{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:39:27Z","timestamp":1784741967605,"version":"3.55.0"},"reference-count":125,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Eriodictyol, a naturally occurring flavanone, has appeared as a biologically versatile compound with increasing relevance in biomedical research, especially in cancers. Evidence over the past few decades indicates that eriodictyol influences cancer cell fate through coordinated modulation of cell-cycle control, survival, and regulated cell death pathways. Eriodictyol appears to reshape oncogenic signaling networks, including PI3K\/Akt\/mTOR and associated kinase cascades, thereby restricting proliferative capacity and lowering resistance thresholds. Studies consistently report cell-cycle arrest at critical checkpoints, accompanied by activation of both mitochondrial- and death-receptor-mediated apoptotic pathways through disruption of BCL-2 family balance, caspase engagement, and mitochondrial destabilization. Furthermore, eriodictyol alters intracellular redox dynamics in a dose-dependent manner, selectively sensitizing cancer cells to oxidative and metabolic stress. More recent findings extend its significance to inflammation-driven tumor progression and to the regulation of ferroptosis. Beyond intrinsic pharmacological activity, advances in nanocarrier-based delivery and balanced combination strategies have started to address critical challenges and limitations regarding solubility and bioavailability, while allowing precise therapeutic applications. In this review, we have discussed the plausible mechanisms, experimental evidence, and translational insights of eriodictyol as a systems-level modulator of cancer biology. We also outlined research priorities essential for progressing its clinical relevance as future perspectives.<\/jats:p>","DOI":"10.3390\/ijms27072924","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:02:49Z","timestamp":1774339369000},"page":"2924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eriodictyol in Cancer Therapy: Reviewing Mechanistic Insights and Translational Opportunities"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-5808","authenticated-orcid":false,"given":"Sohail","family":"Mumtaz","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juie Nahushkumar","family":"Rana","sequence":"additional","affiliation":[{"name":"Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kainat","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Botany, Hazara University, Mansehra 21300, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113993","DOI":"10.1016\/j.biopha.2022.113993","article-title":"Disorders of Cancer Metabolism: The Therapeutic Potential of Cannabinoids","volume":"157","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gieleci\u0144ska, A., Kciuk, M., Mujwar, S., Celik, I., Ko\u0142at, D., Ka\u0142uzi\u0144ska-Ko\u0142at, \u017b., and Kontek, R. (2023). Substances of Natural Origin in Medicine: Plants vs. Cancer. Cells, 12.","DOI":"10.3390\/cells12070986"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41598-024-52413-9","article-title":"Network Pharmacology Combined with Experimental Verification to Explore the Potential Mechanism of Naringenin in the Treatment of Cervical Cancer","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13020-023-00745-5","article-title":"A Novel Microbial and Hepatic Biotransformation-Integrated Network Pharmacology Strategy Explores the Therapeutic Mechanisms of Bioactive Herbal Products in Neurological Diseases: The Effects of Astragaloside IV on Intracerebral Hemorrhage as an Example","volume":"18","author":"Hu","year":"2023","journal-title":"Chin. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jiang, C.-H., Sun, T.-L., Xiang, D.-X., Wei, S.-S., and Li, W.-Q. (2018). Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid from Hops (Humulus lupulus L.). Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00530"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119126","DOI":"10.1016\/j.jep.2024.119126","article-title":"Chrysotoxine Regulates Ferroptosis and the PI3K\/AKT\/MTOR Pathway to Prevent Cervical Cancer","volume":"338","author":"Zhou","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nakadate, K., Ito, N., Kawakami, K., and Yamazaki, N. (2025). Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115206"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Akter, K., Gul, K., and Mumtaz, S. (2025). Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47090716"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"122000","DOI":"10.1016\/j.saa.2022.122000","article-title":"Serum Raman Spectroscopy Combined with Convolutional Neural Network for Rapid Diagnosis of HER2-Positive and Triple-Negative Breast Cancer","volume":"286","author":"Zeng","year":"2023","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51701","DOI":"10.3788\/COL202018.051701","article-title":"Detection of Breast Cancer Based on Novel Porous Silicon Bragg Reflector Surface-Enhanced Raman Spectroscopy-Active Structure","volume":"18","author":"Ma","year":"2020","journal-title":"Chin. Opt. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/s41597-025-05798-9","article-title":"Whole Genome Sequencing and Annotations of Trametes sanguinea ZHSJ","volume":"12","author":"Lodi","year":"2025","journal-title":"Sci. Data"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jvh.13886","article-title":"CHB Patients with RtA181T-Mutated HBV Infection Are Associated with Higher Risk Hepatocellular Carcinoma Due to Increases in Mutation Rates of Tumour Suppressor Genes","volume":"30","author":"Ning","year":"2023","journal-title":"J. Viral Hepat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/imm.13793","article-title":"Immunotherapy and the Ovarian Cancer Microenvironment: Exploring Potential Strategies for Enhanced Treatment Efficacy","volume":"173","author":"Wang","year":"2024","journal-title":"Immunology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13046-025-03358-y","article-title":"Viral Expression of NE\/PPE Enhances Anti-Colorectal Cancer Efficacy of Oncolytic Adenovirus by Promoting TAM M1 Polarization to Reverse Insufficient Effector Memory\/Effector CD8+ T Cell Infiltration","volume":"44","author":"Wang","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105738","DOI":"10.1016\/j.fbio.2024.105738","article-title":"Identification and Molecular Mechanism of Novel Antioxidant Peptides from Tiger Nut (Cyperus esculentus L.)","volume":"63","author":"Quan","year":"2025","journal-title":"Food Biosci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rana, J.N., Gul, K., and Mumtaz, S. (2025). Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157381"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rana, J.N., and Mumtaz, S. (2025). Prunin: An Emerging Anticancer Flavonoid. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26062678"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110927","DOI":"10.1016\/j.cbi.2024.110927","article-title":"Evaluating Flavonoids as Potential Aromatase Inhibitors for Breast Cancer Treatment: In Vitro Studies and in Silico Predictions","volume":"392","author":"Seo","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"116827","DOI":"10.1016\/j.biopha.2024.116827","article-title":"Unlocking the Potential of Flavonoids: Natural Solutions in the Fight against Colon Cancer","volume":"176","author":"Hasibuan","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Abotaleb, M., Samuel, S.M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A., and B\u00fcsselberg, D. (2019). Flavonoids in Cancer and Apoptosis. Cancers, 11.","DOI":"10.3390\/cancers11010028"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pyo, Y., Kwon, K.H., and Jung, Y.J. (2024). Anticancer Potential of Flavonoids: Their Role in Cancer Prevention and Health Benefits. Foods, 13.","DOI":"10.3390\/foods13142253"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6681352","DOI":"10.1155\/2020\/6681352","article-title":"Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone","volume":"2020","author":"Deng","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s12272-020-01243-0","article-title":"The Pharmacological and Biological Roles of Eriodictyol","volume":"43","author":"Islam","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jfca.2013.11.004","article-title":"A Comprehensive Review on Flavanones, the Major Citrus Polyphenols","volume":"33","author":"Khan","year":"2014","journal-title":"J. Food Compos. Anal."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Li, W., Du, Q., Li, X., Zheng, X., Lv, F., Xi, X., Huang, G., Yang, J., and Liu, S. (2020). Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K\/Akt\/NF-\u039aB Signaling Pathway. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00114"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Shan, H., Zhang, X., Mi, Y., Jia, J., Wang, B., and Yang, Q. (2022). Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K\/AKT Pathway. Pharmaceuticals, 15.","DOI":"10.3390\/ph15121477"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.5114\/aoms.2019.85152","article-title":"Eriodictyol Exerts Potent Anticancer Activity against A549 Human Lung Cancer Cell Line by Inducing Mitochondrial-Mediated Apoptosis, G2\/M Cell Cycle Arrest and Inhibition of m-TOR\/PI3K\/Akt Signalling Pathway","volume":"16","author":"Zhang","year":"2020","journal-title":"Arch. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2004.04.034","article-title":"Potential Toxicity of Flavonoids and Other Dietary Phenolics: Significance for Their Chemopreventive and Anticancer Properties","volume":"37","author":"Galati","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13344","article-title":"Cytoprotective Effects of Dietary Flavonoids against Cadmium-Induced Toxicity","volume":"1398","author":"Li","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zahra, M., Abrahamse, H., and George, B.P. (2024). Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine. Antioxidants, 13.","DOI":"10.3390\/antiox13080922"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Costa, R., Costa Lima, S.A., Gameiro, P., and Reis, S. (2021). On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations. Antioxidants, 10.","DOI":"10.3390\/antiox10091376"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1021\/acs.jafc.2c00319","article-title":"Influences of Solubility and Vehicle Carriers on Eriodictyol Pharmacokinetics in Rats","volume":"70","author":"Manthey","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12951-025-03206-3","article-title":"Eriodictyol-Cisplatin Coated Nanomedicine Synergistically Promote Osteosarcoma Cells Ferroptosis and Chemosensitivity","volume":"23","author":"Lin","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00210-022-02270-y","article-title":"Potential Cancer Treatment Effects of Brusatol or Eriodictyol Combined with 5-Fluorouracil (5-FU) in Colorectal Cancer Cell","volume":"395","author":"Alper","year":"2022","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bcp.2010.11.004","article-title":"Eriodictyol: A Flavonoid Antagonist of the TRPV1 Receptor with Antioxidant Activity","volume":"81","author":"Rossato","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1271\/bbb.70.178","article-title":"Flavonoid Composition of Fruit Tissues of Citrus Species","volume":"70","author":"Nogata","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1080\/10408398.2020.1870035","article-title":"Citrus Flavonoids and Their Antioxidant Evaluation","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0955-2863(02)00208-5","article-title":"Flavonoid Antioxidants: Chemistry, Metabolism and Structure-Activity Relationships","volume":"13","author":"Heim","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and Prooxidant Properties of Flavonoids","volume":"82","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1080\/10408398.2019.1679085","article-title":"The Pharmacokinetics of Flavanones","volume":"60","author":"Saso","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3177\/jnsv.52.54","article-title":"Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans","volume":"52","author":"Miyake","year":"2006","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/med.10033","article-title":"Flavonoids: Promising Anticancer Agents","volume":"23","author":"Ren","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tcb.2023.05.012","article-title":"The Bidirectional Relationship between Metabolism and Cell Cycle Control","volume":"34","author":"Diehl","year":"2024","journal-title":"Trends Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e11087","DOI":"10.15252\/msb.202211087","article-title":"The Molecular Architecture of Cell Cycle Arrest","volume":"18","author":"Stallaert","year":"2022","journal-title":"Mol. Syst. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"154159","DOI":"10.1016\/j.phymed.2022.154159","article-title":"Eriodictyol Inhibits Breast Carcinogenesis by Targeting Circ_0007503 and Repressing PI3K\/Akt Pathway","volume":"102","author":"He","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_47","first-page":"2389","article-title":"Eriodictyol Inhibits the Growth of CNE1 Human Nasopharyngeal Cancer Growth by Targeting MEK\/ERK Signalling Pathway, Inducing Cellular Autophagy and Inhibition of Cell Migration and Invasion","volume":"5","author":"Tang","year":"2020","journal-title":"J. BUON"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101433","DOI":"10.1016\/j.tranon.2022.101433","article-title":"Eriodictyol Mediated Selective Targeting of the TNFR1\/FADD\/TRADD Axis in Cancer Cells Induce Apoptosis and Inhibit Tumor Progression and Metastasis","volume":"21","author":"Debnath","year":"2022","journal-title":"Transl. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"117202","DOI":"10.1016\/j.jep.2023.117202","article-title":"The Role of Ginkgo Folium on Antitumor: Bioactive Constituents and the Potential Mechanism","volume":"321","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"EMBJ201899692","DOI":"10.15252\/embj.201899692","article-title":"USP7 Limits CDK1 Activity throughout the Cell Cycle","volume":"40","author":"Galarreta","year":"2021","journal-title":"EMBO J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e23368","DOI":"10.1002\/jbt.23368","article-title":"Eriodictyol Regulated Ferroptosis, Mitochondrial Dysfunction, and Cell Viability via Nrf2\/HO-1\/NQO1 Signaling Pathway in Ovarian Cancer Cells","volume":"37","author":"Wang","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12672-024-01163-1","article-title":"Cellular and Molecular Events in Colorectal Cancer: Biological Mechanisms, Cell Death Pathways, Drug Resistance and Signalling Network Interactions","volume":"15","author":"Yan","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_53","first-page":"11","article-title":"Dysregulation of Calcium Homeostasis in Cancer and Its Role in Chemoresistance","volume":"7","author":"Kumari","year":"2024","journal-title":"Cancer Drug Resist."