{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:15:22Z","timestamp":1790126122167,"version":"4.0.1"},"reference-count":124,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian state contract","award":["FGFU-2025-0004"],"award-info":[{"award-number":["FGFU-2025-0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The effective treatment of neurodegenerative diseases (NDDs), such as Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis, remains a critical challenge in modern medicine. Given the limitations of current therapies, alternative strategies to slow neurodegeneration are urgently needed. This study presents a critical review of the current evidence regarding low-dose ionizing radiation (IR) as a promising modality for modulating neurodegenerative processes. This study examines current experimental data on the effects of low-dose IR (LDIR) on cellular protective and compensatory mechanisms, including evidence from in vivo models of NDDs. Our analysis demonstrates that LDIR enhances antioxidant activity and DNA repair, stimulates autophagy and neuroplasticity, and modulates neuroinflammatory signaling. Collectively, these findings support the hypothesis of the neuroprotective potential of LDIR, underscoring its translational viability provided that strict dosimetric guidelines are followed and individual biological responses are rigorously monitored.<\/jats:p>","DOI":"10.3390\/ijms27083368","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:56:07Z","timestamp":1775724967000},"page":"3368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights into the Impact of Low-Dose Ionizing Radiation on Neurodegenerative Disease Progression in In Vivo Models"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-4303","authenticated-orcid":false,"given":"Valeria V.","family":"Goloborshcheva","sequence":"first","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana S.","family":"Kostikova","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-3581","authenticated-orcid":false,"given":"Valerian G.","family":"Kucheryanu","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei G.","family":"Morozov","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-4356","authenticated-orcid":false,"given":"Viktor S.","family":"Kokhan","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10522-020-09908-5","article-title":"Low-dose ionizing radiation as a hormetin: Experimental observations and therapeutic perspective for age-related disorders","volume":"22","author":"Vaiserman","year":"2021","journal-title":"Biogerontology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s11033-022-08211-5","article-title":"Therapeutic potential of low dose ionizing radiation against cancer, dementia, and diabetes: Evidences from epidemiological, clinical, and preclinical studies","volume":"50","author":"Paithankar","year":"2023","journal-title":"Mol. 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