{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:40:16Z","timestamp":1770892816978,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne zoonotic pathogen that continues to cause a substantial public health burden in South Korea, yet the molecular epidemiology of SFTSV in dogs, particularly shelter populations, remains poorly characterized. To address this gap, blood samples from 715 dogs, including companion and shelter animals, were collected nationwide in 2024 and screened for SFTSV using RT-PCR targeting the S, M, and L genomic segments, followed by sequencing, phylogenetic analysis, and virus isolation. SFTSV was detected in 16 dogs (2.2%), with significantly higher prevalence in autumn, in the southern region, in shelter dogs, and in younger animals. A localized cluster of six infected dogs was identified in a southern shelter during autumn, and phylogenetic analysis revealed the circulation of three genotypes (B2, D, and F). Live virus was successfully isolated from one shelter dog, and this isolate belonged to genotype F, representing the first isolation of this genotype from dogs in South Korea. These findings demonstrate that dogs are exposed to genetically diverse SFTSV strains circulating in tick populations and support the use of canine surveillance, particularly in shelters, as part of a One Health approach to monitor and mitigate the risk of SFTSV transmission.<\/jats:p>","DOI":"10.3390\/ijms27041760","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:48:34Z","timestamp":1770889714000},"page":"1760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetically Diverse Severe Fever with Thrombocytopenia Syndrome Virus Circulates in Shelter and Companion Dogs in South Korea"],"prefix":"10.3390","volume":"27","author":[{"given":"In-Ohk","family":"Ouh","sequence":"first","affiliation":[{"name":"Korea Disease Control and Prevention Agency, Osong-eup, Cheongju-si 28160, Chungcheongbuk-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00705-019-04253-6","article-title":"Taxonomy of the order Bunyavirales: Update 2019","volume":"164","author":"Abudurexiti","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e129531","DOI":"10.1172\/jci.insight.129531","article-title":"Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea","volume":"5","author":"Yun","year":"2020","journal-title":"JCI Insight"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"veae072","DOI":"10.1093\/ve\/veae072","article-title":"The classification, origin, and evolutionary dynamics of severe fever with thrombocytopenia syndrome virus circulating in East Asia","volume":"10","author":"Sang","year":"2024","journal-title":"Virus Evol."},{"key":"ref_4","unstructured":"Korea Diseases Control and Prevention Agency (2026, January 01). Infectious Disease Portal. The Results of the National Infectious Disease Surveillance, Available online: https:\/\/dportal.kdca.go.kr\/pot\/index.do."},{"key":"ref_5","first-page":"597","article-title":"Genotype analysis of severe fever with thrombocytopenia syndrome virus detected in patients","volume":"14","author":"Choi","year":"2021","journal-title":"Public Health Wkly. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Seo, M.G., Noh, B.E., Lee, H.S., Kim, T.K., Song, B.G., and Lee, H.I. (2021). Nationwide Temporal and Geographical Distribution of Tick Populations and Phylogenetic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in Korea, 2020. Microorganisms, 9.","DOI":"10.3390\/microorganisms9081630"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1089\/vbz.2015.1832","article-title":"First Isolation of Severe Fever with Thrombocytopenia Syndrome Virus from Haemaphysalis longicornis Ticks Collected in Severe Fever with Thrombocytopenia Syndrome Outbreak Areas in the Republic of Korea","volume":"16","author":"Yun","year":"2016","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3201\/eid2502.180859","article-title":"Severe Fever with Thrombocytopenia Syndrome Virus in Dogs, South Korea","volume":"25","author":"Kang","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/vms3.261","article-title":"Unusual case of severe fever with thrombocytopenia syndrome showing clinical manifestations in a companion dog","volume":"6","author":"Nam","year":"2020","journal-title":"Vet. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s11259-022-09979-4","article-title":"Clinical features and epidemiology of severe fever with thrombocytopenia syndrome in dogs in the Republic of Korea: An observational study (2019\u20132020)","volume":"46","author":"Han","year":"2022","journal-title":"Vet. Res. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ttbdis.2017.04.008","article-title":"Molecular detection and phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in shelter dogs and cats in the Republic of Korea","volume":"8","author":"Lee","year":"2017","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11259-025-11035-w","article-title":"Clinical characteristics of two companion canines with severe fever with thrombocytopenia syndrome virus (Bandavirus dabieense) in Seoul, Republic of Korea","volume":"50","author":"Byun","year":"2026","journal-title":"Vet. Res. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.4142\/jvs.22104","article-title":"Confirmed cases of severe fever with thrombocytopenia syndrome in companion cats with a history of tick exposure in the Republic of Korea","volume":"23","author":"Han","year":"2022","journal-title":"J. Vet. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3347\/PHD.24024","article-title":"Current status of intestinal parasite infections in fecal samples of dogs in Korea","volume":"62","author":"Lee","year":"2024","journal-title":"Parasites Hosts Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105620","DOI":"10.1016\/j.rvsc.2025.105620","article-title":"Prevalence and molecular characterization of intestinal parasites in shelter dogs from South Korea","volume":"188","author":"Lee","year":"2025","journal-title":"Res. Vet. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kwak, D., and Seo, M.G. (2020). Genetic Analysis of Zoonotic Gastrointestinal Protozoa and Microsporidia in Shelter Cats in South Korea. Pathogens, 9.","DOI":"10.3390\/pathogens9110894"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106934","DOI":"10.1016\/j.actatropica.2023.106934","article-title":"Molecular analysis of Rickettsia spp. and related tick-borne pathogens detected in dogs in Korea","volume":"243","author":"Kim","year":"2023","journal-title":"Acta Trop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101357","DOI":"10.1016\/j.ttbdis.2019.101357","article-title":"Molecular detection and phylogenetic analysis of canine tick-borne pathogens from Korea","volume":"11","author":"Seo","year":"2020","journal-title":"Ticks Tick Borne Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5544660","DOI":"10.1155\/2024\/5544660","article-title":"Surveillance of Vector-Borne Zoonotic Diseases in South Korea: Uncovering Novel Pathogen Carriers Among Rodents and Mites Nationwide","volume":"2024","author":"Kim","year":"2024","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3201\/eid2008.131857","article-title":"Severe fever with thrombocytopenia syndrome virus in ticks collected from humans, South Korea, 2013","volume":"20","author":"Yun","year":"2014","journal-title":"Emerg. Infect. Dis"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ouh, I.O. (2026). Molecular Epidemiology and Genotype Diversity of Severe Fever with Thrombocytopenia Syndrome Virus in Goats in South Korea. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031264"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1089\/vbz.2024.0008","article-title":"Prevalence, Isolation, and Molecular Characterization of Severe Fever with Thrombocytopenia Syndrome Virus in Cattle from the Republic of Korea","volume":"24","author":"Chae","year":"2024","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.3201\/eid2612.191513","article-title":"Direct Transmission of Severe Fever with Thrombocytopenia Syndrome Virus from Domestic Cat to Veterinary Personnel","volume":"26","author":"Yamanaka","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Oh, B., Park, S.C., Yang, M.S., Yang, D., Ham, G., Tark, D., You, M.J., Oh, S.I., and Kim, B. (2024). Difference in Intraspecies Transmissibility of Severe Fever with Thrombocytopenia Syndrome Virus Depending on Abrogating Type 1 Interferon Signaling in Mice. Viruses, 16.","DOI":"10.3390\/v16030401"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Thrusfield, M.V., and Christley, R. (2018). Veterinary Epidemiology, Wiley. [4th ed.].","DOI":"10.1002\/9781118280249"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/vbz.2015.1848","article-title":"Detection of Severe Fever with Thrombocytopenia Syndrome Virus from Wild Animals and Ixodidae Ticks in the Republic of Korea","volume":"16","author":"Oh","year":"2016","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4142\/jvs.2016.17.3.307","article-title":"Development and evaluation of a competitive enzyme-linked immunosorbent assay using a monoclonal antibody for diagnosis of severe fever with thrombocytopenia syndrome virus in bovine sera","volume":"17","author":"Lee","year":"2016","journal-title":"J. Vet. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1128\/JVI.00612-12","article-title":"Suppression of the interferon and NF-\u03baB responses by severe fever with thrombocytopenia syndrome virus","volume":"86","author":"Qu","year":"2012","journal-title":"J. Virol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/4\/1760\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:51:09Z","timestamp":1770889869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/4\/1760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27041760"],"URL":"https:\/\/doi.org\/10.3390\/ijms27041760","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}