{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:14:27Z","timestamp":1782753267014,"version":"3.54.5"},"reference-count":105,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Key Laboratory of Human Performance","award":["11DZ2261100"],"award-info":[{"award-number":["11DZ2261100"]}]},{"name":"Gansu Provincial Science and Technology Program Project-Soft Science Special Funding: \u201cResearch on Digital Preservation Strategies for Red Dance in the Yellow River Basin\u201d","award":["24JRZA056"],"award-info":[{"award-number":["24JRZA056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>From a mechanical stimulation perspective, this study aims to explore the mechanisms by which dance training affects bone metabolism and to clarify its potential as a preventive and therapeutic measure for osteoporosis (OP). A comprehensive search was conducted on the PubMed, Web of Science, and China National Knowledge Infrastructure databases, utilizing search terms related to dance, mechanical stimulation, and OP. The present study incorporated a wide range of research methodologies, including randomized controlled trials, observational studies, systematic reviews, and narrative reviews, with the overarching objective of encompassing all pertinent concepts within the purview of our investigation. The synthesis and description of the search results were conducted through a narrative approach. A preliminary investigation of extant literature suggests that studies that comprehensively delineate the mechanism of action between dance and OP are few and far between. However, a thorough review of the extant literature indicates that dance training can enhance bone density and promote skeletal health by influencing mechanical characteristics. Concurrently, dance can function as a mechanical stimulus, thereby regulating bone metabolism by activating relevant cellular signaling pathways, thus contributing to the reduction of bone loss. Dance training, as a form of mechanical stimulation, has the potential to play a crucial role in the prevention and treatment of OP. However, the precise nature of the dance styles, the training intensities and frequencies remains unclear. It is recommended that future research endeavors concentrate on the comprehensive integration of these measures, with the objective of addressing the existing knowledge gaps. This approach is expected to provide a more robust evidence base for the utilization of dance-based strategies in the prevention and management of OP.<\/jats:p>","DOI":"10.3390\/ijms27052185","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:31:32Z","timestamp":1772098292000},"page":"2185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress on Dance Training as a Mechanical Stimulus for the Prevention and Treatment of Osteoporosis: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"given":"Yunli","family":"Jia","sequence":"first","affiliation":[{"name":"School of Dance, Northwest Minzu University, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7363","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1002\/mco2.244","article-title":"Mechanistic advances in osteoporosis and anti-osteoporosis therapies","volume":"4","author":"Wang","year":"2023","journal-title":"MedComm"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1186\/s13018-023-04448-3","article-title":"Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis","volume":"18","author":"Yang","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gao, L., Li, Y., Yang, Y.J., and Zhang, D.Y. (2021). The Effect of Moderate-Intensity Treadmill Exercise on Bone Mass and the Transcription of Peripheral Blood Mononuclear Cells in Ovariectomized Rats. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.729910"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jbmr.3284","article-title":"High-Intensity Resistance and Impact Training Improves Bone Mineral Density and Physical Function in Postmenopausal Women with Osteopenia and Osteoporosis: The LIFTMOR Randomized Controlled Trial","volume":"33","author":"Watson","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/bjsports-2021-104634","article-title":"Strong, steady and straight: UK consensus statement on physical activity and exercise for osteoporosis","volume":"56","author":"Skelton","year":"2022","journal-title":"Br. J. Sports Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chang, X., Xu, S., and Zhang, H. (2022). Regulation of bone health through physical exercise: Mechanisms and types. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1029475"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cavedon, V., Sandri, M., Zancanaro, C., and Milanese, C. (2024). Assessing the Muscle-Bone Unit in Girls Exposed to Different Amounts of Impact-Loading Physical Activity-A Cross-Sectional Association Study. Children, 11.","DOI":"10.3390\/children11091099"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e14898","DOI":"10.1097\/MD.0000000000014898","article-title":"The effects of high impact exercise intervention on bone mineral density, physical fitness, and quality of life in postmenopausal women with osteopenia: A retrospective cohort study","volume":"98","author":"Yu","year":"2019","journal-title":"Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Milanese, C., Cavedon, V., Peluso, I., Toti, E., and Zancanaro, C. (2022). The Limited Impact of Low-Volume Recreational Dance on Three-Compartment Body Composition and Apparent Bone Mineral Density in Young Girls. Children, 9.","DOI":"10.3390\/children9030391"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00198-007-0400-6","article-title":"Simple, novel physical activity maintains proximal femur bone mineral density, and improves muscle strength and balance in sedentary, postmenopausal Caucasian women","volume":"18","author":"Young","year":"2007","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.21091\/mppa.2018.2015","article-title":"Bone Mineral Density in Collegiate Dance Majors Compared to Healthy Controls","volume":"33","author":"Farnell","year":"2018","journal-title":"Med. Probl. Perform. Artist."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/1089313X1101500104","article-title":"Bone mineral density and body composition of collegiate modern dancers","volume":"15","author":"Friesen","year":"2011","journal-title":"J. Danc. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Montalb\u00e1n-M\u00e9ndez, C., Gim\u00e9nez-Blasi, N., Garc\u00eda-Rodr\u00edguez, I.A., Latorre, J.A., Conde-Pipo, J., L\u00f3pez-Moro, A., Mariscal-Arcas, M., and Gil-Antu\u00f1ano, N.P. (2023). Body Composition and Nutritional Status of the Spanish National Breaking Team Aspiring to the Paris 2024 Olympic Games. Nutrients, 15.","DOI":"10.3390\/nu15051218"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1249\/00005768-199511000-00003","article-title":"Contributions of exercise, body composition, and age to bone mineral density in premenopausal women","volume":"27","author":"Alekel","year":"1995","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sun, J., Yao, C., Wang, Z., Wu, J., Zhang, B., Zhou, Z., Liu, F., and Zhang, Y. (2022). The beneficial effects of square dance on musculoskeletal system in early postmenopausal Chinese women: A cross-sectional study. BMC Women\u2019s Health, 22.","DOI":"10.1186\/s12905-022-01832-9"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.54097\/hiaad.v4i2.13425","article-title":"Research on the Integration Path of Sports Dance and Chinese Traditional Cultural Elements","volume":"4","author":"Feng","year":"2023","journal-title":"Highlights Art Des."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pavlin, T., Cech, J., and Matas, J. (2021). Ballroom Dance Recognition from Audio Recordings. Proceedings of the 2020 25th International Conference on Pattern Recognition (ICPR), Milan, Italy, 10\u201315 January 2021, IEEE.","DOI":"10.1109\/ICPR48806.2021.9412255"},{"key":"ref_18","unstructured":"Xie, Z. (2013). Influence of Sports Dancing on Female Undergraduate Bone Mineral Density and Body Composition. [Master\u2019s Thesis, Xi\u2019an Physical Education University]."},{"key":"ref_19","first-page":"34","article-title":"The effect of sport dance on the menopause women with their related index of estrogen, blood lipid, immunity and bone density","volume":"34","author":"Zhou","year":"2012","journal-title":"Liaoning Sport Sci. Technol."},{"key":"ref_20","first-page":"28","article-title":"Effect of Long-Term Physical Dance Practice on Bone Mineral Density in Elderly Women","volume":"11","author":"Bao","year":"2021","journal-title":"Contemp. Sports Technol."},{"key":"ref_21","first-page":"82","article-title":"Effects of 18 weeks sports dance on body composition and bone mineral density of recessive obese female college students","volume":"36","author":"Qu","year":"2020","journal-title":"Chin. J. Appl. Physiol."},{"key":"ref_22","first-page":"117","article-title":"Influence of sex and age on biochemical bone metabolism parameters","volume":"20","author":"Resch","year":"1994","journal-title":"Miner. Electrolyte Metab."},{"key":"ref_23","first-page":"502","article-title":"The Effect of the Senior Aerobics on Density of Menopause Women\u2019s Bone","volume":"29","author":"Li","year":"2006","journal-title":"J. Liaoning Norm. Univ. (Nat. Sci. Ed.)"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, W., Gao, R., Rong, X., Zhu, S., Cui, Y., Liu, H., and Li, M. (2022). Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.965258"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1519\/JSC.0000000000003944","article-title":"Bone Mineral Density Differences Across Female Olympic Lifters, Power Lifters, and Soccer Players","volume":"35","author":"Jeon","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00223-021-00836-1","article-title":"Disuse Osteoporosis: Clinical and Mechanistic Insights","volume":"110","author":"Rolvien","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00302070","article-title":"Mechanotransduction and the functional response of bone to mechanical strain","volume":"57","author":"Duncan","year":"1995","journal-title":"Calcif. Tissue Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biomaterials.2004.02.045","article-title":"Tissue engineering of bone: Effects of mechanical strain on osteoblastic cells in type I collagen matrices","volume":"26","author":"Ignatius","year":"2005","journal-title":"Biomaterials"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2011.03.128","article-title":"Mechanisms involved in regulation of osteoclastic differentiation by mechanical stress-loaded osteoblasts","volume":"408","author":"Kaneuji","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"23037","DOI":"10.1038\/s41598-021-02368-y","article-title":"Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging","volume":"11","author":"Wehrle","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.actaastro.2025.09.008","article-title":"Primary cilia shortening alters osteocyte mechanotransduction: Spaceflight vs. simulated microgravity","volume":"238","author":"Tian","year":"2026","journal-title":"Acta Astronaut."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Choi, J.U.A., Kijas, A.W., Lauko, J., and Rowan, A.E. (2021). The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.770143"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bone.2012.10.013","article-title":"Mechanosensation and transduction in osteocytes","volume":"54","author":"Bakker","year":"2013","journal-title":"Bone"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20417314231172573","DOI":"10.1177\/20417314231172573","article-title":"Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization","volume":"14","author":"Ma","year":"2023","journal-title":"J. Tissue Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","article-title":"Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction","volume":"5","author":"Tatsumi","year":"2007","journal-title":"Cell Metab."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Katoh, K. (2025). Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction. Biomolecules, 15.","DOI":"10.3390\/biom15020166"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Chen, P.C., Liu, J.F., Fong, Y.C., Huang, Y.L., Chao, C.C., and Tang, C.H. (2019). CCN3 Facilitates Runx2 and Osterix Expression by Inhibiting miR-608 through PI3K\/Akt Signaling in Osteoblasts. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133300"},{"key":"ref_40","first-page":"912","article-title":"Advances in mechanotransduction signaling pathways in distraction osteogenesis","volume":"39","author":"Yang","year":"2025","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jds.2019.03.001","article-title":"Fak silencing impairs osteogenic differentiation of bone mesenchymal stem cells induced by uniaxial mechanical stretch","volume":"14","author":"Hu","year":"2019","journal-title":"J. Dent. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3892\/ijmm.2016.2636","article-title":"Mechanical strain promotes osteoblastic differentiation through integrin-\u03b21-mediated \u03b2-catenin signaling","volume":"38","author":"Yan","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","article-title":"Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"8","author":"Kocarnik","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ohba, S. (2016). Hedgehog Signaling in Endochondral Ossification. J. Dev. Biol., 4.","DOI":"10.3390\/jdb4020020"},{"key":"ref_46","first-page":"234","article-title":"Indian Hedgehog signaling is involved in the stretch induced proliferation of osteoblast","volume":"30","author":"Han","year":"2012","journal-title":"West China J. Stomatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1177\/15353702231199079","article-title":"Primary cilium-mediated mechanotransduction in cartilage chondrocytes","volume":"248","author":"Zhang","year":"2023","journal-title":"Exp. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11005\/jbm.2022.29.1.1","article-title":"The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts","volume":"29","author":"Greenblatt","year":"2022","journal-title":"J. Bone Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"32533","DOI":"10.1074\/jbc.M109.040980","article-title":"Identification and functional characterization of ERK\/MAPK phosphorylation sites in the Runx2 transcription factor","volume":"284","author":"Ge","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kim, J.M., Yang, Y.S., Park, K.H., Oh, H., Greenblatt, M.B., and Shim, J.H. (2019). The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081803"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e2204592","DOI":"10.1002\/advs.202204592","article-title":"Oscillating Fluid Flow Activated Osteocyte Lysate-Based Hydrogel for Regulating Osteoblast\/Osteoclast Homeostasis to Enhance Bone Repair","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/jbmr.1574","article-title":"Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor","volume":"27","author":"Li","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gao, Y., Chen, N., Fu, Z., and Zhang, Q. (2023). Progress of Wnt Signaling Pathway in Osteoporosis. Biomolecules, 13.","DOI":"10.3390\/biom13030483"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"115491","DOI":"10.1016\/j.bone.2020.115491","article-title":"Wnt modulation in bone healing","volume":"138","author":"Schupbach","year":"2020","journal-title":"Bone"},{"key":"ref_55","first-page":"1519","article-title":"Mechanism of Wnt\/\u03b2-catenin signaling pathway in motion regulation of bone formation","volume":"34","author":"Guo","year":"2022","journal-title":"Chin. Bull. Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bone.2015.03.019","article-title":"In vivo mechanical loading rapidly activates \u03b2-catenin signaling in osteocytes through a prostaglandin mediated mechanism","volume":"76","author":"Kamel","year":"2015","journal-title":"Bone"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.coph.2018.04.011","article-title":"Targeting WNT signaling in the treatment of osteoporosis","volume":"40","author":"Baron","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41413-024-00342-8","article-title":"Wnt\/\u03b2-catenin signaling components and mechanisms in bone formation, homeostasis, and disease","volume":"12","author":"Hu","year":"2024","journal-title":"Bone Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Liu, C., Zhang, J., Ye, Z., Luo, J., Peng, B., and Wang, Z. (2025). Research on the role and mechanism of the PI3K\/Akt\/mTOR signalling pathway in osteoporosis. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1541714"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jcp.10221","article-title":"Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: A role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3","volume":"194","author":"Pavalko","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41413-020-00126-w","article-title":"Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels","volume":"9","author":"Riquelme","year":"2021","journal-title":"Bone Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"110404","DOI":"10.1016\/j.cellsig.2022.110404","article-title":"The effect of AKT in extracellular matrix stiffness induced osteogenic differentiation of hBMSCs","volume":"99","author":"Shen","year":"2022","journal-title":"Cell. Signal."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Song, F., Wang, Y., Jiang, D., Wang, T., Zhang, Y., Ma, H., and Kang, Y. (2016). Cyclic Compressive Stress Regulates Apoptosis in Rat Osteoblasts: Involvement of PI3K\/Akt and JNK MAPK Signaling Pathways. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165845"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of TGF-\u03b2 and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res."},{"key":"ref_65","first-page":"37","article-title":"Biomechanical forces exert anabolic effects on osteoblasts by activation of SMAD 1\/5\/8 through type 1 BMP receptor","volume":"48","author":"Rath","year":"2011","journal-title":"Biorheology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e2000051","DOI":"10.1002\/adbi.202000051","article-title":"Differential Impact of Fluid Shear Stress and YAP\/TAZ on BMP\/TGF-\u03b2 Induced Osteogenic Target Genes","volume":"5","author":"Reichenbach","year":"2021","journal-title":"Adv. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Nguyen, J., Tang, S.Y., Nguyen, D., and Alliston, T. (2013). Load regulates bone formation and Sclerostin expression through a TGF\u03b2-dependent mechanism. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053813"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12013-013-9543-6","article-title":"Mechanical induction of BMP-7 in osteocyte blocks glucocorticoid-induced apoptosis through PI3K\/AKT\/GSK3\u03b2 pathway","volume":"67","author":"Wang","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/EJA.0000000000000319","article-title":"Chronic postsurgical pain in Europe: An observational study","volume":"32","author":"Fletcher","year":"2015","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Miner. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6910312","DOI":"10.1155\/2020\/6910312","article-title":"RANKL\/RANK\/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling","volume":"2020","author":"Tobeiha","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1038\/s41467-024-53119-2","article-title":"A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression","volume":"15","author":"Liang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_73","first-page":"1185","article-title":"RANKL is downregulated in bone cells by physical activity (treadmill and vibration stimulation training) in rat with glucocorticoid-induced osteoporosis","volume":"28","author":"Pichler","year":"2013","journal-title":"Histol. Histopathol."},{"key":"ref_74","first-page":"578","article-title":"Effects of Exercises on Bone Metabolism and OPG-RANKL-RANK System of OsteoclastDifferentiation in Rats with Disuse Osteoporosis","volume":"36","author":"Ma","year":"2017","journal-title":"Chin. J. Sports Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.febslet.2011.06.019","article-title":"Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4","volume":"585","author":"Galea","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e657","DOI":"10.1002\/mco2.657","article-title":"Regulation of bone homeostasis: Signaling pathways and therapeutic targets","volume":"5","author":"Wu","year":"2024","journal-title":"MedComm"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1302\/2046-3758.91.BJR-2019-0043.R2","article-title":"Mechanotransduction in osteogenesis","volume":"9","author":"Stewart","year":"2020","journal-title":"Bone Jt. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"418","DOI":"10.15283\/ijsc23165","article-title":"IGF-1 Induces Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells by Promoting SOX4 via the MAPK\/ERK Pathway","volume":"17","author":"Zeng","year":"2024","journal-title":"Int. J. Stem Cells"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e23799","DOI":"10.1002\/jcla.23799","article-title":"Insulin-like growth factor-1 positively associated with bone formation markers and creatine kinase in adults with general physical activity","volume":"35","author":"Lee","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1249\/MSS.0b013e3181b07d2d","article-title":"Exercise and the growth hormone-insulin-like growth factor axis","volume":"42","author":"Frystyk","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1038\/s41598-025-89985-z","article-title":"The association between sex hormones and bone mineral density in US females","volume":"15","author":"Tian","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1743-7075-8-71","article-title":"Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: A randomized, repeated measures study","volume":"8","author":"Tartibian","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.62347\/ZMAL4724","article-title":"The effects of alfacalcidol combined with calcitonin in the treatment of osteoporosis and its influence on levels of inflammation","volume":"16","author":"Rui","year":"2024","journal-title":"Am. J. Transl. Res."},{"key":"ref_84","first-page":"36","article-title":"Efficacy of Dance Sports Combined with Alfacalcidol in Treating Osteoporosis in the Middle-Aged and Elderly","volume":"45","author":"Tan","year":"2024","journal-title":"Sport Sci. Technol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"165","DOI":"10.12678\/1089-313X.091522c","article-title":"Comparison of Tibial Geometry, Density, and Strength in College-Aged Female Eumenorrheic Dancers, Gymnasts, and Runners: A Peripheral Quantitative Computed Tomography Study","volume":"26","author":"Bruininks","year":"2022","journal-title":"J. Danc. Med. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wells, M.D., Hackney, M.E., and Yang, F. (2025). Effect of Dance Experience on Loading Patterns Among Ballroom Dancers. J. Danc. Med. Sci.","DOI":"10.1177\/1089313X251359492"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Gao, X., Xu, D., Li, F., Baker, J.S., Li, J., and Gu, Y. (2023). Biomechanical Analysis of Latin Dancers\u2019 Lower Limb during Normal Walking. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101128"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1080\/02640414.2014.889839","article-title":"Ground reaction forces and osteogenic index of the sport of cyclocross","volume":"32","author":"Tolly","year":"2014","journal-title":"J. Sports Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yu, L., Mei, Q., Xiang, L., Liu, W., Mohamad, N.I., Istv\u00e1n, B., Fernandez, J., and Gu, Y. (2021). Principal Component Analysis of the Running Ground Reaction Forces with Different Speeds. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.629809"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"655","DOI":"10.70252\/BPJD2691","article-title":"Relationship Between Ground Reaction Force Characteristics and Bone Mineral Density of the Hip and Spine in Male Runners","volume":"15","author":"Leblanc","year":"2022","journal-title":"Int. J. Exerc. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jocd.2021.07.001","article-title":"More than Sports Participation: The Role of Ground Reaction Force, Osteocalcin and Lean Soft Tissue on Bone Density Accrual in Adolescents: ABCD Growth Study","volume":"25","author":"Narciso","year":"2022","journal-title":"J. Clin. Densitom."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1519\/JSC.0b013e3181c27da3","article-title":"Magnitude and rate of mechanical loading of a variety of exercise modes","volume":"24","author":"Ebben","year":"2010","journal-title":"J. Strength Cond. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e19616","DOI":"10.7717\/peerj.19616","article-title":"Effects of high-impact jumping versus resistance exercise on bone mineral content in children and adolescents: A systematic review and meta-analysis","volume":"13","author":"Miao","year":"2025","journal-title":"PeerJ"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1359\/jbmr.1997.12.2.255","article-title":"High-impact exercise promotes bone gain in well-trained female athletes","volume":"12","author":"Taaffe","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/jbmr.4899","article-title":"Effects of Moderate- to High-Impact Exercise Training on Bone Structure Across the Lifespan: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"38","author":"Ng","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1089313X1001400101","article-title":"Lower extremity kinetics in tap dance","volume":"14","author":"Mayers","year":"2010","journal-title":"J. Danc. Med. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2478\/hukin-2021-0086","article-title":"Biomechanical Effects of Flamenco Footwork","volume":"80","author":"Gorwa","year":"2021","journal-title":"J. Hum. Kinet."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sui, H., Dou, J., Shi, B., and Cheng, X. (2024). The reciprocity of skeletal muscle and bone: An evolving view from mechanical coupling, secretory crosstalk to stem cell exchange. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1349253"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zhu, C., Ding, X., Chen, M., Feng, J., Zou, J., and Zhang, L. (2025). Exercise-Mediated Skeletal Muscle-Derived IL-6 Regulates Bone Metabolism: A New Perspective on Muscle-Bone Crosstalk. Biomolecules, 15.","DOI":"10.3390\/biom15060893"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1123\/jab.2017-0206","article-title":"Lower Leg Morphology and Stretch-Shortening Cycle Performance of Dancers","volume":"34","author":"Rice","year":"2018","journal-title":"J. Appl. Biomech."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"M862","DOI":"10.1093\/gerona\/58.9.M862","article-title":"Older women with osteoporosis have increased postural sway and weaker quadriceps strength than counterparts with normal bone mass: Overlooked determinants of fracture risk?","volume":"58","author":"Eng","year":"2003","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_102","first-page":"49","article-title":"The relationship of bone mineral density to balance ability and grip strength in elderly men during aging","volume":"2004","author":"Chen","year":"2004","journal-title":"J. Phys. Educ."},{"key":"ref_103","first-page":"1598","article-title":"Correlations among body mass index, body balance and bone mineral density in elderly women","volume":"25","author":"Nabil","year":"2021","journal-title":"Med. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/JNR.0b013e318236cfb2","article-title":"The effects of low-impact dance on knee torque and lower extremity mobility in middle-aged and older women","volume":"19","author":"Wu","year":"2011","journal-title":"J. Nurs. Res. JNR"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/bjsm.31.2.143","article-title":"Bone mineral density in professional female dancers","volume":"31","author":"Keay","year":"1997","journal-title":"Br. J. Sports Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2185\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:40:27Z","timestamp":1772098827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":105,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ijms27052185"],"URL":"https:\/\/doi.org\/10.3390\/ijms27052185","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}