{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:13:53Z","timestamp":1790885633057,"version":"4.1.0"},"reference-count":230,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"RSF","doi-asserted-by":"publisher","award":["23-75-30001"],"award-info":[{"award-number":["23-75-30001"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"RSF","doi-asserted-by":"publisher","award":["24-75-10047"],"award-info":[{"award-number":["24-75-10047"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research start-up funds for introduced talents of the Fudan University","award":["IDH2315001 Y"],"award-info":[{"award-number":["IDH2315001 Y"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a serious medical challenge, representing an incurable and insidious disease. Current treatments can slow AD progression but cannot cure it. Promising new methods for AD therapy are essential for addressing the growing number of people with dementia, especially after the COVID-19 pandemic. The review highlights pioneering approaches to AD treatment based on innovative methods for the stimulation of brain drainage and clearance, in which the meningeal lymphatic vessels (MLVs) play a key role. Clinically promising noninvasive technologies using photobiomodulation for the effective clearance of metabolites, including amyloid beta (A\u03b2), and for the improvement of cognitive impairment during AD progression are discussed. An interesting part of the review is its analysis of innovative methods of improving the efficacy of anti-A\u03b2 immunotherapy by stimulating MLV growth. The review is also focused on lifestyle, including sleep and physical exercises, discussing their support for the efficient lymphatic removal of waste products from the brain. Overall, the review provides an important, informative platform to excite the interest of a wide range of readers in the development of promising and clinically significant strategies for the treatment of AD, based on new strategies for the stimulation of brain drainage and clearance.<\/jats:p>","DOI":"10.3390\/ijms27052312","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:39:56Z","timestamp":1772455196000},"page":"2312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New Strategies for the Prevention and Therapy of Alzheimer\u2019s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-7513","authenticated-orcid":false,"given":"Oxana","family":"Semyachkina-Glushkovskaya","sequence":"first","affiliation":[{"name":"Department of Biology, Saratov State University, Astrakhanskaya 83 Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Sursaev","sequence":"additional","affiliation":[{"name":"Department of Nervous Diseases and Neurosurgery, First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya 2, Building 4, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-0918","authenticated-orcid":false,"given":"Mikhail","family":"Poluektov","sequence":"additional","affiliation":[{"name":"Department of Nervous Diseases and Neurosurgery, First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya 2, Building 4, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Diduk","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Leeners LLC, 117186 Moscow, Russia"},{"name":"Research Institute of Carcinogenesis of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Kashirskoe Shosse 24, 115522 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov","family":"Rychkova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Madaeva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Yakubova","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice and Polyclinic Therapy, Grodno State Medical University, 230009 Grodno, Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-4276","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Kurths","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Complex Systems, Fudan University, 220 Handan Rd, Yangpu District, Shanghai 200437, China"},{"name":"Potsdam Institute for Climate Impact Research, Telegrafenberg A 31, 14473 Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"ref_1","unstructured":"Alzheimer\u2019s Association (2025). 2025 Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s Dement., 21, e70235."},{"key":"ref_2","unstructured":"(2022). GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 7, e105\u2013e125."},{"key":"ref_3","first-page":"e51705","article-title":"Alzheimer\u2019s Disease: The Past, Present, and Future of a Globally Progressive Disease","volume":"16","author":"Vejandla","year":"2024","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2023). 2023 Alzheimer\u2019s disease facts and figures. Alzheimer\u2019s Dement., 19, 1598\u20131695.","DOI":"10.1002\/alz.13016"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s44400-025-00034-y","article-title":"COVID-19 infection associated with increased risk of new-onset vascular dementia in adults \u2265 50 years","volume":"1","author":"Shan","year":"2025","journal-title":"npj Dement."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shan, D., Li, S., Xu, R., Nie, G., Xie, Y., Han, J., Gao, X., Zheng, Y., Xu, Z., and Dai, Z. (2022). Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.1077384"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S2215-0366(22)00260-7","article-title":"Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: An analysis of 2-year retrospective cohort studies including 1 284 437 patients","volume":"9","author":"Taquet","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1038\/s41467-022-30932-1","article-title":"Neurotoxic amyloidogenic peptides in the proteome of SARS-CoV-2: Potential implications for neurological symptoms in COVID-19","volume":"13","author":"Charnley","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-220717","article-title":"Association of COVID-19 with New-Onset Alzheimer\u2019s Disease","volume":"89","author":"Wang","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, N., Jiang, X., and Li, H. (2023). The viral hypothesis in Alzheimer\u2019s disease: SARS-CoV-2 on the cusp. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1129640"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Navolokin, N., Adushkina, V., Zlatogorskaya, D., Telnova, V., Evsiukova, A., Vodovozova, E., Eroshova, A., Dosadina, E., Diduk, S., and Semyachkina-Glushkovskaya, O. (2024). Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer\u2019s Disease. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060788"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hoang, M.T., Wastesson, J.W., Szilcz, M., Maura, G., Bloti\u00e8re, P., and Johnell, K. (2025). Impact of dementia on risks of COVID-19 infection and outcomes among older adults in Sweden. BMC Geriatr., 25.","DOI":"10.1186\/s12877-025-06576-3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100539","DOI":"10.1016\/j.ensci.2024.100539","article-title":"Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review","volume":"38","author":"Crivelli","year":"2025","journal-title":"eNeurologicalSci"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/psychiatryint5040046","article-title":"COVID-19 and Its Influence on Prevalence of Dementia and Agitation in Australian Residential Aged Care: A Comparative Study","volume":"5","author":"Zhu","year":"2024","journal-title":"Psychiatry Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"117486","DOI":"10.1016\/j.jns.2021.117486","article-title":"A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications","volume":"426","author":"Frontera","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S355","DOI":"10.3233\/JAD-221016","article-title":"Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer\u2019s Disease","volume":"94","author":"Guo","year":"2023","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/1570159X20666220411091332","article-title":"The Lymphatic System in the Brain Clearance Mechanisms\u2014New Therapeutic Perspectives for Alzheimer\u2019s Disease","volume":"21","author":"Chachaj","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00018-024-05225-z","article-title":"Involvement of the glymphatic\/meningeal lymphatic system in Alzheimer\u2019s disease: Insights into proteostasis and future directions","volume":"81","author":"Yamada","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e70709","DOI":"10.1002\/alz.70709","article-title":"Glymphatic and meningeal lymphatic dysfunction in Alzheimer\u2019s disease: Mechanisms and therapeutic perspectives","volume":"21","author":"Ding","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1002\/alz.13789","article-title":"Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer\u2019s disease","volume":"20","author":"Huang","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41392-025-02177-z","article-title":"Meningeal lymphatic drainage: Novel insights into central nervous system disease","volume":"10","author":"Zhang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2025.09.008","article-title":"Glymphatic-meningeal lymphatic system, a new therapeutic target for sleep disorders","volume":"585","author":"Xiao","year":"2025","journal-title":"Neuroscience"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Penzel, T., Poluektov, M., Fedosov, I., Tzoy, M., Terskov, A., Blokhina, I., Sidorov, V., and Kurths, J. (2023). Phototherapy of Alzheimer\u2019s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310946"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Fedosov, I., Penzel, T., Li, D., Yu, T., Telnova, V., Kaybeleva, E., Saranceva, E., Terskov, A., and Khorovodov, A. (2023). Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043221"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13578-022-00942-z","article-title":"Overview of the meningeal lymphatic vessels in aging and central nervous system disorders","volume":"12","author":"Jiang","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer\u2019s disease","volume":"560","author":"Louveau","year":"2018","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"010601","DOI":"10.1117\/1.NPh.11.1.010601","article-title":"Transcranial photobiomodulation for brain diseases: Review of animal and human studies including mechanisms and emerging trends","volume":"11","author":"Lin","year":"2024","journal-title":"Neurophotonics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"776","DOI":"10.7150\/thno.120374","article-title":"Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases","volume":"16","author":"Liu","year":"2026","journal-title":"Theranostics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7200911","DOI":"10.1109\/JSTQE.2023.3246587","article-title":"Direct Laser-Induced Singlet Oxygen in Biological Systems: Application From in Vitro to in Vivo","volume":"29","author":"Dremin","year":"2023","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1073\/pnas.88.17.7552","article-title":"Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein","volume":"88","author":"Cras","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"fcac016","DOI":"10.1093\/braincomms\/fcac016","article-title":"Regional amyloid correlates of cognitive performance in ageing and mild cognitive impairment","volume":"4","author":"Stevens","year":"2022","journal-title":"Brain Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41586-021-03489-0","article-title":"Meningeal lymphatics affect microglia responses and anti-A\u03b2 immunotherapy","volume":"593","author":"Papadopoulos","year":"2021","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S1474-4422(23)00128-X","article-title":"The complex pathway between amyloid \u03b2 and cognition: Implications for therapy","volume":"22","author":"Jagust","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0006-8993(88)90673-7","article-title":"Protein chemical and immunocytochemical studies of meningovascular \u03b2-amyloid protein in Alzheimer\u2019s disease and normal aging","volume":"474","author":"Joachim","year":"1988","journal-title":"Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Schreiner, T.G., Schreiner, O.D., Adam, M., and Popescu, B.O. (2023). The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051411"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5607\/en22004","article-title":"Physiological Roles of Monomeric Amyloid-\u03b2 and Implications for Alzheimer\u2019s Disease Therapeutics","volume":"31","author":"Jeong","year":"2022","journal-title":"Exp. Neurobiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1074\/jbc.M110.191262","article-title":"Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro","volume":"286","author":"Moghekar","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1523\/JNEUROSCI.2085-06.2006","article-title":"Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism","volume":"26","author":"Yin","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biocel.2007.07.013","article-title":"Mechanisms of A beta-mediated neurodegeneration in Alzheimer\u2019s disease","volume":"40","author":"Crouch","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nm1438","article-title":"Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo","volume":"12","author":"Bateman","year":"2006","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1126\/science.1059946","article-title":"Metabolic regulation of brain Abeta by neprilysin","volume":"292","author":"Iwata","year":"2001","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1111\/febs.16939","article-title":"Molecular basis of selective amyloid-\u03b2 degrading enzymes in Alzheimer\u2019s disease","volume":"291","author":"Moss","year":"2024","journal-title":"FEBS J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cerasuolo, M., Auriemma, M.C., Di Meo, I., Lenti, C., Papa, M., Paolisso, G., and Rizzo, M. (2025). Understanding the Insulin-Degrading Enzyme: A New Look at Alzheimer\u2019s Disease and A\u03b2 Plaque Management. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26146693"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nazere, K., Takahashi, T., Hara, N., Muguruma, K., Nakamori, M., Yamazaki, Y., Morino, H., and Maruyama, H. (2022). Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.804702"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8128","DOI":"10.1038\/s41467-025-63458-3","article-title":"Targeting phagocytosis for amyloid-\u03b2 clearance: Implications of morphology remodeling and microglia activation probed by bifunctional chimaeras","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hassan, H., Rawlinson, C., Lan, Y.-L., Jenkins, S., and Chen, R. (2025). Microglia-Mediated Phagocytosis in Alzheimer\u2019s Disease: Mechanisms, Heterogeneity, and Therapeutic Insights. Biomolecules, 15.","DOI":"10.3390\/biom15111629"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Park, G., Jin, Z., Lu, H., and Du, J. (2024). Clearing Amyloid-Beta by Astrocytes: The Role of Rho GTPases Signaling Pathways as Potential Therapeutic Targets. Brain Sci., 14.","DOI":"10.3390\/brainsci14121239"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e2102191118","DOI":"10.1073\/pnas.2102191118","article-title":"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41392-025-02426-1","article-title":"Rapid amyloid-\u03b2 clearance and cognitive recovery through multivalent modulation of blood\u2013brain barrier transport","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer\u2019s amyloid-\u03b21\u201340 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40035-024-00397-x","article-title":"The interaction between ageing and Alzheimer\u2019s disease: Insights from the hallmarks of ageing","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhu, Z., and Xu, Y. (2025). Signs of Alzheimer\u2019s Disease: Tied to Aging. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26114974"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102514","DOI":"10.1016\/j.arr.2024.102514","article-title":"Sleep disorders and risk of Alzheimer\u2019s disease: A two-way road","volume":"101","author":"Lacerda","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Niazi, N.U.K., Jiang, J., Ou, H., Chen, R., and Yang, Z. (2025). Sleep Deprivation and Alzheimer\u2019s Disease: A Review of the Bidirectional Interactions and Therapeutic Potential of Omega-3. Brain Sci., 15.","DOI":"10.3390\/brainsci15060641"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1007\/s11357-025-01637-2","article-title":"Sleep disorders increase the risk of dementia, Alzheimer\u2019s disease, and cognitive decline: A meta-analysis","volume":"47","author":"Ungvari","year":"2025","journal-title":"GeroScience"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13195-023-01308-4","article-title":"Stress, depression, and risk of dementia\u2014A cohort study in the total population between 18 and 65 years old in Region Stockholm","volume":"15","author":"Wallensten","year":"2023","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"\u00c1vila-Villanueva, M., G\u00f3mez-Ram\u00edrez, J., Maest\u00fa, F., Venero, C., \u00c1vila, J., and Fern\u00e1ndez-Bl\u00e1zquez, M. (2020). The Role of Chronic Stress as a Trigger for the Alzheimer Disease Continuum. Front. Aging Neurosci., 12.","DOI":"10.3389\/fnagi.2020.561504"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm.4443","article-title":"Amyloid-\u03b2 plaques enhance Alzheimer\u2019s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbi.2018.07.020","article-title":"Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer\u2019s dementia subjects","volume":"73","author":"Goodman","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12200-023-00080-5","article-title":"Mechanisms of phototherapy of Alzheimer\u2019s disease during sleep and wakefulness: The role of the meningeal lymphatics","volume":"16","author":"Shirokov","year":"2023","journal-title":"Front. Optoelectron."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1126\/science.424741","article-title":"Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord","volume":"203","author":"Prineas","year":"1979","journal-title":"Science"},{"key":"ref_67","first-page":"125","article-title":"Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature","volume":"14","author":"Chaitanya","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e2002574118","DOI":"10.1073\/pnas.2002574118","article-title":"An immunohistochemical study of lymphatic elements in the human brain","volume":"118","author":"Mezey","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Fedosov, I., Navolokin, N., Shirokov, A., Maslyakova, G., Bucharskaya, A., Blokhina, I., Terskov, A., Khorovodov, A., and Postnov, D. (2021). Pilot identification of the Live-1\/Prox-1 expressing lymphatic vessels and lymphatic elements in the unaffected and affected human brain. bioRxiv.","DOI":"10.1101\/2021.09.05.458990"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.mjafi.2017.04.002","article-title":"Brain stem death certification protocol","volume":"74","author":"Srivastava","year":"2018","journal-title":"Med. J. Armed Forces India"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41586-019-1099-1","article-title":"Restoration of brain circulation and cellular functions hours post-mortem","volume":"568","author":"Vrselja","year":"2019","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14432","DOI":"10.1073\/pnas.1308285110","article-title":"Surge of neurophysiological coherence and connectivity in the dying brain","volume":"110","author":"Borjigin","year":"2013","journal-title":"PNAS"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"0120","DOI":"10.34133\/research.0120","article-title":"Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress","volume":"13","author":"Chang","year":"2023","journal-title":"Research"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"113693","DOI":"10.1016\/j.isci.2025.113693","article-title":"Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery","volume":"28","author":"Albayram","year":"2025","journal-title":"iScience"},{"key":"ref_75","unstructured":"Eimas, R. (2026, January 21). The Great Anatomy of Paolo Mascagni. The University of Iowa Libraries Special Collections and University Archives. The University of Iowa Libraries. Available online: http:\/\/www.lib.uiowa.edu\/scua\/bai\/eimas.htm."},{"key":"ref_76","unstructured":"Mascagni, P., and Bellini, G.B. (1816). Istoria Completa Dei Vasi Linfatici, Presso Eusebio Pacini e Figlio."},{"key":"ref_77","first-page":"84","article-title":"The anatomical world of Paulo Mascagni. Reasoned reading of the anatomy works of his library","volume":"1","author":"Orsini","year":"2017","journal-title":"Med. Hist."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/joa.12381","article-title":"Lymphatic vessels of the dura mater: A new discovery?","volume":"227","author":"Bucchieri","year":"2015","journal-title":"J. Anat."