{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:09:17Z","timestamp":1773277757973,"version":"3.50.1"},"reference-count":84,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002811","name":"Cathay General Hospital","doi-asserted-by":"publisher","award":["CGH-MR-A11406"],"award-info":[{"award-number":["CGH-MR-A11406"]}],"id":[{"id":"10.13039\/501100002811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a heterogeneous chronic inflammatory disorder associated with substantial diagnostic delay and limited therapeutic options, highlighting the need of robust non-invasive biomarkers and actionable molecular targets to complement existing low-sensitivity tests. To identify conserved pathogenic mechanisms with translational potential, here, we uniformly reprocessed three independent the Gene Expression Omnibus (GEO) microarray cohorts (GSE7305, GSE25628, and GSE11691) and applied a strict, directionally consistent intersection strategy to identify conserved transcriptional signals. We identified 262 consensus differentially expressed genes enriched for immunity\/inflammation, cell adhesion and migration, and angiogenesis, consistent with key biological hallmarks of lesion establishment and persistence. Protein\u2013protein interaction topology prioritized 11 highly connected hub genes (VCAM1, CCL2, MCAM, CD14, CD24, FGFR1, SIRPA, CSF1R, S100A9, S100A8, and LY96) that likely act as an integrated immune-adhesion-angiogenesis axis. Notably, 63\/262 (24%) of the consensus genes were annotated to the extracellular exosome compartment, supporting their translational relevance as liquid-biopsy candidates. Finally, connectivity mapping using the LINCS L1000 framework nominated small-molecule perturbagens predicted to reverse the endometriosis-associated signature, providing a rational starting point for drug-repurposing experiments. In conclusion, this study elucidates a conserved immune\u2013adhesion\u2013angiogenesis axis driven by an 11-gene hub network in endometriosis. These core regulators represent promising candidates for the development of non-invasive liquid biopsies and precision, non-hormonal therapeutics.<\/jats:p>","DOI":"10.3390\/ijms27062572","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:43:27Z","timestamp":1773225807000},"page":"2572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosome-Enriched Hub Gene Networks Identify Diagnostic Biomarkers and Repurposable Therapeutic Targets in Endometriosis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8578-4428","authenticated-orcid":false,"given":"Meng-Hsiu","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Engineering, National Central University, Taoyuan City 320317, Taiwan"},{"name":"IHMED Reproductive Center, Taipei City 106028, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Ping","family":"Weng","sequence":"additional","affiliation":[{"name":"IHMED Reproductive Center, Taipei City 106028, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-9800","authenticated-orcid":false,"given":"Li-Jen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Engineering, National Central University, Taoyuan City 320317, Taiwan"},{"name":"IHMED Reproductive Center, Taipei City 106028, Taiwan"},{"name":"Education and Research Center for Technology Assisted Substance Abuse Prevention and Management, National Central University, Taoyuan City 320317, Taiwan"},{"name":"Core Facilities for High Throughput Experimental Analysis, Department of Biomedical Science and Engineering, National Central University, Taoyuan City 320317, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-7816","authenticated-orcid":false,"given":"Tsung-Hsuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei City 106438, Taiwan"},{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Terzic, M., Aimagambetova, G., Kunz, J., Bapayeva, G., Aitbayeva, B., Terzic, S., and Lagan\u00e0, A.S. 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