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e693","DOI":"10.1002\/mco2.693","article-title":"Cell Death Pathways: Molecular Mechanisms and Therapeutic Targets for Cancer","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mustafa, M., Ahmad, R., Tantry, I.Q., Ahmad, W., Siddiqui, S., Alam, M., Abbas, K., Hassan, M.I., and Habib, S. (2024). Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications. Cells, 13.","DOI":"10.3390\/cells13221838"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"116465","DOI":"10.1016\/j.ecoenv.2024.116465","article-title":"The Male Reproductive Toxicity after 5-Fluorouracil Exposure: DNA Damage, Oxidative Stress, and Mitochondrial Dysfunction In Vitro and In Vivo","volume":"278","author":"Yuan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2024.09.054","article-title":"Harnessing the Synergy of Nanosecond High-Power Microwave Pulses and Cisplatin to Increase the Induction of Apoptosis in Cancer Cells through the Activation of ATR\/ATM and Intrinsic Pathways","volume":"225","author":"Rana","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.fmre.2024.02.001","article-title":"Formation of Reactive Species via High Power Microwave Induced DNA Damage and Promoted Intrinsic Pathway-Mediated Apoptosis in Lung Cancer Cells: An In Vitro Investigation","volume":"4","author":"Rana","year":"2024","journal-title":"Fundam. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/15376516.2024.2369666","article-title":"Naturally-Derived Phenethyl Isothiocyanate Modulates Apoptotic Induction through Regulation of the Intrinsic Cascade and Resulting Apoptosome Formation in Human Malignant Melanoma Cells","volume":"34","author":"Tragkola","year":"2024","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41556-024-01429-4","article-title":"Mitochondria and Cell Death","volume":"26","author":"Glover","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"AL-Ishaq, R.K., Liskova, A., Kubatka, P., and B\u00fcsselberg, D. (2021). Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer. Cancers, 13.","DOI":"10.3390\/cancers13163934"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","article-title":"Oxidative Cell Death in Cancer: Mechanisms and Therapeutic Opportunities","volume":"15","author":"An","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Buranasudja, V., Muangnoi, C., Sanookpan, K., Halim, H., Sritularak, B., and Rojsitthisak, P. (2022). Eriodictyol Attenuates H2O2-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery. Nutrients, 14.","DOI":"10.3390\/nu14122553"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Maquera-Huacho, P.M., Spolidorio, D.P., Manthey, J.A., and Grenier, D. (2022). Eriodictyol Suppresses Porphyromonas Gingivalis-Induced Reactive Oxygen Species Production by Gingival Keratinocytes and the Inflammatory Response of Macrophages. Front. Oral Health, 3.","DOI":"10.3389\/froh.2022.847914"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"101817","DOI":"10.1016\/j.jsps.2023.101817","article-title":"Protective Effect of Eriodictyol against Hyperglycemia-Induced Diabetic Nephropathy in Rats Entails Antioxidant and Anti-Inflammatory Effects Mediated by Activating Nrf2","volume":"31","author":"AlTamimi","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1039\/D2FO03417D","article-title":"Eriodictyol: A Review of Its Pharmacological Activities and Molecular Mechanisms Related to Ischemic Stroke","volume":"14","author":"Guo","year":"2023","journal-title":"Food Funct."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e24401","DOI":"10.1016\/j.heliyon.2024.e24401","article-title":"Eriodictyol Inhibits the Motility, Angiogenesis and Tumor Growth of Hepatocellular Carcinoma via NLRP3 Inflammasome Inactivation","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"174069","DOI":"10.1016\/j.ejphar.2021.174069","article-title":"Eriodictyol Inhibits Glioblastoma Migration and Invasion by Reversing EMT via Downregulation of the P38 MAPK\/GSK-3\u03b2\/ZEB1 Pathway","volume":"900","author":"Lv","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/med.21966","article-title":"The Role of Flavonoids in the Regulation of Epithelial-Mesenchymal Transition in Cancer: A Review on Targeting Signaling Pathways and Metastasis","volume":"43","author":"Freitas","year":"2023","journal-title":"Med. Res. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Baek, J.-Y., Kwak, J.-E., and Ahn, M.