{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:41Z","timestamp":1787028581868,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oral squamous cell carcinoma (OSCC) remains a major cause of cancer-related mortality worldwide, with limited biomarker-driven tools for risk stratification. CD147 is a membrane glycoprotein implicated in tumor metabolism, invasion, immune evasion, and therapy resistance. This study aimed to evaluate the prognostic and predictive relevance of CD147 expression in distinct tumor compartments of OSCC. Formalin-fixed tumor samples from 229 OSCC patients were analyzed via tissue microarray and immunohistochemistry to assess CD147 expression in the tumor center, periphery, and adjacent mucosa. Associations with clinicopathological parameters, survival, and therapy response were evaluated using non-parametric statistical tests, Kaplan\u2013Meier, multivariate Cox, and binary logistic regression analyses. Complementary transcriptomic and immunological analyses were performed using The Cancer Genome Atlas (TCGA), the University of Alabama at Birmingham Cancer data analysis (UALCAN), Tumor and Immune System Interaction Database (TISIDB), and the Genotype-Tissue Expression (GTEx) project\u2019s datasets. Low CD147 expression in the tumor invasive front was independently associated with improved overall survival, while expression in the tumor center or mucosa showed no prognostic value. No significant associations between CD147 and adjuvant therapy response were identified. TCGA-based analyses confirmed CD147 overexpression in tumors and its correlation with immunosuppressive signaling and resistance-associated transcriptional networks. Peripheral CD147 expression serves as a compartment-specific, independent prognostic marker in OSCC in this retrospective single-center cohort. Its spatially restricted prognostic relevance and association with immune modulation and therapy resistance highlight CD147 as a promising candidate for future biomarker-driven and therapeutic strategies.<\/jats:p>","DOI":"10.3390\/ijms27052172","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:31:32Z","timestamp":1772098292000},"page":"2172","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TCGA-Informed Spatial Profiling Reveals Peripheral CD147 Expression at the Invasive Tumor Front as a Prognostic Indicator in OSCC"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-6879","authenticated-orcid":false,"given":"Felix","family":"Nieberle","sequence":"first","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Spoerl","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-2589","authenticated-orcid":false,"given":"Quirin","family":"Strotzer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Facial Plastic Surgery, Ludwig-Maximilians-University (LMU), Lindwurmstrasse 2a, 80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Erber","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Regensburg, 93053 Regensburg, Germany"},{"name":"Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg (FAU), 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Spoerl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5\u2014Haematology and Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-N\u00fcrnberg (FAU), 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G.","family":"Schuderer","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Himmelsto\u00df","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Ettl","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten E.","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-3703","authenticated-orcid":false,"given":"Juergen","family":"Taxis","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.oraloncology.2009.01.004","article-title":"Oral squamous cell carcinoma overview","volume":"45","author":"Scully","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","first-page":"57","article-title":"The Hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell Press"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41368-023-00249-w","article-title":"Oral squamous cell carcinomas: State of the field and emerging directions","volume":"15","author":"Tan","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ctrv.2015.11.007","article-title":"The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: A systematic review of the literature","volume":"42","author":"Pillay","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1758-3284-3-2","article-title":"Oral squamous cell cancer: Early detection and the role of alcohol and smoking","volume":"3","author":"Zygogianni","year":"2011","journal-title":"Head Neck Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.3390\/curroncol30040283","article-title":"Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature","volume":"30","author":"Badwelan","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/jop.12733","article-title":"Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction","volume":"47","author":"Thomson","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Nyalali, A.M.K., Leonard, A.U., Xu, Y., Li, H., Zhou, J., Zhang, X., Rugambwa, T.K., Shi, X., and Li, F. (2023). CD147: An integral and potential molecule to abrogate hallmarks of cancer. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1238051"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Barillari, G., Melaiu, O., Gargari, M., Pomella, S., Bei, R., and Campanella, V. (2022). The Multiple Roles of CD147 in the Development and Progression of Oral Squamous Cell Carcinoma: An Overview. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158336"},{"key":"ref_13","first-page":"6700","article-title":"EMMPRIN is an emerging protein capable of regulating cancer hallmarks","volume":"26","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1158\/jcr.1925.148","article-title":"The Metabolism of Carcinoma Cells1","volume":"9","author":"Warburg","year":"1925","journal-title":"J. Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Landras, A., Reger de Moura, C., Jouenne, F., Lebbe, C., Menashi, S., and Mourah, S. (2019). CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker. Cancers, 11.","DOI":"10.3390\/cancers11111803"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1136\/jclinpath-2018-205342","article-title":"CD147 expression is associated with poor overall survival in chemotherapy treated triple-negative breast cancer","volume":"71","author":"Liu","year":"2018","journal-title":"J. Clin. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jop.12046","article-title":"Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells","volume":"42","author":"Huang","year":"2013","journal-title":"J. Oral Pathol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/B978-0-12-800092-2.00013-7","article-title":"CD147: Regulator of hyaluronan signaling in invasiveness and chemoresistance","volume":"123","author":"Grass","year":"2014","journal-title":"Adv. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ajpath.2012.10.011","article-title":"CD147-Dependent Heterogeneity in Malignant and Chemoresistant Properties of Cancer Cells","volume":"182","author":"Dai","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1158\/1078-0432.CCR-13-0621","article-title":"HAb18G\/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s","volume":"19","author":"Li","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12672-025-02150-w","article-title":"Hypoxia signaling in cancer: HIF-1\u03b1 stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC)","volume":"16","author":"Eghbalifard","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e38434","DOI":"10.1097\/MD.0000000000038434","article-title":"The potential mechanism of HIF-1\u03b1 and CD147 in the development of triple-negative breast cancer","volume":"103","author":"Chen","year":"2024","journal-title":"Medicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2559.2011.04130.x","article-title":"Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma","volume":"60","author":"Huang","year":"2012","journal-title":"Histopathology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.cell.2020.07.005","article-title":"Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front","volume":"182","author":"Bhate","year":"2020","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jcms.2017.01.033","article-title":"Biomarkers in diagnosis and therapy of oral squamous cell carcinoma: A review of the literature","volume":"45","author":"Blatt","year":"2017","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/jb\/mvv127","article-title":"Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners","volume":"159","author":"Muramatsu","year":"2016","journal-title":"J. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"32804","DOI":"10.1038\/srep32804","article-title":"CD147\/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis","volume":"6","author":"Xin","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1074\/jbc.M801876200","article-title":"Basigin-2 Is a Cell Surface Receptor for Soluble Basigin Ligand","volume":"283","author":"Belton","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12935-018-0578-z","article-title":"Integrin \u03b21 regulates the invasion and radioresistance of laryngeal cancer cells by targeting CD147","volume":"18","author":"Li","year":"2018","journal-title":"Cancer Cell Int."},{"key":"ref_31","first-page":"2498","article-title":"Extracellular matrix metalloproteinase inducer (CD147\/BSG\/EMMPRIN)-induced radioresistance in cervical cancer by regulating the percentage of the cells in the G2\/m phase of the cell cycle and the repair of DNA Double-strand Breaks (DSBs)","volume":"8","author":"Ju","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1111\/cas.15081","article-title":"Improving function of cytotoxic T-lymphocytes by transforming growth factor-\u03b2 inhibitor in oral squamous cell carcinoma","volume":"112","author":"Kondo","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Qiao, B., Huang, J., Mei, Z., Lam, A.K.-y., Zhao, J., and Ying, L. (2020). Analysis of Immune Microenvironment by Multiplex Immunohistochemistry Staining in Different Oral Diseases and Oral Squamous Cell Carcinoma. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.555757"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Starska-Kowarska, K. (2023). The Role of Different Immunocompetent Cell Populations in the Pathogenesis of Head and Neck Cancer\u2014Regulatory Mechanisms of Pro- and Anti-Cancer Activity and Their Impact on Immunotherapy. Cancers, 15.","DOI":"10.3390\/cancers15061642"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or Adaptive Immunity? The Example of Natural Killer Cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"ref_36","first-page":"1","article-title":"Lactate as a Metabolic Regulator in the Tumor Microenvironment: Linking Immunosuppression to Epigenetic Reprogramming","volume":"27","author":"Cheng","year":"2026","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41368-023-00267-8","article-title":"Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma","volume":"16","author":"Liu","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lescaille, G., Menashi, S., Cavelier-Balloy, B., Khayati, F., Quemener, C., Podgorniak, M.P., Na\u00efmi, B., Calvo, F., Lebbe, C., and Mourah, S. (2012). EMMPRIN\/CD147 up-regulates urokinase-type plasminogen activator: Implications in oral tumor progression. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-115"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ijom.2009.03.004","article-title":"Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma","volume":"38","author":"Cao","year":"2009","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2400611","DOI":"10.1002\/advs.202400611","article-title":"CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5\/CCR5 Axis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gong, J., Xie, Y., Weng, Z., Wu, Y., Li, L., and Li, B. (2026). Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy. Adv. Sci., e15403.","DOI":"10.1002\/advs.202515403"},{"key":"ref_42","first-page":"0019","article-title":"Immunotherapy for Head and Neck Cancer: Mechanisms, Challenges, and Future Perspectives","volume":"7","author":"Deenadhayalan","year":"2024","journal-title":"J. Bio-X Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12957-017-1163-y","article-title":"Clinical and prognostic significance of HIF-1\u03b1 overexpression in oral squamous cell carcinoma: A meta-analysis","volume":"15","author":"Zhou","year":"2017","journal-title":"World J. Surg. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"23141","DOI":"10.18632\/oncotarget.8153","article-title":"The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"177222","DOI":"10.1016\/j.ejphar.2024.177222","article-title":"Oral cancer stem cells: A comprehensive review of key drivers of treatment resistance and tumor recurrence","volume":"989","author":"Nagarathna","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccell.2018.06.012","article-title":"MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation","volume":"34","author":"Jin","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e5324","DOI":"10.1097\/MD.0000000000005324","article-title":"Prognostic value of GLUT-1 expression in oral squamous cell carcinoma: A prisma-compliant meta-analysis","volume":"95","author":"Li","year":"2016","journal-title":"Medicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.18632\/aging.202583","article-title":"Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: A meta-analysis","volume":"13","author":"Wang","year":"2021","journal-title":"Aging"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhu, J., Wu, Y.-N., Zhang, W., Zhang, X.-M., Ding, X., Li, H.-Q., Geng, M., Xie, Z.-Q., and Wu, H.-M. (2014). Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087904"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/1078-0432.CCR-0864-02","article-title":"Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis","volume":"10","author":"Katayama","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Magnussen, S., Rikardsen, O.G., Hadler-Olsen, E., Uhlin-Hansen, L., Steigen, S.E., and Svineng, G. (2014). Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) Are Potential Predictive Biomarkers in Early Stage Oral Squamous Cell Carcinomas (OSCC). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101895"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Christensen, A., Kiss, K., Lelkaitis, G., Juhl, K., Persson, M., Charabi, B.W., Mortensen, J., Forman, J.L., S\u00f8rensen, A.L., and Jensen, D.H. (2017). Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): Tumor expression patterns and prognostic value in oral cancer. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3563-3"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2410438","DOI":"10.1002\/advs.202410438","article-title":"An Anti-CD147 Antibody\u2212Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey","volume":"12","author":"Huang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1158\/1078-0432.CCR-22-2263","article-title":"A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer","volume":"29","author":"Halford","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3892\/ijo.2013.2238","article-title":"Combined inhibition of EMMPRIN and epidermal growth factor receptor prevents the growth and migration of head and neck squamous cell carcinoma cells","volume":"44","author":"Suzuki","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"102292","DOI":"10.1016\/j.xcrm.2025.102292","article-title":"A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma","volume":"6","author":"Li","year":"2025","journal-title":"Cell Rep. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Erber, R., Spoerl, S., Mamilos, A., Krupar, R., Hartmann, A., Ruebner, M., Taxis, J., Wittenberg, M., Reichert, T.E., and Spanier, G. (2021). Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010087"},{"key":"ref_58","first-page":"122","article-title":"Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual","volume":"67","author":"Lydiatt","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nm0798-844","article-title":"Tissue microarrays for high-throughput molecular profiling of tumor specimens","volume":"4","author":"Kononen","year":"1998","journal-title":"Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Eichberger, J., Spoerl, S., Spanier, G., Erber, R., Taxis, J., Schuderer, J., Ludwig, N., Fiedler, M., Nieberle, F., and Ettl, T. (2022). TIGIT Expression on Intratumoral Lymphocytes Correlates with Improved Prognosis in Oral Squamous Cell Carcinoma. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123236"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2172\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:58:39Z","timestamp":1772517519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ijms27052172"],"URL":"https:\/\/doi.org\/10.3390\/ijms27052172","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}