{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:47:26Z","timestamp":1789681646105,"version":"4.0.1"},"reference-count":180,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder characterized by memory decline, cognitive impairment, and behavioral changes, ultimately leading to a loss of independence and reduced quality of life. Although understanding of the molecular basis of AD has advanced, effective disease-modifying therapies remain scarce. Neuropeptides are small protein-like signaling molecules that regulate diverse physiological processes, including mood, memory, and neuronal function. Growing evidence indicates that neuropeptides are promising therapeutic candidates for AD, particularly through modulation of neuroinflammation, synaptic plasticity, and amyloid-beta (A\u03b2) aggregation. Preclinical AD models show that neuroprotective neuropeptides, such as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating peptide (PACAP), exert neuroprotective effects, enhance memory, and attenuate cognitive decline. This review summarizes current research on neuropeptide-based therapies for AD, detailing their molecular mechanisms, therapeutic actions, and the barriers to their clinical translation. We specifically highlight neuropeptides whose clinical potential in AD remains comparatively underrecognized, discuss strategies for optimizing their delivery and overcoming pharmacokinetic limitations, and outline future perspectives for integrating neuropeptide-based interventions into AD therapy.<\/jats:p>","DOI":"10.3390\/ijms27073206","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:59:01Z","timestamp":1775055541000},"page":"3206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuropeptides in the Management of Alzheimer\u2019s Disease: From Pathophysiology to Therapeutic Opportunities"],"prefix":"10.3390","volume":"27","author":[{"given":"Shraddha","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Botany, Government Lal Bahadur Shastri P.G. College, Sironj 464228, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-7119","authenticated-orcid":false,"given":"Meenakshi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Botany, Career Point University, Kota 324003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-058X","authenticated-orcid":false,"given":"Nidhi","family":"Puranik","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sohrabi, H.R., and Weinborn, M. (2019). Cognitive Impairments in Alzheimer\u2019s Disease and Other Neurodegenerative Diseases. Neurodegeneration and Alzheimer\u2019s Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle, John Wiley & Sons.","DOI":"10.1002\/9781119356752.ch9"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Puranik, N., Yadav, D., and Song, M. (2023). Advancements in the Application of Nanomedicine in Alzheimer\u2019s Disease: A Therapeutic Perspective. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814044"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Puranik, N., and Song, M. (2025). Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer\u2019s and Parkinson\u2019s Diseases. Neurol. Int., 17.","DOI":"10.3390\/neurolint17020026"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2174\/0118715273355336250226055826","article-title":"Oxidative Stress and the Role of Immune Cells in Alzheimer\u2019s Disease: Therapeutic Implications and Future Perspectives","volume":"24","author":"Puranik","year":"2025","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Puranik, N., and Song, M. (2024). Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer\u2019s Disease, a Potential Therapeutic Target. Molecules, 29.","DOI":"10.3390\/molecules29235744"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Puranik, N., and Song, M. (2024). Insights into the Role of microRNAs as Clinical Tools for Diagnosis, Prognosis, and as Therapeutic Targets in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189936"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Erkkinen, M.G., Kim, M.O., and Geschwind, M.D. (2018). Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harb. Perspect. Biol., 10.","DOI":"10.1101\/cshperspect.a033118"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12640-013-9398-z","article-title":"Memantine and cholinesterase inhibitors: Complementary mechanisms in the treatment of Alzheimer\u2019s disease","volume":"24","author":"Parsons","year":"2013","journal-title":"Neurotox. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yeo, X.Y., Cunliffe, G., Ho, R.C., Lee, S.S., and Jung, S. (2022). Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020343"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/187152710793361595","article-title":"Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders","volume":"9","author":"MWhite","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1021\/acs.molpharmaceut.2c00523","article-title":"Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges","volume":"19","author":"Parrasia","year":"2022","journal-title":"Mol. