{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:09:17Z","timestamp":1772615357205,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cWestern Young Scholars\u201d Program of the Chinese Academy of Sciences"},{"name":"The Ningxia Autonomous Region Youth Leading Talent Project in 2023"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560099"],"award-info":[{"award-number":["82560099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271626"],"award-info":[{"award-number":["82271626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Ningxia Natural Science Foundation","doi-asserted-by":"publisher","award":["2022AAC05025"],"award-info":[{"award-number":["2022AAC05025"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningxia Medical University","award":["XJKF230106"],"award-info":[{"award-number":["XJKF230106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Triclosan (TCS) exposure is linked to increased acute myocardial infarction (AMI) risk, but underlying mechanisms remain unclear. Here, we integrated network toxicology, machine learning, molecular simulations, and in vitro assays to delineate this pathway. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) identified 37 candidate genes, which were refined via machine learning to 8 core regulators (including PTGS2). Molecular docking and molecular dynamics (MD) simulations confirmed high-affinity, stable binding of TCS to PTGS2. In cardiomyocytes, TCS upregulated PTGS2 and the injury marker cTnI, an effect reversed by the PTGS2 inhibitor celecoxib. These findings establish PTGS2 as a critical mediator of TCS-induced cardiomyocyte injury, providing a potential therapeutic target for TCS-associated cardiovascular damage.<\/jats:p>","DOI":"10.3390\/ijms27052343","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:06:59Z","timestamp":1772467619000},"page":"2343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Network Toxicology, Machine Learning, and Molecular Dynamics to Explore the Molecular Network of Triclosan-Induced Acute Myocardial Infarction"],"prefix":"10.3390","volume":"27","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siwei","family":"Zou","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyao","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingbo","family":"Cao","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Fu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjie","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Medical Information and Engineering, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-0811","authenticated-orcid":false,"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0606-5937","authenticated-orcid":false,"given":"Anning","family":"Yang","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University, School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10937404.2017.1399306","article-title":"Triclosan exposure, transformation, and human health effects","volume":"20","author":"Weatherly","year":"2017","journal-title":"J. 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