{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:57:26Z","timestamp":1790452646782,"version":"4.1.0"},"reference-count":192,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Healthcare Talent Development Project of the Finance Department of Jilin Province","award":["jcsz2023481-10"],"award-info":[{"award-number":["jcsz2023481-10"]}]},{"name":"Healthcare Talent Development Project of the Finance Department of Jilin Province","award":["jcsz2023481-10"],"award-info":[{"award-number":["jcsz2023481-10"]}]},{"award":["jcsz2023481-10"],"award-info":[{"award-number":["jcsz2023481-10"]}],"id":[{"id":"https:\/\/ror.org\/05782e512","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Periodontitis (PD) is a chronic inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. As one of the most prevalent chronic diseases, PD affects more than 743 million people globally, some with serious systemic health implications. Plaque accumulation constitutes the key driver of periodontitis, initiating host inflammatory cascades and compromising periodontal microbiome equilibrium. Conventional treatment methods, such as scaling and root planing, are limited by a constrained operative field, resulting in blind spots that impede the complete eradication of bacterial biofilms and the modulation of the inflammatory microenvironment. Therefore, employing new therapeutic strategies (e.g., drug delivery systems) is essential. This review focuses on local drug delivery systems for the treatment of PD, including fibers, strips and films, microspheres, gels, nanoparticles, and vesicle systems, to deliver drugs directly into the periodontal pockets, targeting inflammation and providing sustained antibacterial effects while reducing systemic side effects. The characteristics and clinical implications of each type of local drug delivery system are discussed, along with emerging technologies such as 3D printing and nanotechnology.<\/jats:p>","DOI":"10.3390\/ijms27072983","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:57:34Z","timestamp":1774447054000},"page":"2983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application and Potential of Local Drug Delivery Systems for Antibacterial Treatment of Periodontitis"],"prefix":"10.3390","volume":"27","author":[{"given":"Xinchao","family":"Wang","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengli","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Hong","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8584-1013","authenticated-orcid":false,"given":"Shujun","family":"Dong","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12200","article-title":"Periodontitis epidemiology: Is periodontitis under-recognized, over-diagnosed, or both?","volume":"75","author":"Papapanou","year":"2017","journal-title":"Periodontology 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: A global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/prd.12355","article-title":"Environmental factors and periodontal microbiome","volume":"85","author":"Buduneli","year":"2021","journal-title":"Periodontology 2000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12331","article-title":"Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy","volume":"84","author":"Hajishengallis","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/prd.12298","article-title":"Diabetes as a risk factor for periodontal disease-plausible mechanisms","volume":"83","author":"Polak","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bhuyan, R., Bhuyan, S.K., Mohanty, J.N., Das, S., Juliana, N., and Juliana, I.F. 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