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Omidian, H., Cubeddu, L.X., and Wilson, R.L. (2025). Peptide-Functionalized Nanomedicine: Advancements in Drug Delivery, Diagnostics, and Biomedical Applications. Molecules, 30.","DOI":"10.3390\/molecules30071572"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-024-02107-5","article-title":"Advance in peptide-based drug development: Delivery platforms, therapeutics and vaccines","volume":"10","author":"Xiao","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12017-024-08815-z","article-title":"The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer\u2019s Disease","volume":"27","author":"Zhuang","year":"2024","journal-title":"Neuromolecular Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40035-025-00479-4","article-title":"Dual modulation of amyloid beta and tau aggregation and dissociation in Alzheimer\u2019s disease: A comprehensive review of the characteristics and therapeutic strategies","volume":"14","author":"Nam","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pharep.2014.09.004","article-title":"A review on Alzheimer\u2019s disease pathophysiology and its management: An update","volume":"67","author":"Kumar","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.14283\/jpad.2023.109","article-title":"Neuroinflammation, Its Role in Alzheimer\u2019s Disease and Therapeutic Strategies","volume":"10","author":"Kiraly","year":"2023","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jurcau, A. (2021). Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111847"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Misrani, A., Tabassum, S., and Yang, L. (2021). Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease. Front. Aging Neurosci, 13.","DOI":"10.3389\/fnagi.2021.617588"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102713","DOI":"10.1016\/j.arr.2025.102713","article-title":"Mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"107","author":"Kanaan","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11033-023-09021-z","article-title":"Oxidative stress in Alzheimer\u2019s disease: Current knowledge of signaling pathways and therapeutics","volume":"51","author":"Dhapola","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: Synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jnc.14052","article-title":"Cholinergic modulation of the hippocampal region and memory function","volume":"142","author":"Haam","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Villa, C., Lavitrano, M., Salvatore, E., and Combi, R. (2020). Molecular and Imaging Biomarkers in Alzheimer\u2019s Disease: A Focus on Recent Insights. J. Pers. Med., 10.","DOI":"10.3390\/jpm10030061"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.4103\/NRR.NRR-D-24-00230","article-title":"The dopaminergic system and Alzheimer\u2019s disease","volume":"20","author":"Zhang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, Z.R., Huang, J.B., Yang, S.L., and Hong, F.F. (2022). Role of Cholinergic Signaling in Alzheimer\u2019s Disease. Molecules, 27.","DOI":"10.3390\/molecules27061816"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Benita, B.A., and Koss, K.M. (2024). Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1443985"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sol\u00e9s-Tarr\u00e9s, I., Cabezas-Llobet, N., Vaudry, D., and Xifr\u00f3, X. (2020). Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Against Cognitive Decline in Neurodegenerative Diseases. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.00221"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.brs.2018.02.017","article-title":"Neuropeptide Y as a possible homeostatic element for changes in cortical excitability induced by repetitive transcranial magnetic stimulation","volume":"11","author":"Roux","year":"2018","journal-title":"Brain Stimul."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuron.2012.09.014","article-title":"Neuropeptide transmission in brain circuits","volume":"76","year":"2012","journal-title":"Neuron"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1124\/pharmrev.124.001117","article-title":"Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting","volume":"76","author":"Sandoval","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102270","DOI":"10.1016\/j.arr.2024.102270","article-title":"Somatostatin and the pathophysiology of Alzheimer\u2019s disease","volume":"96","author":"Almeida","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1038\/s41380-021-01368-8","article-title":"Somatostatin-evoked A\u03b2 catabolism in the brain: Mechanistic involvement of \u03b1-endosulfine-KATP channel pathway","volume":"27","author":"Watamura","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"J\u00e1szber\u00e9nyi, M., Thurz\u00f3, B., Jayakumar, A.R., and Schally, A.V. (2024). The Aggravating Role of Failing Neuropeptide Networks in the Development of Sporadic Alzheimer\u2019s Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313086"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.31083\/j.jin2004107","article-title":"Vasoactive neuropeptides and Alzheimer\u2019s disease: A systematic review focusing on calcitonin gene-related peptide","volume":"20","author":"Papiri","year":"2021","journal-title":"J. Integr. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00726-011-1184-8","article-title":"Vasoactive intestinal peptide: A neuropeptide with pleiotropic immune functions","volume":"45","author":"Delgado","year":"2013","journal-title":"Amino Acids"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/01616412.2016.1250458","article-title":"The effects of vasoactive intestinal peptide in neurodegenerative disorders","volume":"39","author":"Deng","year":"2017","journal-title":"Neurol. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12031-018-1226-8","article-title":"Vasoactive Intestinal Peptide Decreases \u03b2-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer\u2019s Disease","volume":"68","author":"Korkmaz","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodr\u00edguez, I., Cadena-Su\u00e1rez, A.R., S\u00e1nchez-Garibay, C., Pozo-Molina, G., M\u00e9ndez-Catal\u00e1, C.F., Cardenas-Aguayo, M.-D., and Diaz-Cintra, S. (2023). Alzheimer\u2019s Disease: An Updated Overview of Its Genetics. