{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:30Z","timestamp":1785412530245,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretar\u00eda de Educaci\u00f3n, Ciencia, Tecnolog\u00eda e Innovaci\u00f3n of Mexico City","award":["SECTEI\/162\/2023"],"award-info":[{"award-number":["SECTEI\/162\/2023"]}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["R-2020-785-131"],"award-info":[{"award-number":["R-2020-785-131"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R-2020-785-131"],"award-info":[{"award-number":["R-2020-785-131"]}],"id":[{"id":"https:\/\/ror.org\/03xddgg98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To analyze, in an analytical cross-sectional observational study, the relationship between the plasma microRNA (miRNA) expression profile in children living with obesity and their metabolic health status. Based on body mass index percentiles (BMIp), the children were grouped into a control group (C) or an obesity group (Ob). Glucose, insulin, and low- and high-density lipoproteins (LDLs and HDLs, respectively), triacylglycerols (TG), and total cholesterol (TC) were measured. RNA from plasma was used for miRNA sequencing analysis (NextSeq 2000 platform). Differential miRNA expression was determined using counts obtained from the reference genome. Fifty controls (BMIp: 50.4 \u00b1 23) and fifty children with obesity (BMIp: 97.54 \u00b1 1.46) were included. The obese group presented hyperinsulinemia and insulin resistance. Sequencing revealed nine underexpressed and six overexpressed miRNAs in the obese group. In silico analysis suggested that these miRNAs may participate in regulating insulin secretion, protein synthesis, apoptosis, and the glycolytic pathway in pancreatic \u03b2-cells. Childhood obesity was associated with altered circulating levels of microRNAs linked to glucose metabolism, insulin resistance (IR) and \u03b2-cell survival. Reduced plasma levels of miR-126-3p, let-7a-5p, and miR-16-5p showed a high predictive value for hypertriglyceridemia and insulin resistance, indicating their potential relevance as early biomarkers or therapeutic targets in pediatric metabolic dysfunction.<\/jats:p>","DOI":"10.3390\/ijms27083396","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:55:12Z","timestamp":1775807712000},"page":"3396","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Expression of microRNAs in Obese Mexican Children: Links to Insulin Resistance and Dyslipidemia"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-9927","authenticated-orcid":false,"given":"Alejandra","family":"Contreras-Ramos","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico Federico G\u00f3mez (HIMFG), Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-5771","authenticated-orcid":false,"given":"Guadalupe","family":"D\u00edaz-Rosas","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico Federico G\u00f3mez (HIMFG), Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-6172","authenticated-orcid":false,"given":"Miguel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5512-7224","authenticated-orcid":false,"given":"Ana","family":"Nava-Cabrera","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-0488","authenticated-orcid":false,"given":"Miguel","family":"Vazquez-Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1768-9952","authenticated-orcid":false,"given":"Omar","family":"G\u00f3mez-Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico Federico G\u00f3mez (HIMFG), Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Guerrero-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico Federico G\u00f3mez (HIMFG), Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Dom\u00ednguez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"OOAD Campeche, Coordinaci\u00f3n de Planeaci\u00f3n y Enlace Institucional, Instituto Mexicano del Seguro Social, Campeche 24010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-536X","authenticated-orcid":false,"given":"Aleyda","family":"P\u00e9rez-Herrera","sequence":"additional","affiliation":[{"name":"M\u00e9xico SECIHTI, CIIDIR-Unidad Oaxaca, Instituto Polit\u00e9cnico Nacional, Santa Cruz Xoxocotl\u00e1n 71233, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-2288","authenticated-orcid":false,"given":"Rosalinda","family":"Jim\u00e9nez-Aguilar","sequence":"additional","affiliation":[{"name":"Unidad M\u00e9dica de Alta Especialidad, Hospital General Gaudencio Gonz\u00e1lez de la Garza, Centro M\u00e9dico Nacional \u201cLa Raza\u201d, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 02990, 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