, W. (2022). The Relationship Between Cord Blood Cytokine Levels and Perinatal Characteristics and Bronchopulmonary Dysplasia: A Case\u2013Control Study. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.807932"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Forte, A.R.C.C., Lessa, P.H.C., Chaves Filho, A.J.M., Aquino PEAde Brito, L.M., Pinheiro, L.C., Juruena, M.F., Lucena DFde de Rezende, P.H.F., and de Vasconcelos, S.M.M. (2023). Oxidative stress and inflammatory process in borderline personality disorder (BPD): A narrative review. Braz. J. Med. Biol. Res., 56.","DOI":"10.1590\/1414-431x2023e12484"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1203\/00006450-199408000-00017","article-title":"Increased Activity of Interleukin-6 but not Tumor Necrosis Factor-\u03b1 in Lung Lavage of Premature Infants is Associated with the Development of Bronchopulmonaiy Dysplasia","volume":"36","author":"Bagchi","year":"1994","journal-title":"Pediatr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1164\/ajrccm.163.2.2003122","article-title":"Granulocyte Inflammatory Markers and Airway Infection during Acute Exacerbation of Chronic Obstructive Pulmonary Disease","volume":"163","author":"Aaron","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_52","first-page":"55","article-title":"IL-8 Gene Variants are Associated with Lung Function Decline and Multidimensional BODE Index in COPD Patients But Not with Disease Susceptibility: A Validation Study","volume":"12","author":"Varo","year":"2015","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"Bradley","year":"2008","journal-title":"J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yao, Y., Zhou, J., Diao, X., and Wang, S. (2019). Association between tumor necrosis factor-\u03b1 and chronic obstructive pulmonary disease: A systematic review and meta-analysis. Ther. Adv. Respir. Dis., 13.","DOI":"10.1177\/1753466619866096"},{"key":"ref_55","first-page":"365","article-title":"Cytokine response during hyperoxia: Sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats","volume":"2","author":"Makhoul","year":"2000","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4137\/BMI.S834","article-title":"Pulmonary Biomarkers of Bronchopulmonary Dysplasia","volume":"3","author":"Thompson","year":"2008","journal-title":"Biomark. Insights"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF03257159","article-title":"The Role of Interleukin-8 and its Receptors in Inflammatory Lung Disease","volume":"1","author":"Pease","year":"2002","journal-title":"Am. J. Respir. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1155\/2012\/925632","article-title":"Cord blood levels of IL-6, IL-8 and IL-10 may be early predictors of bronchopulmonary dysplasia in preterm newborns small for gestational age","volume":"33","author":"Rocha","year":"2012","journal-title":"Dis. Markers"},{"key":"ref_59","first-page":"13","article-title":"The Significance of Serum Interleukin-8 in Acute Exacerbations of Chronic Obstructive Pulmonary Disease","volume":"17","author":"Zhang","year":"2018","journal-title":"Tanaffos"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000063608","article-title":"Comparison of Tracheal Aspirate and Bronchoalveolar Lavage Specimens from Premature Infants","volume":"82","author":"Basavegowda","year":"2002","journal-title":"Neonatology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2022.04.028","article-title":"Perinatal Inflammatory Biomarkers and Respiratory Disease in Preterm Infants","volume":"246","author":"Collaco","year":"2022","journal-title":"J. Pediatr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/01902149709039242","article-title":"Comparison of Adult and Newborn Pulmonary Cytokine Mrna Expression After Hyperoxia","volume":"23","author":"Johnston","year":"1997","journal-title":"Exp. Lung Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Shams, S.E., Dastgheib, S.A., Mousavi-Beni, S.A., Lookzadeh, M.H., Mirjalili, S.R., Golshan-Tafti, M., Bahrami, R., Yeganegi, M., Shahbazi, A., and Masoudi, A. (2024). Association of TNF-\u03b1 genetic variants with neonatal bronchopulmonary dysplasia: Consolidated results. Front. Pediatr., 12.","DOI":"10.3389\/fped.2024.1511355"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/S0002-9440(10)63612-7","article-title":"Transfer of the Active Form of Transforming Growth Factor-\u03b21 Gene to Newborn Rat Lung Induces Changes Consistent with Bronchopulmonary Dysplasia","volume":"163","author":"Gauldie","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1165\/rcmb.2004-0092OC","article-title":"Conditional Overexpression of Bioactive Transforming Growth Factor\u2013\u03b21 in Neonatal Mouse Lung","volume":"31","author":"Vicencio","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Papaioannou, A.I., Kostikas, K., Kollia, P., and Gourgoulianis, K.I. (2006). Clinical implications for Vascular Endothelial Growth Factor in the lung: Friend or foe?. Respir. Res., 7.","DOI":"10.1186\/1465-9921-7-128"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Shahzad, T., Radajewski, S., Chao, C.