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The pharmacological mechanisms that regulate intestinal inflammation are associated with the colonic microbiota, protection against oxidative stress, preservation of epithelial barrier function, and immune homeostasis. This review describes the main flavonoids present in the diet and examines their role in mitigating colon inflammation, as well as their impact when chronic inflammation progresses to colitis-associated colorectal cancer (CAC), in which flavonoids may promote immune evasion and tumor growth. Understanding the effects of flavonoids on colon physiology offers an opportunity to use these compounds rationally in the treatment of colitis and prevention of the development of colorectal cancer (CRC).<\/jats:p>","DOI":"10.3390\/ijms27041883","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:14:32Z","timestamp":1771236872000},"page":"1883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunomodulatory Effects of Flavonoids in Colitis-Associated Colorectal Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-9996","authenticated-orcid":false,"given":"Sonia H.","family":"Navia","sequence":"first","affiliation":[{"name":"Laboratory of Innate Immunity, Research Unit in Biomedicine (UBIMED), Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Bariios 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-5267","authenticated-orcid":false,"given":"Libia","family":"Vega","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Av. IPN 2508, Zacatenco, Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-1648","authenticated-orcid":false,"given":"Tonathiu","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Research Unit in Biomedicine (UBIMED), Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Bariios 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-9390","authenticated-orcid":false,"given":"Miriam","family":"Rodr\u00edguez-Sosa","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Research Unit in Biomedicine (UBIMED), Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. De los Bariios 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.dld.2021.01.012","article-title":"From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies","volume":"53","author":"Fantini","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative Colitis in Adults: A Review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Vezza, T., Rodriguez-Nogales, A., Algieri, F., Utrilla, M.P., Rodriguez-Cabezas, M.E., and Galvez, J. (2016). Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients, 8.","DOI":"10.3390\/nu8040211"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/187221311797264937","article-title":"Dietary flavonoids: Molecular mechanisms of action as anti-inflammatory agents","volume":"5","author":"Marzocchella","year":"2011","journal-title":"Recent. Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1017\/S0954422416000159","article-title":"Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity","volume":"29","author":"Pinent","year":"2016","journal-title":"Nutr. Res. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Catal\u00e1n, M., Ferreira, J., and Carrasco-Pozo, C. (2020). The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines. Molecules, 25.","DOI":"10.3390\/molecules25184138"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10555-012-9347-y","article-title":"Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities","volume":"31","author":"Weng","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal Cancer in Inflammatory Bowel Disease: Mechanisms and Management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fernandez-Munoz, K.V., Sanchez-Barrera, C.A., Meraz-Rios, M., Reyes, J.L., Perez-Yepez, E.A., Ortiz-Melo, M.T., Terrazas, L.I., and Mendoza-Rodriguez, M.G. (2025). Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective. Biomolecules, 15.","DOI":"10.3390\/biom15030326"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41389-023-00492-0","article-title":"Molecular mechanisms in colitis-associated colorectal cancer","volume":"12","author":"Zhou","year":"2023","journal-title":"Oncogenesis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00262-003-0445-0","article-title":"Role of IL-13 in regulation of anti-tumor immunity and tumor growth","volume":"53","author":"Terabe","year":"2004","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pena-Romero, A.C., and Orenes-Pinero, E. (2022). Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers. Cancers, 14.","DOI":"10.3390\/cancers14071681"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1002\/cam4.2327","article-title":"Crosstalk between cancer and immune cells: Role of tumor-associated macrophages in the tumor microenvironment","volume":"8","author":"Wang","year":"2019","journal-title":"Cancer Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1365-2036.2006.03075.x","article-title":"Review article: Immune suppression and colorectal cancer","volume":"24","author":"Evans","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/gutjnl-2015-309595","article-title":"Tumour-associated and non-tumour-associated microbiota in colorectal cancer","volume":"66","author":"Flemer","year":"2017","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1053\/j.gastro.2021.02.020","article-title":"Microbial Community Heterogeneity Within Colorectal Neoplasia and its Correlation With