-R. (2024). Eriocitrin Inhibits Angiogenesis by Targeting VEGFR2-Mediated PI3K\/AKT\/MTOR Signaling Pathways. Nutrients, 16.","DOI":"10.3390\/nu16071091"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110331","DOI":"10.1016\/j.abb.2025.110331","article-title":"Eriodictyol 5-O-Methyl Ether Inhibits Prostate Cancer Progression through Targeting STAT3 Signaling and Inducing Apoptosis and Paraptosis","volume":"766","author":"Yang","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.biopha.2018.08.103","article-title":"Eriodictyol Inhibits IL-1\u03b2-Induced Inflammatory Response in Human Osteoarthritis Chondrocytes","volume":"107","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.fct.2012.03.059","article-title":"Eriodictyol-7-O-Glucoside, a Novel Nrf2 Activator, Confers Protection against Cisplatin-Induced Toxicity","volume":"50","author":"Hu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.taap.2013.10.018","article-title":"Eriodictyol-7-O-Glucoside Activates Nrf2 and Protects against Cerebral Ischemic Injury","volume":"273","author":"Jing","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"112350","DOI":"10.1016\/j.jphotobiol.2021.112350","article-title":"Eriodictyol Protects Skin Cells from UVA Irradiation-Induced Photodamage by Inhibition of the MAPK Signaling Pathway","volume":"226","author":"Nisar","year":"2022","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tsilioni, I., Kempuraj, D., and Theoharides, T.C. (2025). Nobiletin and Eriodictyol Suppress Release of IL-1\u03b2, CXCL8, IL-6, and MMP-9 from LPS, SARS-CoV-2 Spike Protein, and Ochratoxin A-Stimulated Human Microglia. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020636"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s12272-011-0418-3","article-title":"Anti-Inflammatory Effects of Eriodictyol in Lipopolysaccharidestimulated Raw 264.7 Murine Macrophages","volume":"34","author":"Lee","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1002\/jcb.27848","article-title":"Eriodictyol Inhibits High Glucose-Induced Oxidative Stress and Inflammation in Retinal Ganglial Cells","volume":"120","author":"Lv","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2015.12.042","article-title":"Eriodictyol Attenuates Cisplatin-Induced Kidney Injury by Inhibiting Oxidative Stress and Inflammation","volume":"772","author":"Li","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s12192-016-0702-8","article-title":"Investigation of Immunomodulatory and Anti-Inflammatory Effects of Eriodictyol through Its Cellular Anti-Oxidant Activity","volume":"21","author":"Mustapha","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e22434","DOI":"10.1002\/jbt.22434","article-title":"Eriodictyol Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing the Inflammatory COX-2\/NLRP3\/NF-\u039aB Pathway in Mice","volume":"34","author":"Wang","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/kjm2.12400","article-title":"Eriodictyol Attenuates TNBS-Induced Ulcerative Colitis through Repressing TLR4\/NF-KB Signaling Pathway in Rats","volume":"37","author":"Hu","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"14526","DOI":"10.3390\/ijms160714526","article-title":"Eriodictyol Protects Endothelial Cells against Oxidative Stress-Induced Cell Death through Modulating ERK\/Nrf2\/ARE-Dependent Heme Oxygenase-1 Expression","volume":"16","author":"Lee","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Abusaliya, A., Jeong, S.H., Bhosale, P.B., Kim, H.H., Park, M.Y., Kim, E., Won, C.K., Park, K.I., Heo, J.D., and Kim, H.W. (2023). Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt\/MTOR and Activation of P38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin\u2014A Flavonoid with Therapeutic Potential. Nutrients, 15.","DOI":"10.3390\/nu15153407"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1159\/000329973","article-title":"Cytoprotective Effect of Eriodictyol in UV-Irradiated Keratinocytes via Phosphatase-Dependent Modulation of Both the P38 MAPK and Akt Signaling Pathways","volume":"27","author":"Lee","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"115368","DOI":"10.1016\/j.jep.2022.115368","article-title":"The Licorice Flavonoid Isoliquiritigenin Attenuates Mycobacterium Tuberculosis-Induced Inflammation through Notch1\/NF-\u039aB and MAPK Signaling Pathways","volume":"294","author":"Sun","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1021\/acs.jafc.1c00199","article-title":"Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK\/NF-\u039aB\/MLCK and Nrf2 Signaling Pathways","volume":"69","author":"Yuan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1074\/jbc.M110.147306","article-title":"Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-Induced Neoplastic Cell Transformation","volume":"286","author":"Liu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"112538","DOI":"10.1016\/j.fct.2021.112538","article-title":"Neuroprotective and Anti-Inflammatory Effect of Pectolinarigenin, a Flavonoid from Amazonian Aegiphila integrifolia (Jacq.), against Lipopolysaccharide-Induced Inflammation in Astrocytes via NF\u03baB and MAPK Pathways","volume":"157","author":"Heimfarth","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e22943","DOI":"10.1002\/jbt.22943","article-title":"Eriocitrin, a Dietary Flavonoid Suppressed Cell Proliferation, Induced Apoptosis through Modulation of JAK2\/STAT3 and JNK\/P38 MAPKs Signaling Pathway in MCF-7 Cells","volume":"36","author":"Yuan","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Russo, M., Moccia, S., Luongo, D., and Russo, G.L. (2023). Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK\/MAPK Pathway. Cancers, 15.","DOI":"10.3390\/cancers15092660"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00432-023-05572-7","article-title":"Natural Products Targeting the MAPK-Signaling Pathway in Cancer: Overview","volume":"150","author":"Shi","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"18853","DOI":"10.1038\/s41598-024-69028-9","article-title":"Eriodictyol Attenuates Osteoarthritis Progression through Inhibiting Inflammation via the PI3K\/AKT\/NF-\u039aB Signaling Pathway","volume":"14","author":"Kang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1111\/jcmm.17391","article-title":"Mitochondrial-Derived Vesicles: Recent Insights","volume":"26","author":"Popov","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Peng, Y., Wang, Y., Zhou, C., Mei, W., and Zeng, C. (2022). PI3K\/Akt\/MTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.819128"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zughaibi, T.A., Suhail, M., Tarique, M., and Tabrez, S. (2021). Targeting PI3K\/Akt\/MTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212455"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Kiliccioglu, I., Dulger, G., and Dulger, B. (2025). Eriodictyol Enhances the Antiproliferative and Apoptotic Activity of Cisplatin by Inhibiting PI3K\/Akt Signaling Pathway in PC-3 Prostate Cancer Cell Line. Iran. J. Sci.","DOI":"10.1007\/s40995-025-01908-9"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3839\/jabc.2022.011","article-title":"Eriodictyol Induces Apoptosis via Regulating Phosphorylation of JNK, ERK, and FAK\/AKT in Pancreatic Cancer Cells","volume":"65","author":"Oh","year":"2022","journal-title":"J. Appl. Biol. Chem."},{"key":"ref_99","first-page":"2329","article-title":"Eriodictyol Modulates Glioma Cell Autophagy and Apoptosis by Inhibition of PI3K\/Akt\/MTOR Signaling Pathway","volume":"19","author":"Zeng","year":"2021","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1080\/21655979.2022.2039485","article-title":"Eriodictyol Suppresses the Malignant Progression of Colorectal Cancer by Downregulating Tissue Specific Transplantation Antigen P35B (TSTA3) Expression to Restrain Fucosylation","volume":"13","author":"Huang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_101","first-page":"1","article-title":"Eriodictyol Inhibits Oral Cancer Proliferation and Activates ROS-Mediated Apoptosis via the Attenuation of MAPK\/STAT-3 Signaling Pathways","volume":"26","author":"Xu","year":"2024","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zheng, X., Wu, X., Wen, Q., Tang, H., Zhao, L., Shi, F., Li, Y., Yin, Z., Zou, Y., and Song, X. (2023). Eriodictyol Alleviated LPS\/D-GalN-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Cell Apoptosis via PI3K\/AKT Signaling Pathway. Nutrients, 15.","DOI":"10.3390\/nu15204349"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"156926","DOI":"10.1016\/j.phymed.2025.156926","article-title":"Eriodictyol from Scutellariae Barbata Alleviates Inflammation and Necrosis via ZBP1-Dependent Signaling in Acute Pancreatitis","volume":"145","author":"Tian","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Qu, M., Liu, L., Wang, J., Sui, F., Zhang, M., Wu, X., Luo, S., and Sun, M. (2025). Eriodictyol Alleviates Ovarian Dysfunction in a Mouse Model of Premature Ovarian Failure via the PI3K\/Akt\/NF-\u039aB Pathway and Suppression of Macrophage Inflammation. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1710805"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"106041","DOI":"10.1016\/j.jff.2024.106041","article-title":"Eriodictyol Downregulates UBA52 to Promote Autophagy and Upregulates Nrf2\/HO-1 to Inhibit Oxidative Stress to Ameliorate Non-Alcoholic Fatty Liver Disease","volume":"113","author":"Cai","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.2174\/1389201024666230314101654","article-title":"An Overview of Dietary Flavonoids as a Nutraceutical Nanoformulation Approach to Life-Threatening Diseases","volume":"24","author":"Singh","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13346-022-01174-x","article-title":"Nanoformulations of Flavonoids for Diabetes and Microvascular Diabetic