-M., Bellusci, S., and Ehrhardt, H. (2016). Pathogenesis of bronchopulmonary dysplasia: When inflammation meets organ development. Mol. Cell. Pediatr., 3.","DOI":"10.1186\/s40348-016-0051-9"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.2147\/COPD.S176122","article-title":"Role of inflammatory cells in airway remodeling in COPD","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/978-1-59745-292-2_39","article-title":"Transforming Growth Factor-\u03b2 Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema","volume":"Volume I","author":"Warburton","year":"2008","journal-title":"Transforming Growth Factor-\u03b2 in Cancer Therapy"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2147\/COPD.S159915","article-title":"Blood MCP-1 levels are increased in chronic obstructive pulmonary disease patients with prevalent emphysema","volume":"13","author":"Coccini","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ppul.22540","article-title":"IFN-\u03b3 and IP-10 in tracheal aspirates from premature infants: Relationship with bronchopulmonary dysplasia","volume":"48","author":"Aghai","year":"2013","journal-title":"Pediatr. Pulmonol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.med.55.091902.103810","article-title":"Mechanisms of Pulmonary Fibrosis","volume":"55","author":"Thannickal","year":"2004","journal-title":"Annu. Rev. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.stem.2020.03.009","article-title":"The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future","volume":"26","author":"Basil","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ymgme.2011.07.018","article-title":"Epigenetics and the developmental origins of lung disease","volume":"104","author":"Albertine","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Froidure, A., Marchal-Duval, E., Homps-Legrand, M., Ghanem, M., Justet, A., Crestani, B., and Mailleux, A. (2020). Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis. Eur. Respir. Rev., 29.","DOI":"10.1183\/16000617.0140-2019"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"He, H., Chen, J., Zhao, J., Zhang, P., Qiao, Y., Wan, H., Wang, J., Mei, M., Bao, S., and Li, Q. (2021). PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis. Cell Death Dis., 12.","DOI":"10.1038\/s41419-021-04129-1"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Al-Mudares, F., Reddick, S., Ren, J., Venkatesh, A., Zhao, C., and Lingappan, K. (2020). Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan. Front. Med., 7.","DOI":"10.3389\/fmed.2020.594137"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Nissen, G., Hinsenbrock, S., Rausch, T.K., Stichtenoth, G., Ricklefs, I., Weckmann, M., Franke, A., Herting, E., K\u00f6nig, I.R., and Kopp, M.V. (2023). Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD. NEJM Evid., 2.","DOI":"10.1056\/EVIDoa2200279"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ppul.26197","article-title":"Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates","volume":"58","author":"Almudares","year":"2023","journal-title":"Pediatr. Pulmonol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Lan, J., Ribeiro, L., Mandeville, I., Nadeau, K., Bao, T., Cornejo, S., Sweezey, N.B., and Kaplan, F. (2009). Inflammatory cytokines, goblet cell hyperplasia and altered lung mechanics in Lgl1 +\/\u2212 mice. Respir. Res., 10.","DOI":"10.1186\/1465-9921-10-83"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Himes, B.E., Jiang, X., Wagner, P., Hu, R., Wang, Q., Klanderman, B., Whitaker, R.M., Duan, Q., Lasky-Su, J., and Nikolos, C. (2014). RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099625"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Freeman, D.W., Hooten, N.N., Kim, Y., Mode, N.A., Ejiogu, N., Zonderman, A.B., and Evans, M.K. (2020). Association between GDF15, poverty and mortality in urban middle-aged African American and white adults. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237059"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1164\/rccm.201302-0263OC","article-title":"Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers","volume":"188","author":"Zhou","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1542\/peds.2005-1414","article-title":"Familial and Genetic Susceptibility to Major Neonatal Morbidities in Preterm Twins","volume":"117","author":"Bhandari","year":"2006","journal-title":"Pediatrics"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.rmed.2011.02.002","article-title":"The discovery of \u03b11-antitrypsin and its role in health and disease","volume":"105","author":"Janciauskiene","year":"2011","journal-title":"Respir. Med."