{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:57:44Z","timestamp":1791493064254,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["BNW-02-058\/N\/3\/J."],"award-info":[{"award-number":["BNW-02-058\/N\/3\/J."]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adult neurogenesis, the process of generating new, functional neurons in the mature central nervous system, represents a key mechanism of brain plasticity and a potential source of regeneration. This process occurs primarily within specialised neurogenic niches: the subgranular zone of the hippocampal dentate gyrus (SGZ) and the subependymal zone (SEZ). It is regulated by a complex network of endogenous factors (e.g., hormones, neurotrophins, growth factors) and exogenous factors (environment, stress, diet, physical activity). Impairments in neurogenesis are linked to the pathogenesis of neurodegenerative diseases, such as Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). In their course, chronic inflammation, mitochondrial dysfunction, oxidative stress, and the accumulation of pathological proteins (\u03b2-amyloid, Tau protein, \u03b1-synuclein) create a microenvironment that inhibits the proliferation, differentiation, and survival of new neurons. This results in the exacerbation of cognitive and memory deficits. A review of the literature indicates that modulating neurogenesis through non-pharmacological interventions (e.g., a diet rich in anti-inflammatory compounds, physical exercise) and targeted therapeutic strategies represents a promising, albeit complex, research avenue. The primary challenge remains not only stimulating neuron generation but also ensuring their proper maturation, survival, and functional integration into existing neuronal circuits. A deeper understanding of the molecular and environmental mechanisms regulating adult neurogenesis may open new therapeutic possibilities for slowing the progression of neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms27062742","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:35:08Z","timestamp":1773819308000},"page":"2742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adult Neurogenesis in Neurodegenerative Diseases: Mechanisms of Dysregulation in Alzheimer\u2019s and Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"27","author":[{"given":"Magdalena","family":"D\u0119biec","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0807-5423","authenticated-orcid":false,"given":"Marcin","family":"Rojek","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"},{"name":"Department of Histology and Cell Pathology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/00207454.2018.1545771","article-title":"Neurogenesis in the adult hippocampus: History, regulation, and prospective roles","volume":"129","author":"Fares","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Forrer Charlier, C., and Martins, R.A.P. (2020). Protective mechanisms against DNA replication stress in the nervous system. Genes, 11.","DOI":"10.3390\/genes11070730"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"dev156059","DOI":"10.1242\/dev.156059","article-title":"Neural stem cells: Origin, heterogeneity and regulation in the adult mammalian brain","volume":"146","author":"Obernier","year":"2019","journal-title":"Development"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Morales, A.V., and Mira, H. (2019). Adult neural stem cells: Born to last. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00096"},{"key":"ref_6","first-page":"49","article-title":"Nisze kom\u00f3rek macierzystych i neurogeneza w m\u00f3zgu dojrza\u0142ym","volume":"5","author":"Bogus","year":"2010","journal-title":"Neuropsychiatr. Neuropsychol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2020.12.067","article-title":"Expression of glucose transporters in human neurodegenerative diseases","volume":"540","author":"Pliszka","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.neurobiolaging.2012.07.009","article-title":"The hormone therapy, Premarin, impairs hippocampus-dependent spatial learning and memory and reduces activation of new granule neurons in response to memory in female rats","volume":"34","author":"Barha","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3651735","DOI":"10.1155\/2021\/3651735","article-title":"Reproduction-associated hormones and adult hippocampal neurogenesis","volume":"2021","author":"Wan","year":"2021","journal-title":"Neural Plast."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.psyneuen.2016.01.013","article-title":"Postpartum estrogen withdrawal impairs hippocampal neurogenesis and causes depression- and anxiety-like behaviors in mice","volume":"66","author":"Zhang","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/cne.903360210","article-title":"Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat","volume":"336","author":"Woolley","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1471-4159.2006.03809.x","article-title":"Proliferation and apoptosis of hippocampal granule cells require local oestrogen synthesis","volume":"97","author":"Fester","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Spritzer, M.D., and Roy, E.A. (2020). Testosterone and adult neurogenesis. Biomolecules, 10.","DOI":"10.3390\/biom10020225"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yhbeh.2005.01.004","article-title":"Pair-housing of male and female rats during chronic social stress exposure results in gender-specific behavioral responses","volume":"47","author":"Westenbroek","year":"2005","journal-title":"Horm. Behav."