Colorectal Carcinogenesis","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1016\/j.csbj.2021.05.049","article-title":"Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer","volume":"19","author":"Okuda","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1111\/jgh.15361","article-title":"Heterogeneous distribution of Fusobacterium nucleatum in the progression of colorectal cancer","volume":"36","author":"Yamamoto","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jnutbio.2013.05.001","article-title":"Benefits of polyphenols on gut microbiota and implications in human health","volume":"24","author":"Cardona","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109494","DOI":"10.1016\/j.jnutbio.2023.109494","article-title":"Dietary flavonoids-microbiota crosstalk in intestinal inflammation and carcinogenesis","volume":"125","author":"Wang","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","article-title":"Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer","volume":"25","author":"Yachida","year":"2019","journal-title":"Nat. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1136\/gutjnl-2019-318532","article-title":"A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer","volume":"69","author":"Liang","year":"2020","journal-title":"Gut"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.4049\/jimmunol.174.5.2990","article-title":"IL-10 gene-deficient mice lack TGF-beta\/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis","volume":"174","author":"Ruiz","year":"2005","journal-title":"J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41591-019-0405-7","article-title":"Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation","volume":"25","author":"Thomas","year":"2019","journal-title":"Nat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"abm3233","DOI":"10.1126\/science.abm3233","article-title":"Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites","volume":"378","author":"Cao","year":"2022","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106057","DOI":"10.3748\/wjg.v31.i21.106057","article-title":"Microbiota geography in the colorectal carcinoma microenvironment: A spatiotemporal atlas of colonic mucosal microbial niche reconstruction","volume":"31","author":"Han","year":"2025","journal-title":"World J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm.2015","article-title":"A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses","volume":"15","author":"Wu","year":"2009","journal-title":"Nat. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1473-3099(13)70107-5","article-title":"The itinerary of Streptococcus gallolyticus infection in patients with colonic malignant disease","volume":"13","author":"Boleij","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1224820","article-title":"Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota","volume":"338","author":"Arthur","year":"2012","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chom.2018.01.007","article-title":"Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells","volume":"23","author":"Chung","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1053\/j.gastro.2021.08.003","article-title":"Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p","volume":"161","author":"Cao","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1038\/s41388-022-02395-7","article-title":"Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients","volume":"41","author":"Zhao","year":"2022","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s41564-019-0541-3","article-title":"Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity","volume":"4","author":"Long","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zou, J., and Shankar, N. (2015). Roles of TLR\/MyD88\/MAPK\/NF-\u03baB Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136947"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/2159-8290.CD-20-0304","article-title":"Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1980348","DOI":"10.1080\/19490976.2021.1980348","article-title":"Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model","volume":"13","author":"Chiang","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1007\/s10620-011-1688-9","article-title":"Increase in the tight junction protein claudin-1 in intestinal inflammation","volume":"56","author":"Poritz","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ren, J., Yue, B., Wang, H., Zhang, B., Luo, X., Yu, Z., Zhang, J., Ren, Y., Mani, S., and Wang, Z. (2020). Acacetin Ameliorates Experimental Colitis in Mice via Inhibiting Macrophage Inflammatory Response and Regulating the Composition of Gut Microbiota. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.577237"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shi, N., Chen, X., Chen, T., Shi, N., Chen, X., and Chen, T. (2021). Anthocyanins in Colorectal Cancer Prevention Review. Antioxidants, 10.","DOI":"10.3390\/antiox10101600"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.fct.2009.12.031","article-title":"Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells","volume":"48","author":"Yun","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"106191","DOI":"10.1016\/j.jff.2024.106191","article-title":"Potential anti-cancer properties of malvidin and its glycosides: Evidence from in vitro and in vivo studies","volume":"116","author":"Sood","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jare.2023.01.013","article-title":"Celery soluble dietary fiber antagonizes flavonoids ameliorative effect on dextran-sodium-sulfate-induced colitis in mice","volume":"52","author":"Wang","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105499","DOI":"10.1016\/j.jff.2023.105499","article-title":"Apigenin-7-O-glucoside alleviates DSS-induced colitis by improving intestinal barrier function and modulating gut microbiota","volume":"104","author":"Hu","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, M., and Weigmann, B. (2023). Effect of a Flavonoid Combination of Apigenin and Epigallocatechin-3-Gallate on Alleviating Intestinal Inflammation in Experimental Colitis Models. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216031"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/CM9.0000000000000627","article-title":"Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice","volume":"133","author":"Yao","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3892\/etm.2020.8718","article-title":"Baicalin alleviates TNBS-induced colitis by inhibiting PI3K\/AKT pathway activation","volume":"20","author":"Zhu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"15299","DOI":"10.3748\/wjg.v20.i41.15299","article-title":"Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients","volume":"20","author":"Yu","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.intimp.2014.09.005","article-title":"The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4\/NF-kappaB pathway activation","volume":"23","author":"Cui","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1007\/s00253-020-10527-w","article-title":"Protective effect of baicalin on the regulation of Treg\/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis","volume":"104","author":"Zhu","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.intimp.2019.04.052","article-title":"Regulating effect of baicalin on IKK\/IKB\/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis","volume":"73","author":"Shen","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.bbrc.2009.02.071","article-title":"Chrysin, a natural flavone, improves murine inflammatory bowel diseases","volume":"381","author":"Shin","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018027531","article-title":"Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-kappaB Signaling","volume":"38","author":"Shen","year":"2019","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1440-1746.2008.05714.x","article-title":"Isoflavones regulate innate immunity and inhibit experimental colitis","volume":"24","author":"Morimoto","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"155643","DOI":"10.1016\/j.phymed.2024.155643","article-title":"The potential of EGCG in modulating the oral-gut axis microbiota for treating inflammatory bowel disease","volume":"130","author":"Ge","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.abb.2015.01.024","article-title":"(-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity","volume":"573","author":"Contreras","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1124\/jpet.105.090167","article-title":"Epigallocatechin-3-gallate impairs chemokine production in human colon epithelial cell lines","volume":"315","author":"Porath","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.3892\/etm.2015.2824","article-title":"Epigallocatechin-3-gallate-induced inhibition of interleukin-6 release and adjustment of the regulatory T\/T helper 17 cell balance in the treatment of colitis in mice","volume":"10","author":"Xu","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Du, Y., Ding, H., Vanarsa, K., Soomro, S., Baig, S., Hicks, J., and Mohan, C. (2019). Low dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability. Nutrients, 11.","DOI":"10.3390\/nu11081743"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3057268","DOI":"10.1155\/2017\/3057268","article-title":"EGCG Maintains Th1\/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4\/MyD88\/NF-kappaB Signaling Pathway in Rats","volume":"2017","author":"Bing","year":"2017","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejphar.2007.10.053","article-title":"Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis","volume":"579","author":"Abboud","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.pharep.2015.12.011","article-title":"The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-kappaB pathway","volume":"68","author":"Zhang","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e22400","DOI":"10.1002\/jbt.22400","article-title":"Anti-inflammatory effects of eriocitrin against the dextran sulfate sodium-induced experimental colitis in murine model","volume":"33","author":"Guo","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jnutbio.2015.10.004","article-title":"Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-kappaB signaling","volume":"28","author":"Sahu","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/bcpt.13388","article-title":"The natural flavonoid galangin ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Effect on Toll-like receptor 4, inflammation and oxidative stress","volume":"127","author":"Gerges","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00011-019-01252-w","article-title":"Protective effect of galangin against dextran sulfate sodium (DSS)-induced ulcerative colitis in Balb\/c mice","volume":"68","author":"Sangaraju","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/biof.1710","article-title":"Luteolin, inflammation and cancer: Special emphasis on gut microbiota","volume":"47","author":"Franza","year":"2021","journal-title":"Biofactors"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Xuan, H., Ou, A., Hao, S., Shi, J., and Jin, X. (2020). Galangin Protects against Symptoms of Dextran Sodium Sulfate-induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota. Nutrients, 12.","DOI":"10.3390\/nu12020347"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00394-024-03391-1","article-title":"Genistein alleviates dextran sulfate sodium-induced colitis in mice through modulation of intestinal microbiota and macrophage polarization","volume":"63","author":"Jia","year":"2024","journal-title":"Eur. J. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"115673","DOI":"10.1016\/j.bcp.2023.115673","article-title":"Genistein and\/or sulfasalazine ameliorate acetic acid-induced ulcerative colitis in rats via modulating INF-gamma\/JAK1\/STAT1\/IRF-1, TLR-4\/NF-kappaB\/IL-6, and JAK2\/STAT3\/COX-2 crosstalk","volume":"214","author":"Elhefnawy","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Abron, J.D., Singh, N.P., Price, R.L., Nagarkatti, M., Nagarkatti, P.S., and Singh, U.P. (2018). Genistein induces macrophage polarization and systemic cytokine to ameliorate experimental colitis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199631"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.intimp.2019.01.021","article-title":"Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling","volume":"71","author":"Chen","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00394-009-0004-3","article-title":"Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis","volume":"48","author":"Seibel","year":"2009","journal-title":"Eur. J. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e1970058","DOI":"10.1002\/mnfr.201970058","article-title":"Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up-Regulating Treg Cells","volume":"64","author":"Guo","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"172992","DOI":"10.1016\/j.ejphar.2020.172992","article-title":"Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3\/MLKL necroptosis signaling","volume":"873","author":"Zhang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e22312","DOI":"10.1002\/jbt.22312","article-title":"Hesperidin modulates dextran sulfate sodium-induced ulcerative colitis in rats: Targeting sphingosine kinase-1- sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis","volume":"33","author":"Shafik","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.phymed.2009.02.021","article-title":"Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium","volume":"16","author":"Xu","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10620-011-1883-8","article-title":"Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice","volume":"57","author":"Park","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"10574","DOI":"10.1039\/D2FO02128E","article-title":"Linarin ameliorates dextran sulfate sodium-induced colitis in C57BL\/6J mice via the improvement of intestinal barrier, suppression of inflammatory responses and modulation of gut microbiota","volume":"13","author":"Jin","year":"2022","journal-title":"Food Funct."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00011-021-01468-9","article-title":"Luteolin alleviates ulcerative colitis through SHP-1\/STAT3 pathway","volume":"70","author":"Li","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/biof.1091","article-title":"Intestinal anti-inflammatory activity of luteolin: Role of the aglycone in NF-kappaB inactivation in macrophages co-cultured with intestinal epithelial cells","volume":"39","author":"Nishitani","year":"2013","journal-title":"Biofactors"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"111680","DOI":"10.1016\/j.fct.2020.111680","article-title":"Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy","volume":"145","author":"Vukelic","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2016.08.020","article-title":"Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway","volume":"40","author":"Li","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s10753-020-01354-2","article-title":"Luteolin Relieved DSS-Induced Colitis in Mice via HMGB1-TLR-NF-kappaB Signaling Pathway","volume":"44","author":"Zuo","year":"2021","journal-title":"Inflammation"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/jphp.13197","article-title":"Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis","volume":"72","author":"Qu","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/mmr.2012.1225","article-title":"Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis","volume":"7","author":"Zhao","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/mnfr.201300134","article-title":"Oral administration of the flavonoid myricitrin prevents dextran sulfate sodium-induced experimental colitis in mice through modulation of PI3K\/Akt signaling pathway","volume":"57","author":"Schwanke","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e4011","DOI":"10.1002\/cbf.4011","article-title":"A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes","volume":"42","author":"Zamanian","year":"2024","journal-title":"Cell Biochem. Funct."