{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:23:19Z","timestamp":1790871799134,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peripheral nerve injury is a leading cause of disability, which can result in partial or complete loss of motor, sensory, and autonomic function, and currently, there is no effective treatment for this incapacitating condition. It is important to identify new compounds that enable rapid and complete functional recovery. This study evaluated the effects of isorhamnetin (ISO) on functional rehabilitation in a mouse model of sciatic nerve injury. A total of 30 BALB\/c mice, aged 8\u201310 weeks, were randomly assigned to three groups: sham, control, and treatment (n = 10\/group). The mice in the ISO and Ctrl groups were operated on, whilst the animals in the sham group had their sciatic nerves exposed but left intact without crushing. The Ctrl and Sham groups received DMSO and normal saline intraperitoneally in equal volumes. In contrast, the ISO-treated group received ISO (10 mg\/kg) dissolved in DMSO intraperitoneally from the day of nerve crush until the end of the study. All groups were fed regular chow and provided with sufficient water throughout the experiment. Behavioural analyses evaluated sensorimotor function recovery. Biochemical and haematological assays quantified oxidative stress markers and total blood count, while morphometric analysis determined structural recovery of muscle fibers. Nerve regeneration was indirectly evaluated by analyzing S100\u03b2 protein levels and proinflammatory cytokines (IL-6 and TNF-\u03b1) expression. In the mouse model, ISO treatment resulted in substantial improvement in sensorimotor function recovery (p &lt; 0.001). A substantial difference (p &lt; 0.001) in blood glucose levels and oxidative stress markers was observed among all groups. The treated group displayed a remarkable improvement in the cross-sectional area of muscle fibers. At the end of the study, it was noted that ISO treatment significantly downregulated the expression of S100\u03b2, TNF-\u03b1, and IL-6, suggesting a positive impact of ISO on nerve regeneration. These findings indicate that ISO expedites the restoration of sensorimotor function following sciatic nerve injury by modulating S100\u03b2 and proinflammatory cytokine expression and improving oxidative stress.<\/jats:p>","DOI":"10.3390\/ijms27083624","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:24:23Z","timestamp":1776673463000},"page":"3624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of S100\u03b2 and Inflammatory Signalling by Isorhamnetin Enhances Peripheral Nerve Regeneration"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3527-9825","authenticated-orcid":false,"given":"Ammara","family":"Tehreem","sequence":"first","affiliation":[{"name":"Neuroregeneration and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-3455","authenticated-orcid":false,"given":"Arslan","family":"Iftikhar","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-0180","authenticated-orcid":false,"given":"Ikram Ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-7789","authenticated-orcid":false,"given":"Ghulam","family":"Hussain","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1545968315604399","article-title":"Electrical stimulation to promote peripheral nerve regeneration","volume":"30","author":"Willand","year":"2016","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.21037\/atm.2019.11.18","article-title":"Isoquercitrin promotes peripheral nerve regeneration through inhibiting oxidative stress following sciatic crush injury in mice","volume":"7","author":"Qiu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"116645","DOI":"10.1016\/j.biopha.2024.116645","article-title":"Advances of Schwann cells in peripheral nerve regeneration: From mechanism to cell therapy","volume":"175","author":"Wei","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dong, S., Feng, S., Chen, Y., Chen, M., Yang, Y., Zhang, J., Li, H., Li, X., Ji, L., and Yang, X. (2021). Nerve suture combined with ADSCs injection under real-time and dynamic NIR-II fluorescence imaging in peripheral nerve regeneration in vivo. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.676928"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jphs.2017.08.007","article-title":"Crocetin attenuates spared nerve injury-induced neuropathic pain in mice","volume":"135","author":"Wang","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16431","DOI":"10.1523\/JNEUROSCI.2119-15.2015","article-title":"Role of IL-10 in resolution of inflammation and functional recovery after peripheral nerve injury","volume":"35","author":"Mietto","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gu, D., Xia, Y., Ding, Z., Qian, J., Gu, X., Bai, H., Jiang, M., and Yao, D. (2024). Inflammation in the peripheral nervous system after injury. Biomedicines, 12.","DOI":"10.3390\/biomedicines12061256"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/mus.27086","article-title":"Metabolic syndrome and peripheral neuropathy","volume":"63","author":"Kazamel","year":"2021","journal-title":"Muscle Nerve"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1007\/s12035-023-03342-7","article-title":"Oxidative stress in diabetic peripheral neuropathy: Pathway and mechanism-based treatment","volume":"60","author":"Lin","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Andr\u00e9-L\u00e9vigne, D., Pignel, R., Boet, S., Jaquet, V., Kalbermatten, D.F., and Madduri, S. (2024). Role of oxygen and its radicals in peripheral nerve regeneration: From hypoxia to physoxia to hyperoxia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042030"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrneurol.2013.227","article-title":"Advances in peripheral nerve regeneration","volume":"9","author":"Scheib","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1002\/fsn3.1620","article-title":"Moringa oleifera Lam. ameliorates the muscles function