{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:05:04Z","timestamp":1773414304965,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","award":["2021R1A6C101A416"],"award-info":[{"award-number":["2021R1A6C101A416"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Climate, Energy and Environment"},{"name":"Ministry of Education","award":["2025-RISE-03-001"],"award-info":[{"award-number":["2025-RISE-03-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>WIB-801CE, a standardized Cordyceps militaris extract containing 7.0% cordycepin, suppresses platelet activation induced by thrombin, collagen, and adenosine diphosphate (ADP). As these agonists generate thromboxane A2 (TXA2), which amplifies platelet activation via a self-propagating feedback loop, blockade of TXA2-mediated signaling offers strong antithrombotic potential. TXA2-antagonistic effects were evaluated using U46619, a stable TXA2 analog. Platelet activation was assessed by fibrinogen binding to integrin \u03b1IIb\u03b23, aggregation, and phosphorylation of platelet-activating proteins\u2014PI3K (Tyr458), Akt (Ser473), p38 MAPK (Thr180\/Tyr182), ERK1 (Thr202\/Tyr204), JNK1 (Thr183\/Tyr185)\u2014and inhibitory proteins\u2014VASP (Ser157) and IP3RI (Ser1756)\u2014via immunoblotting. Thrombin-induced fibrin clot retraction, cytotoxicity, coagulation parameters, and antioxidant capacity were also examined. WIB-801CE significantly inhibited U46619-induced fibrinogen binding to integrin \u03b1IIb\u03b23 and platelet aggregation, without inducing cytotoxicity or impairing hemostatic function. It also significantly downregulated the phosphorylation of platelet-activating proteins and upregulated the phosphorylation of platelet-inhibiting proteins. Additionally, WIB-801CE abolished thrombin-induced fibrin clot retraction and demonstrated antioxidant capacity. WIB-801CE disrupts TXA2-driven platelet activation and thrombus stabilization by selectively modulating phosphorylation of key signaling proteins at defined regulatory sites. These properties highlight its promise as a therapeutic candidate for thrombotic disorders with platelet hyperreactivity.<\/jats:p>","DOI":"10.3390\/ijms27052254","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:52:38Z","timestamp":1772207558000},"page":"2254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antithrombotic Effects of Cordycepin-Enriched WIB-801CE via Inhibition of Thromboxane A2-Induced \u03b1IIb\u03b23 Activation and Thrombin-Mediated Fibrin Clot Retraction"],"prefix":"10.3390","volume":"27","author":[{"given":"Min-Kyu","family":"Park","sequence":"first","affiliation":[{"name":"Department of Applied Biosciences, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"KNU NGS Core Facility, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Microbalance Inc., Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Soo","family":"Bae","sequence":"additional","affiliation":[{"name":"Cardiovascular Laboratory, Medical Center of Dong-A University, 26 Daesingongwon-ro, Busan 49201, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5583-9515","authenticated-orcid":false,"given":"Hyeonha","family":"Jang","sequence":"additional","affiliation":[{"name":"College of Pharmacology, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-9787","authenticated-orcid":false,"given":"Jae-Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Applied Biosciences, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"KNU NGS Core Facility, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Microbalance Inc., Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa-Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Healthcare Medical Science and Engineering, Inje University, 197, Inje-ro, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1073\/pnas.72.8.2994","article-title":"Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides","volume":"72","author":"Hamberg","year":"1975","journal-title":"Proc. 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