{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:40:54Z","timestamp":1773916854615,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2815900"],"award-info":[{"award-number":["2024YFC2815900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82473838"],"award-info":[{"award-number":["82473838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U1906213"],"award-info":[{"award-number":["U1906213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30670219"],"award-info":[{"award-number":["30670219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>By investigating the conditions for the C\u2013C coupling reaction of p-terphenyls, we successfully synthesized C\u2013C coupled dimeric p-terphenyls for the first time using a reaction system involving air, silica gel, and B(OH)3. Additionally, we developed a novel method to synthesize furan-fused p-terphenyl dimers through solvent-free reactions by creatively applying rotary evaporation and heating. Compounds 6\u201312, 16, 20, and 22 demonstrated DPPH radical scavenging activity that was either stronger than or comparable to the positive control (vitamin C), with IC50 values ranging from 0.14 to 4.61 \u03bcM. Compounds 4\u201322 also exhibited significant activity against \u03b1-glucosidase, with IC50 values ranging from 0.37 to 17.9 \u03bcM, exceeding the efficacy of the positive control, acarbose. Moreover, compounds 6\u201314, 16\u201318, 21, and 22 demonstrated greater inhibitory activity against PTP1B compared with the positive control, oleanolic acid, with IC50 values between 0.30 and 9.17 \u03bcM. These findings highlight their potential as promising leads or dietary supplements for the treatment and prevention of diabetes, as well as possible application as oxidative agents in food preservation.<\/jats:p>","DOI":"10.3390\/ijms27062726","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:42:16Z","timestamp":1773751336000},"page":"2726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Antioxidative p-Terphenyl Dimers via Boronic Acid-Mediated C\u2013C Coupling"],"prefix":"10.3390","volume":"27","author":[{"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China"},{"name":"School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 561113, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linmeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China"},{"name":"Natural Products Research Center of Guizhou Province, Guiyang 550014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-4004","authenticated-orcid":false,"given":"Peng","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Marine Science and Technology Center, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang 550014, China"},{"name":"Natural Products Research Center of Guizhou Province, Guiyang 550014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-3264","authenticated-orcid":false,"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Laboratory for Marine Drugs and Bioproducts, Marine Science and Technology Center, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","first-page":"601","article-title":"DPPH Radical Scavenging Activity of Ten Natural p-Terphenyl Derivatives Obtained from Three Edible Mushrooms Indigenous to China","volume":"1","author":"Liu","year":"2004","journal-title":"Chem. 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