{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:02:13Z","timestamp":1775624533632,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute kidney injury (AKI) is a major complication of lupus nephritis and kidney transplantation, inevitably causing ischemia\u2013reperfusion (I\/R) injury. We previously confirmed that high-dose voclosporin induces drug nephropathy through aberrant peroxisome accumulation. The latter induces increased renal indole-3-aceticT acid (IAA) production due to the decreased expression of the IAA-degrading enzyme indolethylamine N-methyltransferase (INMT). Conversely, INMT overexpression prevents this nephropathy, suggesting that high-dose voclosporin could enable a novel therapeutic approach. This prompted us to test whether INMT overexpression with high-dose voclosporin could avert nephrotoxicity and protect against I\/R injury. Inmt-overexpressing mice treated with high-dose voclosporin exhibited absence of peroxisomal abnormalities and resistance to I\/R injury. RNA sequencing revealed the downregulation of tubular injury markers NGAL (Lcn2) and KIM-1 (Havcr1) concurrent with significant cytokine suppression. Mechanistic analysis revealed the robust induction of Regnase-2, an mRNA decay factor, which directly targeted stem\u2013loop structures within the 3\u2032 untranslated region of Lcn2 and Havcr1, thereby promoting their degradation in proximal tubular cells. Importantly, Regnase-2 knockdown mice showed Lcn2 upregulation, mitochondrial dysfunction, and peroxisomal abnormalities culminating in AKI, underscoring its renal protective effects. High-dose voclosporin under Inmt overexpression promoted Regnase-2-mediated mRNA decay to suppress tubular injury. This protective effect extended beyond I\/R to rhabdomyolysis- and lipopolysaccharide-induced AKI to prevent nephropathy. Our findings demonstrate the potential transformative therapeutic approach of administering high-dose voclosporin to promote the prophylactic effect of Regnase-2 augmentation against AKI in both native and transplanted human kidneys.<\/jats:p>","DOI":"10.3390\/ijms27073150","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:09:18Z","timestamp":1774944558000},"page":"3150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Dose Voclosporin Protects Against Acute Kidney Injury via Regnase-2-Mediated NGAL MRNA Decay"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-4522","authenticated-orcid":false,"given":"Kazuhiro","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa 359-8513, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-0098","authenticated-orcid":false,"given":"Masanori","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiyo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Miyakami","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Okinari","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Minato","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Wakino","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/S0140-6736(21)00578-X","article-title":"Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): A double-blind, randomized, multicentre, placebo-controlled, phase 3 trial","volume":"397","author":"Rovin","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1681\/ASN.0000000751","article-title":"Voclosporin overdose\u2013induced peroxisomal structural changes and AKI are prevented by renal indole detoxifier INMT","volume":"36","author":"Hasegawa","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e70047","DOI":"10.1111\/apha.70047","article-title":"Calcineurin inhibitor\u2013associated nephrotoxicity in kidney transplantation\u2014A transplant nephrologist\u2019s perspective","volume":"241","author":"Hansen","year":"2025","journal-title":"Acta Physiol"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lasorsa, F., Rutigliano, M., Milella, M., D\u2019amati, A., Crocetto, F., Pandolfo, S.D., Barone, B., Ferro, M., Spilotros, M., and Battaglia, M. (2024). Ischemia-reperfusion injury in kidney transplantation: Mechanisms and potential therapeutic targets. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084332"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ekir.2023.01.018","article-title":"Clinical-pathological characteristics of renal injuries identify different clusters in patients with antiphospholipid antibodies","volume":"8","author":"Sciascia","year":"2023","journal-title":"Kidney Int. Rep."},{"key":"ref_6","first-page":"e65838","article-title":"Bilateral renal ischemia-reperfusion model for acute kidney injury in mice","volume":"204","author":"Wang","year":"2024","journal-title":"J. Vis. Exp."