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Experimental evidence reveals that BPC-157 supports angiogenesis, collagen synthesis, fibroblast activity, and modulation of nitric oxide pathways, contributing to enhanced healing of muscle, tendon, ligament, bone, and gastrointestinal tissue. Studies also report reduced inflammatory cytokine activity, improved microvascular integrity, and beneficial effects on pain modulation through peripheral and dopaminergic mechanisms. Although animal data indicate favorable safety and pharmacokinetics, human research remains limited to small pilot studies investigating musculoskeletal pain, interstitial cystitis, and intravenous administration, all suggesting potential therapeutic value without reported major adverse effects. However, inconsistent preparation standards, limited clinical validation, and regulatory restrictions underscore the need for rigorous controlled trials. BPC-157 remains a promising candidate for regenerative medicine, yet comprehensive evaluation is required before clinical translation can be recommended.<\/jats:p>","DOI":"10.3390\/ijms27062876","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:48:42Z","timestamp":1774259322000},"page":"2876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management"],"prefix":"10.3390","volume":"27","author":[{"given":"Claire","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of History and Philosophy of Science, Christ\u2019s College, University of Cambridge, Cambridge CB2 1TN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Demers","sequence":"additional","affiliation":[{"name":"Joint Vitality Institute, Sonora, CA 95370, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-5881","authenticated-orcid":false,"given":"Victor","family":"Silva-Ortiz","sequence":"additional","affiliation":[{"name":"Pain Management Department, Hospital Zambrano Heli\u00f3n, Monterrey, Nuevo Le\u00f3n 66278, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-1864","authenticated-orcid":false,"given":"Jamal J.","family":"Hasoon","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care, and Pain Medicine, McGovern Medical School, UTHealth, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Dave","sequence":"additional","affiliation":[{"name":"Aurora Life, Grand Cayman KY1-1209, Cayman Islands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Amirdelfan","sequence":"additional","affiliation":[{"name":"Boomerang Healthcare, Walnut Creek, CA 94598, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold W.","family":"Burke","sequence":"additional","affiliation":[{"name":"Division of Pain, Department of Anesthesiology and Critical Care, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-5272","authenticated-orcid":false,"given":"Paul J.","family":"Christo","sequence":"additional","affiliation":[{"name":"Division of Pain, Department of Anesthesiology and Critical Care, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-9056","authenticated-orcid":false,"given":"Christopher L.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Pain, Department of Anesthesiology and Critical Care, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11916-022-01055-5","article-title":"Biomaterials and Regenerative Medicine in Pain Management","volume":"26","author":"Gu","year":"2022","journal-title":"Curr. 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