{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:09:45Z","timestamp":1774948185631,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Factor XII (FXII) deficiency is a coagulation factor disorder inherited in an autosomal recessive manner that causes prolonged activated partial thromboplastin time (aPTT). Although it is clinically benign without additional bleeding risk, it has been associated with paradoxical thrombosis. We report the case of a 38-year-old woman who presented with cardiac arrest secondary to spontaneous coronary artery dissection (SCAD) in the absence of identifiable risk factors. Laboratory investigations revealed an isolated prolonged aPTT, which was corrected with mixing studies, and a severe FXII deficiency with activity levels &lt; 1%. Molecular analysis identified two homozygous FXII gene variants: the 46C&gt;T polymorphism and the c.619G&gt;C (p.Ala207Pro) variant. The two variants are considered clinically benign, although the combination of both in a single individual has not been previously reported. The coexistence of FXII deficiency in this case may be of clinical and hypothesis-generating interest.<\/jats:p>","DOI":"10.3390\/ijms27073154","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:09:18Z","timestamp":1774944558000},"page":"3154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Factor XII Deficiency in a Patient with Spontaneous Coronary Artery Dissection"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6513","authenticated-orcid":false,"given":"Artemis","family":"Zormpa","sequence":"first","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrosyni G.","family":"Nomikou","sequence":"additional","affiliation":[{"name":"Blood Bank and Hemophilia Unit, Hippokration Hospital, 115 27 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kalantzis","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Apergis","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnosis, \u201cHippokration\u201d General Hospital, 115 27 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Zouganeli","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-0895","authenticated-orcid":false,"given":"Efthymia G.","family":"Pavlou","sequence":"additional","affiliation":[{"name":"Blood Bank and Hemophilia Unit, Hippokration Hospital, 115 27 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Mavridou","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Katsadiotis","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-0309","authenticated-orcid":false,"given":"Loukianos S.","family":"Rallidis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliani","family":"Kokoris","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology and Blood Bank Unit, \u201cAttikon\u201d University General Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1182\/blood-2012-07-292094","article-title":"In vivo roles of factor XII","volume":"120","author":"Schmaier","year":"2012","journal-title":"Blood"},{"key":"ref_2","first-page":"e2817","article-title":"Factor XII deficiency mimicking bleeding diathesis: A unique presentation and diagnostic pitfall","volume":"10","author":"Fernandes","year":"2018","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4236\/ojbd.2015.54006","article-title":"Factor XII (Hageman factor) deficiency: A very rare coagulation disorder","volume":"5","author":"Azaad","year":"2015","journal-title":"Open J. 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