{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:13:47Z","timestamp":1788581627391,"version":"build-2803163510"},"reference-count":163,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["APP465536"],"award-info":[{"award-number":["APP465536"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"award":["APP465536"],"award-info":[{"award-number":["APP465536"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ferroptosis is an iron-dependent cell death driven by lipid peroxidation and failure of cellular antioxidant defenses. It is triggered by oxidative stress and can be aggravated by aging, inflammation, and dysregulation of iron homeostasis. In the central nervous system, iron dyshomeostasis, mitochondrial dysfunction, and membrane lipid remodeling can amplify oxidative injury and increase susceptibility to ferroptotic damage, particularly in vulnerable neurons. There is growing evidence that ferroptosis-related processes are linked to Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and Amyotrophic Lateral Sclerosis. This review addresses novel approaches to track ferroptosis in vivo, such as imaging and biomarker techniques, and important molecular mechanisms linking iron metabolism, reactive oxygen species, and PUFA-driven lipid peroxidation to neuronal damage. We also explore upstream transcriptional control via NRF2, iron chelation and iron-handling modulation, inhibition of lipid peroxidation, and reinforcement of the System Xc-GSH-GPX4 and CoQ10-linked defense pathways. Subsequently, we highlight translational issues that need attention to further progress ferroptosis-targeted therapies for neurodegenerative disease.<\/jats:p>","DOI":"10.3390\/ijms27083353","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:26:39Z","timestamp":1775661999000},"page":"3353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Oxidative Stress-Driven Ferroptosis in Neurodegeneration"],"prefix":"10.3390","volume":"27","author":[{"given":"Asma","family":"Rafique","sequence":"first","affiliation":[{"name":"Human Health Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleena","family":"Junaid","sequence":"additional","affiliation":[{"name":"Human Health Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9081-3539","authenticated-orcid":false,"given":"Marica","family":"Bakovic","sequence":"additional","affiliation":[{"name":"Human Health Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10495-023-01902-9","article-title":"Ferroptosis: Underlying mechanisms and involvement in neurodegenerative diseases","volume":"29","author":"Wang","year":"2024","journal-title":"Apoptosis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: A cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Fei, Y., and Ding, Y. (2024). The role of ferroptosis in neurodegenerative diseases. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1475934"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.tips.2023.07.007","article-title":"Therapeutic inhibition of ferroptosis in neurodegenerative disease","volume":"44","author":"Ryan","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Xu, W., Guo, Z.N., and Shao, A. (2023). Ferroptosis in stroke, neurotrauma and neurodegeneration, volume II. Front. Cell. Neurosci., 17.","DOI":"10.3389\/fncel.2023.1238425"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.tins.2025.06.008","article-title":"Triggering ferroptosis in neurodegenerative diseases","volume":"48","author":"Nguyen","year":"2025","journal-title":"Trends Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: Mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ji, Y., Zheng, K., Li, S., Ren, C., Shen, Y., Tian, L., Zhu, H., Zhou, Z., and Jiang, Y. (2022). Insight into the potential role of ferroptosis in neurodegenerative diseases. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.1005182"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cpt.2022.10.002","article-title":"Inaugurating a novel adjuvant therapy in urological cancers: Ferroptosis","volume":"1","author":"Xie","year":"2023","journal-title":"Cancer Pathog. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: New players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119911","DOI":"10.1016\/j.biomaterials.2020.119911","article-title":"Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator","volume":"241","author":"He","year":"2020","journal-title":"Biomaterials"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2300325","DOI":"10.1002\/advs.202300325","article-title":"Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/febs.15842","article-title":"Understanding the role of cysteine in ferroptosis: Progress & paradoxes","volume":"289","author":"Poltorack","year":"2022","journal-title":"FEBS J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102575","DOI":"10.1016\/j.arr.2024.102575","article-title":"Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways","volume":"102","author":"Alrouji","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2472871","DOI":"10.1080\/07853890.2025.2472871","article-title":"Role of iron in brain development, aging, and neurodegenerative diseases","volume":"57","author":"Gao","year":"2025","journal-title":"Ann. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ma, H., Dong, Y., Chu, Y., Guo, Y., and Li, L. (2022). The mechanisms of ferroptosis and its role in alzheimer\u2019s disease. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.965064"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/brv.12521","article-title":"Brain iron transport","volume":"94","author":"Qian","year":"2019","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175909142096268","DOI":"10.1177\/1759091420962681","article-title":"Iron metabolism in oligodendrocytes and astrocytes, implications for myelination and remyelination","volume":"12","author":"Cheli","year":"2020","journal-title":"ASN Neuro"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/WNL.0000000000207730","article-title":"What is the role of ferroptosis in neurodegeneration?","volume":"101","author":"Benarroch","year":"2023","journal-title":"Neurology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s11033-025-10338-0","article-title":"Ferroptosis in senescence and age-related diseases: Pathogenic mechanisms and potential intervention targets","volume":"52","author":"Liu","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Reichert, C.O., de Freitas, F.A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P.D., Levy, D., and Bydlowski, S.P. (2020). Ferroptosis mechanisms involved in neurodegenerative diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228765"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cerasuolo, M., Di Meo, I., Auriemma, M.C., Trojsi, F., Maiorino, M.I., Cirillo, M., Esposito, F., Polito, R., Colangelo, A.M., and Paolisso, G. (2023). Iron and ferroptosis more than a suspect: Beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and dementia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119637"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41420-023-01517-8","article-title":"Ferroptosis and the bidirectional regulatory factor p53","volume":"9","author":"Xu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: The new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lei, L., Lu, Q., Ma, G., Li, T., Deng, J., and Li, W. (2023). P53 protein and the diseases in central nervous system. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.1051395"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chen, X., Pang, X., Yeo, A.J., Xie, S., Xiang, M., Shi, B., Yu, G., and Li, C. (2022). The molecular mechanisms of ferroptosis and its role in blood-brain barrier dysfunction. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.889765"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106013","DOI":"10.1016\/j.phrs.2021.106013","article-title":"p53: A double-edged sword in tumor ferroptosis","volume":"177","author":"Ji","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: Implications for neurodegenerative diseases","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1093\/brain\/awaf398","article-title":"Iron on trial: Recasting the role of iron in neurodegeneration","volume":"148","author":"Ayton","year":"2025","journal-title":"Brain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2361202","DOI":"10.1080\/21688370.2024.2361202","article-title":"The role of reactive oxygen species in the regulation of the blood-brain barrier","volume":"13","author":"Shuvalova","year":"2025","journal-title":"Tissue Barriers"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chen, K., Jiang, X., Wu, M., Cao, X., Bao, W., and Zhu, L.Q. (2021). Ferroptosis, a potential therapeutic target in Alzheimer\u2019s disease. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.704298"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s10020-025-01208-3","article-title":"The interplay of iron, oxidative stress, and \u03b1-synuclein in Parkinson\u2019s disease progression","volume":"31","author":"Chen","year":"2025","journal-title":"Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhou, M., Xu, K., Ge, J., Luo, X., Wu, M., Wang, N., and Zeng, J. (2024). Targeting ferroptosis in Parkinson\u2019s disease: Mechanisms and emerging therapeutic strategies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313042"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dusek, P., Hofer, T., Alexander, J., Roos, P.M., and Aaseth, J.O. (2022). Cerebral iron deposition in neurodegeneration. Biomolecules, 12.","DOI":"10.3390\/biom12050714"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuint.2006.02.003","article-title":"Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration","volume":"49","author":"Radad","year":"2006","journal-title":"Neurochem. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"127190","DOI":"10.1016\/j.jtemb.2023.127190","article-title":"Meta-analysis of iron metabolism markers levels of Parkinson\u2019s disease patients determined by fluid and MRI measurements","volume":"78","author":"Xu","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/s12640-022-00538-y","article-title":"LUHMES dopaminergic neurons are uniquely susceptible to ferroptosis","volume":"40","author":"Tong","year":"2022","journal-title":"Neurotox. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00702-023-02630-9","article-title":"Lewy bodies, iron, inflammation and neuromelanin: Pathological aspects underlying Parkinson\u2019s disease","volume":"130","author":"Riederer","year":"2023","journal-title":"J. Neural Transm."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00018-022-04240-2","article-title":"Initiation and progression of \u03b1-synuclein pathology in Parkinson\u2019s disease","volume":"79","author":"Tofaris","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1007\/s12035-023-03245-7","article-title":"The role of iron metabolism, lipid metabolism, and redox homeostasis in Alzheimer\u2019s disease: From the perspective of ferroptosis","volume":"60","author":"Wu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pal, A., Cerchiaro, G., Rani, I., Ventriglia, M., Rongioletti, M., Longobardi, A., and Squitti, R. (2022). Iron in Alzheimer\u2019s disease: From physiology to disease disabilities. Biomolecules, 12.","DOI":"10.3390\/biom12091248"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wu, Y.H., and Hsieh, H.L. (2022). Roles of heme oxygenase-1 in neuroinflammation and brain disorders. Antioxidants, 11.","DOI":"10.3390\/antiox11050923"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/physrev.00030.2022","article-title":"Oxidative damage in neurodegeneration: Roles in the pathogenesis and progression of Alzheimer disease","volume":"104","author":"Perluigi","year":"2024","journal-title":"Physiol. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1055\/a-2084-3561","article-title":"Ferroptosis signaling pathways: Alzheimer\u2019s disease","volume":"55","author":"Maheshwari","year":"2023","journal-title":"Horm. Metab. Res."},{"key":"ref_51","first-page":"e98243","article-title":"Overview of Huntington\u2019s Disease and Emerging Treatment Strategies: A Narrative Review","volume":"17","author":"Vega","year":"2025","journal-title":"Cureus"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3999083","DOI":"10.1155\/2022\/3999083","article-title":"Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1002\/mco2.298","article-title":"Iron homeostasis imbalance and ferroptosis in brain diseases","volume":"4","author":"Long","year":"2023","journal-title":"MedComm"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Maity, S., Komal, P., Kumar, V., Saxena, A., Tungekar, A., and Chandrasekar, V. (2022). Impact of ER stress and ER-mitochondrial crosstalk in Huntington\u2019s disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020780"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ma, J., Liu, J., Chen, S., Zhang, W., Wang, T., Cao, M., Yang, Y., Du, Y., Cui, G., and Du, Z. (2024). Understanding the Mechanism of Ferroptosis in Neurodegenerative Diseases. Front. Biosci., 29.","DOI":"10.31083\/j.fbl2908291"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tucci, P., Lattanzi, R., Severini, C., and Saso, L. (2022). Nrf2 pathway in huntington\u2019s disease (hd): What is its role?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315272"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhou, C.H., and Zhu, Y.C. (2025). Imaging of cerebral iron as an emerging marker for brain aging, neurodegeneration, and cerebrovascular diseases. Brain Sci., 15.","DOI":"10.3390\/brainsci15090944"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1101\/gad.350211.122","article-title":"ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington\u2019s disease","volume":"37","author":"Song","year":"2023","journal-title":"Genes Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e70641","DOI":"10.1111\/jcmm.70641","article-title":"Downregulation of Alox5 Inhibits Ferroptosis to Improve Doxorubicin-Induced Cardiotoxicity via the P53\/SLC7A11 Pathway","volume":"29","author":"Fang","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Liu, M., Zhao, J., Xue, C., Yang, J., and Ying, L. (2024). Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington\u2019s disease. BMC Genom., 25.","DOI":"10.1186\/s12864-024-10534-5"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Verma, A., and DM, M. (2021). Clinical manifestation and management of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis, Exon Publications.","DOI":"10.36255\/exonpublications.amyotrophiclateralsclerosis.management.2021"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s12035-021-02658-6","article-title":"Neuromuscular junction dysfunction in amyotrophic lateral sclerosis","volume":"59","author":"Verma","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, L., Fang, X., Ling, B., Wang, F., Xia, Y., Zhang, W., Zhong, T., and Wang, X. (2024). Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1359453"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dong, K., Liu, B., Cheng, G., Li, Y., Xie, F., Zhang, J., and Qian, L. (2025). Stress-Induced Dysregulation of Brain Iron Metabolism and Its Links to Neurological Disorders. Biology, 14.","DOI":"10.3390\/biology14111575"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Park, H.R., and Yang, E.J. (2021). Oxidative stress as a therapeutic target in amyotrophic lateral sclerosis: Opportunities and limitations. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091546"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jare.2022.02.016","article-title":"GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS","volume":"43","author":"Tu","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1046\/j.1471-4159.2003.01923.x","article-title":"Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson\u2019s disease","volume":"86","author":"Faucheux","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00702-017-1695-x","article-title":"Alpha-synuclein and iron: Two keys unlocking Parkinson\u2019s disease","volume":"124","author":"Lingor","year":"2017","journal-title":"J. Neural Transm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41419-024-07152-0","article-title":"The link between amyloid \u03b2 and ferroptosis pathway in Alzheimer\u2019s disease progression","volume":"15","author":"Salinas","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12017-018-8518-6","article-title":"The emerging roles of ferroptosis in Huntington\u2019s disease","volume":"21","author":"Mi","year":"2019","journal-title":"Neuromol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/neup.13033","article-title":"Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis","volume":"45","author":"Shibata","year":"2025","journal-title":"Neuropathology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"eado8499","DOI":"10.1126\/sciadv.ado8499","article-title":"Amyloid fibril structures and ferroptosis activation induced by ALS-causing SOD1 mutations","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Russo, A., Putaggio, S., Tellone, E., Calderaro, A., Cirmi, S., Lagan\u00e0, G., Ficarra, S., Barreca, D., and Patan\u00e8, G.T. (2025). Emerging ferroptosis involvement in amyotrophic lateral sclerosis pathogenesis: Neuroprotective activity of polyphenols. Molecules, 30.","DOI":"10.3390\/molecules30061211"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41556-024-01377-z","article-title":"A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility","volume":"26","author":"Morgan","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11011-025-01587-w","article-title":"Ferroptosis and Alzheimer\u2019s: Unveiling new avenues for the treatment and prevention","volume":"40","author":"Sharma","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s10787-025-01672-7","article-title":"Ferroptosis role in complexity of cell death: Unrevealing mechanisms in Parkinson\u2019s disease and therapeutic approaches","volume":"33","author":"Awasthi","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1056\/NEJMoa2209254","article-title":"Trial of deferiprone in Parkinson\u2019s disease","volume":"387","author":"Devos","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41598-017-01402-2","article-title":"Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson\u2019s disease","volume":"7","author":"Ward","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"da Cunha Germano, B.C., de Morais, L.C., Idalina Neta, F., Fernandes, A.C., Pinheiro, F.I., do Rego, A.C., Ara\u00fajo Filho, I., de Azevedo, E.P., de Paiva Cavalcanti, J.R., and Guzen, F.P. (2023). Vitamin E and its molecular effects in experimental models of neurodegenerative diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311191"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chu, J., Li, J., Sun, L., and Wei, J. (2023). The role of cellular defense systems of ferroptosis in Parkinson\u2019s disease and Alzheimer\u2019s disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814108"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Artusi, I., Rubin, M., Cravin, G., and Cozza, G. (2025). Ferroptosis in Human Diseases: Fundamental Roles and Emerging Therapeutic Perspectives. Antioxidants, 14.","DOI":"10.3390\/antiox14121411"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"776","DOI":"10.2174\/1389450121666200220123305","article-title":"Edaravone may prevent ferroptosis in ALS","volume":"21","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Tian, H.Y., Huang, B.Y., Nie, H.F., Chen, X.Y., Zhou, Y., Yang, T., Cheng, S.W., Mei, Z.G., and