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S0007114512005594","article-title":"Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4\/NF-kappaB signalling","volume":"110","author":"Dou","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nutres.2019.01.004","article-title":"Naringenin promotes recovery from colonic damage through suppression of epithelial tumor necrosis factor-alpha production and induction of M2-type macrophages in colitic mice","volume":"64","author":"Chaen","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.3748\/wjg.v19.i34.5633","article-title":"Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats","volume":"19","author":"Abuohashish","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3945\/jn.113.174508","article-title":"Supplemental naringenin prevents intestinal barrier defects and inflammation in colitic mice","volume":"143","author":"Azuma","year":"2013","journal-title":"J. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Cao, R., Wu, X., Guo, H., Pan, X., Huang, R., Wang, G., and Liu, J. (2021). Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier-Dependent Manner. Molecules, 26.","DOI":"10.3390\/molecules26216604"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.7555\/JBR.27.20120082","article-title":"Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats","volume":"28","author":"Kumar","year":"2014","journal-title":"J. Biomed. Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Dong, J., Chen, Y., Yang, F., Zhang, W., Wei, K., Xiong, Y., Wang, L., Zhou, Z., Li, C., and Wang, J. (2021). Naringin Exerts Therapeutic Effects on Mice Colitis: A Study Based on Transcriptomics Combined With Functional Experiments. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.729414"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"BSR20200986","DOI":"10.1042\/BSR20200986","article-title":"Pinocembrin alleviates ulcerative colitis in mice via regulating gut microbiota, suppressing TLR4\/MD2\/NF-kappaB pathway and promoting intestinal barrier","volume":"40","author":"Yue","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hu, L., Wu, C., Zhang, Z., Liu, M., Maruthi Prasad, E., Chen, Y., and Wang, K. (2019). Pinocembrin Protects Against Dextran Sulfate Sodium-Induced Rats Colitis by Ameliorating Inflammation, Improving Barrier Function and Modulating Gut Microbiota. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00908"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Valero, \u00c1., Magad\u00e1n-Corpas, P., Ye, S., Serna-Diestro, J., Sordon, S., Huszcza, E., Pop\u0142o\u0144ski, J., Villar, C.J., and Lomb\u00f3, F. (2024). Antitumor Effect and Gut Microbiota Modulation by Quercetin, Luteolin, and Xanthohumol in a Rat Model for Colorectal Cancer Prevention. Nutrients, 16.","DOI":"10.3390\/nu16081161"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Riemschneider, S., Hoffmann, M., Slanina, U., Weber, K., Hauschildt, S., and Lehmann, J. (2021). Indol-3-Carbinol and Quercetin Ameliorate Chronic DSS-Induced Colitis in C57BL\/6 Mice by AhR-Mediated Anti-Inflammatory Mechanisms. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052262"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1142\/S0192415X14500554","article-title":"Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK\/NF-kappaB signaling pathway","volume":"42","author":"Liu","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/np300670w","article-title":"Quercetin-loaded microcapsules ameliorate experimental colitis in mice by anti-inflammatory and antioxidant mechanisms","volume":"76","author":"Guazelli","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1007\/s10620-018-5221-2","article-title":"Quercetin Attenuates Adhesion Molecule Expression in Intestinal Microvascular Endothelial Cells by Modulating Multiple Pathways","volume":"63","author":"Bian","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4103\/0253-7613.132160","article-title":"Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: Role of quercetin","volume":"46","author":"Dodda","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1021\/acsomega.0c00804","article-title":"Quercetin Alleviates Intestinal Oxidative Damage Induced by H2O2 via Modulation of GSH: In Vitro Screening and In Vivo Evaluation in a Colitis Model of Mice","volume":"5","author":"Dong","year":"2020","journal-title":"ACS Omega"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.1039\/D1FO01557E","article-title":"Rutin prevents inflammation-associated colon damage via inhibiting the p38\/MAPKAPK2 and PI3K\/Akt\/GSK3beta\/NF-kappaB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis","volume":"12","author":"Sharma","year":"2021","journal-title":"Food Funct."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bcp.2004.10.015","article-title":"Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: Attenuation of pro-inflammatory gene expression","volume":"69","author":"Kwon","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_113","first-page":"527","article-title":"Tangeretin Inhibits IL-12 Expression and NF-kappaB Activation in Dendritic Cells and Attenuates Colitis in Mice","volume":"83","author":"Eun","year":"2017","journal-title":"Planta Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1039\/D3FO02998K","article-title":"Dietary tangeretin improved antibiotic-associated diarrhea in mice by enhancing the intestinal barrier function, regulating the gut microbiota, and metabolic homeostasis","volume":"14","author":"Chen","year":"2023","journal-title":"Food Funct."