{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:07:33Z","timestamp":1787666853167,"version":"build-2736575974"},"reference-count":122,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Royal Society of New Zealand"},{"name":"Heath Research Council of New Zealand"},{"name":"Mercia Barnes Research Grant"},{"DOI":"10.13039\/501100001563","name":"Otago Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001563","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Maurice and Phyllis Paykel Trust grants"},{"name":"Otago Innovation \u201cProof of Concept\u201d grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dedifferentiation\u2014the acquisition of an early developmental state\u2014is a hallmark of cancer. However, the underlying mechanisms that lead to cancer-associated dedifferentiation are not fully understood. Transposable elements (TEs) are becoming increasingly recognised as important regulators of development and disease. The recruitment of TE sequences has played an important role in placental evolution, and TE-derived genes play critical roles in placental development. Although important biological differences exist between tumours and the placenta, the placenta shares certain features with tumours, including the capacity to invade surrounding tissue and modulate the maternal immune response. In this regard, TEs have been implicated in cancer development, and are documented to contribute to oncogenesis through multiple different mechanisms. Moreover, cancers reacquire an epigenetic landscape, which is reflective of early development, and which corresponds to increased phenotypic plasticity, including facilitating the activation of early developmental genes. Many cancers can repurpose developmental genes, including TE-associated genes, which may contribute to pathways involved in invasion and metastasis. Determining whether TE activation is a consequence of broader epigenetic reprogramming or actively contributes to dedifferentiation will be important for understanding cancer biology and may facilitate improvements in cancer diagnosis and treatment.<\/jats:p>","DOI":"10.3390\/ijms27062690","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:10:43Z","timestamp":1773655843000},"page":"2690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigenetic Deregulation of Transposable Elements Links Developmental Processes and Tumorigenesis"],"prefix":"10.3390","volume":"27","author":[{"given":"Chiemi","family":"Lynch-Sutherland","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Dunedin School of Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand"},{"name":"Children\u2019s Medical Research Institute, Westmead, NSW 2145, Australia"},{"name":"Kids Neuroscience Centre, Kids Research, The Children\u2019s Hospital at Westmead, Westmead, NSW 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-3493","authenticated-orcid":false,"given":"Peter","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Dunedin School of Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-2248","authenticated-orcid":false,"given":"Aniruddha","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Dunedin School of Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-8761","authenticated-orcid":false,"given":"Michael R.","family":"Eccles","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Dunedin School of Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Macaulay","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Dunedin School of Medicine, University of Otago, P.O. 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