{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:59:58Z","timestamp":1776722398823,"version":"3.51.2"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romania\u2019s National Recovery and Resilience Plan","award":["PNRR-III-C9-2023-I8"],"award-info":[{"award-number":["PNRR-III-C9-2023-I8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multicentric reticulohistiocytosis (MRH) is a rare systemic histiocytic disorder of uncertain etiology characterized by papulonodular cutaneous lesions and potentially destructive polyarthritis, with variable multisystem involvement. Owing to its low prevalence, evidence for optimal management remains limited, and treatment responses are heterogeneous. Emerging reports suggest that Janus kinase (JAK) inhibition may provide benefit in refractory disease. We report a 60-year-old woman with MRH presenting with papulonodular skin lesions, symmetric polyarthritis, constitutional symptoms, and interstitial lung disease (nonspecific interstitial pneumonia pattern) in the context of co-existing primary biliary cholangitis and no evidence of malignancy. Prior therapies (glucocorticoids, methotrexate, leflunomide) achieved suboptimal control. Upadacitinib, a selective JAK1 inhibitor, induced rapid and complete remission of cutaneous and articular disease with improvement of pulmonary involvement. Secondary weight gain and incident diabetes were managed with tirzepatide. This case adds to the limited literature supporting JAK inhibition as a targeted option for refractory MRH, including multisystem disease with pulmonary involvement. Systematic evaluation of efficacy, durability, and safety is warranted.<\/jats:p>","DOI":"10.3390\/ijms27062898","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:59:36Z","timestamp":1774267176000},"page":"2898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upadacitinib-Induced Remission in Multicentric Reticulohistiocytosis: Expanding the Therapeutic Role of JAK Inhibition"],"prefix":"10.3390","volume":"27","author":[{"given":"Cristina","family":"Pamfil","sequence":"first","affiliation":[{"name":"Rheumatology Department, Emergency County Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"},{"name":"Department of Dermatology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Amin","family":"Taki","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u201cOctavian Fodor\u201d, 3rd Medical Clinic, 400394 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeta","family":"Candrea","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"},{"name":"Department of Dermatology, Emergency County Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-3929","authenticated-orcid":false,"given":"Laura","family":"Damian","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Emergency County Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maia Ioana","family":"Mihon","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Emergency County Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Maria Margareta","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"},{"name":"Medical and Surgical Sciences Department, University of Cordoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Rednic","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Emergency County Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"},{"name":"Department of Dermatology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e7846","DOI":"10.1002\/ccr3.7846","article-title":"Multicentric Reticulohistiocytosis\u2014A rare and disabling disease","volume":"11","author":"Ashaolu","year":"2023","journal-title":"Clin. 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