{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:28:07Z","timestamp":1785432487845,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277099"],"award-info":[{"award-number":["22277099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201249"],"award-info":[{"award-number":["32201249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["22277099"],"award-info":[{"award-number":["22277099"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["32201249"],"award-info":[{"award-number":["32201249"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shaanxi Province Innovation Support Project","award":["2025ZY1-GNYZ-13"],"award-info":[{"award-number":["2025ZY1-GNYZ-13"]}]},{"name":"Shaanxi Key Laboratory of Natural Product & Chemical Biology Open Foundation","award":["SXNPCB 2024008"],"award-info":[{"award-number":["SXNPCB 2024008"]}]},{"name":"Shaanxi Provincial Key Project\u2014\u2018Four Chains\u2019 Integration Project of the Qinchuangyuan Industrial Cluster","award":["2024CY-JJQ-42"],"award-info":[{"award-number":["2024CY-JJQ-42"]}]},{"name":"Key Research and Development Program of Shaanxi Province\u2014Key Project\u2014Qinchuangyuan Industrial Innovation Cluster Area","award":["2025CY-JJQ-88"],"award-info":[{"award-number":["2025CY-JJQ-88"]}]},{"name":"Yangling Demonstration Zone Sci-Tech Program Projects","award":["S20251747"],"award-info":[{"award-number":["S20251747"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sanghuangporus vaninii (Ljub.) is an edible and medicinal macrofungus that has become the main strain for artificial cultivation of Sanghuang. In this study, twenty-six compounds (1\u201326), including five previously undescribed ergosterols, named sanghusterols A\u2013E (1\u20135), were isolated from the fruiting bodies of S. vaninii. Their structures were elucidated by spectroscopic methods and electronic circular dichroism (ECD) calculations. Compounds 1, 15, 17, 21 and 25 exhibited potent inhibitory activity against NO production with the IC50 value of 8.3\u201314.8 \u03bcM and dose-dependently decreased iNOS and COX-2 protein expression in RAW264.7 cells. Molecular docking studies confirmed the capacity of compounds 1, 15, 17, 21 and 25 to interact with iNOS and COX-2 proteins. These findings may provide a solid phytochemical and pharmacological basis for developing the mushroom as potential anti-inflammatory agents.<\/jats:p>","DOI":"10.3390\/ijms27073315","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:40:31Z","timestamp":1775554831000},"page":"3315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ergosteroid and Phenolic Constituents from the Mushroom Sanghuangporus vaninii with Anti-Inflammatory Activity"],"prefix":"10.3390","volume":"27","author":[{"given":"Yu-Xin","family":"Gao","sequence":"first","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Tong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almutamad","family":"Sheikho","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Northwest University, Xi\u2019an 710069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-6514","authenticated-orcid":false,"given":"Jin-Ming","family":"Gao","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shen, Z.Q., Jiang, J.H., Li, C.T., Li, Y., and Zhou, L.W. 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