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043754"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/glia.20681","article-title":"Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels","volume":"56","author":"Delgado","year":"2008","journal-title":"Glia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106160","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106160","article-title":"Protection of Vasoactive Intestinal Peptide on the Blood-Brain Barrier Dysfunction Induced by Focal Cerebral Ischemia in Rats","volume":"31","author":"Yang","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.peptides.2013.01.007","article-title":"Vasoactive intestinal peptide increases VEGF expression to promote proliferation of brain vascular endothelial cells via the cAMP\/PKA pathway after ischemic insult in vitro","volume":"42","author":"Yang","year":"2013","journal-title":"Peptides"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Song, M., Xiong, J.X., Wang, Y.Y., Tang, J., Zhang, B., and Bai, Y. (2012). VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP\/PS1 mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029790"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1471-4159.1988.tb01816.x","article-title":"Effect of 2-(4-Phenylpiperidino)cyclohexanol (AH 5183) on the Veratridine-Induced Increase in Acetylcholine Synthesis by Rat Hippocampal Tissue","volume":"51","author":"Carroll","year":"1988","journal-title":"J. Neurochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/BF00964869","article-title":"The phosphorylation of choline acetyltransferase","volume":"14","author":"Bruce","year":"1989","journal-title":"Neurochem. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/hipo.20559","article-title":"Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission","volume":"19","author":"Yang","year":"2009","journal-title":"Hippocampus"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1124\/pr.56.2.7","article-title":"The significance of vasoactive intestinal peptide in immunomodulation","volume":"56","author":"Delgado","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02740606","article-title":"VIP: Molecular biology and neurobiological function","volume":"3","author":"Gozes","year":"1989","journal-title":"Mol. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-3-0348-8845-5_3","article-title":"Peptide drug delivery into the central nervous system","volume":"51","author":"Prokai","year":"1998","journal-title":"Prog. Drug Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16463","DOI":"10.1523\/JNEUROSCI.2131-15.2015","article-title":"Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice","volume":"35","author":"Olson","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.apcsb.2014.11.006","article-title":"Vasoactive Intestinal Peptide (VIP) Nanoparticles for Diagnostics and for Controlled and Targeted Drug Delivery","volume":"98","author":"Klippstein","year":"2015","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0006-8993(99)02375-6","article-title":"Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: Relevance to neuroprotection in Parkinson\u2019s disease","volume":"854","author":"Offen","year":"2000","journal-title":"Brain Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gilmartin, M.R., and Ferrara, N.C. (2021). Pituitary Adenylate Cyclase-Activating Polypeptide in Learning and Memory. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.663418"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1515\/cmble-2015-0008","article-title":"Therapeutic potential of PACAP for neurodegenerative diseases","volume":"20","author":"Yang","year":"2015","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.14336\/AD.2020.0626","article-title":"Pituitary Adenylate Cyclase-Activating Polypeptide: A Promising Neuroprotective Peptide in Stroke","volume":"11","author":"Fang","year":"2020","journal-title":"Aging Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/MED.0000000000000617","article-title":"Pituitary adenylate cyclase-activating polypeptide\/vasoactive intestinal peptide [Part 1]: Biology, pharmacology, and new insights into their cellular basis of action\/signaling which are providing new therapeutic targets","volume":"28","author":"Moody","year":"2021","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1096\/fj.10-180133","article-title":"Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer\u2019s disease-like pathology in amyloid precursor protein-transgenic mice","volume":"25","author":"Rat","year":"2011","journal-title":"FASEB J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuroscience.2005.11.028","article-title":"Pituitary adenylate cyclase activating polypeptide reduces expression of Kv1.4 and Kv4.2 subunits underlying A-type K+ current in adult mouse olfactory neuroepithelia","volume":"138","author":"Han","year":"2006","journal-title":"Neuroscience"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/bph.12181","article-title":"VIP and PACAP: Neuropeptide modulators of CNS inflammation, injury, and repair","volume":"169","author":"Waschek","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Denes, V., Geck, P., Mester, A., and Gabriel, R. (2019). Pituitary Adenylate Cyclase-Activating Polypeptide: 30 Years in Research Spotlight and 600 Million Years in Service. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091488"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Apostol, C.R., Bernard, K., Tanguturi, P., Molnar, G., Bartlett, M.J., Szab\u00f2, L., Liu, C., Ortiz, J.B., Saber, M., and Giordano, K.R. (2022). Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP with Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism. Front. Drug Discov., 1.","DOI":"10.3389\/fddsv.2021.818003"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Sadanandan, N., Cozene, B., Park, Y.J., Farooq, J., Kingsbury, C., Wang, Z.J., Moscatello, A., Saft, M., Cho, J., and Gonzales-Portillo, B. (2021). Pituitary Adenylate Cyclase-Activating Polypeptide: A Potent Therapeutic Agent in Oxidative Stress. Antioxidants, 10.","DOI":"10.3390\/antiox10030354"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12031-008-9087-1","article-title":"Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: A better understanding towards therapeutic applications in neurodegenerative diseases","volume":"36","author":"Dejda","year":"2008","journal-title":"J. Mol. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1152\/jn.00594.2014","article-title":"PACAP modulation of calcium ion activity in developing granule cells of the neonatal mouse olfactory bulb","volume":"113","author":"Irwin","year":"2015","journal-title":"J. Neurophysiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.peptides.2018.04.006","article-title":"Pituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships","volume":"104","author":"Starr","year":"2018","journal-title":"Peptides"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Chen, X.Y., Du, Y.F., and Chen, L. (2019). Neuropeptides Exert Neuroprotective Effects in Alzheimer\u2019s Disease. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00493"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Cherait, A., Banks, W.A., and Vaudry, D. (2023). The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15082032"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s13346-013-0133-3","article-title":"Nanotechnology for CNS Delivery of Bio-Therapeutic Agents","volume":"3","author":"Shah","year":"2013","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Ciranna, L., and Costa, L. (2019). Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00524"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"Goode","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_77","first-page":"2870","article-title":"The Double-Edged Effects of Substance P in the Pathology of Alzheimer\u2019s Disease","volume":"16","author":"Lin","year":"2024","journal-title":"Aging Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"150597","DOI":"10.1016\/j.bbrc.2024.150597","article-title":"Recent advances in the molecular signaling pathways of Substance P in Alzheimer\u2019s disease: Link to neuroinflammation associated with toll-like receptors","volume":"733","author":"Satarker","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"D\u2019amico, A.G., Maugeri, G., Saccone, S., Federico, C., Cavallaro, S., Reglodi, D., and D\u2019agata, V. (2020). PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082943"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Cinzia, S. (2025). Substance P in Alzheimer\u2019s and Parkinson\u2019s disease. Substance P: From Pain to Cancer, Academic Press.","DOI":"10.1016\/B978-0-443-22194-1.00024-0"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/MED.0000000000000621","article-title":"Pituitary adenylate cyclase-activating polypeptide\/vasoactive intestinal peptide (Part 2): Biology and clinical importance in central nervous system and inflammatory disorders","volume":"28","author":"Moody","year":"2021","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Kageyama, K., Iwasaki, Y., and Daimon, M. (2021). Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212242"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Johnson, M.B., Young, A.D., and Marriott, I. (2017). The Therapeutic Potential of Targeting Substance P\/NK-1R Interactions in Inflammatory CNS Disorders. Front. Cell. Neurosci., 10.","DOI":"10.3389\/fncel.2016.00296"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"E8741","DOI":"10.1073\/pnas.1711267114","article-title":"Substance P induces plasticity and synaptic tagging\/capture in rat hippocampal area CA2","volume":"114","author":"Dasgupta","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12974-017-1012-5","article-title":"Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P","volume":"14","author":"Burmeister","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1073\/pnas.88.16.7247","article-title":"An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P","volume":"88","author":"Kowall","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Muqaku, B., and Oeckl, P. (2022). Peptidomic Approaches and Observations in Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137332"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/emmm.201000100","article-title":"Therapeutic potential of neuropeptide Y (NPY) receptor ligands","volume":"2","author":"Brothers","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Li, C., Wu, X., Liu, S., Zhao, Y., Zhu, J., and Liu, K. (2019). Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00869"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1212\/WNL.0000000000000417","article-title":"Pituitary adenylate cyclase\u2013activating polypeptide is reduced in Alzheimer disease","volume":"82","author":"Han","year":"2014","journal-title":"Neurology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.npep.2015.09.008","article-title":"Neuropeptide Y: A stressful review","volume":"55","author":"Reichmann","year":"2016","journal-title":"Neuropeptides"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1172\/JCI30085","article-title":"Corticotropin-releasing factor receptors and stress-related alterations of gut motor function","volume":"117","author":"Bonaz","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molcel.2020.01.013","article-title":"Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors","volume":"77","author":"Ma","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Peng, T., Gaur, U., Silva, M., Little, P., Chen, Z., Qiu, W., Zhang, Y., and Zheng, W. (2019). Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00290"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1152\/physrev.00042.2017","article-title":"The Corticotropin-Releasing Factor Family: Physiology of the Stress Response","volume":"98","author":"Deussing","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Morito, T., Hashimoto, S., Takamura, R., Watamura, N., Kakiya, N., Fujioka, R., Mihara, N., Sekiguchi, M., Watanabe-Iwata, K., and Kamano, N. (2025). The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer\u2019s Disease. J. Neurosci., 45.","DOI":"10.1523\/JNEUROSCI.2152-24.2025"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neubiorev.2015.07.011","article-title":"Evidence for the role of corticotropin-releasing factor in major depressive disorder","volume":"58","author":"Waters","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1074\/jbc.M115.678185","article-title":"Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease","volume":"291","author":"Spencer","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00204-025-04164-3","article-title":"A coral-derived neuropeptide suppresses pentylenetetrazol (PTZ)-induced epileptic seizures and improves recognition memory deficits by modulating NPY-Y1R","volume":"100","author":"Chen","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1523\/JNEUROSCI.3333-14.2015","article-title":"Posttraumatic stress disorder-like induction elevates \u03b2-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses","volume":"35","author":"Justice","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41398-019-0581-8","article-title":"Corticotropin releasing factor-binding protein (CRF-BP) as a potential new therapeutic target in Alzheimer\u2019s disease and stress disorders","volume":"9","author":"Vandael","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/mp.2016.185","article-title":"Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer\u2019s disease-related signaling","volume":"22","author":"Bangasser","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jalz.2015.09.007","article-title":"CRF receptor-1 antagonism mitigates A\u03b2 pathology and cognitive and synaptic deficits in a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Zhang","year":"2015","journal-title":"Alzheimers Dement."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3233\/JAD-141722","article-title":"Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer\u2019s Disease Transgenic Mouse Model","volume":"45","author":"Zhang","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1590\/2237-6089-2018-0027","article-title":"Corticotropin-releasing factor receptor signaling and modulation: Implications for stress response and resilience","volume":"42","author":"Vasconcelos","year":"2020","journal-title":"Trends Psychiatry Psychother."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kim, S., Jung, U.J., and Kim, S.R. (2025). The Crucial Role of the Blood\u2013Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications. J. Clin. Med., 14.","DOI":"10.3390\/jcm14020386"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pneurobio.2009.07.002","article-title":"Somatostatin, Alzheimer\u2019s disease and cognition: An old story coming of age?","volume":"89","author":"Epelbaum","year":"2009","journal-title":"Prog Neurobiol"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.neurobiolaging.2014.03.022","article-title":"Pituitary adenylate cyclase-activating polypeptide protects against \u03b2-amyloid toxicity","volume":"35","author":"Han","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Toth, D., Szabo, E., Tamas, A., Juhasz, T., Horvath, G., Fabian, E., Opper, B., Szabo, D., Maugeri, G., and D\u2019AMico, A.G. (2020). Protective Effects of PACAP in Peripheral Organs. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00377"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Ogata, K., Shintani, N., Hayata-Takano, A., Kamo, T., Higashi, S., Seiriki, K., Momosaki, H., Vaudry, D., Vaudry, H., and Galas, L. (2015). PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120526"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"118325","DOI":"10.1016\/j.biopha.2025.118325","article-title":"Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer\u2019s treatment","volume":"189","author":"Metzendorf","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"789","DOI":"10.7150\/thno.50263","article-title":"Enhanced neprilysin-mediated degradation of hippocampal A\u03b242 with a somatostatin peptide that enters the brain","volume":"11","author":"Rofo","year":"2021","journal-title":"Theranostics"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/neup.12649","article-title":"Histological characterization of interneurons in Alzheimer\u2019s disease reveals a loss of somatostatin interneurons in the temporal cortex","volume":"40","author":"Waller","year":"2020","journal-title":"Neuropathology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00429-020-02044-3","article-title":"Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid \u03b2 oligomers in vivo","volume":"225","author":"Chung","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.2147\/IJN.S442876","article-title":"Engineered Exosomes Containing microRNA-29b-2 and Targeting the Somatostatin Receptor Reduce