{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:21:05Z","timestamp":1770211265960,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["NSTC 112-2320-B-019-001-"],"award-info":[{"award-number":["NSTC 112-2320-B-019-001-"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC 113-2320-B-019-007-MY3"],"award-info":[{"award-number":["NSTC 113-2320-B-019-007-MY3"]}]},{"name":"National Human Microbiome Core Facility, Taiwan","award":["NSTC 114-2740-B-A49-003-"],"award-info":[{"award-number":["NSTC 114-2740-B-A49-003-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The increasing prevalence of obesity and metabolic disorders poses a major global health challenge. In the present study, purple sweet potato Tainung No. 73 was fermented using Lactobacillus amylovorus OFMLa-73 and Levilactobacillus brevis OFMLb-143 to enrich the specific bioactive metabolite indolelactic acid. Furthermore, supplementation with fermented sweet potato (FSPE) ethanol extract resulted in a significant reduction in body weight gain, adipocyte hypertrophy, and hepatic lipid accumulation, while also improving serum lipid profiles in high-fat diet-induced obesity mice. These physiological improvements were associated with the downregulated expression of adipogenic and inflammatory genes in both liver and adipose tissues. Furthermore, lipidomic analysis revealed that FSPE modulated key lipid species, including ceramides and acylcarnitines, which are implicated in metabolic dysfunction. Collectively, these findings demonstrated that lactic acid fermentation enhanced purple sweet potato\u2019s functional potential, positioning FSPE as a promising candidate for dietary intervention in obesity management.<\/jats:p>","DOI":"10.3390\/ijms27031489","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:46:11Z","timestamp":1770122771000},"page":"1489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Lipidomics and Lipid Metabolism Elucidate Anti-Obesity Effects of Lactic Acid Bacteria-Fermented Purple Sweet Potato Tainung No. 73 Extract in Obese Mice"],"prefix":"10.3390","volume":"27","author":[{"given":"Hsien-Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Food Science, National Taiwan Ocean University, Keelung 202301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-1161","authenticated-orcid":false,"given":"Chien-Hsun","family":"Huang","sequence":"additional","affiliation":[{"name":"Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute, Hsinchu 30062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-7173","authenticated-orcid":false,"given":"Shang-Tse","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Wood-Based Materials and Design, National Chiayi University, Chiayi 600355, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Hui","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Food Science, National Taiwan Ocean University, Keelung 202301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0621-6219","authenticated-orcid":false,"given":"Yen-Po","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, National Chung Hsing University, Taichung 40227, Taiwan"},{"name":"The iEGG and Animal Biotechnology Research Center, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-0548","authenticated-orcid":false,"given":"Yung-Tsung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Food Science, National Taiwan Ocean University, Keelung 202301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5534\/wjmh.200010","article-title":"Anti-obesity drugs: Long-term efficacy and safety: An updated review","volume":"39","author":"Tak","year":"2020","journal-title":"World J. 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