{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:05:27Z","timestamp":1776791127695,"version":"3.51.2"},"reference-count":67,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Colorectal cancer (CRC) is the second most common cancer in Europe. There is a need to explore and validate new blood-based tumor markers to improve the selection of patients who are likely to benefit from an early, non-invasive diagnosis of CRC. The purpose of this report is to present the test protocol and its verification. The study is planned in four phases. The first trial phase involves collecting material, consisting of healthy tissue, diseased tissue, and plasma, from 120 CRC patients over 50 years old during surgery. This phase also involves identifying microRNAs (miRNAs) and comparing their expressed levels in colorectal cancer cells with those in healthy tissue taken from a standard resection margin. We detected measurable levels of miRNAs in tissue samples taken from patients, confirming that the material was correctly removed for testing. Statistically significant differences were obtained between healthy and cancerous tissue for selected miRNAs. Some of the selected miRNAs have higher expression levels in CRC tissue and could be potential candidate biomarkers for laboratory-based colorectal cancer diagnosis.<\/jats:p>","DOI":"10.3390\/ijms27083702","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:10:44Z","timestamp":1776787844000},"page":"3702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Preliminary Study for the Trial of Using Selected miRNAs for the Laboratory Diagnosis of Colorectal Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9223-6046","authenticated-orcid":false,"given":"Michal","family":"Sulikowski","sequence":"first","affiliation":[{"name":"Department of General, Mini-Invasive and Gastroenterological Surgery Clinic, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Sulikowski","sequence":"additional","affiliation":[{"name":"Department of General, Mini-Invasive and Gastroenterological Surgery Clinic, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Kurzawski","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-9627","authenticated-orcid":false,"given":"Damian","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Urasi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-346X","authenticated-orcid":false,"given":"Monika","family":"Rac","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref_1","first-page":"104","article-title":"Colorectal cancer statistics","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"5","article-title":"Cancer statistics","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/ijc.23388","article-title":"Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers","volume":"122","author":"Barault","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1399-0004.2006.00630.x","article-title":"Frequency and nature of hMSH6 germline mutations in Polish patients with colorectal, endometrial and ovarian cancers","volume":"70","author":"Suchy","year":"2006","journal-title":"Clin. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.dld.2011.10.010","article-title":"MicroRNA and colorectal cancer","volume":"44","author":"Manceau","year":"2012","journal-title":"Dig. Liver Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding RNA revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1073\/pnas.0307323101","article-title":"Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers","volume":"101","author":"Calin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs\u2014microRNAs with a role in cancer","volume":"6","author":"Slack","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.3748\/wjg.v20.i45.17011","article-title":"MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives","volume":"20","author":"Muhammad","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Seyhan, A.A. (2023). Circulating microRNAs as Potential Biomarkers in Pancreatic Cancer-Advances and Challenges. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713340"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc2867","article-title":"Genetic variation in microRNA networks: The implications for cancer research","volume":"10","author":"Ryan","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00439-013-1397-x","article-title":"MicroRNA-related sequence variations in human cancers","volume":"133","author":"Wojcicka","year":"2014","journal-title":"Hum. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1586\/14737159.2014.946907","article-title":"An update on microRNAs as colorectal cancer biomarkers: Where are we and what\u2019s next?","volume":"14","author":"Okugawa","year":"2014","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Rac, M. (2024). Synthesis and Regulation of miRNA, Its Role in Oncogenesis, and Its Association with Colorectal Cancer Progression, Diagnosis, and Prognosis. Diagnostics, 14.","DOI":"10.3390\/diagnostics14131450"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.3748\/wjg.v22.i23.5317","article-title":"MicroRNAs: Novel immunotherapeutic targets in colorectal carcinoma","volume":"22","author":"Li","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/gcc.20844","article-title":"MicroRNAs and colon and rectal cancer: Differential expression by tumor location and subtype","volume":"50","author":"Slattery","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1248\/bpb.29.903","article-title":"let-7 microRNA functions as a potential growth suppressor in human colon cancer cells","volume":"29","author":"Akao","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1093\/annonc\/mdv285","article-title":"Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: Results of the EXPERT-C trial","volume":"26","author":"Sclafani","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1159\/000493818","article-title":"miR-128 Targets the SIRT1\/ROS\/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis","volume":"49","author":"Lian","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/onc.2008.474","article-title":"Role of miR-143 targeting KRAS in colorectal tumorigenesis","volume":"28","author":"Chen","year":"2009","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1038\/onc.2014.348","article-title":"miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II\/III colorectal cancer","volume":"34","author":"Gao","year":"2015","journal-title":"Oncogene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1136\/gutjnl-2011-301846","article-title":"MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis","volume":"62","author":"Hur","year":"2013","journal-title":"Gut"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/SLA.0b013e3182a6909d","article-title":"Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer","volume":"259","author":"Toiyama","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.3748\/wjg.v24.i27.2949","article-title":"MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside","volume":"24","author":"To","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1136\/gut.2008.167817","article-title":"Differential expression of microRNAs in plasma of patients with colorectal cancer: A potential marker for colorectal cancer screening","volume":"58","author":"Ng","year":"2009","journal-title":"Gut"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ijc.25007","article-title":"Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer","volume":"127","author":"Huang","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1440-1746.2010.06417.x","article-title":"Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression","volume":"25","author":"Pu","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cheng, H., Zhang, L., Cogdell, D.E., Zheng, H., Schetter, A.J., Nykter, M., Harris, C.C., Chen, K., Hamilton, S.R., and Zhang, W. (2011). Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017745"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000463387","article-title":"Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer","volume":"92","author":"Tsukamoto","year":"2017","journal-title":"Oncology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"43393","DOI":"10.1038\/srep43393","article-title":"MiR-139-5p as a novel serum biomarker for recurrence and metastasis in colorectal cancer","volume":"7","author":"Miyoshi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.3748\/wjg.v21.i27.8284","article-title":"MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity","volume":"21","author":"Hollis","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"22996","DOI":"10.18632\/oncotarget.4035","article-title":"MicroRNA-143 is a putative predictive factor for the response to fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer","volume":"6","author":"Simmer","year":"2015","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.biopha.2017.11.046","article-title":"MicroRNAs as novel biomarkers for colorectal cancer: New outlooks","volume":"97","author":"Shirafkan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.biopha.2016.09.099","article-title":"The role of microRNAs in colorectal cancer","volume":"84","author":"Mohammadi","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1080\/14737159.2023.2290646","article-title":"Progress in the field of noninvasive diagnostics for colorectal cancer: A systematic review for the accuracy of blood-based biomarkers for detection of advanced pre-cancerous lesions","volume":"23","author":"Goyal","year":"2023","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"154670","DOI":"10.1016\/j.prp.2023.154670","article-title":"Role of miR-21 in the diagnosis of colorectal cancer: Meta-analysis and bioinformatics","volume":"248","author":"Li","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sur, D., Advani, S., and Braithwaite, D. (2022). MicroRNA panels as diagnostic biomarkers for colorectal cancer: A systematic review and meta-analysis. Front. Med., 9.","DOI":"10.3389\/fmed.2022.915226"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dansero, L., Ricceri, F., De Marco, L., Fiano, V., Nesi, G., Padroni, L., Milani, L., Caini, S., Masala, G., and Agnoli, C. (2022). Investigating the Role of Circulating miRNAs as Biomarkers in Colorectal Cancer: An Epidemiological Systematic Review. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092224"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.31557\/APJCP.2024.25.6.1903","article-title":"Diagnostic and Prognostic Value of miR-451 Expression in Colorectal Cancer: A Meta-Analysis","volume":"25","author":"Koushki","year":"2024","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2217\/epi-2021-0277","article-title":"The prognostic role of miR-31 in colorectal cancer: The results of a meta-analysis of 4720 patients","volume":"14","author":"Moloudizargari","year":"2021","journal-title":"Epigenomics"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Shi, X., Zhao, X., Xue, J., and Jia, E. (2024). Extracellular vesicle biomarkers in circulation for colorectal cancer detection: A systematic review and meta-analysis. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12312-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.21873\/anticanres.17758","article-title":"Oncological Outcomes of Varying Resection Margin Lengths in Colon Cancer Surgery: A Retrospective Analysis","volume":"45","author":"Kimura","year":"2025","journal-title":"Anticancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17404","DOI":"10.18632\/oncotarget.3744","article-title":"MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1","volume":"6","author":"Ma","year":"2015","journal-title":"Oncotarget"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.yexcr.2017.05.021","article-title":"MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor","volume":"357","author":"Islam","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_47","first-page":"4064","article-title":"miR-361 enhances sensitivity to 5-fluorouracil by targeting the FOXM1-ABCC5\/10 signalling pathway in colorectal cancer","volume":"18","author":"Zhang","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/abbs\/gmq125","article-title":"miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines","volume":"43","author":"Chai","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.299.4.425","article-title":"MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma","volume":"299","author":"Schetter","year":"2008","journal-title":"JAMA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21098","DOI":"10.1073\/pnas.1015541107","article-title":"MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)","volume":"107","author":"Valeri","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jso.23415","article-title":"Prognostic implications of serum microRNA-21 in colorectal cancer","volume":"108","author":"Padilla","year":"2013","journal-title":"J. Surg. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ogata-Kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., Gunji, T., Ohta, H., Okamoto, H., and Sonoda, H. (2014). Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092921"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Campayo, M., Navarro, A., Benitez, J.C., Santasusagna, S., Ferrer, C., Monzo, M., and Cirera, L. (2018). Mir 21, mir-99b and mir-375 combination as predictive response signature for preoperative chemoradiotherapy in rectal cancer. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206542"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/jcb.24721","article-title":"MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1\/caspase-9 apoptotic pathway in colorectal cancer cells","volume":"115","author":"Shang","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.3892\/ol.2016.5265","article-title":"Downregulation of mir-23b in plasma is associated with poor prognosis in patients with colorectal cancer","volume":"12","author":"Kou","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12964-023-01106-3","article-title":"MiRNA-93: A novel signature in human disorders and drug resistance","volume":"21","author":"Hussen","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_57","first-page":"65","article-title":"Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3","volume":"39","author":"Chen","year":"2020","journal-title":"J. Exp. Clin. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molonc.2013.09.001","article-title":"Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment","volume":"8","author":"Kjersem","year":"2014","journal-title":"Mol. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/gcc.20580","article-title":"Deregulated expression of miR-106a predicts survival in human colon cancer patients","volume":"47","author":"Silva","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/CAD.0000000000000049","article-title":"Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy","volume":"25","author":"Zhang","year":"2014","journal-title":"Anticancer Drugs"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/15384101.2022.2029240","article-title":"MiR-130b-3p promotes colorectal cancer progression by targeting CHD9","volume":"21","author":"Song","year":"2022","journal-title":"Cell Cycle"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3892\/or.2012.2059","article-title":"microRNA-181a is associated with poor prognosis of colorectal cancer","volume":"28","author":"Nishimura","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1158\/1078-0432.CCR-12-3302","article-title":"The prognostic value of microRNAs varies with patient race\/ethnicity and stage of colorectal cancer","volume":"19","author":"Bovell","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_64","first-page":"317","article-title":"Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer","volume":"3","author":"Nakajima","year":"2006","journal-title":"Cancer Genom. Proteom."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molonc.2013.09.004","article-title":"miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase","volume":"8","author":"Zhou","year":"2014","journal-title":"Mol. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"78598","DOI":"10.18632\/oncotarget.20009","article-title":"Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer","volume":"8","author":"Takano","year":"2017","journal-title":"Oncotarget"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/2211-5463.12623","article-title":"microRNA-222 promotes colorectal cancer cell migration and invasion by targeting MST3","volume":"9","author":"Luo","year":"2019","journal-title":"FEBS Open Bio"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/8\/3702\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:14:22Z","timestamp":1776788062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/8\/3702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":67,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ijms27083702"],"URL":"https:\/\/doi.org\/10.3390\/ijms27083702","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}