Presenilin 1 Expression and Decrease the \u03b2-Amyloid Accumulation in the Brains of Mice with Alzheimer\u2019s Disease","volume":"19","author":"Lin","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Paik, S., Somvanshi, R.K., Oliveira, H.A., Zou, S., and Kumar, U. (2021). Somatostatin Ameliorates \u03b2-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells. Biomedicines, 9.","DOI":"10.3390\/biomedicines9010027"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Varghese, R., Digholkar, G., Deshpande, A., and Kumar, D. (2023). Novel treatment for Alzheimer\u2019s disease: Tapping the somatostatin-evoked A\u03b2 catabolism via \u03b1-endosulfine-KATP channel pathway. Enzymatic Targets for Drug Discovery Against Alzheimer\u2019s Disease, Bentham Science Publishers.","DOI":"10.2174\/9789815136142123010013"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kumar, D., and Tiwari, P. (2023). Enzymatic targets for drug discovery against Alzheimer\u2019s disease. Enzymatic Targets for Drug Discovery Against Alzheimer\u2019s Disease, Bentham Science Publishers.","DOI":"10.2174\/97898151361421230101"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1159\/000495722","article-title":"Pituitary Adenylate Cyclase Activating Polypeptide Elicits Neuroprotection Against Acute Ischemic Neuronal Cell Death Associated with NMDA Receptors","volume":"51","author":"Kaneko","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1749-6632.1996.tb17489.x","article-title":"Transport of pituitary adenylate cyclase-activating polypeptide across the blood-brain barrier and the prevention of ischemia-induced death of hippocampal neurons","volume":"805","author":"Banks","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Santos-Carvalho, A., Elvas, F., \u00c1lvaro, A.R., Ambr\u00f3sio, A.F., and Cavadas, C. (2013). Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Cell Death Dis., 4.","DOI":"10.1038\/cddis.2013.160"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1745-7254.2005.00011.x","article-title":"Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity","volume":"26","author":"Wu","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/157488906778773689","article-title":"Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide","volume":"1","author":"Xapelli","year":"2006","journal-title":"Recent. Pat. CNS Drug Discov."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"101455","DOI":"10.1016\/j.molmet.2022.101455","article-title":"NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling","volume":"59","author":"Qi","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000377672","article-title":"Cerebrolysin in mild-to-moderate Alzheimer\u2019s disease: A meta-analysis of randomized controlled clinical trials","volume":"39","author":"Gauthier","year":"2015","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.3390\/neurolint16060100","article-title":"The Role of Neuropeptide Y in the Pathogenesis of Alzheimer\u2019s Disease: Diagnostic Significance and Neuroprotective Functions","volume":"16","author":"Shapovalova","year":"2024","journal-title":"Neurol. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2174\/1570159X19666210906120302","article-title":"Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease","volume":"20","author":"Pain","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/apha.12445","article-title":"The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour","volume":"213","author":"Farzi","year":"2015","journal-title":"Acta Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1471-4159.2011.07541.x","article-title":"Neuropeptide Y inhibits interleukin-1 beta-induced microglia motility","volume":"120","author":"Ferreira","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.expneurol.2012.09.004","article-title":"Neuropeptide Y and its role in CNS disease and repair","volume":"238","author":"Decressac","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ana.410200303","article-title":"Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer\u2019s disease","volume":"20","author":"Beal","year":"1986","journal-title":"Ann. Neurol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1634\/stemcells.2008-0056","article-title":"Neuropeptide Y promotes neurogenesis in murine subventricular zone","volume":"26","author":"Agasse","year":"2008","journal-title":"Stem Cells"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8169","DOI":"10.1523\/JNEUROSCI.17-21-08169.1997","article-title":"Inhibition of synaptic transmission by neuropeptide Y in rat hippocampal area CA1, modulation of presynaptic Ca2+ entry","volume":"17","author":"Qian","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"959","DOI":"10.4103\/1673-5374.133140","article-title":"Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function","volume":"9","author":"Li","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cellsig.2015.03.016","article-title":"Neuropeptide Y receptor mediates activation of ERK1\/2 via transactivation of the IGF receptor","volume":"27","author":"Lecat","year":"2015","journal-title":"Cell. Signal."