Ge, J.W. (2023). The interplay between mitochondrial dysfunction and ferroptosis during ischemia-associated central nervous system diseases. Brain Sci., 13.","DOI":"10.20944\/preprints202308.0327.v1"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Parsons, A.L., Bucknor, E.M., Castroflorio, E., Soares, T.R., Oliver, P.L., and Rial, D. (2022). The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy. Antioxidants, 11.","DOI":"10.3390\/antiox11010157"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1007\/s10072-022-06302-6","article-title":"Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures","volume":"43","author":"Sun","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/STROKEAHA.122.037155","article-title":"Role of inflammatory processes in hemorrhagic stroke","volume":"54","author":"Ohashi","year":"2023","journal-title":"Stroke"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: Molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1515\/revneuro-2020-0131","article-title":"The physiopathology of spontaneous hemorrhagic stroke: A systematic review","volume":"32","author":"Rego","year":"2021","journal-title":"Rev. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10571-020-00850-1","article-title":"Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation","volume":"41","author":"Li","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Huang, S., Li, S., Feng, H., and Chen, Y. (2021). Iron metabolism disorders for cognitive dysfunction after mild traumatic brain injury. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.587197"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Lu, X., Tai, B., Li, W., and Li, T. (2021). Ferroptosis and its multifaceted roles in cerebral stroke. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.615372"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"22033","DOI":"10.1021\/acs.jmedchem.5c01512","article-title":"Emerging Molecular PET Imaging for Cell Death in Neurodegenerative Diseases","volume":"68","author":"Zhang","year":"2025","journal-title":"J. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e70112","DOI":"10.1111\/jon.70112","article-title":"Neurodegeneration With Brain Iron Accumulation and Ferroptosis Disorders in Children and Adults: An Imaging Review","volume":"35","author":"Mertiri","year":"2025","journal-title":"J. Neuroimaging"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1080\/15548627.2024.2319901","article-title":"International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis","volume":"20","author":"Chen","year":"2024","journal-title":"Autophagy"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"06RM01","DOI":"10.1088\/1361-6560\/abd4f7","article-title":"Quantitative PET in the 2020s: A roadmap","volume":"66","author":"Meikle","year":"2021","journal-title":"Phys. Med. Biol."},{"key":"ref_96","first-page":"179","article-title":"Visualization of ferroptosis in brain diseases and ferroptosis-inducing nanomedicine for glioma","volume":"13","author":"Wang","year":"2023","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1039\/D0OB00126K","article-title":"18 F-Labeled dihydromethidine: Positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain","volume":"18","author":"Egami","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1039\/D1CS01167G","article-title":"Recent advances in small-molecule fluorescent probes for studying ferroptosis","volume":"51","author":"Qi","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"127519","DOI":"10.1016\/j.saa.2026.127519","article-title":"A rapid-response NIR fluorescent probe for imaging Cys\/Hcy in ferroptosis and inflammation models","volume":"352","author":"Gong","year":"2026","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1039\/C6SC05457A","article-title":"A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells","volume":"8","author":"Hirayama","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Flores, C.A., and Yang, W.S. (2026). Detection of Ferroptosis by Liperfluo and BODIPY\u2122 581\/591 C11. Immune Mediators in Cancer: Methods in Molecular Biology, Springer.","DOI":"10.1007\/978-1-0716-4901-5_13"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: A review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"104039","DOI":"10.1016\/j.redox.2026.104039","article-title":"A LNK\u2013CBL\u2013HNRPA2B1\u2013GPX4 Signaling Axis Mediates Dopaminergic Neuron Vulnerability to Ferroptosis in Parkinson\u2019s disease","volume":"90","author":"Liu","year":"2026","journal-title":"Redox Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"983245","DOI":"10.1155\/2012\/983245","article-title":"Chelators in the treatment of iron accumulation in Parkinson\u2032s disease","volume":"2012","author":"Mounsey","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"101890","DOI":"10.1016\/j.pneurobio.2020.101890","article-title":"Ferroptosis and its