{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:41Z","timestamp":1787028581346,"version":"build-2736575974"},"reference-count":78,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT","award":["FORDECYT-PRONACES\/3203"],"award-info":[{"award-number":["FORDECYT-PRONACES\/3203"]}]},{"name":"SECIHTI","award":["CBF-2025_I-3072"],"award-info":[{"award-number":["CBF-2025_I-3072"]}]},{"award":["CBF-2025_I-3072"],"award-info":[{"award-number":["CBF-2025_I-3072"]}],"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Campus France Short Stay","award":["CBF-2025_I-3072"],"award-info":[{"award-number":["CBF-2025_I-3072"]}]},{"name":"SECIHTI postdoctoral fellowship"},{"id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"publisher"}]},{"name":"IBRO Early Career Awards program"},{"id":[{"id":"https:\/\/ror.org\/0040b6869","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To explore the regulatory aspects of mRNAs and miRNAs in suicide, we integrated transcriptomic data from GEO datasets. The analysis of mRNA expression in the prefrontal cortex of suicide victims with major depressive disorder revealed a differential profile with 27 downregulated mRNAs, including HSPA1A, HSPA1B, DNAJB1, NR4A1, and GADD45B, which are involved in proteostasis, transcriptional regulation, and apoptosis. Functional enrichment analysis using KEGG and Gene Ontology (GO) revealed significant associations with synaptic plasticity, neuronal survival, and signaling pathways, including MAPK, TGF-\u03b2, Wnt, p53, and neurotrophins. Subsequently, using the GSE34120 GEO dataset of miRNAs from the frontal cortex of suicide victims, 105 dysregulated miRNAs were identified. The networks revealed compact regulatory modules with hsa-miR-576-3p, hsa-miR-493, and hsa-miR-550, as well as highly connected central nodes such as hsa-miR-30b, hsa-miR-16a-5p, hsa-miR-181a-5p, and hsa-miR-184. The integration of both profiles allowed the elaboration of miRNA\u2013mRNA regulatory networks in which TP53, FOXO3, RELA, and FOS interact with multiple dysregulated miRNAs. These findings support the notion that suicide involves complex post-transcriptional dysregulation, particularly related to astrocytic function and neurotrophic signaling, with potential diagnostic and therapeutic applications.<\/jats:p>","DOI":"10.3390\/ijms27073126","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:41:03Z","timestamp":1774878063000},"page":"3126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative In Silico Analysis of miRNA\u2013mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide"],"prefix":"10.3390","volume":"27","author":[{"given":"Jos\u00e9 Luis","family":"Cort\u00e9z-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Environmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche 24085, Mexico"},{"name":"Health Sciences, University of the Americas, Puebla (UDLAP), Puebla 72810, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-4059","authenticated-orcid":false,"given":"Hern\u00e1n Mauricio","family":"Rivera-Escobar","sequence":"additional","affiliation":[{"name":"Research Group on Biosciences, Pedagogy, and Socio-Environmental Sciences BIOPESA, University of Tolima, Ibagu\u00e9 730006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1368-7732","authenticated-orcid":false,"given":"Esther Natalia","family":"Mu\u00f1oz Roa","sequence":"additional","affiliation":[{"name":"PhD Program in Biological Sciences, Pontificia Universidad Javeriana, Bogot\u00e1 110211, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-6223","authenticated-orcid":false,"given":"Carlos Andr\u00e9s","family":"Zabala-Bello","sequence":"additional","affiliation":[{"name":"Animal Science and Veterinary Medicine Faculty, Universidad Nacional de Colombia, Bogot\u00e1 15372, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-0631","authenticated-orcid":false,"given":"Gilberto","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Psychoimmunology Laboratory, Neuroscience Department, Ram\u00f3n de la Fuente Mu\u00f1iz National Institute of Psychiatry, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Chin Chan","sequence":"additional","affiliation":[{"name":"Environmental Epigenetics and Mental Health Laboratory, Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche 24085, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat","family":"Bautista-Ortiz","sequence":"additional","affiliation":[{"name":"Centro Tlaxcala de Biolog\u00eda de la Conducta, Universidad Aut\u00f3noma de Tlaxcala, Tlaxcala 90062, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-6258","authenticated-orcid":false,"given":"Karla Mar\u00eda","family":"L\u00f3pez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Independent Researcher, Puebla 72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-2663","authenticated-orcid":false,"given":"Federico","family":"Osorio-Antonio","sequence":"additional","affiliation":[{"name":"Hospital Infantil de Tlaxcala (HIT), Tlaxcala 90606, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"G\u00e1lvez-Romero","sequence":"additional","affiliation":[{"name":"Hospital Regional del ISSSTE, Puebla 72570, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-4211","authenticated-orcid":false,"given":"Alan","family":"Carrasco Carballo","sequence":"additional","affiliation":[{"name":"SECIHTI, LESQO Adscrito a la Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla 72590, Mexico"},{"name":"Decanato de Ciencias M\u00e9dicas, Universidad Popular Aut\u00f3noma del Estado de Puebla (UPAEP)-SECIHTI-Puebla, Puebla 72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Sede\u00f1o-Monge","sequence":"additional","affiliation":[{"name":"Decanato