recovery following an induced insult to the sciatic nerve in a mouse model","volume":"8","author":"Razzaq","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.7150\/ijbs.35653","article-title":"Current status of therapeutic approaches against peripheral nerve injuries: A detailed story from injury to recovery","volume":"16","author":"Hussain","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Stromsnes, K., Lagzdina, R., Olaso-Gonzalez, G., Gimeno-Mallench, L., and Gambini, J. (2021). Pharmacological properties of polyphenols: Bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081074"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ajcn\/nqz328","article-title":"Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts and Healthy Aging (WAHA) study: A randomized controlled trial","volume":"111","author":"Rajaram","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Muratori, L., Fregnan, F., Maurina, M., Haastert-Talini, K., and Ronchi, G. (2022). The potential benefits of dietary polyphenols for peripheral nerve regeneration. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095177"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Restani, P. (2020). Polyphenol-rich foods for human health. Nutrients, 12.","DOI":"10.3390\/nu12123738"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111729","DOI":"10.1016\/j.biopha.2021.111729","article-title":"Mechanistic insights and perspectives involved in neuroprotective action of quercetin","volume":"140","author":"Grewal","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bellavite, P. (2023). Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action. Antioxidants, 12.","DOI":"10.3390\/antiox12020280"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6038996","DOI":"10.1155\/2022\/6038996","article-title":"Flavonoids as promising neuroprotectants and their therapeutic potential against Alzheimer\u2019s disease","volume":"2022","author":"Minocha","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1017\/S0007114515002950","article-title":"Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: A randomised double-blinded placebo-controlled cross-over trial","volume":"114","author":"Burak","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16210","DOI":"10.1038\/s41598-019-52736-y","article-title":"Isorhamnetin alleviates steatosis and fibrosis in mice with nonalcoholic steatohepatitis","volume":"9","author":"Ganbold","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110301","DOI":"10.1016\/j.biopha.2020.110301","article-title":"Isorhamnetin: A review of pharmacological effects","volume":"128","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12032-023-02050-5","article-title":"Isorhamnetin exerts anti-tumor activity in DEN + CCl4-induced HCC mice","volume":"40","author":"Sarkar","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Alqudah, A., Qnais, E.Y., Wedyan, M.A., Altaber, S., Bseiso, Y., Oqal, M., AbuDalo, R., Alrosan, K., Alrosan, A.Z., and Bani Melhim, S. (2023). Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet\/Streptozotocin Diabetic Mice Model. Molecules, 28.","DOI":"10.3390\/molecules28020502"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, J., Yuan, H., Zhao, Z., Li, L., Li, X., Zhu, L., Wang, X., Sun, P., and Xiao, Y. (2022). The mitigative effect of isorhamnetin against type 2 diabetes via gut microbiota regulation in mice. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1070908"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s11064-016-1904-2","article-title":"Treatment with isorhamnetin protects the brain against ischemic injury in mice","volume":"41","author":"Zhao","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_28","first-page":"707","article-title":"Improved gut microbiota escalates muscle function rehabilitation and ameliorates oxidative stress following mechanically induced peripheral nerve injury in mice","volume":"43","author":"Jabeen","year":"2023","journal-title":"Pak. Vet. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e08281","DOI":"10.1016\/j.heliyon.2021.e08281","article-title":"The role of exercise on peripheral nerve regeneration: From animal model to clinical application","volume":"7","author":"Maugeri","year":"2021","journal-title":"Heliyon"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, M., Li, L., An, H., Zhang, P., and Liu, P. (2021). Repair of peripheral nerve injury using hydrogels based on self-assembled peptides. Gels, 7.","DOI":"10.3390\/gels7040152"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jnr.24538","article-title":"Peripheral nerve injury and myelination: Potential therapeutic strategies","volume":"98","author":"Modrak","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/fsn3.2033","article-title":"Methanolic extract of fennel (Foeniculum vulgare) escalates functional restoration following a compression injury to the sciatic nerve in a mouse model","volume":"9","author":"Maqbool","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5455\/jice.20170403094055","article-title":"Phytochemical screening and study of antioxidant, antimicrobial, antidiabetic, anti-inflammatory and analgesic activities of extracts from stem wood of Pterocarpus marsupium Roxburgh","volume":"6","author":"Pant","year":"2017","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101709","DOI":"10.1016\/j.jchemneu.2019.101709","article-title":"Isorhamnetin exerts neuroprotective effects in STZ-induced diabetic rats via attenuation of oxidative stress, inflammation and apoptosis","volume":"102","author":"Baluchnejadmojarad","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.4314\/tjpr.v19i9.15","article-title":"Ferula asafoetida Linn. is effective for early functional recovery following mechanically induced insult to the sciatic nerve of a mouse model","volume":"19","author":"Kamran","year":"2020","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jff.2015.02.005","article-title":"Flavanone naringenin: An effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats","volume":"14","author":"Priscilla","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_37","first-page":"648","article-title":"Isorhamnetin prevents H2O2-induced oxidative stress in human retinal pigment epithelial cells","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Rubio, C.P., Hern\u00e1ndez-Ruiz, J., Martinez-Subiela, S., Tvarijonaviciute, A., and Ceron, J.J. (2016). Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: An update. BMC Vet. Res., 12.","DOI":"10.1186\/s12917-016-0792-7"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lee, K.H., Cha, M., and Lee, B.H. (2020). Neuroprotective effect of antioxidants in the brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197152"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4306\/pi.2015.12.2.260","article-title":"Serum S100B protein levels in patients with panic disorder: Effect of treatment with selective serotonine reuptake inhibitors","volume":"12","author":"Kaya","year":"2015","journal-title":"Psychiatry Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/37.4.2926122","article-title":"Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves","volume":"37","author":"Spreca","year":"1989","journal-title":"J. Histochem. Cytochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e2004433","DOI":"10.1002\/advs.202004433","article-title":"Cytokines: From clinical significance to quantification","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"119089","DOI":"10.1016\/j.jep.2024.119089","article-title":"HPLC-PDA and in vivo anti-inflammatory potential of isorhamnetin-3-O-\u03b2-D-glucoside from Zygophyllum simplex L.","volume":"338","author":"Alonazi","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10258","DOI":"10.1523\/JNEUROSCI.2085-17.2017","article-title":"Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration","volume":"37","author":"Lindborg","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.2106\/JBJS.G.00557","article-title":"Erythropoietin accelerates functional recovery after peripheral nerve injury","volume":"90","author":"Elfar","year":"2008","journal-title":"J Bone Joint Surg Am."},{"key":"ref_47","first-page":"785","article-title":"Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates haemoglobin level following an induced injury to sciatic nerve in mouse model","volume":"32","author":"Aziz","year":"2019","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/fsn3.3255","article-title":"Comparative evaluation of ethyl acetate and n-hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion","volume":"11","author":"Maqbool","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Muzammil, S., Neves Cruz, J., Mumtaz, R., Rasul, I., Hayat, S., Khan, M.A., Khan, A.M., Ijaz, M.U., Lima, R.R., and Zubair, M. (2023). Effects of drying temperature and solvents on in vitro diabetic wound healing potential of Moringa oleifera leaf extracts. Molecules, 28.","DOI":"10.3390\/molecules28020710"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1002\/fsn3.2455","article-title":"Calotropis procera (leaves) supplementation exerts curative effects on promoting functional recovery in a mouse model of peripheral nerve injury","volume":"9","author":"Zafar","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_51","first-page":"231","article-title":"Indian ginseng (N.Hexane and Chloroform extracts) offers ameliorating effects on muscle functions restoration in a mouse model of peripheral nerve injury","volume":"18","author":"Sajid","year":"2021","journal-title":"Int. J. Biosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"396","DOI":"10.53350\/pjmhs22163396","article-title":"Thuja occidentalis L. expedites functional recovery after sciatic nerve crush injury in mice","volume":"16","author":"Naz","year":"2022","journal-title":"Pak. J. Med. Health Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jnutbio.2017.04.006","article-title":"Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL\/6J mice","volume":"46","author":"Chen","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jsps.2015.03.013","article-title":"Diabetes mellitus and oxidative stress\u2014A concise review","volume":"24","author":"Asmat","year":"2016","journal-title":"Saudi Pharm. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wu, R., Feng, J., Yang, Y., Dai, C., Lu, A., Li, J., Liao, Y., Xiang, M., Huang, Q., and Wang, D. (2017). Significance of serum total oxidant\/antioxidant status in patients with colorectal cancer. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170003"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.sjbs.2012.06.005","article-title":"Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats","volume":"19","author":"Khan","year":"2012","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Momo, C.M.M., Ferdinand, N., Bebe, N.K.O., Marquise, M.N.A., Augustave, K., Narcisse, V.B., Herve, T., and Joseph, T. (2019). Oxidative effects of potassium dichromate on biochemical, hematological characteristics, and hormonal levels in rabbit doe (Oryctolagus cuniculus). Vet. Sci., 6.","DOI":"10.3390\/vetsci6010030"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1292\/jvms.17-0387","article-title":"Evaluation of mouse red blood cell and platelet counting with an automated hematology analyzer","volume":"79","author":"Fukuda","year":"2017","journal-title":"J. Vet. Med. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0306-4522(98)00142-0","article-title":"Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats","volume":"87","author":"Pierce","year":"1998","journal-title":"Neuroscience"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/8\/3624\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:15:22Z","timestamp":1777090522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/8\/3624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27083624"],"URL":"https:\/\/doi.org\/10.3390\/ijms27083624","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]}}}