{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:33Z","timestamp":1785418593235,"version":"3.56.0"},"reference-count":21,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Qi Huang Scholar Support Program","award":["GXQH202401"],"award-info":[{"award-number":["GXQH202401"]}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["FN2600640439"],"award-info":[{"award-number":["FN2600640439"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A2004"],"award-info":[{"award-number":["U20A2004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["U20A2004"],"award-info":[{"award-number":["U20A2004"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangxi Science and Technology Base and Talent Project","award":["AA21196009"],"award-info":[{"award-number":["AA21196009"]}]},{"name":"Guangxi Health Science College High-level Talents Project","award":["GXWZY202501"],"award-info":[{"award-number":["GXWZY202501"]}]},{"name":"Foundation of Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization","award":["ZRJJ2024-15"],"award-info":[{"award-number":["ZRJJ2024-15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Munronia pinnata (Meliaceae), a medicinal plant used in Zhuang traditional medicine, is recognized as a rich source of structurally diverse limonoids. In our continuing investigation of bioactive constituents from Guangxi medicinal plants, four new prieurianin-type limonoids, munropins G\u2013J (1\u20134), were isolated from their aerial parts. Their structures were determined through comprehensive spectroscopic analysis, including nuclear magnetic resonance and high-resolution mass spectrometry, and further supported by quantum chemical calculations for electronic circular dichroism and statistical probability analysis. Munropins G (1) and H (2) feature an unprecedented C-12 \u03b2-D-glucosylated \u03b1-methyl-2\u2032-hydroxypentanoate side chain and a C-17 \u03b2-substituted furan ring, with 1 being the 7-O-acetyl derivative of 2. Munropins I (3) and J (4) possess a formyl group at C-11, a 3-methyl-2-hydroxypentanoate ester at C-12, and a C-17 \u03b3-hydroxy-\u03b1,\u03b2-unsaturated \u03b3-lactone unit (21-hydroxy for 3, 23-hydroxy for 4), each existing as an equilibrating mixture of C-21 epimers\u2014a phenomenon observed for the first time within a prieurianin-type framework. The absolute configurations of 1 and 2 were established by quantum chemical electronic circular dichroism calculations, while those of 3 and 4 remain to be assigned. All compounds were evaluated for cytotoxicity against human lung (A549), liver (HepG2), breast (MCF-7), and colon (HCT116) cancer cell lines and for anti-inflammatory activity in lipopolysaccharide-induced RAW 264.7 murine macrophages, but none exhibited significant effects at a concentration of 80 \u03bcM. This study expands the chemical diversity of Munronia limonoids and provides new molecular scaffolds for future structure\u2013activity relationship investigations and chemotaxonomic markers for the Meliaceae family.<\/jats:p>","DOI":"10.3390\/ijms27073331","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:03:47Z","timestamp":1775563427000},"page":"3331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Munropins G\u2013J: Four New Prieurianin-Type Limonoids from Munronia pinnata and Their Structural and Molecular Characterization"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-3055","authenticated-orcid":false,"given":"Xuerong","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Guangxi Health Science College, Nanning 530023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi Health Science College, Nanning 530023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Yan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglai","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-3211","authenticated-orcid":false,"given":"Yoshiki","family":"Kashiwada","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqin","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9281-7098","authenticated-orcid":false,"given":"Naonobu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima 770-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Sciences, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","unstructured":"Wang, G.Q. 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