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/S0140-6736(03)15114-8","article-title":"Virtual dissection: A lesson from the 18th century","volume":"362","author":"Hubenstorf","year":"2003","journal-title":"Lancet"},{"key":"ref_80","first-page":"287","article-title":"Di una probabile modificazione delle fissure linfatiche della della parte dei seni venosi della dura madre","volume":"64","author":"Lecco","year":"1953","journal-title":"Arch. Ital. Otol. Rinol. Laringol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2458\/lymph.6179","article-title":"The Re-Discovery of Dural (Meningeal) Lymphatics: Amnesia or Ambition?","volume":"56","author":"Erickson","year":"2024","journal-title":"Lymphology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/BF02146675","article-title":"Lymphatic drainage of the brain","volume":"24","author":"Csillik","year":"1968","journal-title":"Experientia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0002-8703(77)80181-6","article-title":"Prelymphatic-lymphatic drainage of brain","volume":"93","year":"1977","journal-title":"Am. Heart J."},{"key":"ref_84","first-page":"1","article-title":"The brain and the lymphatic system (I)","volume":"29","year":"1996","journal-title":"Lymphology"},{"key":"ref_85","first-page":"10","article-title":"The brain and the lymphatic system (II)","volume":"29","year":"1996","journal-title":"Lymphology"},{"key":"ref_86","first-page":"40","article-title":"The brain and the lymphatic system revisited","volume":"32","year":"1999","journal-title":"Lymphology"},{"key":"ref_87","unstructured":"F\u00f6ldi, M. (1969). Lymphogenous Encephalopathy. Diseases of Lymphatics and Lymph Circulation, Charles C. Thomas."},{"key":"ref_88","unstructured":"Cruikshank, W. (1790). The Anatomy of the Absorbing Vessels of the Human Body, B. Nicol. [2nd ed.]."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Ruysch, F. (1964). Dilucidatio Valvularum in Vasis Lymphaticis et Lacteis, 1665, B. de Graaf.","DOI":"10.1163\/9789004613836"},{"key":"ref_90","first-page":"29","article-title":"Studies on cerebrospinal fluid. II. The theories of drainage of cerebrospinal fluid with an analysis of the methods of investigation","volume":"31","author":"Weed","year":"1914","journal-title":"J. Med. Res."},{"key":"ref_91","first-page":"51","article-title":"Studies on Cerebro-Spinal Fluid. No. III: The pathways of escape from the Subarachnoid Spaces with particular reference to the Arachnoid Villi","volume":"31","author":"Weed","year":"1914","journal-title":"J. Med. Res."},{"key":"ref_92","first-page":"1","article-title":"Lymphatic Drainage System of the Brain: A New Player in Neuroscience","volume":"59","author":"Postnov","year":"2023","journal-title":"J. Evol. Biochem. Phys."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12987-021-00282-z","article-title":"The glymphatic hypothesis: The theory and the evidence","volume":"19","author":"Hladky","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pathophys.2009.10.007","article-title":"Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis","volume":"17","author":"Weller","year":"2019","journal-title":"Pathophysiology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Morris, A.W., Carare, R.O., Schreiber, S., and Hawkes, C.A. (2014). The Cerebrovascular Basement Membrane: Role in the Clearance of \u03b2-amyloid and Cerebral Amyloid Angiopathy. Front. Aging Neurosci., 19.","DOI":"10.3389\/fnagi.2014.00251"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41467-017-01484-6","article-title":"Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice","volume":"8","author":"Ma","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_97","first-page":"28","article-title":"Is Human Cerebrospinal Fluid Reabsorbed by Lymph? LDT and Manual drainage of the CNS","volume":"8","author":"Chikly","year":"1998","journal-title":"J. Am. Acad. Osteopathy"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ca.23308","article-title":"Our current understanding of the lymphatics of the brain and spinal cord","volume":"32","author":"Dupont","year":"2019","journal-title":"Clin. Anat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tins.2015.04.006","article-title":"Muddying the water in brain edema?","volume":"38","author":"Smith","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00401-018-1812-4","article-title":"The role of brain barriers in fluid movement in the CNS: Is there a \u201cglymphatic\u201d system?","volume":"135","author":"Abbott","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e70261","DOI":"10.1111\/acel.70261","article-title":"1275-nm Photobiomodulation Alleviates Brain Drainage Impairment as a Promising Therapeutic Strategy for Aging-Related Neurological Decline","volume":"15","author":"Lin","year":"2025","journal-title":"Aging Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1364\/BOE.577347","article-title":"NO-ergic mechanisms of age differences in photostimulation of lymphatic drainage, filtration and clearance","volume":"16","author":"Blokhina","year":"2025","journal-title":"Biomed. Opt. Express"},{"key":"ref_105","unstructured":"Terskov, A., Shirokov, A., Blokhina, I., Zlatogorskaya, D., Adushkina, V., Semiachkina-Glushkovskaia, A., Atul, K., Fedosov, I., Evsukova, A., and Semyachkina-Glushkovskaya, O. (2025). Age as a limiting factor for effectiveness of photostimulation of brain drainage and cognitive functions. Front. Optoelectron., 18."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer\u2019s disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e20211275","DOI":"10.1084\/jem.20211275","article-title":"Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration","volume":"219","author":"Ishida","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1038\/s41467-023-41710-y","article-title":"Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/s41467-020-16851-z","article-title":"Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40478-020-0888-y","article-title":"Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels","volume":"8","author":"Liu","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-020-18113-4","article-title":"Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis","volume":"11","author":"Bolte","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41422-020-0287-8","article-title":"Meningeal lymphatic vessels regulate brain tumor drainage and immunity","volume":"30","author":"Hu","year":"2020","journal-title":"Cell Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41586-019-1912-x","article-title":"VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours","volume":"577","author":"Song","year":"2020","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1177\/0271678X221098145","article-title":"The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders","volume":"42","author":"Li","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Zhang, R., Li, J., Li, X., and Zhang, S. (2024). Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: Prospects and challenges. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2024.1467085"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1593630","DOI":"10.3389\/fimmu.2025.1593630","article-title":"Role of meningeal lymphatic vessels in brain homeostasis","volume":"16","author":"Zhao","year":"2025","journal-title":"Front. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13024-023-00618-3","article-title":"Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer\u2019s disease: An updated overview of nonpharmacological therapies","volume":"18","author":"Formolo","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Tian, Y., Zhao, M., Chen, Y., Yang, M., and Wang, Y. (2022). The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease. Biomolecules, 12, Erratum in Biomolecules 2023, 13, 705.","DOI":"10.3390\/biom13040705"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2174\/1570159X21666221115150253","article-title":"The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases","volume":"22","author":"Chen","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-neuro-113023-103045","article-title":"Meningeal Lymphatics in Central Nervous System Diseases","volume":"47","author":"Salvador","year":"2024","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1515\/revneuro-2020-0106","article-title":"The glymphatic system and meningeal lymphatics of the brain: New understanding of brain clearance","volume":"32","author":"Yankova","year":"2021","journal-title":"Rev. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4103\/1673-5374.355741","article-title":"The lymphatic system: A therapeutic target for central nervous system disorders","volume":"18","author":"Xu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","article-title":"Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid","volume":"572","author":"Ahn","year":"2019","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Andrey, T., Viktoria, A., Alexander, S., Nikita, N., Inna, B., Daria, Z., Anastasiia, S.G., Sonina, K., Arina, E., and Inna, E. (2025). Sleep is a therapeutic window for photostimulation of drainage of aging brain. Front. Optoelectron., 18.","DOI":"10.1007\/s12200-025-00168-0"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuron.2024.09.017","article-title":"Waste clearance shapes aging brain health","volume":"113","author":"Drieu","year":"2025","journal-title":"Neuron"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"148868","DOI":"10.1016\/j.brainres.2024.148868","article-title":"Age-related changes in meningeal lymphatic function are closely associated with vascular endothelial growth factor-C expression","volume":"1833","author":"Liu","year":"2024","journal-title":"Brain Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e20221929","DOI":"10.1084\/jem.20221929","article-title":"Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage","volume":"220","author":"Rustenhoven","year":"2023","journal-title":"J. Exp. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.devcel.2011.12.020","article-title":"Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation","volume":"22","author":"Sabine","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1172\/JCI79386","article-title":"Lymph flow regulates collecting lymphatic vessel maturation in vivo","volume":"125","author":"Sweet","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1172\/JCI80454","article-title":"FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature","volume":"125","author":"Sabine","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/CIRCRESAHA.118.313707","article-title":"YAP and TAZ negatively regulate Prox1 during developmental and pathologic lymphangiogenesis","volume":"124","author":"Cho","year":"2019","journal-title":"Circ. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Schreiner, T.G., Croitoru, C.G., Hodorog, D.N., and Cuciureanu, D.I. (2024). Passive Anti-Amyloid Beta Immunotherapies in Alzheimer\u2019s Disease: From Mechanisms to Therapeutic Impact. Biomedicines, 12.","DOI":"10.3390\/biomedicines12051096"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s12967-024-05248-x","article-title":"Passive immunotherapy for Alzheimer\u2019s disease: Challenges & future directions","volume":"22","author":"Yi","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/S0140-6736(24)01883-X","article-title":"Passive anti-amyloid \u03b2 immunotherapy in Alzheimer\u2019s disease-opportunities and challenges","volume":"404","author":"Heneka","year":"2024","journal-title":"Lancet"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.adz8959","article-title":"Improving Alzheimer\u2019s disease immunotherapy","volume":"389","author":"Xing","year":"2025","journal-title":"Science"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"100094","DOI":"10.1016\/j.tjpad.2025.100094","article-title":"French Federation of Memory Clinics Work Group on Anti-Amyloid Immunotherapies. Lecanemab for early Alzheimer\u2019s disease: Appropriate use recommendations from the French federation of memory clinics","volume":"12","author":"Villain","year":"2025","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1126\/science.adj9255","article-title":"Immunotherapies for Alzheimer\u2019s disease","volume":"382","author":"Golde","year":"2023","journal-title":"Science"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41582-019-0295-9","article-title":"Questions EMERGE as Biogen claims aducanumab turnaround","volume":"16","author":"Howard","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaneurol.2021.4161","article-title":"Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients with Early Alzheimer Disease","volume":"79","author":"Salloway","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0319-23.2024","article-title":"Lecanemab and Donanemab as Therapies for Alzheimer\u2019s Disease: An Illustrated Perspective on the Data","volume":"11","author":"Espay","year":"2024","journal-title":"eNeuro"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"943","DOI":"10.17219\/acem\/171379","article-title":"Lecanemab (Leqembi) is not the right drug for patients with Alzheimer\u2019s disease","volume":"32","author":"Kurkinen","year":"2023","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.adg1899","article-title":"Alzheimer\u2019s drug stirs excitement-and concerns","volume":"378","author":"Piller","year":"2022","journal-title":"Science"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer\u2019s Disease","volume":"388","author":"Swanson","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1007\/s10072-024-07477-w","article-title":"The efficacy and safety of lecanemab 10 mg\/kg biweekly compared to a placebo in patients with Alzheimer\u2019s disease: A systematic review and meta-analysis of randomized controlled trials","volume":"45","author":"Abdelazim","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.csbj.2022.12.019","article-title":"EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier","volume":"21","author":"Karavaev","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Shirokov, A., Blokhina, I., Telnova, V., Vodovozova, E., Alekseeva, A., Boldyrev, I., Fedosov, I., Dubrovsky, A., and Khorovodov, A. (2023). Intranasal delivery of liposomes to glioblastoma by photostimulation of the lymphatic system. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020567"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Bragin, D., Bragina, O., Socolovski, S., Shirokov, A., Fedosov, I., Ageev, V., Blokhina, I., Dubrovsky, A., and Telnova, V. (2023). Low-Level Laser Treatment Induces the Blood-Brain Barrier Opening and the Brain Drainage System Activation: Delivery of Liposomes into Mouse Glioblastoma. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020567"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Diduk, S., and Anna, E. (2022). Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1010188"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"18505","DOI":"10.1038\/s41598-021-97427-9","article-title":"Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood\u2013brain barrier leakage","volume":"11","author":"Runnova","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"20202337","DOI":"10.1098\/rspb.2020.2337","article-title":"Phenomenon of music-induced opening of the blood-brain barrier in healthy mice","volume":"287","author":"Esmat","year":"2020","journal-title":"Proc. R. Soc. B"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1140\/epjp\/s13360-021-01715-2","article-title":"Non-invasive analysis of blood-brain barrier permeability based on wavelet and machine learning approaches","volume":"136","author":"Semenova","year":"2021","journal-title":"Eur. Phys. J. Plus"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMoa2308719","article-title":"Ultrasound Blood-Brain Barrier Opening and Aducanumab in Alzheimer\u2019s Disease","volume":"390","author":"Rezai","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1177\/0271678X241237073","article-title":"Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance","volume":"44","author":"Dong","year":"2024","journal-title":"J. Cerebral Blood Flow. Metab."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s40478-024-01870-4","article-title":"Crucial role of Aquaporin-4 extended isoform in brain water Homeostasis and Amyloid-\u03b2 clearance: Implications for Edema and neurodegenerative diseases","volume":"12","author":"Abbrescia","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Achar, A., Myers, R., and Ghosh, C. (2021). Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121834"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1016\/j.crbiot.2024.100235","article-title":"A new frontier in neuropharmacology: Recent progress in natural products research for blood\u2013brain barrier crossing","volume":"8","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Hinkson, I.V., Madej, B., and Stahlberg, E.A. (2020). Accelerating therapeutics for opportunities in medicine: A paradigm shift in drug discovery. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00770"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90% of clinical drug development fails and how to improve it?","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Nairuz, T., and Lee, J.H. (2024). Photobiomodulation Therapy on Brain: Pioneering an Innovative Approach to Revolutionize Cognitive Dynamics. Cells, 13.","DOI":"10.3390\/cells13110966"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Hamblin, M., Ferraresi, C., Huang, Y.-Y., Freitas de Freitas, L., and Carroll, J. (2018). Low-Level Light Therapy: Photobiomodulation, SPIE PRESS.","DOI":"10.1117\/3.2295638"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Wu, C., Wu, T., and Yang, L. (2024). Editorial: Photobiomodulation therapy for brain disorders. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1495715"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"148615","DOI":"10.1016\/j.brainres.2023.148615","article-title":"Recent advances in light energy biotherapeutic strategies with photobiomodulation on central nervous system disorders","volume":"1822","author":"Ma","year":"2024","journal-title":"Brain Res."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Dong, S., Ren, H., Zhang, R., and Wei, X. (2024). Recent advances in photobiomodulation therapy for brain diseases. Interdiscip. Med., 2.","DOI":"10.1002\/INMD.20230027"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/asj\/sjab025","article-title":"Photobiomodulation: The Clinical Applications of Low-Level Light Therapy","volume":"41","author":"Glass","year":"2021","journal-title":"Aesthet. Surg. J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bjps.2020.12.059","article-title":"Photobiomodulation: A review of the molecular evidence for low level light therapy","volume":"74","author":"Glass","year":"2021","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.niox.2022.11.005","article-title":"Photobiomodulation and nitric oxide signaling","volume":"130","author":"Kashiwagi","year":"2023","journal-title":"Nitric Oxide"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Yokomizo, S., Roessing, M., Morita, A., Kopp, T., Ogawa, E., Katagiri, W., Feil, S., Huang, P., Atochin, D., and Kashiwagi, S. (2022). Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase. FASEB J., 36.","DOI":"10.1096\/fj.202101890R"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Wang, M., Yan, C., Li, X., Yang, T., Wu, S., Liu, Q., Luo, Q., and Zhou, F. (2024). Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer\u2019s disease-associated pathology and cognition in mice. Nat. Commun., 15.","DOI":"10.1038\/s41467-024-45656-7"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1364\/BOE.383390","article-title":"Photobiomodulation of lymphatic drainage and clearance: Perspective strategy for augmentation of meningeal lymphatic functions","volume":"11","author":"Abdurashitov","year":"2020","journal-title":"Biomed. Opt. Exp."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Zhinchenko, E., Klimova, M., Mamedova, A., Agranovich, I., Blokhina, I., Antonova, T., Terskov, A., Shirokov, A., Navolokin, N., and Morgun, A. (2020). Photostimulation of extravasation of beta-amyloid through the model of blood-brain barrier. Electronics, 9.","DOI":"10.3390\/electronics9061056"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e201900036","DOI":"10.1002\/tbio.201900036","article-title":"Photostimulation of cerebral and peripheral lymphatic functions","volume":"2","author":"Abdurashitov","year":"2020","journal-title":"Transl. Biophoton"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Sokolovski, S., Fedosov, I., Shirokov, A., Navolokin, N., Bucharskaya, A., Blokhina, I., Terskov, A., Dubrovski, A., and Telnova, V. (2023). Transcranial photosensitiser-free laser treatment of glioblastoma in rat brain. Int. J. Mol. Sci., 24.","DOI":"10.21203\/rs.3.rs-2666422\/v1"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1364\/BOE.10.004003","article-title":"Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: Breakthrough strategies for nonpharmacologic therapy of Alzheimer\u2019s disease","volume":"10","author":"Zhinchenko","year":"2019","journal-title":"Biomed Opt. Exp."