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Muratsu, J., Sanada, F., Koibuchi, N., Shibata, K., Katsuragi, N., Ikebe, S., Tsunetoshi, Y., Rakugi, H., Morishita, R., and Taniyama, Y. (2022). Blocking periostin prevented development of inflammation in rhabdomyolysis-induced acute kidney injury mice model. Cells, 11.","DOI":"10.3390\/cells11213388"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s10157-025-02690-z","article-title":"MiR-760 protects against lipopolysaccharide-induced septic acute kidney injury by targeting ENKD1","volume":"29","author":"Li","year":"2025","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.kint.2021.06.028","article-title":"Harmonizing acute and chronic kidney disease definition and classification: Report of a KDIGO consensus conference","volume":"100","author":"Lameire","year":"2021","journal-title":"Kidney Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113032","DOI":"10.1016\/j.celrep.2023.113032","article-title":"Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation","volume":"42","author":"Marques","year":"2023","journal-title":"Cell Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2005.10.027","article-title":"A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron delivery","volume":"123","author":"Devireddy","year":"2005","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R4562","DOI":"10.1096\/fasebj.2022.36.S1.R4562","article-title":"Effect of Lipocalin-2 expression on mitochondrial function in renal tubular cells in chronic kidney disease","volume":"36","author":"Marques","year":"2022","journal-title":"FASEB J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.7150\/ijbs.79915","article-title":"Lipocalin-2 promotes acute lung inflammation and oxidative stress by enhancing macrophage iron accumulation","volume":"19","author":"An","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/cmi.2016.70","article-title":"Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses","volume":"14","author":"Mao","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2183\/pjab.94.017","article-title":"Post-transcriptional regulation of immune responses by RNA binding proteins","volume":"94","author":"Mino","year":"2018","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.cell.2015.04.029","article-title":"Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms","volume":"161","author":"Mino","year":"2015","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Xu, M., Xu, S., and Yi, X. (2025). A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database. BMC Immunol., 25.","DOI":"10.1186\/s12865-025-00714-7"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1681\/ASN.0000000883","article-title":"Novel role of tryptophan metabolic pathway in mediating peroxisomal dysfunction in high-dose voclosporin-induced acute kidney injury","volume":"36","author":"Singh","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1007\/s10495-025-02182-1","article-title":"LCN2 drives ferroptosis-associated ischemia-reperfusion injury after renal transplantation: Integrated machine learning and in vivo validation","volume":"30","author":"Wu","year":"2025","journal-title":"Apoptosis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e202201978R","DOI":"10.1096\/fj.202201978R","article-title":"The homeostatic function of Regnase-2 restricts neuroinflammation","volume":"37","author":"Sowinska","year":"2023","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1080\/15476286.2020.1795584","article-title":"The immunomodulatory role of Regnase family RNA-binding proteins","volume":"17","author":"Fischer","year":"2020","journal-title":"RNA Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ai, X., Jia, W., Wang, J., Wu, B., Hu, C., Chen, Q., and Kong, L. (2020). Macrophage Regnase-1 deletion deteriorates liver ischemia\/reperfusion injury through regulation of macrophage polarization. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.582347"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ribeiro, A., Dobosz, E., Krill, M., K\u00f6hler, P., Wadowska, M., Steiger, S., Schmaderer, C., Koziel, J., and Lech, M. (2022). Macrophage-specific MCPIP1\/Regnase-1 attenuates kidney ischemia-reperfusion injury by shaping the local inflammatory response and tissue regeneration. Cells, 11.","DOI":"10.3390\/cells11030397"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-017-9540-2","article-title":"MCPIP1 contributes to clear cell renal cell carcinomas development","volume":"20","author":"Ligeza","year":"2017","journal-title":"Angiogenesis"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Virz\u00ec, G.M., Morisi, N., Paulo, C.O., Clementi, A., Ronco, C., and Zanella, M. (2025). Neutrophil gelatinase-associated lipocalin: Biological aspects and potential diagnostic use in acute kidney injury. J. Clin. Med., 14.","DOI":"10.3390\/jcm14051570"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Su, Y., Yang, X., Cheng, W.-W., Shang, X.-M., Wang, H.-L., and Shen, H.-C. (2025). Kidney injury molecule 1 in the early detection of acute kidney injury\u2014A systematic review and meta-analysis. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1574945"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1172\/JCI45361","article-title":"Chronic epithelial kidney injury molecule-1 expression causes murine proximal tubule injury and interstitial fibrosis","volume":"123","author":"Humphreys","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"Grgic","year":"2012","journal-title":"Kidney Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1159\/000458737","article-title":"Kidney injury molecule-1 is elevated in nephropathy and mediates macrophage activation via the MAPK signalling pathway","volume":"41","author":"Tian","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.ymthe.2022.08.013","article-title":"KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells","volume":"31","author":"Chen","year":"2023","journal-title":"Mol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2021.04.004","article-title":"KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease","volume":"33","author":"Mori","year":"2021","journal-title":"Cell Metab."