{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:53:28Z","timestamp":1785430408554,"version":"3.56.0"},"reference-count":79,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Special Scientific Research Fund Project of The Fourth Affiliated Hospital of Harbin Medical University","award":["HYDSYTB202237"],"award-info":[{"award-number":["HYDSYTB202237"]}]},{"award":["HYDSYTB202237"],"award-info":[{"award-number":["HYDSYTB202237"]}],"id":[{"id":"https:\/\/ror.org\/02s7c9e98","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the Innovative Talent Program of The Fourth Affiliated Hospital of Harbin Medical University","award":["HYDSYCXRC202123"],"award-info":[{"award-number":["HYDSYCXRC202123"]}]},{"award":["HYDSYCXRC202123"],"award-info":[{"award-number":["HYDSYCXRC202123"]}],"id":[{"id":"https:\/\/ror.org\/02s7c9e98","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the Heilongjiang Medical Development Foundation","award":["22012240002"],"award-info":[{"award-number":["22012240002"]}]},{"name":"the Heilongjiang Provincial Health Commission Science and Technology Program","award":["20250404070016"],"award-info":[{"award-number":["20250404070016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteosarcoma (OS) is an aggressive bone malignancy with poor prognosis, characterized by high metastasis rates. Kinesin family member 18B (KIF18B), a key protein in cell division and mitosis, has emerged as a potential diagnostic and therapeutic target in various cancers, including OS. This study investigates the role of KIF18B in OS progression and its underlying mechanisms. We found that KIF18B expression is significantly upregulated in OS tissues and correlates with lymph node metastasis (N-stage) and clinical stage. Knockdown of KIF18B inhibited OS cell migration, invasion, proliferation, and tumorigenesis. Mechanistically, KIF18B promotes OS survival through the ubiquitin\u2013proteasome system (UPS) by regulating Skp2 protein degradation. KIF18B knockdown accelerated Skp2 ubiquitination, leading to reduced Skp2 levels and inhibited OS cell viability and glycolytic metabolism. Overexpression of KIF18B enhanced OS cell viability and glycolysis in an Skp2-dependent manner. These findings suggest that the KIF18B-Skp2 axis plays a critical role in the metabolic reprogramming of OS cells and serves as a novel prognostic biomarker and therapeutic target in OS.<\/jats:p>","DOI":"10.3390\/ijms27073235","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:09:54Z","timestamp":1775138994000},"page":"3235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KIF18B Modulates SKP2 Ubiquitination to Promote Aerobic Glycolysis and Osteosarcoma Progression"],"prefix":"10.3390","volume":"27","author":[{"given":"Haonan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Harbin Medical University, 157 Health Care Road, Nangang District, Harbin 150023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Harbin Medical University, 157 Health Care Road, Nangang District, Harbin 150023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxiang","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Harbin Medical University, 157 Health Care Road, Nangang District, Harbin 150023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daifeng","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Harbin Medical University, 157 Health Care Road, Nangang District, Harbin 150023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100221","DOI":"10.1016\/j.jbo.2019.100221","article-title":"Advances in immune checkpoint inhibitors for bone sarcoma therapy","volume":"15","author":"Thanindratarn","year":"2019","journal-title":"J. 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