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Jezela-Stanek, A., and Chorostowska-Wynimko, J. (2023). SERPINA1 and More? A Putative Genetic Contributor to Pulmonary Dysfunction in Alpha-1 Antitrypsin Deficiency. J. Clin. Med., 12.","DOI":"10.3390\/jcm12051708"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1203\/PDR.0b013e31822a357e","article-title":"Elastase Inhibitory Activity of Airway \u03b11-Antitrypsin Is Protected by Treatment with a Catalytic Antioxidant in a Baboon Model of Severe Bronchopulmonary Dysplasia","volume":"70","author":"Karaaslan","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41390-020-0993-4","article-title":"Pulmonary hypertension in bronchopulmonary dysplasia","volume":"89","author":"Hansmann","year":"2021","journal-title":"Pediatr. Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Siddaiah, R., Oji-Mmuo, C., Aluquin, V.P.R., Kawasawa, Y.I., Donnelly, A., Rousselle, D., Fuentes, N., Austin, E.D., and Silveyra, P. (2023). Multiomics endotyping of preterm infants with bronchopulmonary dysplasia and pulmonary hypertension\u2014A pilot study. Pulm. Circ., 13.","DOI":"10.1002\/pul2.12232"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2478\/acph-2023-0019","article-title":"Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development","volume":"73","author":"Baranasic","year":"2023","journal-title":"Acta Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1183\/09031936.00129509","article-title":"Hedgehog-interacting protein is a COPD susceptibility gene: The Rotterdam Study","volume":"36","author":"Eijgelsheim","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wechsler, M.E., and Wells, J.M. (2024). What every clinician should know about inflammation in COPD. ERJ Open Res., 10.","DOI":"10.1183\/23120541.00177-2024"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Tao, X., Mo, L., and Zeng, L. (2022). Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1\u03b2 Pathway. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.805860"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Wei, J., Xiong, X.-F., Lin, Y.-H., Zheng, B.-X., and Cheng, D.-Y. (2015). Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: A systematic review and meta-analysis. PeerJ, 3.","DOI":"10.7717\/peerj.1199"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1164\/rccm.201110-1792OC","article-title":"Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease","volume":"185","author":"Celli","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S721","DOI":"10.1016\/j.ajog.2019.11.1186","article-title":"1174: IL-6 Knockout decreases severity of lung injury in an experimental model of bronchopulmonary dysplasia (BPD)","volume":"222","author":"Aziz","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1183\/09058180.05.00009401","article-title":"New approaches to COPD","volume":"14","author":"Barnes","year":"2005","journal-title":"Eur. Respir. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1586\/17512433.1.4.547","article-title":"TGF-\u03b21 as a therapeutic target for pulmonary fibrosis and COPD","volume":"1","author":"Kang","year":"2008","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"L344","DOI":"10.1152\/ajplung.00291.2003","article-title":"Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor","volume":"287","author":"Tang","year":"2004","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/thx.2004.023986","article-title":"Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease","volume":"60","author":"Kranenburg","year":"2005","journal-title":"Thorax"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Trend, S., Strunk, T., Hibbert, J., Kok, C.H., Zhang, G., Doherty, D.A., Richmond, P., Burgner, D., Simmer, K., and Davidson, D.J. (2015). Antimicrobial Protein and Peptide Concentrations and Activity in Human Breast Milk Consumed by Preterm Infants at Risk of Late-Onset Neonatal Sepsis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117038"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2147\/COPD.S185602","article-title":"Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease","volume":"14","author":"Uysal","year":"2019","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Ren, Z., Mo, W., Yang, L., Wang, J., Zhang, Q., Zhong, Z., Wei, W., Liu, Z., Wu, Z., and Yao, Y. (2022). Cord blood antimicrobial peptide LL37 levels in preterm neonates and association with preterm complications. Ital. J. Pediatr., 48.","DOI":"10.1186\/s13052-022-01295-6"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Zhang, H., Kho, A.T., Wu, Q., Halayko, A.J., Rempel, K.L., Chase, R.P., Sweezey, N.B., Weiss, S.T., and Kaplan, F. (2016). CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. Physiol. Rep., 4.","DOI":"10.14814\/phy2.12942"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Huseb\u00f8, G.R., Gr\u00f8nseth, R., Lerner, L., Gyuris, J., Hardie, J.A., Bakke, P.S., and Eagan, T.M. (2017). Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD. Eur. Respir. J., 49.","DOI":"10.1183\/13993003.01298-2016"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1055\/s-0031-1286356","article-title":"Chronische obstruktive Lungenerkrankung: Pathophysiologie, Diagnostik und Therapie [Chronic obstructive pulmonary disease: Pathophysiology, diagnosis, and therapy]","volume":"136","author":"Guttmann","year":"2011","journal-title":"DMW-Dtsch. Med. 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