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Karolin, A., Escher, G., Rudloff, S., and Sidler, D. (2021). Nephrotoxicity of calcineurin inhibitors in kidney epithelial cells is independent of NFAT signaling. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.789080"},{"key":"ref_34","first-page":"50","article-title":"Ischemia and reperfusion injury in kidney transplantation","volume":"95","author":"Nicholson","year":"2019","journal-title":"Kidney Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","article-title":"Ischemia\u2013Reperfusion Injury Reduces Long-Term Renal Graft Survival: Mechanism and Beyond","volume":"28","author":"Zhao","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"gfac088.022","DOI":"10.1093\/ndt\/gfac088.022","article-title":"Alkaline phosphatase to prevent ischemia reperfusion injury in living kidney transplantation\u2014A safety pilot study","volume":"37","author":"Steenvoorden","year":"2022","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fan, H., Liu, J., Sun, J., Feng, G., and Li, J. (2023). Advances in the study of B cells in renal ischemia-reperfusion injury. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1216094"},{"key":"ref_38","first-page":"523","article-title":"Immunosuppressive therapy management during sepsis in kidney transplant recipients: A prospective multicenter study","volume":"15","author":"Rivet","year":"2025","journal-title":"Ann. Intensive Care"},{"key":"ref_39","first-page":"45","article-title":"Management of immunosuppressive therapy in kidney transplant recipients with sepsis: A multicenter retrospective study","volume":"56","author":"Kim","year":"2024","journal-title":"Transpl. Proc."},{"key":"ref_40","first-page":"15035","article-title":"Acute kidney injury secondary to urinary tract infection in kidney transplant recipients","volume":"12","author":"Bardowska","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70218","DOI":"10.1111\/ctr.70218","article-title":"Sepsis-Associated Acute Kidney Injury in Kidney Transplant Recipients in Intensive Care Unit","volume":"39","author":"Sato","year":"2025","journal-title":"Clin. Transplant."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000049053","article-title":"Rhabdomyolysis and acute renal graft impairment in a patient treated with simvastatin, tacrolimus, and fusidic acid","volume":"90","author":"Kotanko","year":"2002","journal-title":"Nephron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S1053-2498(01)00369-2","article-title":"Safety and efficacy of atorvastatin in heart transplant recipients","volume":"21","author":"Patel","year":"2002","journal-title":"J. Heart Lung Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Gao, C., Chen, Z.Y., Ma, L., and Gou, S.J. (2024). A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: A case report. BMC Nephrol., 25.","DOI":"10.1186\/s12882-024-03874-7"},{"key":"ref_45","first-page":"46","article-title":"Rhabdomyolysis and acute kidney injury attributable to statin and immunosuppressant drug-drug interaction: A case report","volume":"26","author":"Nonouchi","year":"2023","journal-title":"J. Jpn. Soc. Emerg. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110314","DOI":"10.1016\/j.neuropharm.2025.110314","article-title":"Exploring DMT: Endogenous role and therapeutic potential","volume":"268","author":"Schimmelpfennig","year":"2025","journal-title":"Neuropharmacology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13046-021-02109-z","article-title":"Targeting INMT and interrupting its methylation pathway for the treatment of castration-resistant prostate cancer","volume":"40","author":"Zhong","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10728","DOI":"10.1038\/s41467-024-54475-9","article-title":"Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids","volume":"15","author":"Furusho","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA Package 2.0","volume":"6","author":"Lorenz","year":"2011","journal-title":"Algorithms Mol. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/bioinformatics\/btl023","article-title":"Memory efficient folding algorithms for circular RNA secondary structures","volume":"22","author":"Hofacker","year":"2006","journal-title":"Bioinformatics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1681\/ASN.0000000000000156","article-title":"PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models","volume":"34","author":"Hasegawa","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1681\/ASN.2020081188","article-title":"Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy","volume":"32","author":"Yasuda","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm.3363","article-title":"Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes","volume":"19","author":"Hasegawa","year":"2013","journal-title":"Nat. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41598-024-51809-x","article-title":"Regnase-2 inhibits glioblastoma cell proliferation","volume":"14","author":"Sowinska","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1261\/rna.071381.119","article-title":"ZC3H12B\/MCPIP2, a new active member of the ZC3H12 family","volume":"25","author":"Wawro","year":"2019","journal-title":"RNA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3150\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:23:18Z","timestamp":1775622198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27073150"],"URL":"https:\/\/doi.org\/10.3390\/ijms27073150","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}