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2020.12.022","article-title":"Singlet oxygen stimulates mitochondrial bioenergetics in brain cells","volume":"163","author":"Sokolovski","year":"2021","journal-title":"Free Radical Biol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1039\/D3AN00587A","article-title":"Efficiency of direct photoinduced generation of singlet oxygen at different wavelengths, power density and exposure time of laser irradiation","volume":"148","author":"Makovik","year":"2023","journal-title":"Analyst"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.redox.2017.05.011","article-title":"Direct 1O2 optical excitation: A tool for redox biology","volume":"13","year":"2017","journal-title":"Redox Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.91.16.7583","article-title":"Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase","volume":"91","author":"Archer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1046\/j.1538-7836.2003.00345.x","article-title":"Nitric oxide in vascular biology","volume":"1","author":"Walford","year":"2003","journal-title":"J. Thromb. Haemost."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3858\/emm.2012.44.3.014","article-title":"Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase","volume":"44","author":"Chung","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"H1897","DOI":"10.1152\/ajpheart.00260.2011","article-title":"Nitric oxide formation by lymphatic bulb and valves is a major regulatory component of lymphatic pumping","volume":"301","author":"Bohlen","year":"2011","journal-title":"AJP Heart Circ. Physiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1113\/JP272088","article-title":"Lymphatic pumping: Mechanics, mechanisms and malfunction","volume":"594","author":"Scallan","year":"2016","journal-title":"J. Physiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1073\/pnas.1117710109","article-title":"Nitric oxide (NO) side of lymphatic flow and immune surveillance","volume":"109","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz","year":"2019","journal-title":"Science"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Postnov, D., Penzel, T., and Kurths, J. (2020). Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer\u2019s Disease and the Blood-Brain Barrier. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176293"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4103\/1673-5374.350191","article-title":"Lights at night: Does photobiomodulation improve sleep?","volume":"18","author":"Valverde","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Moro, C., Valverde, A., Dole, M., Hoh Kam, J., Hamilton, C., Liebert, A., Bicknell, B., Benabid, A.L., Magistretti, P., and Mitrofanis, J. (2022). The effect of photobiomodulation on the brain during wakefulness and sleep. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.942536"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Semyachkina-Glushkovskaya, O., Penzel, T., Blokhina, I., Khorovodov, A., Fedosov, I., Yu, T., Karandin, G., Evsukova, A., Elovenko, D., and Adushkina, V. (2021). Night photostimulation of clearance of beta-amyloid from mouse brain: New strategies in preventing Alzheimer\u2019s disease. Cells, 10.","DOI":"10.3390\/cells10123289"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Postnov, D., Merkulova, K., Semyachkina-Glushkovskaya, O., and Kurths, J. (2026). Activity Driven Sleep Dynamics: A Conceptual Modeling Study. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0341279"},{"key":"ref_193","first-page":"208","article-title":"Photobiomodulation under Electroencephalographic Controls of Sleep for Stimulation of Lymphatic Removal of Toxins from Mouse Brain","volume":"28","author":"Blokina","year":"2024","journal-title":"J. Vis. Exp."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s42003-023-05630-3","article-title":"Transcranial photobiomodulation improves insulin therapy in diabetic mice: Modulation of microglia and the brain drainage system","volume":"6","author":"Shaojun","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.24976\/Discov.Med.202537193.27","article-title":"Mechanisms of Age Differences in the Effectiveness of Phototherapy of Glioblastoma","volume":"37","author":"Shirokov","year":"2025","journal-title":"Discov. Med."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Shirokov, A., Blokhina, I., Fedosov, I., Ilyukov, E., Terskov, A., Myagkov, D., Tuktarov, D., Tzoy, M., Adushkina, V., and Zlatogosrkaya, D. (2024). Different Effects of Phototherapy for Rat Glioma during Sleep and Wakefulness. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020262"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/mgr.MEDGASRES-D-24-00092","article-title":"Direct generation of 1O2 in living tissues for the treatment of brain diseases","volume":"15","year":"2025","journal-title":"Med. Gas Res."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Cronshaw, M., Parker, S., Hamadah, O., Arnabat-Dominguez, J., and Grootveld, M. (2025). Photobiomodulation LED Devices for Home Use: Design, Function and Potential: A Pilot Study. Dent. J., 13.","DOI":"10.3390\/dj13020076"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40035-025-00497-2","article-title":"Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Chen","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/s41467-025-58726-1","article-title":"Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans","volume":"16","author":"Yoo","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1148\/radiol.2021203784","article-title":"Contrast-enhanced MRI T1 mapping for quantitative evaluation of putative dynamic glymphatic activity in the human brain in sleep-wake states","volume":"300","author":"Lee","year":"2021","journal-title":"Radiology"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"He, X.-f., Liu, D.X., Zhang, Q., Liang, F.Y., Dai, G.Y., Zeng, J.S., Pei, Z., Xu, G.Q., and Lan, Y. (2017). Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00144"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neulet.2017.10.035","article-title":"Voluntary running enhances glymphatic influx in awake behaving, young mice","volume":"662","author":"Petersen","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12987-023-00446-z","article-title":"Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI","volume":"20","author":"Kim","year":"2023","journal-title":"Fluids Barriers CNS"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.12968\/bjcn.2024.29.2.83","article-title":"Manual lymphatic drainage: The evidence behind the efficacy","volume":"29","author":"Ramadan","year":"2024","journal-title":"Br. J. Community Nurs."