potential role in the physiopathology of Parkinson\u2019s Disease","volume":"196","author":"Bouchaoui","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"ref_106","first-page":"e29696","article-title":"The role of glutathione metabolism in chronic illness development and its potential use as a novel therapeutic target","volume":"14","author":"Hristov","year":"2022","journal-title":"Cureus"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Kumari, M. (2026). Nutritional Strategies for Neuroprotection: Vitamins, Minerals, and Beyond. Nourishing the Brain: Diet and Nutrition Strategies in Managing Neurological Disorders, Springer Nature.","DOI":"10.1007\/978-981-95-4169-0_4"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"7769355","DOI":"10.1155\/2022\/7769355","article-title":"Quercetin Protects against MPP+\/MPTP-Induced Dopaminergic Neuron Death in Parkinson\u2019s Disease by Inhibiting Ferroptosis","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e03337","DOI":"10.1002\/cbdv.202503337","article-title":"Alkaloid Components From Orychophragmus violaceus and Their Ferroptosis Inhibition Activity","volume":"23","author":"Chen","year":"2026","journal-title":"Chem. Biodivers."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tuo, Q.Z., Bush, A.I., and Lei, P. (2026). Ferroptosis in neurological diseases: Moving towards therapeutic intervention. Mol. Psychiatry.","DOI":"10.1038\/s41380-026-03445-2"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Sonkar, P., Saif, M., and Sonkar, A. (2026). Dementia and Diet: How Nutrients Can Influence Cognitive Decline. Nourishing the Brain: Diet and Nutrition Strategies in Managing Neurological Disorders, Springer Nature.","DOI":"10.1007\/978-981-95-4169-0_10"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Du, Z.R., Li, C., Cai, M.Y., Liu, X., Chen, T.Q., Sun, C.C., Chen, W.F., Zhou, S.N., Yuan, S.X., and Zhao, Z.C. (2026). Selenium nanoparticles functionalized by mushroom polysaccharides potentiated neuroprotection of selenium against Parkinson\u2019s disease with lower toxicity. Food Sci. Hum. Wellness, 16.","DOI":"10.26599\/FSHW.2026.9250936"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/08919887251361578","article-title":"Targeting Inflammation in Alzheimer\u2019s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review","volume":"39","author":"Topalis","year":"2026","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10072-025-08689-4","article-title":"Programmed cell death pathways in huntington\u2019s disease: Spotlight on ferroptosis and pyroptosis","volume":"47","author":"Sharma","year":"2026","journal-title":"Neurol. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.7150\/thno.50663","article-title":"Novel insights into ferroptosis: Implications for age-related diseases","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Samaddar, S., Redhwan, M.A., and Eraiah, M.M. (2026). Exploring the Efficacy of Natural Anti-inflammatory Compounds in Neurological Disorders. Nourishing the Brain: Diet and Nutrition Strategies in Managing Neurological Disorders, Springer Nature.","DOI":"10.1007\/978-981-95-4169-0_7"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/bph.14881","article-title":"CuII (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease","volume":"177","author":"Southon","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Fujii, J., Osaki, T., Soma, Y., and Matsuda, Y. (2023). Critical roles of the cysteine\u2013glutathione axis in the production of \u03b3-glutamyl peptides in the nervous system. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098044"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1080\/87559129.2025.2466446","article-title":"Nano-Delivery Systems for Carotenoids: Enhancing Bioavailability and Therapeutic Potential in Neurodegenerative Diseases","volume":"41","author":"Golshany","year":"2025","journal-title":"Food Rev. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"108382","DOI":"10.5498\/wjp.v15.i9.108382","article-title":"Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders","volume":"15","author":"Zhang","year":"2025","journal-title":"World J. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"8832992","DOI":"10.1155\/jare\/8832992","article-title":"Modulating ferroptosis in aging: The therapeutic potential of natural products","volume":"2025","author":"Hamidu","year":"2025","journal-title":"J. Aging Res."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Cheng, H., Wang, P., Wang, N., Dong, W., Chen, Z., Wu, M., Wang, Z., Yu, Z., Guan, D., and Wang, L. (2023). Neuroprotection of NRF2 against ferroptosis after traumatic brain injury in mice. Antioxidants, 12.","DOI":"10.3390\/antiox12030731"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4911205","DOI":"10.1155\/2022\/4911205","article-title":"Iron Chelators in Treatment of Iron Overload","volume":"2022","author":"Entezari","year":"2022","journal-title":"J. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1021\/acs.jafc.5c08948","article-title":"Ferroptosis in Mycotoxin-Induced Toxicity: Molecular Mechanisms, Intervention Implications, and Future Directions","volume":"74","author":"Zhu","year":"2026","journal-title":"J. Agric. Food Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2269331","DOI":"10.1080\/13510002.2023.2269331","article-title":"Deeper insight into ferroptosis: Association with Alzheimer\u2019s, Parkinson\u2019s disease, and brain tumors and their possible treatment by nanomaterials induced ferroptosis","volume":"28","author":"Yadav","year":"2023","journal-title":"Redox Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"107370","DOI":"10.1016\/j.phrs.2024.107370","article-title":"Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases","volume":"208","author":"Jiao","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00204-023-03660-8","article-title":"Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases","volume":"98","author":"Xiang","year":"2024","journal-title":"Arch. Toxicol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e71192","DOI":"10.1002\/brb3.71192","article-title":"Research Progress of Ferroptosis in Cerebral Infarction","volume":"16","author":"Fei","year":"2026","journal-title":"Brain Behav."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1021\/acschemneuro.5c00998","article-title":"Griess\u2019s Reagent-Based Azo Compounds Ameliorate Multifaceted Toxicity and Ferroptosis in Alzheimer\u2019s Disease","volume":"17","author":"Kumar","year":"2026","journal-title":"ACS Chem. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"122629","DOI":"10.1016\/j.lfs.2024.122629","article-title":"Recent advancements in nanomaterial-mediated ferroptosis-induced cancer therapy: Importance of molecular dynamics and novel strategies","volume":"346","author":"Dhas","year":"2024","journal-title":"Life Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/jop.70069","article-title":"Panax notoginseng Saponins Alleviate OSF by Inhibiting Ferroptosis Through GPX4 Activation","volume":"55","author":"Zhang","year":"2026","journal-title":"J. Oral Pathol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Lu, M., Zhou, Y., Sun, L., Shafi, S., Ahmad, N., Sun, M., and Dong, J. (2022). The molecular mechanisms of ferroptosis and its role in glioma progression and treatment. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.917537"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Zaffaroni, N., and Beretta, G.L. (2021). Nanoparticles for ferroptosis therapy in cancer. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111785"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0021-5198(19)40027-9","article-title":"The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice","volume":"52","author":"Ishikawa","year":"1990","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"114930","DOI":"10.1016\/j.biopha.2023.114930","article-title":"Vitamin A metabolites inhibit ferroptosis","volume":"164","author":"Jakaria","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_136","unstructured":"Kumar, S., Mishra, D.K., Usmani, N., and Kumar, H. (2024). Vitamins and Their Role in Brain Function. Optimizing Brain Health and Performance Through Essential Nutrients and Lifestyle Changes, SAAR Publications."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Zhang, M., Chen, X., and Zhang, Y. (2024). Mechanisms of vitamins inhibiting ferroptosis. Antioxidants, 13.","DOI":"10.3390\/antiox13121571"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Gulcin, \u0130., and Alwasel, S.H. (2025). Fe3+ reducing power as the most common assay for understanding the biological functions of antioxidants. Processes, 13.","DOI":"10.3390\/pr13051296"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e70067","DOI":"10.1111\/cns.70067","article-title":"Vitamin D3 Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKC\u03b1\/NOX4 Signaling Pathway","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3892\/ijmm.2023.5330","article-title":"Roles of vitamin K-dependent protein in biomineralization","volume":"53","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","article-title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","volume":"608","author":"Mishima","year":"2022","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s42255-023-00821-y","article-title":"Diverse biological functions of vitamin K: From coagulation to ferroptosis","volume":"5","author":"Mishima","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Winter, A.N., and Bickford, P.C. (2019). Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease. Antioxidants, 8.","DOI":"10.3390\/antiox8090333"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.foodres.2019.02.030","article-title":"Neuroprotective effect of ju\u00e7ara (Euterpe edulis Martius) fruits extracts against glutamate-induced oxytosis in HT22 hippocampal cells","volume":"120","author":"Schulz","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Yang, H., Hong, Y., Gong, M., Cai, S., Yuan, Z., Feng, S., Chen, Q., Liu, X., and Mei, Z. (2024). Fisetin exerts neuroprotective effects in vivo and in vitro by inhibiting ferroptosis and oxidative stress after traumatic brain injury. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1480345"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chahal, S.K., Kabra, A., Saeedan, A.S., and Ansari, M.N. (2026). Fisetin: A multitarget flavonol bridging oxidative stress, inflammation, aging, and cancer. Naunyn Schmiedeberg Arch. Pharmacol.","DOI":"10.1007\/s00210-025-04912-3"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"14","DOI":"10.61186\/nl.3.2.14","article-title":"Neuroprotective role of Fisetin in Alzheimer\u2019s disease: An overview of potential mechanism and clinical findings","volume":"3","author":"Nabizadeh","year":"2024","journal-title":"Neurol. Lett."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/0118715249264078231214074107","article-title":"Effect of flavonoids against Parkinson\u2019s disease","volume":"24","author":"Varshney","year":"2024","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3233\/BPL-200104","article-title":"Preventing and treating neurological disorders with the flavonol fisetin","volume":"6","author":"Maher","year":"2020","journal-title":"Brain Plast."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1007\/s12035-023-03469-7","article-title":"The neuroprotective role of fisetin in different neurological diseases: A systematic review","volume":"60","author":"Jiang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Kontoghiorghes, G.J. (2024). The importance and essentiality of natural and synthetic chelators in medicine: Increased prospects for the effective treatment of iron overload and iron deficiency. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094654"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Khan, M.S., Hu, Q., Okeibunor, K., Ma, L., and Bopassa, J.C. (2025). Targeting ferroptosis for neuroprotection: Potential therapeutic avenues in neurodegenerative and neuropsychiatric diseases. Front. Physiol., 16.","DOI":"10.3389\/fphys.2025.1641323"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s10571-023-01353-5","article-title":"Future perspectives of oxytosis\/ferroptosis research in neurodegeneration diseases","volume":"43","author":"Viktorinova","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Tanaka, M. (2025). Parkinson\u2019s Disease: Bridging Gaps, Building Biomarkers, and Reimagining Clinical Translation. Cells, 14.","DOI":"10.20944\/preprints202506.2099.v2"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12964-021-00799-8","article-title":"Regulated cell death: Discovery, features and implications for neurodegenerative diseases","volume":"19","author":"Cui","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Ficiar\u00e0, E., Munir, Z., Boschi, S., Caligiuri, M.E., and Guiot, C. (2021). Alteration of iron concentration in Alzheimer\u2019s disease as a possible diagnostic biomarker unveiling ferroptosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094479"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Yi, Y., Jia, P., Xie, P., Peng, X., Zhu, X., Yin, S., Luo, Y., Deng, Y., and Wan, L. (2025). Beyond oxidative stress: Ferroptosis as a novel orchestrator in neurodegenerative disorders. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1683876"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.chembiol.2021.04.011","article-title":"Targeted protein degradation: A promise for undruggable proteins","volume":"28","author":"Samarasinghe","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/ddr.22115","article-title":"Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges","volume":"84","author":"Tiwari","year":"2023","journal-title":"Drug Dev. Res."},{"key":"ref_160","first-page":"888292","article-title":"Exploring the Role of Melatonin in Disease Prevention and Anti-Aging","volume":"Volume 14","author":"Das","year":"2024","journal-title":"Biotech Miracles: Harnessing the Power of Microbes"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-024-00728-6","article-title":"Melatonin: A ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration","volume":"19","author":"Yehia","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2174\/0113894501284110240426074746","article-title":"Therapeutic effects of Melatonin in the regulation of ferroptosis: A review of current evidence","volume":"25","author":"Pourhanifeh","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Mollica, L., Cupaioli, F.A., Rossetti, G., and Chiappori, F. (2022). An overview of structural approaches to study therapeutic RNAs. Front. Mol. 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