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/(SICI)1097-4695(19990615)39:4<569::AID-NEU10>3.0.CO;2-F","article-title":"Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory","volume":"39","author":"Nilsson","year":"1999","journal-title":"J. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41583-021-00433-z","article-title":"Formation and integration of new neurons in the adult hippocampus","volume":"22","author":"Jessberger","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00441-017-2735-4","article-title":"Adult neurogenesis contributes to hippocampal plasticity","volume":"373","author":"Toda","year":"2018","journal-title":"Cell Tissue Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-4328(94)90114-7","article-title":"Role of thyroid hormones in the maturation of interhemispheric connections in the rat","volume":"64","author":"Berbel","year":"1994","journal-title":"Behav. Brain Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1460-9568.1993.tb00214.x","article-title":"Organization of auditory callosal connections in hypothyroid adult rats","volume":"5","author":"Berbel","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-45106-5_1","article-title":"NGF, BDNF, NT3, and NT4","volume":"Volume 220","author":"Bothwell","year":"2014","journal-title":"Handbook of Experimental Pharmacology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"19170","DOI":"10.1073\/pnas.0608644103","article-title":"Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids","volume":"103","author":"Mirescu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbr.2011.10.009","article-title":"New neurons in an aged brain","volume":"227","author":"Lee","year":"2012","journal-title":"Behav. Brain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1074\/jbc.M708373200","article-title":"Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2007.01.010","article-title":"Omega-3 fatty acids upregulate adult neurogenesis","volume":"415","author":"Beltz","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neubiorev.2018.05.011","article-title":"Dietary polyphenols and neurogenesis: Molecular interactions and implications for brain ageing and cognition","volume":"90","author":"Sarubbo","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2125.2012.04378.x","article-title":"Cocoa flavanol and cognition","volume":"75","author":"Nehlig","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0954422416000081","article-title":"Modulating adult neurogenesis through dietary interventions","volume":"29","author":"Heberden","year":"2016","journal-title":"Nutr. Res. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"AN20120019","DOI":"10.1042\/AN20120019","article-title":"Neuroglia at the crossroads of homeostasis, metabolism and signalling: Evolution of the concept","volume":"4","author":"Parpura","year":"2012","journal-title":"ASN Neuro"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4103\/1673-5374.274330","article-title":"The role of cofilin in age-related neuroinflammation","volume":"15","author":"Alsegiani","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.arr.2010.11.002","article-title":"Inflammatory markers in population studies of aging","volume":"10","author":"Singh","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., and Xiao, H. (2022). Gut microbiota interact with the brain through systemic chronic inflammation: Implications for neuroinflammation, neurodegeneration, and aging. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.796288"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chidambaram, S.B., Rathipriya, A.G., Mahalakshmi, A.M., Sharma, S., Hediyal, T.A., Ray, B., Sunanda, T., Rungratanawanich, W., Kashyap, R.S., and Qoronfleh, M.W. (2022). The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke. Cells, 11.","DOI":"10.3390\/cells11071239"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Caggiu, E., Arru, G., Hosseini, S., Niegowska, M., Sechi, G., Zarbo, I.R., and Sechi, L.A. (2019). Inflammation, infectious triggers, and Parkinson\u2019s disease. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00122"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in the adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sefiani, A., and Geoffroy, C.G. (2021). The potential role of inflammation in modulating endogenous hippocampal neurogenesis after spinal cord injury. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.682259"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ajpath.2017.09.004","article-title":"Function and dysfunction of adult hippocampal neurogenesis in regeneration and disease","volume":"188","author":"Peng","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in Parkinson disease","volume":"13","author":"Aarsland","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41232-020-00122-x","article-title":"Current understanding of adult neurogenesis in the mammalian brain: How does adult neurogenesis decrease with age?","volume":"40","author":"Kase","year":"2020","journal-title":"Inflamm. Regen."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101636","DOI":"10.1016\/j.arr.2022.101636","article-title":"Neurogenesis in aging and age-related neurodegenerative diseases","volume":"78","author":"Culig","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_43","unstructured":"Kumar, A., Sidhu, J., Goyal, A., and Tsao, J.W. (2022). Alzheimer disease. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3233\/ADR-200218","article-title":"Neurogenesis makes a crucial contribution to the neuropathology of Alzheimer\u2019s disease","volume":"4","author":"Young","year":"2020","journal-title":"J. Alzheimer\u2019s Dis. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1249\/JSR.0000000000000332","article-title":"Alzheimer\u2019s disease and exercise: A literature review","volume":"16","author":"Cass","year":"2017","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Vidal, C., and Zhang, L. (2021). An analysis of the neurological and molecular alterations underlying the pathogenesis of Alzheimer\u2019s disease. Cells, 10.","DOI":"10.3390\/cells10030546"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kametani, F., and Hasegawa, M. (2018). Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer\u2019s disease. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00025"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"109203","DOI":"10.1016\/j.celrep.2021.109203","article-title":"PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome","volume":"35","author":"Ahier","year":"2021","journal-title":"Cell Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"EMBJ201899360","DOI":"10.15252\/embj.201899360","article-title":"Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria","volume":"38","author":"Cummins","year":"2019","journal-title":"EMBO J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"741","DOI":"10.4103\/1673-5374.322429","article-title":"Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases","volume":"17","author":"Ozgen","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1755-5949.2010.00177.x","article-title":"The role of tau in Alzheimer\u2019s disease and related disorders","volume":"17","author":"Medeiros","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbi.2021.09.002","article-title":"Transplantation of gut microbiota derived from an Alzheimer\u2019s disease mouse model impairs memory function and neurogenesis in C57BL\/6 mice","volume":"98","author":"Kim","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e1526","DOI":"10.1002\/wsbm.1526","article-title":"Immunohistochemical evidence for adult human neurogenesis in health and disease","volume":"13","author":"Gault","year":"2021","journal-title":"WIREs Mech. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1056\/NEJMra040223","article-title":"Drug therapy: Alzheimer\u2019s disease","volume":"351","author":"Cummings","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, Z.R., Huang, J.B., Yang, S.L., and Hong, F.F. (2022). Role of cholinergic signaling in Alzheimer\u2019s disease. Molecules, 27.","DOI":"10.3390\/molecules27061816"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/978-94-007-5416-4_16","article-title":"Parkinson\u2019s disease","volume":"65","author":"Mhyre","year":"2012","journal-title":"Subcell. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.31128\/AJGP-07-21-6087","article-title":"The initial diagnosis and management of Parkinson\u2019s disease","volume":"50","author":"Waller","year":"2021","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_58","first-page":"287","article-title":"Neurogenesis in neurodegenerative diseases in the adult human brain","volume":"30","year":"2021","journal-title":"Adv. Psychiatry Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/glia.23337","article-title":"Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop","volume":"66","author":"Rosazza","year":"2018","journal-title":"Glia"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"EMMM201810248","DOI":"10.15252\/emmm.201810248","article-title":"Inflammasomes in neuroinflammatory and neurodegenerative diseases","volume":"11","author":"Voet","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.4103\/1673-5374.301026","article-title":"Hydrogen sulfide enhances adult neurogenesis in a mouse model of Parkinson\u2019s disease","volume":"16","author":"Wang","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2018.01.002","article-title":"Comparative review of adult midbrain and striatum neurogenesis with classical neurogenesis","volume":"134","author":"Farzanehfar","year":"2018","journal-title":"Neurosci. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial activation and chronic neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"5","author":"Breteler","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1212\/WNL.0000000000012868","article-title":"Dopaminergic therapy for motor symptoms in early Parkinson disease: Practice guideline summary","volume":"97","author":"Pringsheim","year":"2021","journal-title":"Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s11011-024-01389-6","article-title":"Alzheimer\u2019s disease: From early pathogenesis to novel therapeutic approaches","volume":"39","author":"Prajapati","year":"2024","journal-title":"Metab. Brain Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"glaf038","DOI":"10.1093\/gerona\/glaf038","article-title":"Age-related cognitive decline and dementia: Interface of microbiome\u2013immune\u2013neuronal interactions","volume":"80","author":"Prajapati","year":"2025","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102271","DOI":"10.1016\/j.arr.2024.102271","article-title":"Sonic hedgehog signalling pathway contributes in age-related disorders and Alzheimer\u2019s disease","volume":"96","author":"Parashar","year":"2024","journal-title":"Ageing Res. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/6\/2742\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:12:04Z","timestamp":1773983524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/6\/2742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":68,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ijms27062742"],"URL":"https:\/\/doi.org\/10.3390\/ijms27062742","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}