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/acschemneuro.1c00303","article-title":"Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer\u2019s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide","volume":"12","author":"Rofo","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Becker, S., Navratilova, E., Nees, F., and Van Damme, S. (2018). Emotional and motivational pain processing: Current state of knowledge and perspectives in translational research. Pain. Res. Manag., 2018.","DOI":"10.1155\/2018\/5457870"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Li, Y., Yu, J., Yang, N., Long, S., Li, Y., Zhao, L., and Yu, Y. (2024). Alterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation. Physiol. Rep., 12.","DOI":"10.14814\/phy2.70153"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Kumar, V., Sharma, S., and Singh, A. (2025). Nanoparticles: A new frontier in neurodegenerative disease therapy. Front. Med. Technol., 7.","DOI":"10.3389\/fmedt.2025.1654003"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Dejeu, I.L., Vica\u0219, L.G., Marian, E., Ganea, M., Fren\u021b, O.D., Maghiar, P.B., Bodea, F.I., and Dejeu, G.E. (2024). Innovative Approaches to Enhancing the Biomedical Properties of Liposomes. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16121525"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"114285","DOI":"10.1016\/j.colsurfb.2024.114285","article-title":"Exploring intranasal drug delivery via nanocarriers: A promising glioblastoma therapy","volume":"245","author":"Deshmukh","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Amo LDel Cano, A., Ettcheto, M., Souto, E.B., Espina, M., Camins, A., Garc\u00eda, M.L., and S\u00e1nchez-L\u00f3pez, E. (2021). Surface Functionalization of PLGA Nanoparticles to Increase Transport across the BBB for Alzheimer\u2019s Disease. Appl. Sci., 11.","DOI":"10.3390\/app11094305"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"114303","DOI":"10.1016\/j.addr.2022.114303","article-title":"Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors\u2014An update","volume":"185","author":"Power","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"124800","DOI":"10.1016\/j.ijpharm.2024.124800","article-title":"Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy","volume":"666","author":"Rafati","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Kumari, M. (2025). A Comprehensive Review of the Ubiquitin-Proteasome System in Synapse Remodeling and Neurodegenerative Diseases. Proteostasis: Investigating Molecular Dynamics in Neurodegenerative Disorders, Springer Nature.","DOI":"10.1007\/978-981-96-6202-9_14"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chen, L., Guan, Y., Wang, S., Han, X., Guo, F., and Wang, Y. (2025). Engineered nanoplatforms for brain-targeted co-delivery of phytochemicals in Alzheimer\u2019s disease: Rational design, blood-brain barrier penetration, and multi-target therapeutic synergy. Neurotherapeutics, 22.","DOI":"10.1016\/j.neurot.2025.e00722"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Puranik, N., Tiwari, S., Kumari, M., Yadav, S.K., Dhakal, T., and Song, M. (2025). Advanced Bioactive Polymers and Materials for Nerve Repair: Strategies and Mechanistic Insights. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16070255"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1002\/ejoc.200900599","article-title":"Peptidomimetics\u2014A versatile route to biologically active compounds","volume":"2009","author":"Grauer","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/ci100431r","article-title":"CycloPs: Generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids","volume":"51","author":"Duffy","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1039\/D1OB00411E","article-title":"Approaches for peptide and protein cyclisation","volume":"19","author":"Hayes","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Amar\u00f9, J., Barbieri, F., Arvigo, M., Solari, A., Bajetto, A., Nista, F., Campana, C., Gaggero, G., Prior, A., and Rossi, D.C. (2021). Octreotide and pasireotide combination treatment in somatotroph tumor cells: Predominant role of sst2 in mediating ligand effects. Cancers, 13.","DOI":"10.3390\/cancers13081816"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Domhan, C., Uhl, P., Kleist, C., Zimmermann, S., Umst\u00e4tter, F., Leotta, K., Mier, W., and Wink, M. (2019). Replacement of l-Amino Acids by d-Amino Acids in the Antimicrobial Peptide Ranalexin and Its Consequences for Antimicrobial Activity and Biodistribution. Molecules, 24.","DOI":"10.3390\/molecules24162987"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Shi, S., Shen, T., Liu, Y., Chen, L., Wang, C., and Liao, C. (2021). Porcine Myeloid Antimicrobial Peptides: A Review of the Activity and Latest Advances. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.664139"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Elfers, C.T., Blevins, J.E., Salameh, T.S., Lawson, E.A., Silva, D., Kiselyov, A., and Roth, C.L. (2022). Novel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911249"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"125888","DOI":"10.1016\/j.ijpharm.2025.125888","article-title":"Novel enabling strategies for oral peptide delivery","volume":"681","author":"Kara","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Lamptey, R.N.L., Gothwal, A., Trivedi, R., Arora, S., and Singh, J. (2022). Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymeric Micelles for Improved Gene Delivery of VGF to the Brain through Intranasal Route. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020493"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic efficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomater. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.coph.2010.03.003","article-title":"Neuropeptides: Keeping the balance between pathogen immunity and immune tolerance","volume":"10","author":"Ganea","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1124\/pr.117.014977","article-title":"International union of basic and clinical pharmacology CIV: The neurobiology of treatment-resistant depression: From antidepressant classifications to novel pharmacological targets","volume":"70","author":"Caraci","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/joim.70059","article-title":"Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder","volume":"299","author":"Ledri","year":"2025","journal-title":"J. Intern. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"17590914231169140","DOI":"10.1177\/17590914231169140","article-title":"Activation of the PACAP\/PAC1 Signaling Pathway Accelerates the Repair of Impaired Spatial Memory Caused by an Ultradian Light Cycle","volume":"15","author":"Xu","year":"2023","journal-title":"ASN Neuro"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"102601","DOI":"10.1016\/j.coi.2025.102601","article-title":"Moving beyond the Janus kinase signaling kinases in the pathogenesis and treatment of psoriasis and psoriatic arthritis","volume":"95","author":"Raychaudhuri","year":"2025","journal-title":"Curr. Opin. Immunol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Khan, M.S., Qureshi, N., Khan, R., Son, Y.O., and Maqbool, T. (2025). CRISPR\/Cas9-Based therapeutics as a promising strategy for management of Alzheimer\u2019s disease: Progress and prospects. Front. Cell. Neurosci., 19.","DOI":"10.3389\/fncel.2025.1578138"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"5048616","DOI":"10.1155\/2017\/5048616","article-title":"Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases","volume":"2017","author":"Carniglia","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pharmthera.2017.11.006","article-title":"Orphan neuropeptides and receptors: Novel therapeutic targets","volume":"185","author":"Fricker","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Rivnyak, A., Kiss, P., Tamas, A., Balogh, D., and Reglodi, D. (2018). Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041020"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"94907916","DOI":"10.26599\/NR.2025.94907916","article-title":"Peptide-based brain distribution improvement strategies for nano delivery systems in CNS diseases treatment","volume":"18","author":"Qian","year":"2025","journal-title":"Nano Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1210\/me.2010-0489","article-title":"Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1\/2 in Leydig cells","volume":"25","author":"Ping","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1582-4934.2010.01038.x","article-title":"Gene therapy in Alzheimer\u2019s disease\u2014Potential for disease modification","volume":"14","author":"Nilsson","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"102538","DOI":"10.1016\/j.npep.2025.102538","article-title":"Neuropeptide Y as a multifaceted modulator of neuroplasticity, Neuroinflammation, and HPA axis dysregulation: Perceptions into treatment-resistant depression","volume":"112","author":"Singanwad","year":"2025","journal-title":"Neuropeptides"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F.T., and Arab-Tehrany, E. (2022). Alzheimer\u2019s Disease: Treatment Strategies and Their Limitations. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213954"},{"key":"ref_172","first-page":"127","article-title":"Enhancing drug discovery with AI: Predictive modeling of pharmacokinetics using Graph Neural Networks and ensemble learning","volume":"3","author":"Satheeskumar","year":"2025","journal-title":"Intell. Pharm."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hussain, R., Zubair, H., Pursell, S., and Shahab, M. (2024). A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer\u2019s disease. Heliyon, 10.","DOI":"10.1016\/j.heliyon.2024.e37533"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1016\/j.apsb.2025.10.026","article-title":"Progress in peptide and protein therapeutics: Challenges and strategies","volume":"15","author":"Liu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/jnc.15314","article-title":"Chemogenetic approaches to identify metabolically important GPCR signaling pathways: Therapeutic implications","volume":"158","author":"Meister","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2300271","DOI":"10.1002\/ejlt.202300271","article-title":"Advancements in oral insulin: A century of research and the emergence of targeted nanoparticle strategies","volume":"126","author":"Han","year":"2024","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"29","DOI":"10.29245\/2572.942X\/2016\/2.1020","article-title":"Substance P and Antagonists of the Neurokinin-1 Receptor in Neuroinflammation Associated with Infectious and Neurodegenerative Diseases of the Central Nervous System","volume":"1","author":"Martinez","year":"2016","journal-title":"J. Neurol. Neuromedicine"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41467-021-21030-9","article-title":"Structural basis for ligand recognition of the neuropeptide Y Y2 receptor","volume":"12","author":"Tang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_179","first-page":"11223","article-title":"SSTR2 is a prognostic factor and a promising therapeutic target in glioma","volume":"13","author":"He","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/mp.2009.141","article-title":"The CRF system, stress, depression and anxiety\u2014Insights from human genetic studies","volume":"15","author":"Binder","year":"2009","journal-title":"Mol. Psychiatry"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3206\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:22:32Z","timestamp":1775276552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":180,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27073206"],"URL":"https:\/\/doi.org\/10.3390\/ijms27073206","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}