{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:31:55Z","timestamp":1772778715044,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002674","name":"Russian Academy of Sciences","doi-asserted-by":"crossref","award":["FURG-2026-0034"],"award-info":[{"award-number":["FURG-2026-0034"]}],"id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002674","name":"Russian Academy of Sciences","doi-asserted-by":"crossref","award":["1025031800121-0-3.1.9"],"award-info":[{"award-number":["1025031800121-0-3.1.9"]}],"id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multimorbidity is a key global trend across healthcare fields, including gynecology. It is strongly associated with an overall poorer health status. Statistics indicate that in the 21st century most women experience at least one gynecological disease. Meanwhile, there is a consistent increase in the prevalence of obesity associated with chronic inflammation and hyperestrogenism. Alongside other factors, it leads to a growing prevalence of hyperproliferative diseases of the female reproductive system (FRS), encompassing both benign and malignant conditions. While advanced-stage malignant tumors can be linked to missed detection and wrong checkup strategies, benign neoplasms can compromise the ovarian reserve and thus cause major concerns. The prevailing benign FRS tumors are uterine fibroids (UFs) and benign ovarian tumors (BOTs), including serous and mucinous cystadenomas. It appears that an increase in certain benign FRS tumors is occurring in parallel with a rise in infertility (especially \u201cunexplained infertility\u201d) and reproduction failures, potentially associated with endometrial dysfunction. Thus, the endometrium is currently considered a critical area of research due to its vital role as the site of blastocyst adhesion and implantation, especially in patients with comorbidities. In this context, this article highlights the significance and pathophysiological characteristics of UFs and BOTs and their impact on defective endometrial receptivity.<\/jats:p>","DOI":"10.3390\/ijms27052376","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:51:33Z","timestamp":1772614293000},"page":"2376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial Dysfunction in Women with Ovarian and Uterine Tumors: What Is Known and What Should Be Learned?"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-914X","authenticated-orcid":false,"given":"Liudmila M.","family":"Mikhaleva","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mekan R.","family":"Orazov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Federal State Autonomous Educational Institution of Higher Education \u00abPeoples\u2019 Friendship University of Russia\u00bb, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-5209","authenticated-orcid":false,"given":"Evgeny D.","family":"Dolgov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"},{"name":"Department of Obstetrics and Gynecology, Federal State Autonomous Educational Institution of Higher Education \u00abPeoples\u2019 Friendship University of Russia\u00bb, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey A.","family":"Mikhalev","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Educational Institution of Higher Education \u201cN.I. Pirogov Russian National Research Medical University\u201d of the Ministry of Health of the Russian Federation, 117997 Moscow, Russia"},{"name":"Savelyeva Moscow City Clinical Hospital No. 31, 119415 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarina V.","family":"Gioeva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-7746","authenticated-orcid":false,"given":"Nikolay K.","family":"Shakhpazyan","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-4556","authenticated-orcid":false,"given":"Valentina V.","family":"Pechnikova","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"},{"name":"Savelyeva Moscow City Clinical Hospital No. 31, 119415 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-8561","authenticated-orcid":false,"given":"Mikhail Y.","family":"Gushchin","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Human Morphology Named After Academician A.P. Avtsyn of the Federal State Budgetary Scientific Institution \u201cRussian Scientific Center of Surgery Named After Academician B.V. Petrovsky\u201d, 117418 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1210\/clinem\/dgad450","article-title":"New horizons: Epidemiology of obesity, diabetes mellitus, and cancer prognosis","volume":"109","author":"Harborg","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10147-024-02473-8","article-title":"Trends in gynecologic cancer in Japan: Incidence from 1980 to 2019 and mortality from 1981 to 2021","volume":"29","author":"Nakai","year":"2024","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/ijgo.15211","article-title":"The global burden of disease due to benign gynecological conditions: A call to action","volume":"164","author":"Wijeratne","year":"2024","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12978-025-01966-7","article-title":"Epidemiological characteristics of infertility, 1990\u20132021, and 15-year forecasts: An analysis based on the global burden of disease study 2021","volume":"22","author":"Feng","year":"2025","journal-title":"Reprod. Health"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bulletti, F.M., Sciorio, R., Conforti, A., De Luca, R., Bulletti, C., Palagiano, A., Berrettini, M., Scaravelli, G., and Pierson, R.A. (2025). Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1429193"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1007\/s10815-024-03257-9","article-title":"Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)\u2014A prospective cohort follow-up study","volume":"41","author":"Roumen","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104827","DOI":"10.1016\/j.rbmo.2025.104827","article-title":"Resolving recurrent implantation failure","volume":"50","author":"Macklon","year":"2025","journal-title":"Reprod. Biomed. Online"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jogc.2020.01.014","article-title":"Guideline No. 404: Initial investigation and management of benign ovarian masses","volume":"42","author":"Wolfman","year":"2020","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1055\/a-1545-4279","article-title":"2020 WHO Classification of Female Genital Tumors","volume":"81","author":"Brambs","year":"2021","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/his.14609","article-title":"Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)","volume":"80","author":"McCluggage","year":"2022","journal-title":"Histopathology"},{"key":"ref_11","first-page":"e38273","article-title":"Histomorphological analysis of ovarian neoplasms according to the 2020 WHO classification of ovarian tumors: A distribution pattern in a tertiary care center","volume":"15","author":"Mehra","year":"2023","journal-title":"Cureus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/0020-7292(95)02404-Z","article-title":"Early de novo ovarian cancer and cancer developing in benign ovarian lesions","volume":"49","author":"Scully","year":"1995","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pap.0000201826.46978.e5","article-title":"Advances in the recognition of tubal intraepithelial carcinoma: Applications to cancer screening and the pathogenesis of ovarian cancer","volume":"13","author":"Lee","year":"2006","journal-title":"Adv. Anat. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer\u2014Shifting the paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.humpath.2022.04.008","article-title":"Precursors in the ovarian stroma: Another pathway to explain the origin of ovarian serous neoplasms","volume":"127","author":"Silva","year":"2022","journal-title":"Hum. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.path.2021.05.006","article-title":"Molecular pathology of ovarian epithelial neoplasms: Predictive, prognostic, and emerging biomarkers","volume":"14","author":"Ordulu","year":"2021","journal-title":"Surg. Pathol. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mackenzie, R., Kommoss, S., Winterhoff, B.J., Kipp, B.R., Garcia, J.J., Voss, J., Halling, K., Karnezis, A., Senz, J., and Anglesio, M.S. (2015). Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1421-8"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"i16","DOI":"10.1093\/annonc\/mdw089","article-title":"The molecular pathology of ovarian serous borderline tumors","volume":"27","author":"Malpica","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.22543\/7674.81.P4452","article-title":"A mini-review regarding the carcinogenesis and morphology of serous tumors of the ovary, fallopian tube and peritoneum","volume":"8","author":"Georgescu","year":"2021","journal-title":"J. Mind Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Vaicekauskait\u0117, I., Kazlauskait\u0117, P., Gineikait\u0117, R., \u010ciurlien\u0117, R., Lazutka, J.R., and Sabaliauskait\u0117, R. (2025). Integrative Analysis of Gene Expression and Promoter Methylation to Differentiate High-Grade Serous Ovarian Cancer from Benign Tumors. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020441"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1097\/JS9.0000000000001814","article-title":"The role of immune cell signatures in the pathogenesis of ovarian-related diseases: A causal inference based on Mendelian randomization","volume":"110","author":"Lu","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ono, M., Qiang, W., Serna, V.A., Yin, P., Coon, J.S., Navarro, A., Monsivais, D., Kakinuma, T., Dyson, M., and Bulun, S.E. (2012). Role of stem cells in human uterine leiomyoma growth. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036935"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1001\/jama.2024.0447","article-title":"Uterine fibroids","volume":"331","author":"Marsh","year":"2024","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.21037\/gpm-23-57","article-title":"Uterine fibroids: A narrative review of epidemiology and management, with a focus on uterine artery embolization","volume":"7","author":"Behairy","year":"2024","journal-title":"Gynecol. Pelvic Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1007\/s43032-024-01727-0","article-title":"The Annual Economic Burden of Uterine Fibroids in the United States (2010 Versus 2022): A Comparative Cost-Analysis","volume":"31","author":"Hazimeh","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/ijgo.70527","article-title":"The epidemiology and pathogenesis of uterine fibroids","volume":"171","author":"Munro","year":"2025","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"hoac056","DOI":"10.1093\/hropen\/hoac056","article-title":"The impact of small and asymptomatic intramural and subserosal fibroids on female fertility: A case\u2013control study","volume":"2023","author":"Bonanni","year":"2023","journal-title":"Hum. Reprod. Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/ijgo.70538","article-title":"Diagnosis and classification of uterine fibroids","volume":"171","author":"Lakabi","year":"2025","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.fertnstert.2011.03.079","article-title":"The FIGO classification of causes of abnormal uterine bleeding in the reproductive years","volume":"95","author":"Munro","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.path.2019.02.004","article-title":"Smooth muscle tumors of the female genital tract","volume":"12","author":"Devereaux","year":"2019","journal-title":"Surg. Pathol. Clin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-021-03747-1","article-title":"Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma","volume":"596","author":"Berta","year":"2021","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s43032-023-01297-7","article-title":"The mediator complex subunit 12 (MED-12) gene and uterine fibroids: A systematic review","volume":"31","author":"Amendola","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ali, M., Ciebiera, M., Vafaei, S., Alkhrait, S., Chen, H.Y., Chiang, Y.F., Huang, K.-C., Feduniw, S., Hsia, S.-M., and Al-Hendy, A. (2023). Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics. Cells, 12.","DOI":"10.3390\/cells12081117"},{"key":"ref_34","first-page":"156","article-title":"Estrogens and uterine fibroids: An integrated view","volume":"7","author":"Alsudairi","year":"2021","journal-title":"Hay\u0447\u043d\u044be Pe\u0437y\u043b\u044cmam\u044b \u0431uo\u043ce\u0434u\u0446u\u043dc\u043aux Ucc\u043be\u0434o\u0432a\u043du\u0439"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"104317","DOI":"10.1016\/j.jri.2024.104317","article-title":"Role of inflammation and immune response in the pathogenesis of uterine fibroids: Including their negative impact on reproductive outcomes","volume":"165","author":"Ishikawa","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9688793","DOI":"10.1155\/jimr\/9688793","article-title":"Systematic Analysis of Peripheral Immune Signatures and Diagnostic Model Construction in Patients with Uterine Fibroids","volume":"2026","author":"Li","year":"2026","journal-title":"J. Immunol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.17116\/patol20228404129","article-title":"Receptive status of the endometrium in patients with benign ovarian tumors before and after organ-preserving operations","volume":"84","author":"Tumasyan","year":"2022","journal-title":"Arkhiv Patol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/cam4.282","article-title":"Early inflammatory response in epithelial ovarian tumor cyst fluids","volume":"3","author":"Partheen","year":"2014","journal-title":"Cancer Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/jwh.2022.0385","article-title":"The risk of infertility after surgery for benign ovarian cysts","volume":"32","author":"Shandley","year":"2023","journal-title":"J. Women\u2019s Health"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ijgo.15284","article-title":"Influence of ovarian cysts on ovarian reserve and fertility: A case\u2013control study","volume":"165","author":"Bareghamyan","year":"2024","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.17116\/patol20258704113","article-title":"Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries","volume":"87","author":"Kudimova","year":"2025","journal-title":"Arkhiv Patol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/09513590600604673","article-title":"Effects of the position of fibroids on fertility","volume":"22","author":"Casini","year":"2006","journal-title":"Gynecol. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s43032-025-01802-0","article-title":"The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium","volume":"32","author":"Tuncay","year":"2025","journal-title":"Reprod. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI1597","article-title":"HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium","volume":"101","author":"Taylor","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s43032-021-00816-8","article-title":"Uterine receptivity is reflected by LIF expression in the cervix","volume":"29","author":"Fukui","year":"2022","journal-title":"Reprod. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1093\/humrep\/dep306","article-title":"HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility","volume":"24","author":"Matsuzaki","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1002\/jcb.27613","article-title":"Decreased expression of LIF mRNA in patients withmyoma uteri","volume":"120","author":"Kara","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e43006","DOI":"10.1016\/j.heliyon.2025.e43006","article-title":"Identifying shared molecular landscape between uterine fibroids and recurrent implantation failure: An integrated bioinformatics study","volume":"11","author":"Hosseini","year":"2025","journal-title":"Heliyon"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Navarro, A., Bariani, M.V., Yang, Q., and Al-Hendy, A. (2021). Understanding the impact of uterine fibroids on human endometrium function. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.633180"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e70022","DOI":"10.1111\/aji.70022","article-title":"Mechanism of endometrial receptivity affected by fibroids","volume":"92","author":"Sun","year":"2024","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_51","first-page":"2153","article-title":"Increased expression of neurogenic factors in uterine fibroids","volume":"34","author":"Luddi","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1177\/1933719117725827","article-title":"Literature review on the role of uterine fibroids in endometrial function","volume":"25","author":"Ikhena","year":"2018","journal-title":"Reprod. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:29:16Z","timestamp":1772774956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/5\/2376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ijms27052376"],"URL":"https:\/\/doi.org\/10.3390\/ijms27052376","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]}}}