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It provides a comprehensive overview that allows for an in-depth understanding of the importance of CXCL1 in tumor-related processes. In this review, however, we did not address the clinical aspects of CXCL1, as these were discussed in our previous review articles. The present paper focuses on the involvement of CXCL1 in cancer processes such as proliferation, cancer stem cell (CSC) function, senescence, angiogenesis, lymphangiogenesis, migration and metastasis, and effects on tumor-associated cells such as neutrophils, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), mesenchymal stem cells (MSCs), and cancer-associated fibroblasts (CAFs). It also describes the significance of CXCL1 in cancer-associated diseases such as cancer cachexia, cancer-associated immunodeficiency, neuroinflammatory-mediated affective-like behaviors, bone cancer pain, and acute kidney injury. We also present the effects of obesity on CXCL1-related cancer processes.<\/jats:p>","DOI":"10.3390\/ijms27062693","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:10:43Z","timestamp":1773655843000},"page":"2693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Significance of CXCL1 in Cancer: An Overview of Molecular Mechanisms"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-1259","authenticated-orcid":false,"given":"Jan","family":"Korbecki","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Collegium Medicum, University of Zielona G\u00f3ra, Zyty 28 St., 65-046 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-4329","authenticated-orcid":false,"given":"Mateusz","family":"Bosiacki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp. 72 St., 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Dzi\u0119cio\u0142owska-Baran","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp. 72 St., 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-7540","authenticated-orcid":false,"given":"Patrycja","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Endodontic Surgery, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp. 72 St., 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4600-8920","authenticated-orcid":false,"given":"Micha\u0142","family":"Lubkowski","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp. 72 St., 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ireneusz","family":"Walaszek","sequence":"additional","affiliation":[{"name":"Department of Nursing, Pomeranian Medical University in Szczecin, \u017bo\u0142nierska 48 St., 71-210 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Barczak","sequence":"additional","affiliation":[{"name":"Department of Endodontic Surgery, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp. 72 St., 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A Guide to Chemokines and Their Receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: A New Classification System and Their Role in Immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2018.02.022","article-title":"CXCL4 and CXCL4L1 in cancer","volume":"16","author":"Ruytinx","year":"2018","journal-title":"Cytokine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/gtc.12013","article-title":"Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history","volume":"18","author":"Nomiyama","year":"2013","journal-title":"Genes Cells"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(94)80454-0","article-title":"Both interleukin-8 receptors independently mediate chemotaxis. 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