{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:21:05Z","timestamp":1773102065480,"version":"3.50.1"},"reference-count":173,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D is widely recognized for its pivotal role in the prevention and treatment of various cancers. The active compounds derived from plants have garnered significant attention due to their multi-faceted anticancer properties. Given the complexity and heterogeneity of cancer, monotherapies often fall short in effectiveness. As a result, combinatorial pharmacological strategies, which utilize multiple drug agents, are increasingly being employed globally. Notably, emerging evidence highlights the potent synergistic anticancer effects of vitamin D in combination with certain phytochemicals against a variety of cancers. This review explores the cooperative mechanisms through which vitamin D and phytochemicals enhance cancer prevention and therapy. In addition to examining their synergistic effects, this review also discusses recent advancements in nanotechnology-based delivery systems for vitamin D, which hold promise for optimizing its therapeutic potential. Collectively, these findings underscore the potential of combining vitamin D with phytochemicals and innovative delivery methods as a promising strategy in the fight against cancer, paving the way for more effective, multi-targeted therapeutic approaches.<\/jats:p>","DOI":"10.3390\/ijms27052507","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:27:18Z","timestamp":1773062838000},"page":"2507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Anticancer Effects of Vitamin D and Plant-Derived Compounds: Molecular Mechanisms, Therapeutic Potential, and Nanotechnology-Enabled Delivery Approaches"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-3514","authenticated-orcid":false,"given":"Arik","family":"Dahan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-7427","authenticated-orcid":false,"given":"Sapir","family":"Ifrah","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4962-4938","authenticated-orcid":false,"given":"Ludmila","family":"Yarmolinsky","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-6544","authenticated-orcid":false,"given":"Boris","family":"Khalfin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-8816","authenticated-orcid":false,"given":"Sigal","family":"Fleisher-Berkovich","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-5488","authenticated-orcid":false,"given":"Shimon","family":"Ben-Shabat","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.drudis.2014.06.008","article-title":"Pharmacological Effects of Vitamin D and Its Analogs: Recent Developments","volume":"19","author":"Sintov","year":"2014","journal-title":"Drug Discov. 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