Complications","volume":"13","author":"Agarawal","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/10408398.2021.1947772","article-title":"Enhancement of Bioavailability and Bioactivity of Diet-Derived Flavonoids by Application of Nanotechnology: A Review","volume":"63","author":"Teng","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/1568026623666221128144258","article-title":"The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and Their Improvement Using Nanoformulation Techniques","volume":"23","author":"Wang","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10787-024-01596-8","article-title":"The Multifaceted Anticancer Potential of Luteolin: Involvement of NF-\u039aB, AMPK\/MTOR, PI3K\/Akt, MAPK, and Wnt\/\u03b2-Catenin Pathways","volume":"33","author":"Singh","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s12013-025-01696-4","article-title":"Modulating NLRP3 Inflammasomes in Idiopathic Pulmonary Fibrosis: A Comprehensive Review on Flavonoid-Based Interventions","volume":"83","author":"Vithalkar","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coph.2009.08.004","article-title":"Novel Trends in High-Throughput Screening","volume":"9","author":"Mayr","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.armc.2017.08.004","article-title":"Chapter Five\u2014High-Throughput Screening","volume":"Volume 50","author":"Goodnow","year":"2017","journal-title":"Platform Technologies in Drug Discovery and Validation"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13237-024-00503-4","article-title":"Plant Flavonol Quercetin Engenders Cytotoxic Effect in Different Pre-Clinical Cancer Models through Modulation of Diverse Epigenetic Regulators","volume":"68","author":"Ganai","year":"2025","journal-title":"Nucleus"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Seigler, D.S., Friesen, J.B., Bisson, J., Graham, J.G., Bedran-Russo, A., McAlpine, J.B., and Pauli, G.F. (2021). Do Certain Flavonoid IMPS Have a Vital Function?. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.762753"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"154152","DOI":"10.1016\/j.phymed.2022.154152","article-title":"Discovery of Processing-Associated Q-Marker of Carbonized Traditional Chinese Medicine: An Integrated Strategy of Metabolomics, Systems Pharmacology and in Vivo High-Throughput Screening Model","volume":"102","author":"Gao","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nrd941","article-title":"Integration of Virtual and High-Throughput Screening","volume":"1","author":"Bajorath","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10020-022-00442-3","article-title":"Eriodictyol Ameliorates Cognitive Dysfunction in APP\/PS1 Mice by Inhibiting Ferroptosis via Vitamin D Receptor-Mediated Nrf2 Activation","volume":"28","author":"Li","year":"2022","journal-title":"Mol. Med."},{"key":"ref_119","first-page":"5902","article-title":"Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases","volume":"71","author":"Zhou","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"156789","DOI":"10.1016\/j.phymed.2025.156789","article-title":"Mori Folium Ethanol Extracts Induce Ferroptosis and Suppress Gastric Cancer Progression by Inhibiting the AKT\/GSK3\u03b2\/NRF2 Axis","volume":"142","author":"Hu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.2174\/0109298673325229240928040758","article-title":"Anticancer Drug Discovery from Natural Compounds Targeting PI3K\/AKT\/MTOR Signaling Pathway","volume":"32","author":"Lins","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"120275","DOI":"10.1016\/j.jep.2025.120275","article-title":"Pharmacological Effects and Mechanism of Maxing Shigan Decoction in the Treatment of Influenza a Viral Pneumonia","volume":"353","author":"Huang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Cano, F.J., and Castell, M. (2016). Flavonoids, Inflammation and Immune System. Nutrients, 8.","DOI":"10.3390\/nu8100659"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e20240247","DOI":"10.1002\/EXP.20240247","article-title":"Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol","volume":"5","author":"Tu","year":"2025","journal-title":"Exploration"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"116725","DOI":"10.1016\/j.ejmech.2024.116725","article-title":"PROTAC Technology: From Drug Development to Probe Technology for Target Deconvolution","volume":"276","author":"Yan","year":"2024","journal-title":"Eur. J. Med. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/2924\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:05:28Z","timestamp":1774339528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/2924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,24]]},"references-count":125,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27072924"],"URL":"https:\/\/doi.org\/10.3390\/ijms27072924","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,24]]}}}