{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:54:15Z","timestamp":1782363255243,"version":"3.54.5"},"reference-count":206,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The ongoing evolutionary struggle between crops and pathogens has highlighted the limitations of resistance gene (R gene)-based control, which often fails due to rapid pathogen adaptation. To address this, we must look beyond R genes and explore susceptibility genes (S genes) that pathogens take over during infection. Recent success stories suggest that S-gene manipulation can provide broad-spectrum resistance. However, moving this technology to the field requires careful balancing to ensure that plant fitness is not compromised. In this review, we focus on integrated multi-omics tools to identify new avenues for resistance, specifically the mechanisms of R-gene breakdown and the potential of omics-driven strategies for long-term crop protection.<\/jats:p>","DOI":"10.3390\/ijms27072938","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:58:59Z","timestamp":1774357139000},"page":"2938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond Resistance Genes: Silencing Susceptibility"],"prefix":"10.3390","volume":"27","author":[{"given":"Anuradha De","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Plant Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-1539","authenticated-orcid":false,"given":"Wannakuwattewaduge Gerard Dilantha","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Plant Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"St. Paul\u2019s College, University of Manitoba, Winnipeg, MB R3T 2M6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0167-7799(03)00053-2","article-title":"Plant Disease Resistance Genes: Recent Insights and Potential Applications","volume":"21","author":"McDowell","year":"2003","journal-title":"Trends Biotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Andolfo, G., and Ercolano, M.R. 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