{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:41:10Z","timestamp":1785426070058,"version":"3.56.0"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DFG","award":["GA 654\/16-1"],"award-info":[{"award-number":["GA 654\/16-1"]}]},{"name":"DFG","award":["GA 654\/18-1"],"award-info":[{"award-number":["GA 654\/18-1"]}]},{"award":["GA 654\/16-1"],"award-info":[{"award-number":["GA 654\/16-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"award":["GA 654\/18-1"],"award-info":[{"award-number":["GA 654\/18-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glomeruli are signal-processing units of the olfactory bulb (OB) that play a key role in many OB computations, including contrast enhancement, gain control, and odorant-selective habituation. In awake mice, we unveil an extremely stable, inhomogeneous map of basal glomerulus-specific activity that serves as the background against which olfactory signal processing occurs. This activity is strongly driven by centrifugal cholinergic inputs; endogenous and airflow-evoked spiking of olfactory sensory neurons; and, to a minor extent, by the odor environment. Moreover, it is brain-state dependent and suppressed under various forms of anesthesia, and is therefore likely attenuated during sleep. These results reveal an important layer in the OB signal-processing network, likely increasing the system\u2019s variance and dynamic range via glomerulus-specific functional inhomogeneity.<\/jats:p>","DOI":"10.3390\/ijms27083684","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:45Z","timestamp":1776771765000},"page":"3684","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glomerulus-Specific Inhomogeneity of the Basal Activity Map in the Olfactory Bulb"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-9869","authenticated-orcid":false,"given":"Stefan","family":"Fink","sequence":"first","affiliation":[{"name":"Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Division Hearing, Cognition and Tinnitus, T\u00fcbingen Hearing Research Centre, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-4645","authenticated-orcid":false,"given":"Natalie","family":"Fomin-Thunemann","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Biomedical Engineering, Boston University, Boston, MA 02446, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-5168","authenticated-orcid":false,"given":"Farzin","family":"Kamari","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-7097","authenticated-orcid":false,"given":"Yury","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-5654","authenticated-orcid":false,"given":"Olga","family":"Garaschuk","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Department of Neurophysiology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/cne.21205","article-title":"Quantitative analysis of neuronal diversity in the mouse olfactory bulb","volume":"501","author":"Shipley","year":"2007","journal-title":"J. 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