{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:40:15Z","timestamp":1787856015899,"version":"build-2784847793"},"reference-count":100,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81802576"],"award-info":[{"award-number":["81802576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["81802576"],"award-info":[{"award-number":["81802576"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Wuxi Commission of Health and Family Planning","award":["M202330"],"award-info":[{"award-number":["M202330"]}]},{"name":"Talent Plan of Taihu Lake in Wuxi","award":["BJ2023051"],"award-info":[{"award-number":["BJ2023051"]}]},{"name":"Jiangsu Province 7th phase \u2018333\u2019 high-level talents"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetic Bladder Disease (DBD), a common urological complication of diabetes mellitus, severely compromises the quality of life of affected patients. Mitochondria, the primary energy-producing organelles in cells, are closely correlated with the pathogenesis and progression of DBD. As an emerging therapeutic modality, mitochondrial transplantation exhibits substantial potential for the management of DBD. This paper presents a comprehensive review of mitochondrial transplantation, with a focus on its fundamental theories, application conditions, safety profiles, and mitochondrial sources. Subsequently, we explore the association between mitochondrial dysfunction and the pathological mechanisms underlying DBD, analyze the disparities between mitochondrial transplantation and conventional therapeutic approaches, and discuss the prospects of combined and personalized treatment regimens. Finally, this review summarizes the ethical controversies surrounding this therapeutic strategy and outlines future research trends, aiming to lay a theoretical foundation for the development of novel therapeutic modalities against DBD.<\/jats:p>","DOI":"10.3390\/ijms27083379","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:21:32Z","timestamp":1775737292000},"page":"3379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Potential of Mitochondrial Transplantation with Focus on DBD"],"prefix":"10.3390","volume":"27","author":[{"given":"Chen","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6690-9708","authenticated-orcid":false,"given":"Sixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"},{"name":"Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-523X","authenticated-orcid":false,"given":"Yuanyuan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hughes, F.M., Odom, M.R., Cervantes, A., and Purves, J.T. 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