{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:09:12Z","timestamp":1784250552624,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Agency of Medical Research and Development","award":["JP224fa627004"],"award-info":[{"award-number":["JP224fa627004"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP24fk0108656"],"award-info":[{"award-number":["JP24fk0108656"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP24fk0108695"],"award-info":[{"award-number":["JP24fk0108695"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP24wm0125006"],"award-info":[{"award-number":["JP24wm0125006"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP24wm0125011"],"award-info":[{"award-number":["JP24wm0125011"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP23fm0208101"],"award-info":[{"award-number":["JP23fm0208101"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP23fk0108656"],"award-info":[{"award-number":["JP23fk0108656"]}]},{"name":"Japan Agency of Medical Research and Development","award":["JP23wm0125006"],"award-info":[{"award-number":["JP23wm0125006"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for Promotion of Sciences","doi-asserted-by":"crossref","award":["22KK0115"],"award-info":[{"award-number":["22KK0115"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for Promotion of Sciences","doi-asserted-by":"crossref","award":["24K02288"],"award-info":[{"award-number":["24K02288"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007684","name":"Asahi Glass Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007684","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Joint\/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki University","award":["2022-Ippan-12"],"award-info":[{"award-number":["2022-Ippan-12"]}]},{"name":"Joint\/Research Center on Tropical Disease, Institute of Tropical Medicine, Nagasaki University","award":["2023-Ippan-16"],"award-info":[{"award-number":["2023-Ippan-16"]}]},{"name":"Nagasaki University through the National BioResource Project (Human pathogen viruses) of MEXT, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Tick-borne viral infections, including severe fever with thrombocytopenia syndrome virus (SFTSV), are increasingly recognized as a significant threat to global public health owing to their rapid dissemination and high mortality rates. While isolated outbreaks within single species have been documented, reports of multi-host cluster cases remain scarce. This study describes a consecutive, cross-species outbreak of severe fever with thrombocytopenia syndrome disease between April and May 2024 on a remote island in Nagasaki Prefecture that involved four cats and four humans. An interdisciplinary investigation integrating molecular phylogenetic analysis of viral genomes\u2014including previously identified Nagasaki strains of SFTSV\u2014and haplotype network analysis provided insights into the infection dynamics. Despite the absence of confirmed direct contact between cats and humans, four animals and one patient succumbed to the infection. Genomic analyses demonstrated high similarity to circulating Nagasaki strains, whereas haplotype analysis indicated multiple viral introduction events and complex transmission pathways, reflecting diverse sources. These findings underscore the critical need for a One Health approach\u2014integrating human, animal, and vector surveillance\u2014to effectively monitor, understand, and control tick-borne viruses globally, in both endemic and emerging regions.<\/jats:p>","DOI":"10.3390\/ijms27041702","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:16:38Z","timestamp":1770722198000},"page":"1702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emerging Multi-Source Transmission of SFTS Virus on a Remote Japanese Island: A One-Health Perspective"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8011-9235","authenticated-orcid":false,"given":"Ryosaku","family":"Oshiro","sequence":"first","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"},{"name":"Graduate 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Sakamoto, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-6119","authenticated-orcid":false,"given":"Kosuke","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"},{"name":"School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xayavong","family":"Dalouny","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-7864","authenticated-orcid":false,"given":"Nhung Hong","family":"Pham Vu","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"},{"name":"Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kurashige","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, 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Sakamoto, Nagasaki 852-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sakai","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo 162-8640, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-4519","authenticated-orcid":false,"given":"Hirotomo","family":"Yamanashi","sequence":"additional","affiliation":[{"name":"Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100003","DOI":"10.5501\/wjv.v14.i1.100003","article-title":"Crimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges","volume":"14","author":"Karanam","year":"2025","journal-title":"World J. 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