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This review synthesizes current evidence to propose and elaborate a novel pathogenic paradigm: a self-reinforcing \u201cmetabolism\u2013epigenetics\u2013inflammation\u201d feedback loop that sustains chronic vascular inflammation in TAK. We detail how immunometabolic reprogramming in immune and vascular wall cells not only meets bioenergetic demands but also generates metabolites (e.g., acetyl-CoA, lactate) that serve as substrates or cofactors for epigenetic modifications. These modifications, in turn, lock in a persistent pro-inflammatory gene expression profile. A central focus is the dissection of the ANK2\u2013MAVS\u2013IL-8 axis, a critical link connecting genetic susceptibility (via ANK2 variants) through mitochondrial dysfunction to sustained, IL-8-driven vascular injury. Building on this mechanistic framework, the review explores the translational potential of emerging biomarker candidates (e.g., IL-8, specific methylation marks) and proposes stratified therapeutic strategies that target distinct nodes within this interactive network, including metabolic drivers, epigenetic stabilizers, and inflammatory effectors. Ultimately, this work provides an integrated conceptual and translational roadmap for advancing precision medicine in TAK.<\/jats:p>","DOI":"10.3390\/ijms27073249","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:06:21Z","timestamp":1775441181000},"page":"3249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic\u2013Epigenetic Crosstalk in Takayasu Arteritis: The ANK2\u2013MAVS\u2013IL-8 Axis as a Novel Therapeutic Paradigm"],"prefix":"10.3390","volume":"27","author":[{"given":"Tianjian","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"},{"name":"The First Clinical Medical College, Kunming Medical University, Kunming 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"},{"name":"School of Clinical Oncology, Kunming Medical University, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Li","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Kunming Medical University, Kunming 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benmo","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Clinical Oncology, Kunming Medical University, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Shang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Kunming Medical University, Kunming 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxuan","family":"Xi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Kunming Medical University, Kunming 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Kunming Medical University, Kunming 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8571-8523","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0797-496X","authenticated-orcid":false,"given":"Hengxi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology\/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(00)02701-X","article-title":"Takayasu\u2019s arteritis","volume":"356","author":"Numano","year":"2000","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.lpm.2017.05.034","article-title":"Epidemiology of Takayasu arteritis","volume":"46","author":"Onen","year":"2017","journal-title":"Presse Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e15360","DOI":"10.1111\/1756-185X.15360","article-title":"Epidemiology of large vasculitis in Shanghai, China: A 10-year multicenter hospital-based study and systematic review","volume":"27","author":"Sun","year":"2024","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nrrheum.2010.82","article-title":"Takayasu arteritis\u2014Advances in diagnosis and management","volume":"6","author":"Mason","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/1756-185X.12309","article-title":"Recent advances in Takayasu arteritis","volume":"17","author":"Terao","year":"2014","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3400\/avd.ra.23-00003","article-title":"Complexity of Inflammation in the Trajectory of Vascular Disease: Interleukin 6 and Beyond","volume":"16","author":"Sano","year":"2023","journal-title":"Ann. Vasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Watanabe, R., Berry, G.J., Liang, D.H., Goronzy, J.J., and Weyand, C.M. (2020). Cellular Signaling Pathways in Medium and Large Vessel Vasculitis. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.587089"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e42844","DOI":"10.1097\/MD.0000000000042844","article-title":"Elevated soluble CD226 in Takayasu arteritis is useful for differentiation from giant cell arteritis, disease activity assessment, and prognosis prediction","volume":"104","author":"Nakano","year":"2025","journal-title":"Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e11766","DOI":"10.1002\/acr2.11766","article-title":"Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis","volume":"7","author":"Sawalha","year":"2025","journal-title":"ACR Open Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13667","DOI":"10.1038\/s41598-021-93213-9","article-title":"A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis","volume":"11","author":"Kadoba","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"rxaf027","DOI":"10.1093\/mrcr\/rxaf027","article-title":"Successful treatment with tocilizumab in a case of familial Mediterranean fever with Takayasu arteritis","volume":"9","author":"Kondo","year":"2025","journal-title":"Mod. Rheumatol. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107803","DOI":"10.1016\/j.phrs.2025.107803","article-title":"The metabolism-immunity axis in Immune thrombocytopenia: From energy regulation to targeted therapy","volume":"217","author":"Zhou","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"113702","DOI":"10.1016\/j.intimp.2024.113702","article-title":"Emerging role of metabolic reprogramming in the immune microenvironment and immunotherapy of thyroid cancer","volume":"144","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kabeerdoss, J., Danda, D., Goel, R., Mohan, H., Danda, S., and Scofield, R.H. (2022). Genome-Wide DNA Methylation Profiling in CD8 T-Cells and Gamma Delta T-Cells of Asian Indian Patients with Takayasu Arteritis. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.843413"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.freeradbiomed.2025.11.022","article-title":"ANK2-MAVS signaling dysfunction triggers mitochondrial stress and enhances IL-8 mediated inflammatory responses in Takayasu arteritis","volume":"243","author":"Chen","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., and Shi, Y. (2022). An Epigenetic Role of Mitochondria in Cancer. Cells, 11.","DOI":"10.3390\/cells11162518"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.copbio.2019.12.008","article-title":"Metabolic regulation of epigenetic remodeling in immune cells","volume":"63","author":"Britt","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"155515","DOI":"10.1016\/j.cyto.2021.155515","article-title":"Elevated chemokines concentration is associated with disease activity in Takayasu arteritis","volume":"143","author":"Dong","year":"2021","journal-title":"Cytokine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"C570","DOI":"10.1152\/ajpcell.00201.2022","article-title":"Epigenetic modifications in metabolic memory: What are the memories, and can we erase them?","volume":"323","author":"Chen","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"G\u00f3mez de Cedr\u00f3n, M., Moreno Palomares, R., and Ram\u00edrez de Molina, A. (2023). Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1169168"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sun, Y.H., Zhang, J.X., Jin, H.S., and Huang, J. (2025). Crosstalk Between Metabolic Reprogramming and Epigenetic Modifications in Colorectal Cancer: Mechanisms and Clinical Applications. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47090751"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/BOR.0000000000000962","article-title":"Vasculitis and the NLRP3 inflammasome","volume":"36","author":"Hamzaoui","year":"2024","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10557-024-07545-5","article-title":"Metabolism Serves as a Bridge Between Cardiomyocytes and Immune Cells in Cardiovascular Diseases","volume":"39","author":"Hang","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2025.02.017","article-title":"Regular exercise alleviates metabolic dysfunction-associated steatohepatitis through rescuing mitochondrial oxidative stress and dysfunction in liver","volume":"230","author":"Lin","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s10741-021-10109-6","article-title":"Mitochondrial abnormalities: A hub in metabolic syndrome-related cardiac dysfunction caused by oxidative stress","volume":"27","author":"Li","year":"2022","journal-title":"Heart Fail. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2022.09.032","article-title":"Altered glucose metabolism in Alzheimer\u2019s disease: Role of mitochondrial dysfunction and oxidative stress","volume":"193","author":"Dewanjee","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mohan, J., Ghazi, T., Sibiya, T., and Chuturgoon, A.A. (2023). Antiretrovirals Promote Metabolic Syndrome through Mitochondrial Stress and Dysfunction: An In Vitro Study. Biology, 12.","DOI":"10.3390\/biology12040580"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s11695-024-07244-y","article-title":"Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome","volume":"34","author":"Rossi","year":"2024","journal-title":"Obes. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.it.2022.10.006","article-title":"Secreted immune metabolites that mediate immune cell communication and function","volume":"43","author":"Zhang","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, Y., Wu, Y., and Hu, Y. (2021). Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.641883"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"114034","DOI":"10.1016\/j.intimp.2025.114034","article-title":"Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions","volume":"147","author":"Cai","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/intimm\/dxaa041","article-title":"The impact of metabolites derived from the gut microbiota on immune regulation and diseases","volume":"32","author":"Ohno","year":"2020","journal-title":"Int. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s42255-022-00676-9","article-title":"Myeloid-derived itaconate suppresses cytotoxic CD8(+) T cells and promotes tumour growth","volume":"4","author":"Zhao","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cytogfr.2022.11.001","article-title":"Crosstalk between glucose metabolism, lactate production and immune response modulation","volume":"68","author":"Ye","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mortazavi Farsani, S.S., and Verma, V. (2023). Lactate mediated metabolic crosstalk between cancer and immune cells and its therapeutic implications. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1175532"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2020.03.028","article-title":"Metabolic regulation of endothelial SK channels and human coronary microvascular function","volume":"312","author":"Liu","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/s12967-024-05120-y","article-title":"Quinic acid regulated TMA\/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic","volume":"22","author":"Jin","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"120446","DOI":"10.1016\/j.atherosclerosis.2025.120446","article-title":"Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport","volume":"408","author":"Wang","year":"2025","journal-title":"Atherosclerosis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/s41467-020-15088-0","article-title":"Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis","volume":"11","author":"Mutoh","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jaci.2021.05.003","article-title":"Mast cells drive pathologic vascular lesions in Takayasu arteritis","volume":"149","author":"Desbois","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ruan, X., and Zhao, W. (2025). Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1546325"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"BSR20210308","DOI":"10.1042\/BSR20210308","article-title":"RAGE-mediated functional DNA methylated modification contributes to cigarette smoke-induced airway inflammation in mice","volume":"41","author":"Li","year":"2021","journal-title":"Biosci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"112587","DOI":"10.1016\/j.biopha.2021.112587","article-title":"Epigenetic changes in inflammatory genes and the protective effect of cooked rhubarb on pancreatic tissue of rats with chronic alcohol exposure","volume":"146","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.2147\/COPD.S369702","article-title":"DNA Methylation Profiling in a Cigarette Smoke-Exposed Mouse Model of Airway Inflammation","volume":"17","author":"Li","year":"2022","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"25424823251341176","DOI":"10.1177\/25424823251341176","article-title":"DNA methylation in peripheral blood leukocytes in late onset Alzheimer\u2019s disease","volume":"9","year":"2025","journal-title":"J. Alzheimer\u2019s Dis. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"156693","DOI":"10.1016\/j.cyto.2024.156693","article-title":"Epigenetic modulation of cytokine expression in Mycobacterium tuberculosis-infected monocyte derived-dendritic cells: Implications for tuberculosis diagnosis","volume":"181","author":"Meskini","year":"2024","journal-title":"Cytokine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cytogfr.2023.08.002","article-title":"Tumor microenvironment, histone modifications, and myeloid-derived suppressor cells","volume":"74","author":"Tian","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Chen, J., Liu, H., Mi, R., Huang, R., Li, X., Fan, F., Xie, X., and Ding, J. (2022). The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1099892"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1080\/17501911.2024.2410695","article-title":"Dysregulation of epigenetic modifications in inborn errors of immunity","volume":"16","author":"Xiao","year":"2024","journal-title":"Epigenomics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14971","DOI":"10.2147\/JIR.S535690","article-title":"Identification of SIN3A as a Promising Epigenetic Target Against Allergic Rhinitis","volume":"18","author":"Li","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.semcancer.2022.02.018","article-title":"Targeting the epigenetic processes to enhance antitumor immunity in small cell lung cancer","volume":"86","author":"Luo","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"218038","DOI":"10.1016\/j.canlet.2025.218038","article-title":"Lactate metabolic checkpoint in immuno-oncology: Mechanisms and therapeutic implications","volume":"633","author":"Wang","year":"2025","journal-title":"Cancer Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00018-025-05955-8","article-title":"Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8(+) T cell survival in gastric cancer","volume":"83","author":"Qian","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Fadaei, S., Zarepour, F., Parvaresh, M., Motamedzadeh, A., Tamehri Zadeh, S.S., Sheida, A., Shabani, M., Hamblin, M.R., Rezaee, M., and Zarei, M. (2022). Epigenetic regulation in myocardial infarction: Non-coding RNAs and exosomal non-coding RNAs. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.1014961"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"103186","DOI":"10.1016\/j.jaut.2024.103186","article-title":"miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis","volume":"144","author":"Bonacini","year":"2024","journal-title":"J. Autoimmun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"103739","DOI":"10.1016\/j.autrev.2024.103739","article-title":"Current state of epigenetics in giant cell arteritis: Focus on microRNA dysregulation","volume":"24","author":"Bolha","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/BST20210860","article-title":"Epigenetic regulation of human non-coding RNA gene transcription","volume":"50","author":"Morselli","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Garratt, H., Ashburn, R., Sopi\u0107, M., Nogara, A., Caporali, A., and Miti\u0107, T. (2021). Long Non-Coding RNA Regulation of Epigenetics in Vascular Cells. Noncoding RNA, 7.","DOI":"10.3390\/ncrna7040062"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/1389202923666220531105035","article-title":"Long Non-coding RNAs: Pivotal Epigenetic Regulators in Diabetic Retinopathy","volume":"23","author":"Song","year":"2022","journal-title":"Curr. Genom."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bure, I.V., Nemtsova, M.V., and Kuznetsova, E.B. (2022). Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105801"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Saadi, W., Fatmi, A., Pallard\u00f3, F.V., Garc\u00eda-Gim\u00e9nez, J.L., and Mena-Molla, S. (2022). Long Non-Coding RNAs as Epigenetic Regulators of Immune Checkpoints in Cancer Immunity. Cancers, 15.","DOI":"10.3390\/cancers15010184"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1071\/RD22203","article-title":"Metabolism-epigenetic interactions on in vitro produced embryos","volume":"35","author":"Milazzotto","year":"2022","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"152608","DOI":"10.1016\/j.bbrc.2025.152608","article-title":"Metabolic-epigenetic interactions in heart failure: Current understanding and future directions","volume":"783","author":"Flowers","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.tem.2025.09.002","article-title":"Target compartmentalized metabolism to regulate epigenetics","volume":"36","author":"Mao","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"107936","DOI":"10.1016\/j.phrs.2025.107936","article-title":"Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions","volume":"220","author":"Lin","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Giuliani, S., Accetta, C., di Martino, S., De Vitis, C., Messina, E., Pescarmona, E., Fanciulli, M., Ciliberto, G., Mancini, R., and Falcone, I. (2025). Metabolic Reprogramming in Melanoma: An Epigenetic Point of View. Pharmaceuticals, 18.","DOI":"10.3390\/ph18060853"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13148-020-00862-0","article-title":"Symphony of epigenetic and metabolic regulation-interaction between the histone methyltransferase EZH2 and metabolism of tumor","volume":"12","author":"Zhang","year":"2020","journal-title":"Clin. Epigenet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4252\/wjsc.v14.i7.490","article-title":"Metabolic-epigenetic nexus in regulation of stem cell fate","volume":"14","author":"Liu","year":"2022","journal-title":"World J. Stem Cells"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12929-025-01146-6","article-title":"Meta-epigenetic shifts in T cell aging and aging-related dysfunction","volume":"32","author":"Rousseau","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41423-023-01065-2","article-title":"MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade","volume":"20","author":"Liu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41594-023-00988-8","article-title":"MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation","volume":"30","author":"Dai","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Li, W., Qiao, J., You, Q., Zong, S., Peng, Q., Liu, Y., Hu, S., Liu, W., Li, S., and Shu, X. (2021). SARS-CoV-2 Nsp5 Activates NF-\u03baB Pathway by Upregulating SUMOylation of MAVS. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.750969"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"113256","DOI":"10.1016\/j.isci.2025.113256","article-title":"MAVS phosphorylation acts as a cellular stress sensor that modulates antiviral immunity","volume":"28","author":"Zhao","year":"2025","journal-title":"iScience"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1038\/s41467-022-32628-y","article-title":"The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation","volume":"13","author":"Bai","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-025-01512-9","article-title":"Old dogs-new tricks: Multifaceted functions of MAVS beyond antivirus activity in human health and diseases","volume":"16","author":"Lu","year":"2025","journal-title":"Cell Biosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.2147\/JIR.S316262","article-title":"The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders","volume":"14","author":"Gao","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1097\/QAD.0000000000003675","article-title":"Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy","volume":"37","author":"Guha","year":"2023","journal-title":"Aids"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13880209.2022.2099430","article-title":"The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p\/IGF1 pathway","volume":"61","author":"Li","year":"2023","journal-title":"Pharm. Biol."},{"key":"ref_79","first-page":"293","article-title":"Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER\/Sirt1\/HMGB1 signaling pathway in type 1 diabetic rats","volume":"22","author":"Yao","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"168032","DOI":"10.1016\/j.bbadis.2025.168032","article-title":"Variant rs13045 reduces EIF2AK3 expression and inhibits pro-inflammatory cytokine secretion via the MAPK-ERK1\/2 pathway in Kawasaki disease","volume":"1872","author":"Yang","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e70081","DOI":"10.1002\/acr2.70081","article-title":"Understanding Cardiovascular Events with JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines","volume":"7","author":"Zavoriti","year":"2025","journal-title":"ACR Open Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e11790","DOI":"10.1002\/acr2.11790","article-title":"Understanding Cardiovascular Events with JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endothelium","volume":"7","author":"Zavoriti","year":"2025","journal-title":"ACR Open Rheumatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13075-022-02960-1","article-title":"Augmented PFKFB3-mediated glycolysis by interferon-\u03b3 promotes inflammatory M1 polarization through the JAK2\/STAT1 pathway in local vascular inflammation in Takayasu arteritis","volume":"24","author":"Chen","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Hamid, M.A., Moustafa, M.T., Nashine, S., Costa, R.D., Schneider, K., Atilano, S.R., Kuppermann, B.D., and Kenney, M.C. (2021). Anti-VEGF Drugs Influence Epigenetic Regulation and AMD-Specific Molecular Markers in ARPE-19 Cells. Cells, 10.","DOI":"10.3390\/cells10040878"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Yang, Y., Yao, Y., Cai, X., Tao, Y., Zhuge, Z., Zhou, J., and Zheng, C. (2025). DNA methylation and immune regulation in osteoporosis: Emerging epigenetic targets for drug discovery. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1688305"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"114228","DOI":"10.1016\/j.bcp.2020.114228","article-title":"LncRNA regulation: New frontiers in epigenetic solutions to drug chemoresistance","volume":"189","author":"Zhou","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1124\/dmd.120.000008","article-title":"Epigenetic Regulation of Differentially Expressed Drug-Metabolizing Enzymes in Cancer","volume":"48","author":"Wang","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Mogol, A.N., Yoo, J.Y., Eve, A.A., Goel, M., Dutton, D.J., Schane, C.P., Lam, A., Dutta, D., Barnick, B., and Erdogan, E.D. (2025). ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target. bioRxiv.","DOI":"10.1101\/2025.09.23.678089"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e169993","DOI":"10.1172\/JCI169993","article-title":"Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3\/4-COMPASS epigenetic regulator mutations","volume":"133","author":"Zhao","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s11010-025-05465-y","article-title":"Lactylation-mitochondria axis in chronic kidney disease: Metabolic reprogramming, epigenetic dysregulation, and therapeutic potential","volume":"481","author":"Gan","year":"2026","journal-title":"Mol. Cell Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kong, X., Xu, M., Cui, X., Ma, L., Cheng, H., Hou, J., Sun, X., Ma, L., and Jiang, L. (2021). Potential Role of Macrophage Phenotypes and CCL2 in the Pathogenesis of Takayasu Arteritis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.646516"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10067-024-06880-0","article-title":"Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study","volume":"43","author":"Pineda","year":"2024","journal-title":"Clin. Rheumatol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Repiso, C., Linares-Pineda, T.M., Gonzalez-Jimenez, A., Aguilar-Lineros, F., Vald\u00e9s, S., Soriguer, F., Rojo-Mart\u00ednez, G., Tinahones, F.J., and Morcillo, S. (2021). Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910417"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13075-021-02433-x","article-title":"Serum complement 3 is a potential biomarker for assessing disease activity in Takayasu arteritis","volume":"23","author":"Chen","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1093\/rheumatology\/kead056","article-title":"PET vascular activity score for predicting new angiographic lesions in patients with Takayasu arteritis: A Chinese cohort study","volume":"62","author":"Ma","year":"2023","journal-title":"Rheumatology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/cmb.2021.0477","article-title":"Single-Cell Multiomics Integration by SCOT","volume":"29","author":"Demetci","year":"2022","journal-title":"J. Comput. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"btaf302","DOI":"10.1093\/bioinformatics\/btaf302","article-title":"CrossAttOmics: Multiomics data integration with cross-attention","volume":"41","author":"Beaude","year":"2025","journal-title":"Bioinformatics"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1021\/acs.analchem.3c03785","article-title":"Windows Scanning Multiomics: Integrated Metabolomics and Proteomics","volume":"95","author":"Shi","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1021\/acs.jproteome.2c00730","article-title":"Executable Network Models of Integrated Multiomics Data","volume":"22","author":"Palshikar","year":"2023","journal-title":"J. Proteome Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1200\/CCI.19.00119","article-title":"Multiomic Integration of Public Oncology Databases in Bioconductor","volume":"4","author":"Ramos","year":"2020","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"bbab485","DOI":"10.1093\/bib\/bbab485","article-title":"Multiomics integration-based molecular characterizations of COVID-19","volume":"23","author":"Li","year":"2022","journal-title":"Brief. Bioinform."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"lqad063","DOI":"10.1093\/nargab\/lqad063","article-title":"SUPREME: Multiomics data integration using graph convolutional networks","volume":"5","author":"Kesimoglu","year":"2023","journal-title":"NAR Genom. Bioinform."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"20058","DOI":"10.1021\/acs.analchem.5c01812","article-title":"A New Approach to Large Multiomics Data Integration","volume":"97","author":"Dexter","year":"2025","journal-title":"Anal. Chem."},{"key":"ref_104","first-page":"275","article-title":"BaySyn: Bayesian Evidence Synthesis for Multi-system Multiomic Integration","volume":"28","author":"Bhattacharyya","year":"2023","journal-title":"Pac. Symp. Biocomput."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"101211","DOI":"10.1016\/j.crmeth.2025.101211","article-title":"Single-cell multiomics data integration and generation with scPairing","volume":"5","author":"Niu","year":"2025","journal-title":"Cell Rep. Methods"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Arnroth, L., and Vickovic, S. (2025). INLAomics for Scalable and Interpretable Spatial Multiomic Data Integration. bioRxiv.","DOI":"10.1101\/2025.05.02.651831"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Chen, G., Liu, J., Guo, Y., and Sun, P. (2025). Mechanisms for Regulatory Effects of Exercise on Metabolic Diseases from the Lactate-Lactylation Perspective. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083469"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Chen, K., Chen, Z., Wang, J., Zhou, M., Liu, Y., Xu, B., Yu, Z., Li, Y., Yang, G., and Xu, T. (2025). Single-Cell Sequencing Unravels Pancreatic Cancer: Novel Technologies Reveal Novel Aspects of Cellular Heterogeneity and Inform Therapeutic Strategies. Biomedicines, 13.","DOI":"10.3390\/biomedicines13123024"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41388-024-02967-9","article-title":"Heterogeneity and tumoral origin of medulloblastoma in the single-cell era","volume":"43","author":"Sheng","year":"2024","journal-title":"Oncogene"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"14459","DOI":"10.1007\/s12035-025-04997-0","article-title":"Decoding Alzheimer\u2019s Disease: Single-Cell Sequencing Uncovers Brain Cell Heterogeneity and Pathogenesis","volume":"62","author":"Ma","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"217117","DOI":"10.1016\/j.canlet.2024.217117","article-title":"Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer","volume":"598","author":"Wang","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.canlet.2021.12.008","article-title":"Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing","volume":"527","author":"Madurga","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/path.6430","article-title":"NSD1 mutation status determines metabolic inhibitor sensitivity in head and neck squamous cell carcinomas by regulating mitochondrial respiration","volume":"266","author":"Tang","year":"2025","journal-title":"J. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"147504","DOI":"10.1016\/j.ijbiomac.2025.147504","article-title":"Single-cell and spatial transcriptomics identify dihydrolipoic acid succinyltransferase as a promoter of tumor invasion via vascular pathways in cutaneous melanoma","volume":"327","author":"Gu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"126677","DOI":"10.1016\/j.jtemb.2020.126677","article-title":"Differential epigenetic profiles induced by sodium selenite in breast cancer cells","volume":"64","author":"Liang","year":"2021","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/17501911.2025.2518918","article-title":"Dynamic modifications of circular RNAs drive oncogenesis","volume":"17","author":"Dai","year":"2025","journal-title":"Epigenomics"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"115177","DOI":"10.1016\/j.intimp.2025.115177","article-title":"Identification and prognostic potential of lactylation-related genes in sepsis: Implications of the RBM25-acly axis","volume":"162","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1007\/s11357-024-01137-9","article-title":"Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model","volume":"46","author":"Abudahab","year":"2024","journal-title":"Geroscience"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2478\/rir-2023-0002","article-title":"Animal models for large vessel vasculitis\u2014The unmet need","volume":"4","author":"Chu","year":"2023","journal-title":"Rheumatol. Immunol. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13550-023-01039-5","article-title":"[(18)F]FDG PET-MR characterization of aortitis in the IL1rn(-\/-) mouse model of giant-cell arteritis","volume":"13","author":"Deshayes","year":"2023","journal-title":"EJNMMI Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.191.2.303","article-title":"Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene","volume":"191","author":"Nicklin","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1161\/CIRCULATIONAHA.104.519132","article-title":"Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor","volume":"111","author":"Shepherd","year":"2005","journal-title":"Circulation"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"102804","DOI":"10.1016\/j.autrev.2021.102804","article-title":"Antibody glycosylation in autoimmune diseases","volume":"20","author":"Zhou","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41581-024-00850-0","article-title":"The role of antibody glycosylation in autoimmune and alloimmune kidney diseases","volume":"20","author":"Beyze","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40001-023-01035-4","article-title":"Altered glycosylation profiles of serum IgG in Takayasu arteritis","volume":"28","author":"Liu","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41584-022-00867-4","article-title":"Glycobiology of rheumatic diseases","volume":"19","author":"Kissel","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"111359","DOI":"10.1016\/j.isci.2024.111359","article-title":"Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis","volume":"27","author":"Gao","year":"2024","journal-title":"iScience"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"114815","DOI":"10.1016\/j.celrep.2024.114815","article-title":"Metabolite regulation of epigenetics in cancer","volume":"43","author":"Wang","year":"2024","journal-title":"Cell Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1093\/rheumatology\/keae225","article-title":"Fibroblast activation protein inhibitor-positron emission tomography in aortitis: Fibroblast pathology in active inflammation and remission","volume":"63","author":"Rosales","year":"2024","journal-title":"Rheumatology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.2147\/JIR.S478413","article-title":"Multi-Omics Exploration of the Role of PTGS2 as a Hub Gene in Ferroptosis Within the Artery of Takayasu Arteritis","volume":"17","author":"Gao","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Li, A., Wang, R., Zhao, Y., Zhao, P., and Yang, J. (2024). Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight. Metabolites, 14.","DOI":"10.3390\/metabo14060325"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Liu, W., Yang, R., Zhan, Y., Yang, X., Zeng, H., Chen, B., Zeng, J., Hu, T., Hu, J., and Xiao, Q. (2025). Lactate and lactylation: Emerging roles in autoimmune diseases and metabolic reprogramming. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1589853"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ajhg.2020.11.014","article-title":"Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study","volume":"108","author":"Coit","year":"2021","journal-title":"Am. J. Hum. Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:16:56Z","timestamp":1775449016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/7\/3249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":133,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27073249"],"URL":"https:\/\/doi.org\/10.3390\/ijms27073249","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}