de Ciencias M\u00e9dicas, Universidad Popular Aut\u00f3noma del Estado de Puebla (UPAEP)-SECIHTI-Puebla, Puebla 72410, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-3335","authenticated-orcid":false,"given":"Francisco","family":"Castel\u00e1n","sequence":"additional","affiliation":[{"name":"Centro Tlaxcala de Biolog\u00eda de la Conducta, Universidad Aut\u00f3noma de Tlaxcala, Tlaxcala 90062, Mexico"},{"name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Bautista-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Multidisciplinary Laboratory in Biomedicine, Biotechnology and Integrative Bioinformatics Applied to Health (LAMB3IS), Faculty of Health Sciences, Autonomous University of Tlaxcala (UATx), Zacatelco 90750, Mexico"},{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS-CNRS), 31077 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Suicide Worldwide in 2019: Global Health Estimates, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1176\/ajp.156.2.181","article-title":"Toward a clinical model of suicidal behavior in psychiatric patients","volume":"156","author":"Mann","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nugent, A.C., Ballard, E.D., Park, L.T., and Zarate, C.A. (2019). Research on the pathophysiology, treatment, and prevention of suicide: Practical and ethical issues. BMC Psychiatry, 19.","DOI":"10.1186\/s12888-019-2301-6"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Genis-Mendoza, A.D., Dionisio-Garc\u00eda, D.M., Gonzalez-Castro, T.B., Tovilla-Zar\u00e1te, C.A., Ju\u00e1rez-Rojop, I.E., L\u00f3pez-Narv\u00e1ez, M.L., Castillo-Avila, R.G., and Nicolini, H. (2022). Increased Levels of Cortisol in Individuals with Suicide Attempt and Its Relation with the Number of Suicide Attempts and Depression. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.912021"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0006-3223(86)90241-6","article-title":"Biochemistry and suicidal behavior in depressed patients","volume":"21","author":"Secunda","year":"1986","journal-title":"Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0006-8993(93)90666-B","article-title":"Quantitative autoradiography of \u03b11- and \u03b12-adrenergic receptors in the cerebral cortex of controls and suicide victims","volume":"630","author":"Arango","year":"1993","journal-title":"Brain Res."},{"key":"ref_7","first-page":"185","article-title":"Role of microRNAs in anxiety and anxiety-related disorders","volume":"42","author":"Murphy","year":"2019","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Smalheiser, N.R., Lugli, G., Zhang, H., Rizavi, H., Cook, E.H., and Dwivedi, Y. (2014). Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086469"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/mp.2016.130","article-title":"Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: Evidence for altered glial, endothelial and ATPase activity","volume":"22","author":"Pantazatos","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pnpbp.2006.06.024","article-title":"Low plasma BDNF is associated with suicidal behavior in major depression","volume":"31","author":"Kim","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbrainres.2004.12.020","article-title":"Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs","volume":"136","author":"Karege","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Maussion, G., Yang, J., Yerko, V., Barker, P., Mechawar, N., Ernst, C., and Turecki, G. (2012). Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039301"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tessarollo, L., and Yanpallewar, S. (2022). TrkB truncated isoform receptors as transducers and determinants of BDNF functions. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.847572"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archpsyc.66.1.22","article-title":"Altered gene expression of brain-derived neurotrophic factor and its truncated receptor TrkB-T1 in the hippocampus of suicides","volume":"66","author":"Ernst","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1503\/jpn.170192","article-title":"Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide","volume":"43","author":"Pandey","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpsychires.2021.01.037","article-title":"A meta-study on transcription factor networks in the suicidal brain","volume":"136","author":"Nicolini","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Huang, M., Wang, J., Liu, W., and Zhou, H. (2024). Advances in the role of the GADD45 family in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1349409"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Shen, X.-y., Shi, S.-h., Liu, B., and Li, Y.-b. (2022). The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.1021207"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/ejn.15876","article-title":"Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10","volume":"57","author":"Shriebman","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Davalieva, K., Maleva Kostovska, I., and Dwork, A.J. (2016). Proteomics research in schizophrenia. Front. Cell. Neurosci., 10.","DOI":"10.3389\/fncel.2016.00018"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.1192\/j.eurpsy.2024.620","article-title":"Concentration of HSPA1A and transthyretin proteins in the blood serum of patients with bipolar disorder","volume":"67","author":"Smirnova","year":"2024","journal-title":"Eur. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41398-019-0488-4","article-title":"Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder","volume":"9","author":"Guan","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_24","first-page":"5701","article-title":"Insight into susceptibility genes associated with bipolar disorder: A systematic review","volume":"25","author":"Kalcev","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1523\/JNEUROSCI.2793-17.2017","article-title":"The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex","volume":"38","author":"Jeanneteau","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fu, J., Guo, O., Zhen, Z., and Zhen, J. (2020). Essential functions of the transcription factor Npas4 in neural circuit development, plasticity, and diseases. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.603373"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jpsychires.2019.01.019","article-title":"Brain-enriched MicroRNA-184 is downregulated in older adults with major depressive disorder: A translational study","volume":"111","author":"Fujimura","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jagp.2016.07.017","article-title":"Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies","volume":"24","author":"Pereira","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5498\/wjp.v10.i8.175","article-title":"Serum levels of chemokines in adolescents with major depression treated with fluoxetine","volume":"10","author":"Palacios","year":"2020","journal-title":"World J. Psychiatry"},{"key":"ref_30","first-page":"4074051","article-title":"Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study","volume":"2018","author":"Arreola","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2016.02.006","article-title":"A meta-analysis of chemokines in major depression","volume":"68","author":"Eyre","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: A meta-analysis of 82 studies","volume":"135","author":"Freitas","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/mp.2017.205","article-title":"Chemokines in Depression in Health and in Inflammatory Illness: A Systematic Review and Meta-Analysis","volume":"23","author":"Leighton","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.05.007","article-title":"Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides","volume":"42","author":"Cruceanu","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41398-020-00979-z","article-title":"Childhood trauma, suicide risk and inflammatory phenotypes of depression: Insights from monocyte gene expression","volume":"10","author":"Schiweck","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jad.2017.06.001","article-title":"The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression","volume":"233","author":"Kageyama","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100598","DOI":"10.1016\/j.bpsgos.2025.100598","article-title":"Decreased Mitochondrial DNA Integrity and Elevated Inflammatory Markers in Late-Life Depression: A Longitudinal Study","volume":"5","author":"Costa","year":"2025","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e75631","DOI":"10.7554\/eLife.75631","article-title":"NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses","volume":"12","author":"Hughes","year":"2023","journal-title":"eLife"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"21596","DOI":"10.1038\/s41598-023-48646-9","article-title":"Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder","volume":"13","author":"Aksu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41380-023-02311-9","article-title":"Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls","volume":"29","author":"Sha","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Senese, N.B., Rasenick, M.M., and Traynor, J.R. (2018). The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01289"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbi.2011.03.006","article-title":"TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors","volume":"25","author":"Weigelt","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gajewski, P.A., Turecki, G., and Robison, A.J. (2016). Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160355"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1098\/rstb.2008.0067","article-title":"Transcriptional mechanisms of addiction: Role of \u0394FosB","volume":"363","author":"Nestler","year":"2008","journal-title":"Phil. Trans. R. Soc. B"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/00952990.2014.933840","article-title":"Molecular neurobiology of addiction: What\u2019s all the \u0394FosB about?","volume":"40","author":"Ruffle","year":"2014","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jad.2011.04.021","article-title":"Activation of a \u0394FOSB dependent gene expression pattern in the dorsolateral prefrontal cortex of patients with major depressive disorder","volume":"133","author":"Teyssier","year":"2011","journal-title":"J. Affect. Disord."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/00207454.2020.1835899","article-title":"Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson\u2019s disease","volume":"132","author":"Xie","year":"2022","journal-title":"Int. J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kumar, P., Dezso, Z., MacKenzie, C., Oestreicher, J., Agoulnik, S., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., and Oda, Y. (2013). Circulating miRNA Biomarkers for Alzheimer\u2019s Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069807"},{"key":"ref_49","first-page":"321","article-title":"Plasma-based circulating microRNA biomarkers for Parkinson\u2019s disease","volume":"2","author":"Khoo","year":"2012","journal-title":"J. Park. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2031407","DOI":"10.1155\/2021\/2031407","article-title":"MiR-29c-3p May Promote the Progression of Alzheimer\u2019s Disease through BACE1","volume":"2021","author":"Cao","year":"2021","journal-title":"J. Healthc. Eng."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.14283\/jpad.2023.99","article-title":"Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults","volume":"11","author":"Sadlon","year":"2024","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1007\/s12035-016-0088-8","article-title":"Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer\u2019s Disease: Potential and Limitations","volume":"54","author":"Antonell","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1007\/s12035-019-1500-y","article-title":"Systematic Review of miRNA as Biomarkers in Alzheimer\u2019s Disease","volume":"56","author":"Swarbrick","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression","volume":"105","author":"Papadopoulou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","first-page":"1565","article-title":"Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer\u2019s disease","volume":"8","author":"Lei","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_56","first-page":"21","article-title":"Serum Exosomal miRNA-125b and miRNA-451a are Potential Diagnostic Biomarker for Alzheimer\u2019s Diseases","volume":"14","author":"Duan","year":"2024","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.55730\/1300-0144.5484","article-title":"Determination of miR-373 and miR-204 levels in neuronal exosomes in Alzheimer\u2019s disease","volume":"52","author":"Aydemir","year":"2022","journal-title":"Turk. J. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10571-016-0338-3","article-title":"miR-373 Inhibits Glioma Cell U251 Migration and Invasion by Down-Regulating CD44 and TGFBR2","volume":"36","author":"Wei","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2018.10.031","article-title":"LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL","volume":"1707","author":"Zhou","year":"2019","journal-title":"Brain Res."},{"key":"ref_60","first-page":"1376","article-title":"Evaluation of miR-302c-3p as prognostic biomarkers in glioma patients","volume":"22","author":"Zheng","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"149366","DOI":"10.1016\/j.gene.2025.149366","article-title":"Unraveling the role of miR-767 in tumor progression: Mechanisms and clinical implications","volume":"949","author":"Fu","year":"2025","journal-title":"Gene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41386-020-0622-2","article-title":"Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis","volume":"45","author":"Wei","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12974-024-03281-7","article-title":"Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-\u03b2\/SMAD2 pathway","volume":"21","author":"Tang","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12031-021-01945-0","article-title":"MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia","volume":"72","author":"Davarinejad","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"35934","DOI":"10.1007\/s11356-021-17478-3","article-title":"Circular RNA circ_0005835 promotes neural stem cells proliferation and differentiation to neuron and inhibits inflammatory cytokines levels through miR-576-3p in Alzheimer\u2019s disease","volume":"29","author":"Xu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11060-017-2425-9","article-title":"MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT","volume":"133","author":"Nie","year":"2017","journal-title":"J. Neurooncol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Hansen, T., Olsen, L., Lindow, M., Jakobsen, K.D., Ullum, H., Jonsson, E., Andreassen, O.A., Djurovic, S., Melle, I., and Agartz, I. (2007). Brain expressed microRNAs implicated in schizophrenia etiology. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000873"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1533033819854132","DOI":"10.1177\/1533033819854132","article-title":"MiR-32 Inhibits Proliferation and Metastasis by Targeting EZH2 in Glioma","volume":"18","author":"Zhang","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11569","DOI":"10.1038\/s41598-017-11885-8","article-title":"TGF-\u03b21-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells","volume":"7","author":"Guo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zhao, Y., and Peng, H. (2022). The Role of N6-Methyladenosine (m6A) Methylation Modifications in Hematological Malignancies. Cancers, 14.","DOI":"10.3390\/cancers14020332"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.1038\/s41598-018-31020-5","article-title":"Plasma microRNA markers of upper limb recovery following human stroke","volume":"8","author":"Edwardson","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.gene.2019.02.086","article-title":"MiR-921 directly downregulates GPx3 in A549 lung cancer cells","volume":"700","author":"Choi","year":"2019","journal-title":"Gene"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: Network-based visual analytics for miRNA functional analysis and systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.7717\/peerj.610","article-title":"Construction and comparison of gene co-expression networks shows complex plant transcriptome dynamics","volume":"2","author":"Leal","year":"2014","journal-title":"PeerJ"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:49:58Z","timestamp":1775058598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":78,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27073126"],"URL":"https:\/\/doi.org\/10.3390\/ijms27073126","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}