{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:43Z","timestamp":1787028583139,"version":"build-2736575974"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"crossref","award":["theme FEUZ-2026-0008"],"award-info":[{"award-number":["theme FEUZ-2026-0008"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This manuscript presents the synthesis of eight novel noracronycine derivatives containing 1,2,4-triazine moiety and evaluates their anticancer activity in vitro. The obtained compounds exhibit activity in the micromolar range and show selectivity towards glioblastoma A172 and breast cancer Hs578T cells. Compounds incorporating a dihydrotriazine moiety demonstrate an enhanced anticancer profile when compared to a noracronycine derivative lacking a triazine substituent. Furthermore, introducing a pyridyl group into the triazine core increases selective cytotoxicity toward cancerous cells. The lead compound exhibits an IC50 value of 3.4 \u03bcM for glioblastoma A172, with a selectivity index of 7.59. Mechanistic studies reveal that the obtained compounds slow down cell division, while no significant apoptosis was detected.<\/jats:p>","DOI":"10.3390\/ijms27041969","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:28:18Z","timestamp":1771428498000},"page":"1969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anticancer Acridones, Part 2\u2014Acronycine-Type Derivatives Modified with 2,5-Dihydro-1,2,4-Triazine Moiety: Synthesis and In Vitro Evaluation"],"prefix":"10.3390","volume":"27","author":[{"given":"Andrey A.","family":"Zonov","sequence":"first","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-8658","authenticated-orcid":false,"given":"Ramil F.","family":"Fatykhov","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor A.","family":"Khalymbadzha","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"},{"name":"Research Center for Translational Medicine, Sirius University of Science and Technology, Olympic Ave. 1, 354340 Sochi, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-5462","authenticated-orcid":false,"given":"Ainur D.","family":"Sharapov","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"},{"name":"Department of Biochemistry, Ural State Medical University, Repina 3, 620028 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia P.","family":"Potapova","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-5079","authenticated-orcid":false,"given":"Ilya I.","family":"Butorin","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod V.","family":"Melekhin","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4268-8113","authenticated-orcid":false,"given":"Anastasia V.","family":"Paramonova","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-1582","authenticated-orcid":false,"given":"Emiliya V.","family":"Nosova","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Ural Federal University, 620002 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1590\/0001-3765201820170823","article-title":"Recent advances and perspectives in cancer drug design","volume":"90","author":"Magalhaes","year":"2018","journal-title":"An. 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