{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:23:02Z","timestamp":1792804982624,"version":"4.5.0"},"reference-count":215,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comunidad de Madrid\n\t\t\t\t\t\t\t\t              https:\/\/ror.org\/040scgh75","award":["P2022\/BMD-7321"],"award-info":[{"award-number":["P2022\/BMD-7321"]}]},{"name":"ProACapital"},{"name":"HALEKULANI, S. L."},{"name":"MJR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Immunogenic cell death (ICD) links tumor cell demise to the activation of anti-tumor immunity, but its adoption has also generated inconsistent definitions and frequent overinterpretation of surrogate biomarkers. Here, we synthesize mechanistic and methodological evidence showing that danger-associated molecular patterns (DAMPs), cytokine release, and endoplasmic reticulum stress report immunogenic potential rather than ICD itself. We propose that ICD should be defined by its functional immunological endpoint, namely efficient antigen presentation and antigen-specific adaptive immunity, ideally culminating in protective immunological memory. To operationalize this principle, we introduce a hierarchy of experimental validation ranging from correlative hallmarks (Level 0) to innate immune integration (Level 1), antigen-specific T-cell priming (Level 2), definitive vaccination-rechallenge protection with immune-dependence testing (Level 3), and translational relevance supported by convergent human data (Level 4). We also discuss common pitfalls, equating inflammation, necrosis-associated DAMP release, or therapeutic benefit with ICD, and outline minimal immune-context controls (e.g., MHC-I, CD8+ T cells, Batf3-dependent dendritic cells, and innate sensing pathways) required to support robust claims. Finally, we highlight why ICD remains strongly context-dependent, shaped by dendritic-cell competence, innate licensing, purinergic metabolism, and microenvironmental constraints. Evidence-graded standards should improve reproducibility, strengthen peer review, and accelerate clinically meaningful ICD-based strategies.<\/jats:p>","DOI":"10.3390\/ijms27073061","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:45:53Z","timestamp":1774615553000},"page":"3061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["What Is\u2014and What Is Not\u2014Immunogenic Cell Death? Functional Definitions, Experimental Standards, and Common Pitfalls"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5909-788X","authenticated-orcid":false,"given":"Diego Liviu","family":"Boaru","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Specialties, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas (CIBEREHD), Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcala de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-6397","authenticated-orcid":false,"given":"Oscar","family":"Fraile-Martinez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas (CIBEREHD), Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcala de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8591-6116","authenticated-orcid":false,"given":"Patricia","family":"De Castro-Martinez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas (CIBEREHD), Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcala de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-1708","authenticated-orcid":false,"given":"Miguel A.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas (CIBEREHD), Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcala de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-7855","authenticated-orcid":false,"given":"Cielo","family":"Garcia-Montero","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas (CIBEREHD), Faculty of Medicine and Health Sciences, University of Alcal\u00e1, 28801 Alcala de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1042\/BST20220925","article-title":"Messenger Functions of Cell Death during Development and Homeostasis","volume":"51","author":"Fort","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Carafa, V., and Altucci, L. (2020). Deregulation of Cell Death in Cancer: Recent Highlights. Cancers, 12.","DOI":"10.3390\/cancers12123517"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated Cell Death (RCD) in Cancer: Key Pathways and Targeted Therapies","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Metzig, M.O., and Hoffmann, A. (2022). Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity. Biomedicines, 10.","DOI":"10.3390\/biomedicines10050974"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Arimoto, K.I., Miyauchi, S., Liu, M., and Zhang, D.E. (2024). Emerging Role of Immunogenic Cell Death in Cancer Immunotherapy. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1390263"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000334245","article-title":"Dendritic Cells and Damage-Associated Molecular Patterns: Endogenous Danger Signals Linking Innate and Adaptive Immunity","volume":"4","author":"Nace","year":"2012","journal-title":"J. Innate Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e134356","DOI":"10.1172\/jci.insight.134356","article-title":"A Role for TNF-\u03b1 in Alveolar Macrophage Damage-Associated Molecular Pattern Release","volume":"5","author":"Collins","year":"2020","journal-title":"JCI Insight"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1893466","DOI":"10.1080\/2162402X.2021.1893466","article-title":"Tumor-Intrinsic Determinants of Immunogenic Cell Death Modalities","volume":"10","author":"Workenhe","year":"2021","journal-title":"Oncoimmunology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kielbik, M., Szulc-Kielbik, I., and Klink, M. (2021). Calreticulin\u2014Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients. Cells, 10.","DOI":"10.3390\/cells10010130"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e631","DOI":"10.1038\/cddis.2013.156","article-title":"Many Faces of DAMPs in Cancer Therapy","volume":"4","author":"Krysko","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fang, K., Yuan, S., Zhang, X., Zhang, J., Sun, S.L., and Li, X. (2025). Regulation of Immunogenic Cell Death and Potential Applications in Cancer Therapy. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1571212"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/imr.13301","article-title":"Decoding Immunogenic Cell Death from a Dendritic Cell Perspective","volume":"321","author":"Janssens","year":"2024","journal-title":"Immunol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1192739","DOI":"10.1080\/2162402X.2016.1192739","article-title":"Human CD1c+ DCs Are Critical Cellular Mediators of Immune Responses Induced by Immunogenic Cell Death","volume":"5","author":"Wortel","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mitra, A., Kumar, A., Amdare, N.P., and Pathak, R. (2024). Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion. Biology, 13.","DOI":"10.3390\/biology13050307"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy","volume":"11","author":"Fucikova","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41577-020-0391-5","article-title":"Constitutive Immune Mechanisms: Mediators of Host Defence and Immune Regulation","volume":"21","author":"Paludan","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41392-023-01407-6","article-title":"Oncolytic Virotherapy: Basic Principles, Recent Advances and Future Directions","volume":"8","author":"Lin","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5414\/ALX02299E","article-title":"Is in Vitro Cytokine Release a Suitable Marker to Improve the Diagnosis of Suspected Mold-Related Respiratory Symptoms? A Proof-of-Concept Study","volume":"6","author":"Liebers","year":"2022","journal-title":"Allergol. Sel."},{"key":"ref_19","unstructured":"Janeway, C.A., Travers, P., Walport, M., and Shlomchik, M.J. (2001). Principles of Innate and Adaptive Immunity, Garland Science."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/imr.13271","article-title":"Molecular Determinants of Immunogenic Cell Death Elicited by Radiation Therapy","volume":"321","author":"Galassi","year":"2024","journal-title":"Immunol. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Roy, O., and Anderson, K.S. (2025). Engineering Anti-Tumor Immunity: An Immunological Framework for MRNA Cancer Vaccines. Vaccines, 13.","DOI":"10.3390\/vaccines13121222"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.cell.2024.03.037","article-title":"Principles and Therapeutic Applications of Adaptive Immunity","volume":"187","author":"Chi","year":"2024","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1158\/2326-6066.CIR-18-0337","article-title":"Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments","volume":"7","author":"Kataru","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Xie, D., Wang, Q., and Wu, G. (2022). Research Progress in Inducing Immunogenic Cell Death of Tumor Cells. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1017400"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"132919","DOI":"10.1016\/j.neucom.2026.132919","article-title":"The Double-Edged Sword: A Critical Review of Foundational Medical Datasets for AI Benchmarks, Biases, and the Future of Equitable Healthcare","volume":"675","author":"Ramadan","year":"2026","journal-title":"Neurocomputing"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/jamiaopen\/ooz066","article-title":"A Narrative Review of the Impact of the Transition to ICD-10 and ICD-10-CM\/PCS","volume":"3","author":"Kusnoor","year":"2019","journal-title":"JAMIA Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/emboj.2009.1","article-title":"Mechanisms of Pre-Apoptotic Calreticulin Exposure in Immunogenic Cell Death","volume":"28","author":"Panaretakis","year":"2009","journal-title":"EMBO J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-319-39406-0_6","article-title":"Immunogenic Apoptotic Cell Death and Anticancer Immunity","volume":"Volume 930","author":"Vandenabeele","year":"2016","journal-title":"Apoptosis in Cancer Pathogenesis and Anti-Cancer Therapy: New Perspectives and Opportunities; Advances in Experimental Medicine and Biology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41419-022-05066-3","article-title":"Regulated Necrosis, a Proinflammatory Cell Death, Potentially Counteracts Pathogenic Infections","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102448","DOI":"10.1016\/j.omtn.2025.102448","article-title":"Transcriptomic Analysis of the Immune Response to In Vivo Gene Electrotransfer in Colorectal Cancer","volume":"36","author":"Bozic","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101781","DOI":"10.1016\/j.smim.2023.101781","article-title":"Pyroptosis-Induced Inflammation and Tissue Damage","volume":"69","author":"Vasudevan","year":"2023","journal-title":"Semin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12935-022-02585-z","article-title":"Biological Causes of Immunogenic Cancer Cell Death (ICD) and Anti-Tumor Therapy; Combination of Oncolytic Virus-Based Immunotherapy and CAR T-Cell Therapy for ICD Induction","volume":"22","author":"Mardi","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1039\/D5RA08026F","article-title":"wei Ferroptosis and Immunity: Rewiring the Tumor Microenvironment for Therapy","volume":"16","author":"Ailun","year":"2026","journal-title":"RSC Adv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"118422","DOI":"10.1016\/j.biopha.2025.118422","article-title":"Cuproptosis: Current Insights into Its Multifaceted Role in Disease, Cancer, and Translational\/Therapeutic Opportunities","volume":"190","author":"Boaru","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pacifico, F., Magni, F., Leonardi, A., and Crescenzi, E. (2024). Therapy-Induced Senescence: Novel Approaches for Markers Identification. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158448"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/cdd.2008.47","article-title":"Death through a Tragedy: Mitotic Catastrophe","volume":"15","author":"Vakifahmetoglu","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1039\/D3CS00162H","article-title":"Advancing Nanotechnology for Neoantigen-Based Cancer Theranostics","volume":"53","author":"Zou","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e000337","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus Guidelines for the Definition, Detection and Interpretation of Immunogenic Cell Death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1038\/s41467-022-32738-7","article-title":"In Vivo Tumor Immune Microenvironment Phenotypes Correlate with Inflammation and Vasculature to Predict Immunotherapy Response","volume":"13","author":"Sahu","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/imr.13269","article-title":"Immunogenic Cell Death (ICD) Enhancers\u2014Drugs That Enhance the Perception of ICD by Dendritic Cells","volume":"321","author":"Liu","year":"2024","journal-title":"Immunol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular Identification of a Danger Signal That Alerts the Immune System to Dying Cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/cdd.2013.75","article-title":"Molecular Mechanisms of ATP Secretion during Immunogenic Cell Death","volume":"21","author":"Martins","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rufo, N., Yang, Y., De Vleeschouwer, S., and Agostinis, P. (2022). The \u201cYin and Yang\u201d of Unfolded Protein Response in Cancer and Immunogenic Cell Death. Cells, 11.","DOI":"10.3390\/cells11182899"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s44337-025-00478-4","article-title":"The Cell\u2019s Autonomous Response Window for Advanced Healing","volume":"2","author":"Redondo","year":"2025","journal-title":"Discov. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Gusev, E., Sarapultsev, A., and Zhuravleva, Y. (2026). Insulin Resistance and Inflammation. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031237"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imr.12702","article-title":"Type 2 Innate Lymphoid Cells in the Induction and Resolution of Tissue Inflammation","volume":"286","author":"Wallrapp","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, Inflammation, and Cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12929-025-01191-1","article-title":"Innovative Gene Engineering and Drug Delivery Systems for Dendritic Cells in Cancer Immunotherapy","volume":"32","author":"Prakash","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2024.12.003","article-title":"The Immunopathogenesis of a Cytokine Storm: The Key Mechanisms Underlying Severe COVID-19","volume":"82","author":"Hiti","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1386829","DOI":"10.1080\/2162402X.2017.1386829","article-title":"Trial Watch: Immunogenic Cell Death Induction by Anticancer Chemotherapeutics","volume":"6","author":"Garg","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1158\/0008-5472.CAN-07-6012","article-title":"Tumor-Specific T-Cell Memory: Clearing the Regulatory T-Cell Hurdle","volume":"68","author":"Usherwood","year":"2008","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-1-4939-8885-3_21","article-title":"Gold Standard Assessment of Immunogenic Cell Death in Oncological Mouse Models","volume":"Volume 1884","author":"Humeau","year":"2019","journal-title":"Cancer Immunosurveillance"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbi.2024.07.047","article-title":"Constitutive DAMPs in CNS Injury: From Preclinical Insights to Clinical Perspectives","volume":"122","author":"Bretheau","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.2147\/IJN.S457782","article-title":"Sensitize Tumor Immunotherapy: Immunogenic Cell Death Inducing Nanosystems","volume":"19","author":"Peng","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2008.10.044","article-title":"Identification of a Molecular Signaling Network That Regulates a Cellular Necrotic Cell Death Pathway by a Genome Wide SiRNA Screen","volume":"135","author":"Hitomi","year":"2008","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev-phyto-082718-100146","article-title":"Damage-Associated Molecular Patterns (DAMPs) in Plant Innate Immunity: Applying the Danger Model and Evolutionary Perspectives","volume":"59","author":"Tanaka","year":"2021","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-020-00449-4","article-title":"Advantages of Targeting the Tumor Immune Microenvironment over Blocking Immune Checkpoint in Cancer Immunotherapy","volume":"6","author":"Tang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/imr.13263","article-title":"Using Immunogenic Cell Death to Improve Anticancer Efficacy of Immune Checkpoint Inhibitors: From Basic Science to Clinical Application","volume":"321","author":"Ghiringhelli","year":"2024","journal-title":"Immunol. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"122218","DOI":"10.1016\/j.biomaterials.2023.122218","article-title":"Antigenicity and Adjuvanticity Co-Reinforced Personalized Cell Vaccines Based on Self-Adjuvanted Hydrogel for Post-Surgical Cancer Vaccination","volume":"301","author":"He","year":"2023","journal-title":"Biomaterials"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102343","DOI":"10.1016\/j.mtbio.2025.102343","article-title":"Cell Membrane Biomimetic Nanoplatforms: A New Strategy for Immune Escape and Precision Targeted Therapy","volume":"35","author":"Feng","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Catanzaro, E., Feron, O., Skirtach, A.G., and Krysko, D.V. (2022). Immunogenic Cell Death and Role of Nanomaterials Serving as Therapeutic Vaccine for Personalized Cancer Immunotherapy. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.925290"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1038\/s41467-025-58266-8","article-title":"Effective Extracellular Payload Release and Immunomodulatory Interactions Govern the Therapeutic Effect of Trastuzumab Deruxtecan (T-DXd)","volume":"16","author":"Tsao","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000512729","article-title":"Antigen-Presenting Cells: Potential of Proven Und New Players in Immune Therapies","volume":"47","author":"Schmetzer","year":"2020","journal-title":"Transfus. Med. Hemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.trecan.2022.10.006","article-title":"Once upon a Prime: DCs Shape Cancer Immunity","volume":"9","author":"Zagorulya","year":"2022","journal-title":"Trends Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"a038661","DOI":"10.1101\/cshperspect.a038661","article-title":"CD8+ T-Cell Memory: The Why, the When, and the How","volume":"13","author":"Turner","year":"2021","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e010331","DOI":"10.1136\/jitc-2024-010331","article-title":"Cancer Vaccines Compensate for the Insufficient Induction of Protective Tumor-Specific Immunity of CD3 Bispecific Antibody Therapy","volume":"13","author":"Middelburg","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"101481","DOI":"10.1016\/j.smim.2021.101481","article-title":"The Role of Dendritic Cells in Cancer and Anti-Tumor Immunity","volume":"52","author":"Marciscano","year":"2021","journal-title":"Semin. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.mcb.2023.05.003","article-title":"Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies","volume":"183","author":"Mishchenko","year":"2024","journal-title":"Methods Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.molcel.2020.05.031","article-title":"Rational Cancer Treatment Combinations: An Urgent Clinical Need","volume":"78","author":"Boshuizen","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/d41573-019-00182-w","article-title":"Trends in Clinical Development for PD-1\/PD-L1 Inhibitors","volume":"19","author":"Yu","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic Cell Death in Cancer and Infectious Disease","volume":"17","author":"Galluzzi","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PRS.0b013e318219c171","article-title":"The Levels of Evidence and Their Role in Evidence-Based Medicine","volume":"128","author":"Burns","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1002\/1878-0261.12851","article-title":"Targeting Immunogenic Cell Death in Cancer","volume":"14","author":"Ahmed","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12935-023-03058-7","article-title":"Stimulators of Immunogenic Cell Death for Cancer Therapy: Focusing on Natural Compounds","volume":"23","author":"Amiri","year":"2023","journal-title":"Cancer Cell Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1007\/s12094-025-03858-5","article-title":"Dendritic Cell Immunotherapy Has Its Antitumor Action Improved by the LPS in the Maturation Process","volume":"27","author":"Lopes","year":"2025","journal-title":"Clin. Transl. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ccell.2014.09.007","article-title":"Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity","volume":"26","author":"Broz","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/CJI.0b013e3181a1c24e","article-title":"Maturation Pathways of Dendritic Cells Determine TAP1 and TAP2 Levels and Cross-Presenting Function","volume":"32","author":"Mailliard","year":"2009","journal-title":"J. Immunother."},{"key":"ref_79","first-page":"365","article-title":"Mechanisms of Over-Activated Innate Immune System Regulation in Autoimmune and Neurodegenerative Disorders","volume":"3","author":"Leszek","year":"2007","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.it.2008.10.003","article-title":"Do Adaptive Immune Cells Suppress or Activate Innate Immunity?","volume":"30","author":"Zhao","year":"2008","journal-title":"Trends Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-immunol-030409-101308","article-title":"Functional Anatomy of T Cell Activation and Synapse Formation","volume":"28","author":"Fooksman","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41392-023-01377-9","article-title":"Activation of Immune Signals during Organ Transplantation","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nprot.2014.064","article-title":"Antigen-Specific Activation and Cytokine-Facilitated Expansion of Naive, Human CD8+ T Cells","volume":"9","author":"Greenberg","year":"2014","journal-title":"Nat. Protoc."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1084\/jem.20050915","article-title":"Caspase-Dependent Immunogenicity of Doxorubicin-Induced Tumor Cell Death","volume":"202","author":"Casares","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nm1622","article-title":"Toll-like Receptor 4-Dependent Contribution of the Immune System to Anticancer Chemotherapy and Radiotherapy","volume":"13","author":"Apetoh","year":"2007","journal-title":"Nat. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/eji.200526158","article-title":"Soluble, Dimeric HLA DR4-Peptide Chimeras: An Approach for Detection and Immunoregulation of Human Type-1 Diabetes","volume":"35","author":"Preda","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00018-017-2686-7","article-title":"CD4 and CD8 T Lymphocyte Interplay in Controlling Tumor Growth","volume":"75","author":"Ostroumov","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"100677","DOI":"10.1016\/j.medj.2025.100677","article-title":"Emerging Trends in Clinical Allogeneic CAR Cell Therapy","volume":"6","author":"Li","year":"2025","journal-title":"Med"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Liao, X., Liu, H., Zhang, Z., Zhang, J., Zhang, C., and Zhao, W. (2022). An Immunogenic Cell Death-Associated Classification Predictions Are Important for Breast Invasive Carcinoma Prognosis and Immunotherapy. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.1010787"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41582-020-0362-2","article-title":"Discovery and Validation of Biomarkers to Aid the Development of Safe and Effective Pain Therapeutics: Challenges and Opportunities","volume":"16","author":"Davis","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ijcard.2016.12.097","article-title":"Genomic Translational Research: Paving the Way to Individualized Cardiac Functional Analyses and Personalized Cardiology","volume":"230","author":"Pasipoularides","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Ruden, D.M. (2025). The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?. Pathogens, 14.","DOI":"10.20944\/preprints202509.1188.v1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41591-025-04126-3","article-title":"Interpretable Inflammation Landscape of Circulating Immune Cells","volume":"32","author":"Maspero","year":"2026","journal-title":"Nat. Med."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Dai, Q., Yuan, X., Dong, H., and Xue, H. (2025). From Immune Suppression to Immunotherapy Sensitization: The Dual Roles of CircRNAs in Cancer Progression. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1723383"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kennedy, B.E., Noftall, E.B., Dean, C., Roth, A., Clark, K.N., Rowles, D., Singh, K., Pagliaro, L., and Giacomantonio, C.A. (2024). Targeted Intra-Tumoral Hyperthermia Using Uniquely Biocompatible Gold Nanorods Induces Strong Immunogenic Cell Death in Two Immunogenically \u2018Cold\u2019 Tumor Models. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1512543"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1007\/s44411-025-00312-4","article-title":"Challenges in the Clinical Application of Machine Learning for Pancreatic Cancer","volume":"126","year":"2025","journal-title":"Bratisl. Med. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"153712","DOI":"10.1016\/j.phymed.2021.153712","article-title":"Cascade of Immune Mechanism and Consequences of Inflammatory Disorders","volume":"91","author":"Megha","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s43018-025-00986-3","article-title":"The Tumor Microenvironment\u2019s Role in the Response to Immune Checkpoint Blockade","volume":"6","author":"Aliazis","year":"2025","journal-title":"Nat. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"104702","DOI":"10.1016\/j.critrevonc.2025.104702","article-title":"A Comprehensive Review on Targeting Diverse Immune Cells for Anticancer Therapy: Beyond Immune Checkpoint Inhibitors","volume":"210","author":"Liu","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41392-025-02178-y","article-title":"Deep Insight into Cytokine Storm: From Pathogenesis to Treatment","volume":"10","author":"Nie","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41392-024-01868-3","article-title":"Targeting Cytokine and Chemokine Signaling Pathways for Cancer Therapy","volume":"9","author":"Yi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.ccell.2024.09.010","article-title":"The Hallmarks of Cancer Immune Evasion","volume":"42","author":"Galassi","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40364-024-00599-5","article-title":"The War between the Immune System and the Tumor-Using Immune Biomarkers as Tracers","volume":"12","author":"Yang","year":"2024","journal-title":"Biomark. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/bs.mcb.2024.10.012","article-title":"Use of Drug-Killed Cancer Cells: A Method to Assess the Therapeutic Effectiveness of Immunogenic Cell Death","volume":"191","year":"2025","journal-title":"Methods Cell Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1111\/jcmm.14356","article-title":"Immunogenic Cell Death in Cancer Therapy: Present and Emerging Inducers","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.aad0395","article-title":"RIPK1 and NF-\u039aB Signaling in Dying Cells Determines Cross-Priming of CD8+ T Cells","volume":"350","author":"Yatim","year":"2015","journal-title":"Science"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic Cell Death and DAMPs in Cancer Therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41423-024-01245-8","article-title":"Immunogenicity of Cell Death and Cancer Immunotherapy with Immune Checkpoint Inhibitors","volume":"22","author":"Catanzaro","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/imr.12574","article-title":"Cell Death and Immunity in Cancer: From Danger Signals to Mimicry of Pathogen Defense Responses","volume":"280","author":"Garg","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev-immunol-041015-055254","article-title":"The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC I Molecules","volume":"35","author":"Cruz","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41590-025-02407-0","article-title":"Cell Cycle Arrest Enhances CD8+ T Cell Effector Function by Potentiating Glucose Metabolism and IL-2 Signaling","volume":"27","author":"Hepp","year":"2026","journal-title":"Nat. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4049\/jimmunol.1500669","article-title":"Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen\u2013Mismatched Grafts","volume":"195","author":"Atif","year":"2015","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4049\/jimmunol.2300669","article-title":"Nucleic Acid Sensing by STING Induces an IFN-like Antiviral Response in a Marine Invertebrate","volume":"212","author":"Li","year":"2024","journal-title":"J. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ni.3754","article-title":"Nutrition, Inflammation and Cancer","volume":"18","author":"Zitvogel","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Garg, A.D., and Agostinis, P. (2016). Editorial: Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00110"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev-immunol-030409-101317","article-title":"Systems Biology in Immunology\u2014A Computational Modeling Perspective","volume":"29","author":"Germain","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Lima, T.S.M., and Lebre, F. (2025). Exploring the Interplay Between Particles and the Immune System. Nanosafety: A Comprehensive Approach to Assess Nanomaterial Exposure on the Environment and Health, Springer.","DOI":"10.1007\/978-3-031-93871-9_3"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Honigsberg, R., Cruz, T., Yoffe, L., Tang, M.S., Dicle, O., Markowitz, G., Michael, M., Singh, A., Altorki, N.K., and Elemento, O. (2025). Tumor-Specific Draining Lymph Node CD8 T Cells Orchestrate an Anti-Tumor Response to Neoadjuvant PD-1 Immune Checkpoint Blockade. bioRxiv.","DOI":"10.1101\/2025.04.27.650862"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.immuni.2023.08.014","article-title":"Dendritic Cells as Shepherds of T Cell Immunity in Cancer","volume":"56","author":"Pittet","year":"2023","journal-title":"Immunity"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/cdd.2013.48","article-title":"Danger Signalling during Cancer Cell Death: Origins, Plasticity and Regulation","volume":"21","author":"Garg","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41423-023-00990-6","article-title":"Dendritic Cell Subsets in Cancer Immunity and Tumor Antigen Sensing","volume":"20","author":"Salvi","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"109465","DOI":"10.1016\/j.matdes.2021.109465","article-title":"Immunogenic Cell Death-Inducing Chemotherapeutic Nanoformulations Potentiate Combination Chemoimmunotherapy","volume":"202","author":"Liu","year":"2021","journal-title":"Mater. Des."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature14404","article-title":"Melanoma-Intrinsic \u03b2-Catenin Signalling Prevents Anti-Tumour Immunity","volume":"523","author":"Spranger","year":"2015","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.trecan.2018.09.001","article-title":"The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity","volume":"4","year":"2018","journal-title":"Trends Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1158\/2159-8290.CD-15-0510","article-title":"Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells","volume":"6","author":"Cueto","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Guti\u00e9rrez, J.C., Ayala-Zavala, J.F., Torres-Moreno, H., Vidal-Guti\u00e9rrez, M., and Esqueda, M. (2025). Can Ganoderma Triterpenoids Exert Immunogenic Cell Death in Human Cancer Cells? A Systematic Review and Protein Network Analysis. Pharmaceuticals, 18.","DOI":"10.3390\/ph18111641"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e013364","DOI":"10.1136\/jitc-2025-013364","article-title":"Overcoming Impaired Antigen Presentation in Tumor-Draining Lymph Nodes Facilitates Immunotherapy","volume":"13","author":"Melia","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1182\/blood-2010-01-264960","article-title":"Cross-Priming CD8+ T Cells by Targeting Antigens to Human Dendritic Cells through DCIR","volume":"116","author":"Klechevsky","year":"2010","journal-title":"Blood"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41392-025-02243-6","article-title":"Advances in Molecular Pathology and Therapy of Non-Small Cell Lung Cancer","volume":"10","author":"Huang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/JLB.3MIR0320-475R","article-title":"The Interplay between Innate and Adaptive Immunity in Cancer Shapes the Productivity of Cancer Immunosurveillance","volume":"108","author":"Chang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.immuni.2023.07.018","article-title":"Targeting Innate Immune Pathways for Cancer Immunotherapy","volume":"56","author":"Cao","year":"2023","journal-title":"Immunity"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The CGAS-STING Pathway Drives Type I IFN Immunopathology in COVID-19","volume":"603","author":"Gulen","year":"2022","journal-title":"Nature"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2308890","DOI":"10.1002\/advs.202308890","article-title":"Activation of the CGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense","volume":"11","author":"Tong","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41423-020-00556-w","article-title":"Implications of Metabolism-Driven Myeloid Dysfunctions in Cancer Therapy","volume":"18","author":"Strauss","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Patente, T.A., Pinho, M.P., Oliveira, A.A., Evangelista, G.C.M., Bergami-Santos, P.C., and Barbuto, J.A.M. (2019). Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03176"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41392-025-02334-4","article-title":"Targeting Metabolic-Epigenetic-Immune Axis in Cancer: Molecular Mechanisms and Therapeutic Implications","volume":"11","author":"Wang","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1021\/acs.molpharmaceut.2c01080","article-title":"Recent Updates on Viral Oncogenesis: Available Preventive and Therapeutic Entities","volume":"20","author":"Chowdhary","year":"2023","journal-title":"Mol. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13045-024-01628-4","article-title":"Personalized Nanovaccines for Treating Solid Cancer Metastases","volume":"17","author":"Feng","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"111281","DOI":"10.1016\/j.cellsig.2024.111281","article-title":"Metabolic Crosstalk: Extracellular ATP and the Tumor Microenvironment in Cancer Progression and Therapy","volume":"121","author":"Shukla","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Jiang, X., Wu, X., Xiao, Y., Wang, P., Zheng, J., Wu, X., and Jin, Z. (2023). The Ectonucleotidases CD39 and CD73 on T Cells: The New Pillar of Hematological Malignancy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1110325"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nri.2016.4","article-title":"Purinergic Regulation of the Immune System","volume":"16","author":"Cekic","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e000610","DOI":"10.1136\/jitc-2020-000610","article-title":"Conversion of ATP to Adenosine by CD39 and CD73 in Multiple Myeloma Can Be Successfully Targeted Together with Adenosine Receptor A2A Blockade","volume":"8","author":"Yang","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3324\/haematol.2015.136739","article-title":"The European Hematology Association Roadmap for European Hematology Research: A Consensus Document","volume":"101","author":"Engert","year":"2016","journal-title":"Haematologica"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2217\/fon-2023-0871","article-title":"Regulatory Role of CD39 and CD73 in Tumor Immunity","volume":"20","author":"Kaplinsky","year":"2024","journal-title":"Future Oncol."},{"key":"ref_145","first-page":"1","article-title":"Translation of Cancer Immunotherapy from the Bench to the Bedside","volume":"143","author":"Guo","year":"2019","journal-title":"Adv. Cancer Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12943-025-02479-4","article-title":"Advances in Engineering Immune\u2013Tumor Microenvironments on-a-Chip: Integrative Microfluidic Platforms for Immunotherapy and Drug Discovery","volume":"24","author":"Anvar","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Mohan, N., Wellach, K., \u00d6zerdem, C., Veits, N., F\u00f6rster, J.D., Foehr, S., Bonsack, M., and Riemer, A.B. (2022). Effects of Hypoxia on Antigen Presentation and T Cell-Based Immune Recognition of HPV16-Transformed Cells. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.918528"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s44318-024-00319-7","article-title":"Hypoxia Promotes Tumor Immune Evasion by Suppressing MHC-I Expression and Antigen Presentation","volume":"44","author":"Estephan","year":"2025","journal-title":"EMBO J."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Fu, Z., Mowday, A.M., Smaill, J.B., Hermans, I.F., and Patterson, A.V. (2021). Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy. Cells, 10.","DOI":"10.3390\/cells10051006"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40364-026-00898-z","article-title":"Lactate-Lactylation in Tumor Angiogenesis and Progression: Mechanisms, Biomarker Potential, and Therapeutic Implications","volume":"14","author":"Wu","year":"2026","journal-title":"Biomark. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"108109","DOI":"10.1016\/j.phrs.2026.108109","article-title":"Immunometabolic Reprogramming of Macrophages: Emerging Roles in Skeletal Muscle Regeneration and Therapeutic Perspectives","volume":"224","author":"Li","year":"2026","journal-title":"Pharmacol. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1162\/tacl_a_00064","article-title":"Colors in Context: A Pragmatic Neural Model for Grounded Language Understanding","volume":"5","author":"Monroe","year":"2017","journal-title":"Trans. Assoc. Comput. Linguist."},{"key":"ref_153","first-page":"e2073","article-title":"Pan-cancer Analyses of Immunogenic Cell Death-derived Gene Signatures: Potential Biomarkers for Prognosis and Immunotherapy","volume":"7","author":"Han","year":"2024","journal-title":"Cancer Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/imr.12432","article-title":"Dendritic Cell Maturation and Cross-presentation: Timing Matters!","volume":"272","author":"Alloatti","year":"2016","journal-title":"Immunol. Rev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The Ins and Outs of MHC Class II-Mediated Antigen Processing and Presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Vultaggio-Poma, V., Sarti, A.C., and Di Virgilio, F. (2020). Extracellular ATP: A Feasible Target for Cancer Therapy. Cells, 9.","DOI":"10.3390\/cells9112496"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Schwestermann, J., Besse, A., Driessen, C., and Besse, L. (2022). Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.899272"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e2519203122","DOI":"10.1073\/pnas.2519203122","article-title":"Divergent Evolutionary Dynamics of Benign and Malignant Tumors","volume":"122","author":"Butler","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/emph\/eov006","article-title":"Divergent and Convergent Evolution in Metastases Suggest Treatment Strategies Based on Specific Metastatic Sites","volume":"2015","author":"Cunningham","year":"2015","journal-title":"Evol. Med. Public Health"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Jiang, M., Fiering, S., and Shao, Q. (2023). Combining Energy-Based Focal Ablation and Immune Checkpoint Inhibitors: Preclinical Research and Clinical Trials. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1153066"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41392-024-01979-x","article-title":"Cold and Hot Tumors: From Molecular Mechanisms to Targeted Therapy","volume":"9","author":"Wu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.celrep.2016.03.037","article-title":"Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-Tumor Immunity","volume":"15","author":"Aaes","year":"2016","journal-title":"Cell Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical Role for CD103(+)\/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4097\/kja.25001","article-title":"Heterogeneity in Meta-Analyses: An Unavoidable Challenge Worth Exploring","volume":"78","author":"Choi","year":"2025","journal-title":"Korean J. Anesthesiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1039\/c3pp50333j","article-title":"ER Stress, Autophagy and Immunogenic Cell Death in Photodynamic Therapy-Induced Anti-Cancer Immune Responses","volume":"13","author":"Garg","year":"2014","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/emboj.2012.2","article-title":"Enlightening the Impact of Immunogenic Cell Death in Photodynamic Cancer Therapy","volume":"31","author":"Galluzzi","year":"2012","journal-title":"EMBO J."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Fabian, K.P., Kowalczyk, J.T., Reynolds, S.T., and Hodge, J.W. (2022). Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation. Cells, 11.","DOI":"10.3390\/cells11233826"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"403","DOI":"10.18632\/oncotarget.1719","article-title":"Radiation-Induced Immunogenic Modulation of Tumor Enhances Antigen Processing and Calreticulin Exposure, Resulting in Enhanced T-Cell Killing","volume":"5","author":"Gameiro","year":"2013","journal-title":"Oncotarget"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrclinonc.2015.209","article-title":"Combination Cancer Immunotherapies Tailored to the Tumour Microenvironment","volume":"13","author":"Smyth","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s11427-020-1768-y","article-title":"Current Status and Future Perspectives of Immunotherapy in Bladder Cancer Treatment","volume":"64","author":"Wu","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10238-022-00887-0","article-title":"The New Progress in Cancer Immunotherapy","volume":"23","author":"Shimu","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"ref_172","first-page":"1","article-title":"2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference","volume":"40","year":"2020","journal-title":"J. Clin. Immunol."},{"key":"ref_173","unstructured":"Melendez, A.J. (2013). Calcium Signaling During Phagocytosis, Landes Bioscience."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.65.12.13","article-title":"DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH","volume":"65","author":"Geiduschek","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Turlej, E., Domaradzka, A., Koksharov, R., and Gizak, A. (2026). Immune-Centered Cross-Talk Between Cancer Cells and the Tumor Microenvironment\u2014Implications for Therapy. Cancers, 18.","DOI":"10.3390\/cancers18030344"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12951-025-03933-7","article-title":"Emerging Nano-Immunotherapeutic Strategies Achieve Metastatic Colorectal Cancer Precision Therapy","volume":"24","author":"Jiang","year":"2026","journal-title":"J. Nanobiotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin Exposure Dictates the Immunogenicity of Cancer Cell Death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1158\/2159-8290.CD-19-0761","article-title":"The Cytosolic DNA-Sensing CGAS-STING Pathway in Cancer","volume":"10","author":"Won","year":"2020","journal-title":"Cancer Discov."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/21505594.2017.1292197","article-title":"Immunosenescence and Hurdles in the Clinical Management of Older HIV-Patients","volume":"8","author":"Ripa","year":"2017","journal-title":"Virulence"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.trecan.2024.11.010","article-title":"Cellular Senescence Offers Distinct Immunological Vulnerabilities in Cancer","volume":"11","author":"Zhou","year":"2025","journal-title":"Trends Cancer"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"eadg7291","DOI":"10.1126\/scitranslmed.adg7291","article-title":"Senescent Cells as Thermostats of Anti-Tumor Immunity","volume":"15","author":"Prieto","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1016\/j.apsb.2025.07.022","article-title":"Immunoregulatory Mechanisms in the Aging Microenvironment: Targeting the Senescence-Associated Secretory Phenotype for Cancer Immunotherapy","volume":"15","author":"Wang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12943-025-02475-8","article-title":"The Controversial Role of Senescence-Associated Secretory Phenotype (SASP) in Cancer Therapy","volume":"24","author":"Cao","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00281-020-00818-9","article-title":"Immunosenescence Is Both Functional\/Adaptive and Dysfunctional\/Maladaptive","volume":"42","author":"Fulop","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2533488","DOI":"10.1080\/2162402X.2025.2533488","article-title":"Immunogenic Cell Death and Bystander Killing: Expanding the Therapeutic Potential of Modern Antibody-Drug Conjugates","volume":"14","author":"Kepp","year":"2025","journal-title":"Oncoimmunology"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Wang, T., Koo, D.J., Tessier, P.M., and Thurber, G.M. (2026). Combining Antibody Conjugates with Cytotoxic and Immune-Stimulating Payloads Maximizes Anti-Cancer Activity. Mol. Oncol.","DOI":"10.1002\/1878-0261.70198"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41392-025-02326-4","article-title":"Regulatory T Cells in Homeostasis and Disease: Molecular Mechanisms and Therapeutic Potential","volume":"10","author":"Wang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s12672-025-02827-2","article-title":"Tumor-Infiltrating Nerves: Unraveling the Role of Cancer Neuroscience in Tumorigenesis, Disease Progression, and Emerging Therapies","volume":"16","author":"Wang","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_189","first-page":"80","article-title":"The Effect of Integrative Biopsychosocial Therapy on Comorbid Major Depressive Disorder and Posttraumatic Stress Disorder","volume":"60","author":"Ortibano","year":"2024","journal-title":"Tech. Soc. Sci. J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.mie.2019.04.010","article-title":"Quantification of EIF2alpha Phosphorylation during Immunogenic Cell Death","volume":"629","author":"Bezu","year":"2019","journal-title":"Methods Enzymol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5858\/arpa.2014-0511-SA","article-title":"Interpretive Diagnostic Error Reduction in Surgical Pathology and Cytology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology","volume":"140","author":"Nakhleh","year":"2015","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_192","first-page":"CD006732","article-title":"Interventions for Increasing the Use of Shared Decision Making by Healthcare Professionals","volume":"2018","author":"Adekpedjou","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Wang, M.Y., Qiao, Y., Wei, S.J., Su, Z.L., and Lu, H.Y. (2025). MHC Class II of Different Non-Professional Antigen-Presenting Cells Mediate Multiple Effects of Crosstalk with CD4+T Cells in Lung Diseases. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1388814"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2019.03.025","article-title":"Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells","volume":"177","author":"Miao","year":"2019","journal-title":"Cell"},{"key":"ref_195","first-page":"95","article-title":"Biomarkers in Immunology: Their Impact on Immune Function and Response","volume":"7","author":"Kaushik","year":"2025","journal-title":"Adv. Biomark. Sci. Technol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1093\/cid\/cit578","article-title":"Better Tests, Better Care: Improved Diagnostics for Infectious Diseases","volume":"57","author":"Caliendo","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-025-02233-w","article-title":"Extracellular Vesicles in Tumor Immunity: Mechanisms and Novel Insights","volume":"24","author":"Kuang","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 Receptor: A Main Player in Inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","article-title":"The Cancer-Immunity Cycle: Indication, Genotype, and Immunotype","volume":"56","author":"Mellman","year":"2023","journal-title":"Immunity"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ceb.2020.03.002","article-title":"Higher-Order Assemblies in Innate Immune and Inflammatory Signaling: A General Principle in Cell Biology?","volume":"63","author":"Shi","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-065X.2007.00573.x","article-title":"The Interaction between HMGB1 and TLR4 Dictates the Outcome of Anticancer Chemotherapy and Radiotherapy","volume":"220","author":"Apetoh","year":"2007","journal-title":"Immunol. Rev."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1111\/jcmm.14192","article-title":"The Role of Dendritic Cells Regulated by HMGB1\/TLR4 Signalling Pathway in Myocardial Ischaemia Reperfusion Injury","volume":"23","author":"Xue","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.aad0779","article-title":"Chemotherapy-Induced Antitumor Immunity Requires Formyl Peptide Receptor 1","volume":"350","author":"Vacchelli","year":"2015","journal-title":"Science"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10565-025-10042-6","article-title":"Annexin A1-FPR1 Interaction in Dendritic Cells Promotes Immune Microenvironment Modulation in Thyroid Cancer","volume":"41","author":"Jiang","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s40425-019-0781-z","article-title":"Calreticulin Exposure Correlates with Robust Adaptive Antitumor Immunity and Favorable Prognosis in Ovarian Carcinoma Patients","volume":"7","author":"Kasikova","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1039\/D0QI00991A","article-title":"Induction of Immunogenic Cell Death in Cancer Cells by a Photoactivated Platinum(IV) Prodrug","volume":"7","author":"Novohradsky","year":"2020","journal-title":"Inorg. Chem. Front."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1792037","DOI":"10.1080\/2162402X.2020.1792037","article-title":"Surface-Exposed and Soluble Calreticulin: Conflicting Biomarkers for Cancer Prognosis","volume":"9","author":"Kepp","year":"2020","journal-title":"Oncoimmunology"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00262-019-02458-x","article-title":"Immunogenic Cell Death by Neoadjuvant Oxaliplatin and Radiation Protects against Metastatic Failure in High-Risk Rectal Cancer","volume":"69","author":"Bains","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Ahire, V., Ahmadi Bidakhvidi, N., Boterberg, T., Chaudhary, P., Chevalier, F., Daems, N., Delbart, W., Baatout, S., Deroose, C.M., and Fernandez-Palomo, C. (2023). Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities. Radiobiology Textbook, Springer.","DOI":"10.1007\/978-3-031-18810-7_6"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez, \u00c1.P., Juanes-Velasco, P., Landeira-Vi\u00f1uela, A., Bareke, H., Montalvillo, E., G\u00f3ngora, R., and Fuentes, M. (2021). Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies. Cancers, 13.","DOI":"10.3390\/cancers13112821"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"e005248","DOI":"10.1136\/jitc-2022-005248","article-title":"Tumor Microenvironment Shows an Immunological Abscopal Effect in Patients with NSCLC Treated with Pembrolizumab-Radiotherapy Combination","volume":"10","author":"Gorris","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.ccell.2024.07.004","article-title":"Effect of Neoadjuvant Chemoradiotherapy with or without PD-1 Antibody Sintilimab in PMMR Locally Advanced Rectal Cancer: A Randomized Clinical Trial","volume":"42","author":"Xiao","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamasurg.2023.7996","article-title":"Total Neoadjuvant Therapy with PD-1 Blockade for High-Risk Proficient Mismatch Repair Rectal Cancer","volume":"159","author":"Li","year":"2024","journal-title":"JAMA Surg."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1007\/s00262-021-02986-5","article-title":"A Multi-Center, Single-Arm, Phase Ib Study of Pembrolizumab (MK-3475) in Combination with Chemotherapy for Patients with Advanced Colorectal Cancer: HCRN GI14-186","volume":"70","author":"Herting","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","article-title":"Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy","volume":"170","author":"Ribas","year":"2017","journal-title":"Cell"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3061\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:13:15Z","timestamp":1774872795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":215,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27073061"],"URL":"https:\/\/doi.org\/10.3390\/ijms27073061","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}