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Lu, Y., Li, X., Liu, S., Zhang, Y., and Zhang, D. (2018). Toll-like Receptors and Inflammatory Bowel Disease. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00072"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Bardel\u010d\u00edkov\u00e1, A., \u0160oltys, J., and Moj\u017ei\u0161, J. (2023). Oxidative Stress, Inflammation and Colorectal Cancer: An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12040901"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.3748\/wjg.14.4280","article-title":"Role of cytokines in inflammatory bowel disease","volume":"14","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103017","DOI":"10.1016\/j.autrev.2021.103017","article-title":"The influence of cytokines on the complex pathology of ulcerative colitis","volume":"21","author":"Nakase","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ccell.2021.08.005","article-title":"Activating a collaborative innate-adaptive immune response to control metastasis","volume":"39","author":"Sun","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"116827","DOI":"10.1016\/j.biopha.2024.116827","article-title":"Unlocking the potential of flavonoids: Natural solutions in the fight against colon cancer","volume":"176","author":"Hasibuan","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"115713","DOI":"10.1016\/j.fct.2025.115713","article-title":"Ligand- and tissue-specific differences in the activation of the aryl hydrocarbon receptor by flavonoids: A focus on baicalein and scutellarein","volume":"205","author":"Xu","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Griffith, B.D., and Frankel, T.L. (2024). The Aryl Hydrocarbon Receptor: Impact on the Tumor Immune Microenvironment and Modulation as a Potential Therapy. Cancers, 16.","DOI":"10.3390\/cancers16030472"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"239","DOI":"10.7150\/jca.21336","article-title":"Early and Partial Reduction in CD4+ Foxp3+ Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4+ and CD8+ T Cell Activation Inhibiting Tumorigenesis","volume":"9","author":"Olguin","year":"2018","journal-title":"J. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","article-title":"TGF-beta signalling and its role in cancer progression and metastasis","volume":"31","author":"Drabsch","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.gendis.2020.06.005","article-title":"The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases","volume":"8","author":"Zinatizadeh","year":"2021","journal-title":"Genes Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-\u03baB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/mco2.104","article-title":"NF-kappaB signaling in inflammation and cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"MedComm (2020)"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"100217","DOI":"10.1016\/j.crphar.2025.100217","article-title":"Anti-inflammatory potential of quercetin: From chemistry and mechanistic insight to nanoformulations","volume":"8","author":"Aggarwal","year":"2025","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Alharbi, H.O.A., Alshebremi, M., Babiker, A.Y., and Rahmani, A.H. (2025). The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities. Biomolecules, 15.","DOI":"10.3390\/biom15010151"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.it.2025.08.007","article-title":"Transcriptional control of natural killer cell antitumor activity","volume":"46","author":"Kee","year":"2025","journal-title":"Trends Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1242\/jcs.02470","article-title":"MAP kinase pathways","volume":"118","author":"Qi","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00384-024-04748-y","article-title":"Inflammatory bowel disease, colitis, and cancer: Unmasking the chronic inflammation link","volume":"39","author":"Shahgoli","year":"2024","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1091\/mbc.02-03-0037","article-title":"Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3","volume":"14","author":"Edlund","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"9744","DOI":"10.3748\/wjg.v20.i29.9744","article-title":"p38\u03b1 MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance","volume":"20","author":"Grossi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18388\/abp.2007_3266","article-title":"STAT activation and differential complex formation dictate selectivity of interferon responses","volume":"54","author":"Wesoly","year":"2007","journal-title":"Acta Biochim. Pol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13045-021-01214-y","article-title":"STAT proteins: A kaleidoscope of canonical and non-canonical functions in immunity and cancer","volume":"14","author":"Awasthi","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Le\u00f3n-Cabrera, S., V\u00e1zquez-Sandoval, A., Molina-Guzman, E., Delgado-Ramirez, Y., Delgado-Buenrostro, N., Callejas, B., Chirino, Y., P\u00e9rez-Plasencia, C., Rodr\u00edguez-Sosa, M., and Olgu\u00edn, J. (2018). Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development. Cancers, 10.","DOI":"10.3390\/cancers10090341"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-012-0352-6","article-title":"Inflammation and colorectal cancer: Colitis-associated neoplasia","volume":"35","author":"Grivennikov","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.smim.2013.12.003","article-title":"Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development","volume":"26","author":"Waldner","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.semcancer.2022.11.011","article-title":"The STAT family: Key transcription factors mediating crosstalk between cancer stem cells and tumor immune microenvironment","volume":"88","author":"Zhu","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1478-811X-10-41","article-title":"Interferon-\u03b3-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells","volume":"10","author":"Schmitt","year":"2012","journal-title":"Cell Commun. Signal."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.278.5343.1630","article-title":"Defective TNF-\u03b1-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases","volume":"278","author":"Kumar","year":"1997","journal-title":"Science"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Baier, A., and Szyszka, R. (2020). Compounds from Natural Sources as Protein Kinase Inhibitors. Biomolecules, 10.","DOI":"10.3390\/biom10111546"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e2303259","DOI":"10.1002\/advs.202303259","article-title":"Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1007\/s10620-012-2510-z","article-title":"Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients","volume":"58","author":"Achitei","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-kappaB in Oxidative Stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10555-006-9037-8","article-title":"The signaling mechanism of ROS in tumor progression","volume":"25","author":"Wu","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10555-007-9043-5","article-title":"Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters","volume":"26","author":"Yadav","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","article-title":"The role of glutathione-S-transferase in anti-cancer drug resistance","volume":"22","author":"Townsend","year":"2003","journal-title":"Oncogene"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00210-014-0985-1","article-title":"Review article: The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases","volume":"387","author":"Fichna","year":"2014","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1172\/JCI97953","article-title":"Role of prostanoids in gastrointestinal cancer","volume":"128","author":"Wang","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s004320000225","article-title":"Cyclooxygenase-2: A novel target for cancer chemotherapy?","volume":"127","author":"Dempke","year":"2001","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/carcin\/bgp014","article-title":"The COX-2\/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment","volume":"30","author":"Greenhough","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Jin, K., Qian, C., Lin, J., and Liu, B. (2023). Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1099811"},{"key":"ref_156","unstructured":"International Agency for Research on Cancer (2025, February 01). Cancer Over Time. Available online: https:\/\/gco.iarc.fr\/overtime\/en."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Andrade-Meza, A., Arias-Romero, L.E., Armas-Lopez, L., Avila-Moreno, F., Chirino, Y.I., Delgado-Buenrostro, N.L., Garcia-Castillo, V., Gutierrez-Cirlos, E.B., Juarez-Avelar, I., and Leon-Cabrera, S. (2023). Mexican Colorectal Cancer Research Consortium (MEX-CCRC): Etiology, Diagnosis\/Prognosis, and Innovative Therapies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032115"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.3748\/wjg.14.2187","article-title":"Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence","volume":"14","author":"Hoensch","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Chang, H., Lei, L., Zhou, Y., Ye, F., and Zhao, G. (2018). Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies. Nutrients, 10.","DOI":"10.3390\/nu10070950"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/ijc.30582","article-title":"Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort","volume":"140","author":"Barupal","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3945\/ajcn.116.136051","article-title":"The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids","volume":"105","author":"Cassidy","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/nure.12114","article-title":"Dietary factors affecting polyphenol bioavailability","volume":"72","author":"Bohn","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Pandey, P., Lakhanpal, S., Mahmood, D., Kang, H.N., Kim, B., Kang, S., Choi, J., Choi, M., Pandey, S., and Bhat, M. (2024). An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1513422"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3892\/mmr.2025.13515","article-title":"Advances in research on flavonoids in tumor immunotherapy (Review)","volume":"31","author":"Yan","year":"2025","journal-title":"Mol. Med. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/4\/1883\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T09:24:36Z","timestamp":1771320276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/4\/1883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":164,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["ijms27041883"],"URL":"https:\/\/doi.org\/10.3390\/ijms27041883","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]}}}