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"438","DOI":"10.12968\/bjcn.2024.0101","article-title":"An overview of manual lymphatic drainage","volume":"29","author":"Palmer","year":"2024","journal-title":"Br. J. Community Nurs."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"43","DOI":"10.51507\/j.jams.2022.15.1.43","article-title":"GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces","volume":"15","author":"Blokhina","year":"2022","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41531-025-01179-6","article-title":"The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson\u2019s disease and healthy older adults","volume":"11","author":"Erhardt","year":"2025","journal-title":"npj Park. Dis."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-024-07132-6","article-title":"Multisensory gamma stimulation promotes glymphatic clearance of amyloid","volume":"627","author":"Murdock","year":"2024","journal-title":"Nature"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/a-2513-4313","article-title":"A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer\u2019s Disease: A Primer for Reconstructive Microsurgeons","volume":"52","author":"Hong","year":"2025","journal-title":"Arch. Plast. Surg."},{"key":"ref_211","first-page":"121","article-title":"Expert consensus on lymphatic surgical treatment for Alzheimer\u2019s disease (2025 edition)","volume":"43","author":"Xie","year":"2025","journal-title":"Chin. J. Clin. Anat."},{"key":"ref_212","first-page":"1","article-title":"A surgical therapy for Alzheimer\u2019s disease with lymphaticovenular anastomosis","volume":"9","author":"Ma","year":"2025","journal-title":"J. Alzheimer\u2019s Dis. Rep."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Zhang, R., Liu, Y.Y., Xia, X., and Li, X. (2025). Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer\u2019s disease. Front. Aging Neurosci., 17.","DOI":"10.3389\/fnagi.2025.1671741"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.aee4258","article-title":"Experimental treatments target the brain\u2019s \u2018plumbing\u2019","volume":"390","author":"Smith","year":"2025","journal-title":"Science"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Kope\u0107, K., Koziorowski, D., and Szlufik, S. (2025). The Therapeutic Potential of Glymphatic System Activity to Reduce the Pathogenic Accumulation of Cytotoxic Proteins in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157552"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4103\/NRR.NRR-D-24-00764","article-title":"Targeting the glymphatic system to promote \u03b1-synuclein clearance: A novel therapeutic strategy for Parkinson\u2019s disease","volume":"21","author":"Xiaoyue","year":"2026","journal-title":"Neural Regen. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41591-020-01198-1","article-title":"Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson\u2019s disease","volume":"27","author":"Ding","year":"2021","journal-title":"Nat. Med."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Kciuk, M., Kruczkowska, W., and Ga\u0142\u0119ziewska, J. (2024). Alzheimer\u2019s Disease as Type 3 Diabetes: Understanding the Link and Implications. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252211955"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"100944","DOI":"10.1016\/j.arr.2019.100944","article-title":"Diabetes Mellitus and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 144 Prospective Studies","volume":"55","author":"Xue","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13098-024-01346-4","article-title":"The Relationship between Diabetes and the Dementia Risk: A Meta-Analysis","volume":"16","author":"Cao","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"afab231","DOI":"10.1093\/ageing\/afab231","article-title":"Diabetes Duration and the Risk of Dementia: A Cohort Study Based on German Health Claims Data","volume":"51","author":"Reinke","year":"2022","journal-title":"Age Ageing"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4093\/dmj.2019.0153","article-title":"Contributing Factors to Diabetic Brain Injury and Cognitive Decline","volume":"43","author":"Nirmal","year":"2019","journal-title":"Diabetes Metab. J."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/17512433.2017.1293521","article-title":"Brain injury with diabetes mellitus: Evidence, mechanisms and treatment implications","volume":"10","author":"Hamed","year":"2017","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Shaik, K., Rasmussen, S., Rahme, R., and Karsy, M. (2025). Exploring the Impact of Diabetes Mellitus on Clinical Outcomes in Patients Following Severe Traumatic Brain Injury Using the TriNetX Database. Surgeries, 6.","DOI":"10.3390\/surgeries6020038"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3233\/JAD-220467","article-title":"A Randomized, Double-Blind, and Sham-Controlled 878 Trial of an Innovative Brain-Gut Photobiomodulation Therapy: Safety and Patient Compliance","volume":"90","author":"Blivet","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"102338","DOI":"10.1016\/j.eclinm.2023.102338","article-title":"A Novel Transcranial Photobiomodulation Device to Address Motor Signs of Parkinson\u2019s Disease: A Parallel Randomised 882 Feasibility Study","volume":"66","author":"Herkes","year":"2023","journal-title":"eClinicalMedicine"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3233\/JAD-210170","article-title":"Exploring the Effect of Combined Transcranial and Intra-Oral Photobiomodulation Therapy over a Four-Week Period on Physical and Cognitive Outcome Measures for People with Parkinson\u2019s Disease: A Randomized Double-Blind Placebo-Controlled Pilot Study","volume":"83","author":"Lehn","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Yang, H.M. (2025). Overcoming the Blood-Brain Barrier: Advanced Strategies in Targeted Drug Delivery for Neurodegenerative Diseases. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17081041"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"113604","DOI":"10.1016\/j.inoche.2024.113604","article-title":"Innovative strategies for overcoming blood-brain barrier challenges in Alzheimer\u2019s disease: A focus on green-synthesized metallic nanoparticles","volume":"171","author":"Kushagra","year":"2025","journal-title":"Inorg. Chem. Commun."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"32544","DOI":"10.1021\/acsomega.5c00364","article-title":"Overcoming the Blood-Brain Barrier for Drug Delivery to the Brain","volume":"10","author":"Katz","year":"2025","journal-title":"ACS Omega"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2312\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:48:34Z","timestamp":1772531314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":230,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ijms27052312"],"URL":"https:\/\/doi.org\/10.3390\/ijms27052312","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}